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Final Revision 1 Sec
Final Revision 1 Sec
Somatic cell Sex cell Pair no. (23): Sex chromosomes (Male or
Number of Female):
2 N (46) N (23)
Notes of chromosomes no. (23):
chromosomes
• Follows pair (7) in size, but its order is (23)
Cell division Mitosis Meiosis
• In male: It’s heterozygous XY
Kidney’s cell Gametes
• In Female: It\s homozygous XX
Example – liver’s cell – In Male: Sperm
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skin’s cell In Female: Ova
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Genes: Sequence of Nucleotides on DNA molecule members of Same kind proved that chromosomes
that represent a code for a certain protein that are carry genetic information
gene that are found at the same place on a Pea Plant 14 Wheat plant 42
Hen 32 Dog 78
4) Chromosomal Theory
➢ Principles of Theory
genes.
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5) Mendel’s Law of inheritance B- Mendel’s Second Law
Laws of Mendel based on Chromosomal Theory (Law of independent assortment)
In 1860, G.Mendal reach to the following Concepts • Occurrence: When crossing two pure individuals
after his experiments on Pea plant : that are different in two pairs or more of
1) Each inherited trait is Controlled by one pair of different allelomorphic characters, each pair of
Genes, that may dominant or recessive characters is inherited independently (because
2) Each pair of Trait is Called Allelomorphic every gene exists on an independent
characters chromosome)
A- Mendel’s First law (Law of segregation) • Ratio:
• Occurrence: Occur between two pure 1st generation: Two Dominant traits appears at ratio
allelomorphic character 2nd generation: Both the two Dominant and two
zygote of (2n)
• Ratio:
100%
dominant traits
recessive traits
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(3:1) ratio
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6) Non-Mendelian inheritance B) Inheritance of blood group in human
where NO one of them Dominates over the other, 1) Genetic classification of blood groups
this will lead to appearance of New character and There are three types of genes (alleles) (A, B, O),
this happens due to genes interaction carried on the 9th chromosomes pair in all humans.
Ratio 100% AA , AO A
BB , BO B
2nd Generation: 1 : 2 : 1 OO O
25 % : 50% : 25% AB AB
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(antigen A, b)
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Rhesus Factor
absence of Antigen (A , B)
• Blood carries two kinds of antigens, which are:- 2) Blood group (A) is universal Receiver, due to
✓ Rh+ is Dominant over Rh– . 1) The blood group incompatible with his blood
• Role of Rhesus Factor in Pregnancy and delivery group, the symptoms appear on him as:
• If a (Rh+) man married a (Rh-) woman, and the 1- Headache 2- Chest pain 3- Shiver
of mother 7- Hypotension
• Immune system of Pregnant mother produce These Symptoms end with death
• If mother becomes pregnant with another baby, ❖ Hepatitis C (Transferred through blood only
antibodies (which )
red blood cells causing acute anemia to him, ✓ Free from pathogen, such as Virus
• Prevention:
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2) Determination of the type of blood group 2) Complementary Genes
• Agglutination reaction: Reaction between Antigen The inheritance of this trait is controlled by two
on RBCs and Antibodies found in plasma and may pairs of genes, and the appearance of dominant
• Steps of determining a blood group type gene at least in each pair, Otherwise opposite
1) Two drops Separately of blood from the recessive trait will appear.
2) We put (anti-a) on one drop and put (anti-b) on In 1st generation: 100 % Dominant Character
3) Mix each drop with Antibodies which it’s • Examples : Flower colour in Pea Flower ( sweet
placed Pea )
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3) Lethal genes 7) Effect of environmental conditions on
They are inherited genes when found in a pure state, actions of genes
they cause harms to the organism then lead to death some genes is affected by the factors surrounding
and representing 25 % of the offspring living organisms:
• Types and Examples: - Air pollutants - lack of oxygen - radiation
Dominant Lethal genes Recessive lethal genes - Environmental factors (Ex. Light – temperature).
Gene of: Gene of:
• Effect of light on appearance of chlorophyll
• Yellow fur colour in • Chlorophyll absence in
mice corn plant character in green plant :
• Bulldog strain in • Infantile dementia in
1) when put a group of wheat or corn grains in
cattles humans
lighted place and take care of them, it will grow
with green colour due to presence of chlorophyll
A) Dominant Lethal genes
(presence of light)
1) Yellow Fur colour in Mice
2) when put Same group of wheat or corn grains in
Occur when two mice crossing have a Heterozygous
1 Dark place and take care of them, it willl grow
yellow fur (Yy), the dead mice ( YY ) represent of
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with yellow colour then wilt and die, due to
offspring
absence of chlorophyll (absence of light)
❖ Notes:
1) the light is limiting factor of chlorophyll
formation gene
2) If the chlorophyll absence gene found in plant
it will die, even it put in light place
3) Internal Cabbage leaves are white-coloured
on contrast with external leaves which are
Yellow mice : Grey Mice green colour due to light factor and its effect
2 : 1
on Chlorophyll formation gene
B)
C) Recessive lethal genes
1) Chlorophyll absence in corn plant:
occur when some corn plant
carry hybrid Chlorophyll
gene (Cc), it will notice that
25% of offspring will wilt
and white-colour then dead
due to presence of
chlorophyll absence gene
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8) Sex Determination 9) Abnormal Chromosomal Cases
• Symptoms:
of Extra X
generating cell)
3) Tallness
4) Appearance of Feminine
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3) Down’s Syndrome (Mongolism) (1866) 1) In Drosophila insect
Normal Gametes + Abnormal gametes (either Thomas morgan Crossed a White-eye male with a
Male: (45 + XY) Female: (45 + XX) 2nd Generation: 3 : 1 ( 3 Red : 1 White )
So number of Chromosomes (47 chromosomes) • So the red-eye Colour is Dominant Over White-
• Sex of Fetus: Male or Female The Colour of eye is carried on Sex Chromosome ( X )
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Note:
There are Another Case called: Polyploidy
• Reason:
+X)
• Chromosomal Structure:
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1- Sex-Linked
2- Sex-influenced
3- Sex limited
Sex-linked
• Definition:
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2) In Human B) Haemophilia (Blood liquidity)
Chromosomes (X): Colour blindness, Haemophila, • Definition: Blood increase in Liquidity due to Lack
Muscle atrophy, Short-Sightedness of Some Substances That are necessary for blood
-------------------------------- clotting.
• Definition: Inability to distinguishing the Colours • Causes: If Recessive Gene Found in Pure State in
• Cause: If Recessive Gene Found in Pure State in • Ratio: When a healthy man married a hemophilic
• Ratio: When a Colour-blinded Male marry Healthy healthy and infected offspring
(XX)
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Sex-influenced Sex-limited
• Definition: they are Somatic traits that are • Definition: They are Traits Which there
carried on autosomes but their action affected appearance Limited on on Sex only, Due to Sex
by Sex Hormones which Secret From Gonads
hormones
• Examples:
• Examples:
In Animals: Presence of horns in cattles
1- Milk Production Trait
In Human: Baldness
In Females only due to Certain Female Sex
Hormones
1) Baldness
2- egg Laying trait
• It appear in Males rather Than Females ?
In Females of some birds and animals only due to
As it’s gene Carried on Autosomes and Must be
certain female Sex Hormone
dominant
3- Appearance of Beard
In male: One Dominant Gene is Enough and Male
In Males only, It’s one of the secondary sex
(Masculinity) Hormones.
Characters in male.
In female: Presence of both Dominant Genes
11) Medical Examinations before Marriage
Together
• Why (Causes) ?
• Difference between Genotype Male and female
1) To Be Sure that they are Free from Diseases:
Baldness
a- Genetic Diseases ( Thalassemia )
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12) Science and Technology in Genetics
Definition
Definition themselves Several Times ( DNA
Nucleus of each Somatic cell
Fragments )
( 60000 : 80000 )
• Sir Alec Jeffreys (1984-1985)
Discovering • 1983: Waston and Crick proved that
• At Leicester Univeristy in Lodon
genes carried on Double Helix DNA
• He Stated that these Squence is
• 1980: The Scientists discovered 450
Unique for one individual and
genes
Discovering
impossible to Be Similar in two
• Middle of eighties: The Number of Gene
Individuals, Except in Twins
that
➢ In Medicine: discovered
a) Study Genetic Diseases 1500 genes
b) Operation of tissues
implantation 1) Genetic Map: through it we can
Uses ➢ In Forensic Medicine: identify the genes causing the genetic
a) Identifying deformed carpses. diseases.
b) Tracing the missing Children
Uses
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Taxonomy
Robert Whittaker:
Put Modern classification system → Monera – Fungi – Protista – Plantae – Animalia
Viruses – Viroid – Prions do not subject to Robert Whittaker’s classification?
Because they have the characteristics of both living and nonliving things Monera
Kingdom Monera
✓ unicellular
✓ Don’t have many organelles
✓ Prokaryotic (DNA without nuclear membrane)
✓ Live alone or in colony مستعمرة
✓ Reproduce asexually by binary fission
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Kingdom Protista
✓ Similar to plant and animal but not complex so, they may contain cell wall and plastids
✓ Unicellular or multicellular
✓ Eukaryotic (has nucleus)
✓ Live alone or in colony
✓ Reproduce Asexually or Sexually
Animal-like organisms
Phylum: Protozoa
Class Sarcodina Ciliophoran Flagellate Sporozoan
Pseudopodia رجل
Move by Cilia شعر قصي Flagella ذيل Don’t move
كاذبة
Trypanosoma Plasmodium
Amoeba Paramecium
(Sleeping disease) (Malaria disease)
Example
Plant-like organisms
Phylum: Euglenophyta – Example: Euglena
• Contain chloroplast
• Move by flagella.
• Has eye spot
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•
•
Kingdom: Fungi
Unicellular or majority multicellular
Consists of Hypha filament which form mycelium
Eukaryotic (DNA inside nuclear membrane)
Live alone or in colony
Reproduce asexually by spores or sexually
Cell wall: lignin and chitin
Nutrition: Heterotrophic ( parasites and other saprophyte)
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Kingdom: Plantae
Multicellular
Eukaryotic
Cell wall consists of cellulose
Contain chloroplasts
Reproduce majority Sexually or asexually by Spores
1-Higher algae
Phylum: Rodophyta – Example: polysiphonia
- Contain filaments attached by gelatinous membrane )ملزق
- Contain red pigment
– Example:
- Flat (as riccia)
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3- Vascular plants → Contain xylem or phloem
Phylum: Tracheophyte, has 3 classes:
Gymnospermae
Ferns (Filicatae) Angiospermae
(conifers)
Simple plant Simple plant Simple plant
Complete plant Complete plant Complete plant
Leave: pinnate Leave: Needle Leave: Parallel or Palmate
No flower No flower Has flower
No seed Seed has no cover Seed covered by testa
Reproduce by spores in their Reproduces sexually by
Reproduce sexually by cones
lower wall pollen grain and ova
Live in the valley and well
Most of them are trees Trees
walls
As: As:
- Polypodium - Pinus As:
- Adiantum - Peach
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Kingdom Animalia
Multicellular
Eukaryotic
Move ,Sense, ………
Reproduce Sexually and Asexually by budding and regeneration
Give reason: Sponge is animal although it doesn’t move and fixed on rock
Because it is multicellular, heterotrophic , with no cell wall and have some specific cells
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(6) Phylum: Arthropoda - Segmented - Has EXOSKELETON, has 4 classes:
-Cephalothorax
Head – thorax –
-abdomen -Cephalothorax
Body covered with a -abdomen
Head – trunk abdomen
chitinous cuticle
Three pairs
Wings: two pairs
house fly = one
Legs Joints Four pairs Many legs
pair)
ants =no wings,
One pair of
complex eyes and
Eyes Complex eyes Simple eyes ----------
one pair of
antenna
Gills Lung books Trachea Trachea
(7) Phylum: Mollusca – Example: Snails – Oyster – Octopus
- Soft mass
- Move by muscles called foot
- Contain sense organs
- Contain calcareous shells
- Contain Radula (tongue)
- Unisexual and few hermaphrodite
(8) Phylum: Echinodermata – Example: Starfish – Sea urchin – Sea cucumber
- Contain calcareous plates and spines
- Has ENDOSKELETON
- Has tube feet (arms = Suckers)
- Reproduce by regeneration if contain a part of its mouth - Sexually
- Has Oral side and Aboral side
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vertebrates فيها عمود فقري
(vertebral column = Notochord in fetus)
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Mammalia sub-classes
Prototheria Metatheria Eutheria
Lay eggs through cloacal Give not fully developed
opening (that passes wastes) young, kept in pouch Give fully developed young
but has a mammary gland يولد بدري بيكمل نمو الجنين في بتخلف و بترضع
بتبيض بس بترضع الكيس
As: Duck-pilled platypus As: Kangaroo
Has 11 order
Eutheria orders
Armadillo – Sloth ( (الكسالن
Edentate Animals without teeth
Animals feed on meat & have strong Seal – Cat – Dog – Tiger – Fox –
Carnivora molars and claws Wolf
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