LIMITS OF FUNCTIONS "CALCULATION OF LIMITS IN THE

APPLICATION OF DRUGS".

UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO.

FACULTY OF CHEMISTRY AND PHARMACOBIOLOGY.
DIFFERENTIAL CALCULUS.
JOEL ARTURO RODRÍGUEZ CEBALLOS.
GUADALUPE NATALY MARTÍNEZ HERRERA.
SECTION 13.
MORELIA, MICHOACÁN. 09/01/2024.
1 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.

INDEX.

1. SYNOPSIS.
2. INTRODUCTION.
2.1 BOUNDARY DEFINITION.
2.2 CONSIDERATIONS
WHEN DOING THE
CALCULATIONS.
2.3 STRATEGIES FOR
BETTER RESULTS.
2.4 MANDATORY APPEALS
ON DOSING.
3. METHODOLOGY.
3.1 NOAEL SYSTEM.
3.2 HOW CAN A DRUG LIMIT
BE CALCULATED?
4. DISCUSSION.
5. CONCLUSION.
6. BIOGRAPHIES.
2 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.

1. SYNOPSIS. where mathematics plays its role,

because thanks to the formulas and
Since time immemorial, mathematics methods developed to calculate limits
and its applications have been a and graph them, the strategies for
fundamental part of life, helping the vast applying drugs to the population have
majority of sciences to better understand been improved.
the world and its phenomena.
And the topic that we will talk about in this
section is no exception, since it is about 2. INTRODUCTION.
the well-known "limits of functions",
which have the peculiar characteristic of
being able to be calculated and that in the 2.1 DEFINITION OF LIMIT.
pharmacological field are of great
In order to study the subject in depth, it is
importance at a professional level and it
important to know certain concepts such
is even a requirement for some to be able
as what a limit is, In a mathematical
to master these calculations to perform a
sense, we can define the limit of a
good job in their working life.
function at a point as the place to which
That said, this type of knowledge is the value of the function is directed when
integrated into daily life for those the independent variable approaches a
professionals who make up the health certain value or informally we can
area, mainly for doctors, nurses, express it as a place within the function
pharmaceutical industries, etc. Since to which we can approach as close as
they are the ones who control and possible or even getting to the exact
manage medications and who have the point, as shown in the example below.
knowledge of the quantities or doses that Figure 1.𝑓(𝑥)(𝑥)
must be indicated when such
medications are consumed.
It is well known that the main function of
medicines is to improve the health of the
person who consumes them, or to help
their body to generate defenses, thus
defining that their objective is merely
beneficial, however, there are also
certain disadvantages to the
inappropriate consumption of these.
Figure 1. Graph of the function, boundary at a point.
In the past, there have been several
complications in people's health due to
medication overdose, and this is due to
the lack of information that people have
due to not knowing the adverse factors
and the limits that they have. This is
3 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.
2.2 CONSIDERATIONS IN
MAKING CALCULATIONS.
Now that we know the concept of limit
and have a clearer idea of how it works
and how it works, we can focus a little
more on its objective in the field of
medicine, emphasizing the application of
medicines.
Within medicine, the calculation of limits
is usually used to measure the desired
amount to apply to a patient, taking into
account physiological factors such as the
age of the person, weight and height, as
well as evaluating the medication that will
be applied, from its conservation and
proper handling, taking care that it is safe
and that it does not cause adverse
effects such as allergies and other
reactions in the body.
2.3 STRATEGIES FOR BETTER
RESULTS.
One way to get good results starts mainly
with the organization of the data, and with
a previous investigation or diagnosis of
the patient's medical history, to evaluate
the chances that the medication that will
be applied later will not cause harm.
Since you must evaluate as much data
as possible to obtain a smaller margin of
error.
2.4 MANDATORY APPEALS ON
DOSING.
It is worth mentioning that all
pharmaceutical industries are obliged to
comply with certain standards and rules
that they must adhere to when creating
their medicines, and this refers
specifically to the dosage or quantity that
the drug must contain to be on sale, the
same data that must be visible on the
packaging of the medicine.
The standards to which the
pharmaceutical industries adhere are
mandatory, since the maximum and
minimum points for the dosage of drugs
had to be considered. Figure 2. Data that
had to be obtained from the graphing,
tabulation, and performance of the limit
calculation of a specific function, taken by
the industry for the creation of its product.
Figure 2. Dosing in the active dispensing protocol.
4 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.

3. METHODOLOGY. 3.2 HOW CAN A DRUG

That said, we will rely on an effective
LIMIT BE
method to properly calculate the dosages CALCULATED?
and that the results of the calculation limit
For a limit to exist, two important
of our functions are respected, since
there is a wide variety of problems conditions must first be met:
related to an incorrect dosage, and there • That there are
are notorious variations between the lateral
dose prescribed by the doctor, the dose
boundaries on
administered, etc. the concentration on
the left and on
the site of action and the intensity of the
effect. However, the aim is not to achieve the right.
intoxication but to help with the patient's • Let the
improvement, and we will rely on the boundaries be
NOAEL system. equal.
The following case arises: The function
𝑦 = 100(0.74)𝑡 where it represents
3.1 NOAEL SYSTEM. milligrams and hours determines the
concentration of a drug in a patient.𝑦𝑡
The NOAEL system refers to an How much of the drug does the patient have
abbreviation (no observed adverse effect after 6 hours?
level) and refers to the highest amount or
"limit" of quantity of a substance, in which The function is an exponential function, to
there are no adverse effects that can be determine the amount of drug the patient
detected in a population that has already has, after 6 hours, the value of 6 can be
been exposed. taken to 6.𝑦𝑡 =

Generally, the limit value of an active

ingredient would be established from the 𝑦 = 100(0.74)6
NOAEL, in addition to other parameters.
The following formula was used for the 𝑦 = 100(0.265095)
calculation of limit values: 𝑦 = 26.5095
NOEL (mg/Kg/día) · 70 (Kg)
Valor límite = (1)
10 (m3 /día) · FS
5 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.

4. DISCUSSION. 5. CONCLUSION.

Finally, after the careful analysis

Limits allow us to estimate how high the
that was carried out when carrying
properties of a specific subject are, and
out this research, we can
they are very useful for the well-being of
conclude that limits are a
human beings, and thanks to them,
fundamental part of life, and
people's health has improved a lot in
human beings apply them mainly
recent years, as the advances and tests
in the manufacture of drugs and in
that are carried out little by little improve
their dosage, adhering to strict
in terms of their techniques.
rules and norms established
The number of cases of drug poisoning nationally and internationally.
has been reduced. Doctors should be Limits allow us to calculate the
trained on the subject and make prior values closest to a specific point,
analyses for a better evaluation, since without reaching it exactly, making
the calculation of limits is not a subject it known that the lateral values
that can be taken lightly, but it is not very when evaluated in a graph or
complicated either. tabulation (ways of representing
the limits) must both be the same.
It is thanks to the implementation of the
NOAEL system that, by means of its
formula, we can have a value, range, or
limit of application.
6 CALCULATION OF LIMITS IN THE APPLICATION OF DRUGS.

6. BIBLIOGRAPHIES.
https://www.elsevier.es/es-revista-offarm-4-
articulo-dosificacion-margenes-terapeuticos-
13088618

https://explorable.com/es/redacta-un-articulo-
de-investigacion

https://www.superprof.es/apuntes/escolar/mat
ematicas/calculo/funciones/formulas-de-
calculo-de-limites.html

https://obstevida.blogspot.com/2011/08/aplica
cion-matematica-en-la-medicina.html

https://es.khanacademy.org/math/ap-calculus-
ab/ab-limits-new/ab-1-2/a/limits-
intro#:~:text=Los%20l%C3%ADmites%20describ
en%20c%C3%B3mo%20se,base%20de%20todo
%20el%20c%C3%A1lculo.

https://www.salusplay.com/blog/como-calcular-
la-dosis-exacta-de-medicamentos/