Universal Access To Preferred Primary PCI For STEMI in Malaysia: It Is Time To Roll - Out A Sustainable Primary PCI Program

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Universal Access to Preferred Primary PCI for STEMI in Malaysia: It is time to


Roll-‐out a sustainable Primary PCI Program

Conference Paper · June 2015


DOI: 10.13140/RG.2.1.3715.4728

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Universal  Access  to  Preferred  Primary  PCI  for  STEMI  in  Malaysia:  
It  is  time  to  Roll-­‐out  a  sustainable  Primary  PCI  Program  
Dr  David  KL  Quek,  FRCP,  FNHAM,  FACC,  FESC  
NHAM  Pulse,  June  2015  
 

“I’ve got to defend my children, and yours, and do what’s right health facilities, there is currently no mechanism to ensure that
to save lives… Obesity (STEMI) kills. There’s no question it everyone could access the appropriate medical care without
kills… People are dying every day. This is not a joke. This is any worries about reimbursement or ability to pay.8 Some
about real lives.” ~ Mayor Michael Bloomberg.1 patients have to join long waiting queues and some acute
emergencies are offered sub-optimum therapies for want of
Our Disparate Access to Healthcare better expertise or amenity.
Malaysia is a middle-income economy in South-East Asia,
aspiring to become a fully developed nation by 2020. It has a Clearly we must consider embarking on a national program for
population of 30 million, of which some 70% live in urban greater health equity. But this should be achieved without
locations. Yet despite this aspiration to become fully economically burdening the public any more than it has thus
developed, both economically and also in terms of human far.9 Undoubtedly, legislative policy and regulatory
development, Malaysia has faltered in more ways than one. We frameworks need to be consistently and properly planned to
certainly can do much better. ensure better resource management of public funds, as well as
to rationalize private spending patterns.10 Note too that while
It is true that our primary health care system is among the best most nations enforce some sort of prepayment options and risk
in the world, one that is praised by W.H.O. and emulated by pooling reimbursement mechanisms,11 any new plan that
other less developed nations of the third world.2 But on the side demands or mandates more personal taxes or social/health
of tertiary healthcare, we appear to have stalled. On the one insurance premium contribution would be adversely received,
hand, we have all the state-of-the-art amenities and expertise if not downright rejected! A realignment and/or an increased
for almost every serious ailment including non-communicable reallocation of already budgeted public funds would be the way
diseases such as coronary artery disease and cancers; yet we forward. It is sobering to look at the newly imposed GST that
are grappling losing battles with rising cardiovascular diseases, has been roundly condemned as a regressive tax that is
hypertension, diabetes, obesity as well as communicable burdening the poorer segment more than the rich!12
diseases such as dengue, influenza and multi-drug resistant
tuberculosis.3,4 Unfortunately in Malaysia, most of the treatment pathways for
major illnesses have been defined by one’s ability to pay, i.e.
But for many, diagnostic and therapeutic services are still those with means, health insurance or with third party payer
rather sporadic, inconsistent and not uniformly accessible. options for reimbursement are those who can afford to seek
There are wide differences in service availability or quicker and timelier access to medical care at private health
accessibility among urban, suburban and rural-riverine facilities. Unfortunately this accounts for just around 14% of
communities, as well as intra-city disparities.5 Most of the the population as shown by our national health accounts data.13
urban areas are clearly very well equipped, but this does not As many as 37% or so pay out of pocket. On the other hand,
necessarily translate down into universal access and uniform Malaysians with more limited funds have little choice but to
medical care for everyone. Sadly there is a wide chasm of seek treatment at the hugely-subsidized or low-cost point-of-
service public
amenities, which are
already bursting at the
seams of demand
overload.14 For the
acute treatment of
some conditions,
speedy and universal
access to any
healthcare facility is a
must, if we are to
achieve a fair
modicum of best
practices in health care
as expected of a
modern state.

health outcomes being highest (worst) among the lowest Our less than stellar management of STEMI
income group when compared with the highest income group. The lacklustre treatment of heart attacks or ST-elevation
(See Table 1)6 A gap of nearly 14 to 19 years (male vs. Myocardial Infarction (STEMI) comes to mind when we
female) for life expectancy at birth between the lowest to the examine our NCVD data.15 Here, we have not progressed as
highest income group is unacceptable, and inequitable for a much as we would like to have. The majority of our acute
‘developed’ nation status! coronary syndromes especially STEMI are still treated with
medical only therapy or the less-than optimum fibrinolysis in
The sad aspect of our health system is that we are still stuck in 70% of the cases, with less than 10% being offered primary
the past, with no declared universal access to healthcare for all angioplasty (Primary Percutaneous Coronary Intervention or
our citizens and residents.7 Even if we accept that no one is PPCI). Another 20% or so receive no targeted treatment due to
ever turned away from treatment at most public hospitals and missed diagnosis or delay in first medical contact (FMC).
Malaysia’s Health Service under pressure… multiple factors: some from misdirection as to costs, but mostly
Malaysia spends a total of USD 12 billion per year (latest because of logistics mismatch, many of Malaysia’s heart attack
MYR 42.3 billion, 2012)13 on healthcare expenditure, through a patients still do not receive the best possible care i.e. timely
mixed reimbursement health system. The public-funded health primary angioplasty.
system caters to the bulk of the population. About 55% of the
total health budget comes from the public purse through tax So, as many as 70% of heart attack patients are only able to
revenue allocations, and are used to defray 70% of total access and receive fibrinolytic therapy (‘clot-busting’ therapy);
hospital admissions, as well as 30% of the total number of currently considered a second best option. Some 20% receive
primary care outpatient services. The other 45% of the no proper targeted treatment because of delay or access
country’s total health expenditure is provided by the private issues.15 Only 10% have access to primary angioplasty, which
sector on a fee-for-service mechanism, the bulk of which are is now globally regarded as the treatment of choice. Primary
through third-party-payer mechanisms including health angioplasties for heart attacks are projected to nearly halve the
insurers and employer-provided/subsidized Managed Care risk of death during hospitalization (4% vs. 7%), and over the
Organizations (MCOs).10 first year (7% vs. 12%) when compared to other treatment,
especially when these are carried out at accredited centres.18,19
Thus, wide disparity in timely access to the most advanced
forms of medical care is the norm in Malaysia. While basic At the current time in Malaysia, there is no national program to
health services are readily and universally accessible, tertiary address the issue of primary angioplasty as first choice for
and more advanced care is still sporadic and inconsistent, treatment of heart attacks (STEMI). The government-funded
depending to a large extent on locale, proximity, availability of public sector has always maintained a hands-off approach to
amenities/expertise and costs (who’s paying). By and large the coordinating or sharing of services with the private sector,
public sector provides a more limited and constrained basket of presumably because priorities elsewhere demand their greater
services, based on tight finite budgets, and more queue-based attention! Yet, there have been many areas and precedents
prioritization of needs and costs. Conversely the private sector where public-private sharing and cross-referrals have taken
provides facilitated access to more advanced technology and place, i.e. the shorthanded oncology and neurosurgical
modern state-of-the-art medical therapies on the basis of disciplines that regularly employ private specialists.
capacity of reimbursement, either via third party payers
(including self- or employer-provided health insurance Recently Institut Jantung Negara (IJN) our National Heart
schemes) or out-of-pocket means. Institute, has embarked on a collaborative strategy to involve
the Kuala Lumpur Hospital to strategize more timely referrals
Cardiology Services: public, academic vs. private of STEMI to its nearby facility. Furthermore, cardiology
Let’s consider a more focused area, i.e. Kuala Lumpur our services officials from the Ministry of Health for the Selangor
captial city. Greater Kuala Lumpur (‘the Klang Valley’) has 21 and Kuala Lumpur area have agreed on a more streamlined
cardiology centers with catheterization laboratories that can approach to refer STEMI patients to some public and academic
offer expertise and access for primary angioplasty for heart cardiac centers for PPCI where appropriate.
attacks. However of these 21 centers, only 5 are public sector
health facilities that are heavily subsidized for reimbursements Alas, private establishments have been omitted because of
of all health care costs. The other 16 centers are private concerns about reimbursement uncertainties. Sadly therefore,
hospitals that provide tertiary medical care on a fee-for-service this leaves out a chunk of the available private facilities and
model. However, only 12 of these 16 private medical centers expertise that can perform PPCI in a more efficient manner.
provide routine tertiary cardiology care and primary However, not long after these strategies have been mooted, the
angioplasty services. 16 About half of the 200+ accredited Health Ministry started issuing cost-cutting directives about not
specialist cardiologists in the country are located in the Klang referring patients across public-academic platforms, because
Valley, who are credentialed to perform angioplasty. this would increase costs for the federal government. The
reasons given were economic: budget cuts, belt-tightening to
But when it comes to seeking urgent treatment for STEMI, the mitigate our looming recession and address our runaway
luck of the draw determines who and where you are presented budget deficit concerns!20
to, especially for those without any prepayment plans of
reimbursement. The bulk of newly incident STEMI patients are Therefore, for heart attacks occurring among the public, there
referred to public centers where the overloaded system cannot is an implicit practice, based on some intra-governmental
guarantee the best approach possible, so it’s either just medical directive, for patients to be referred directly and only to the
therapy or fibrinolysis based on timing and availability. public medical centres. Such a practice or directive is however
shortsighted and inefficient, because it is fraught with logistic
It is sobering to note that Myocardial Infarction is still the
anomalies: more often than not, transfer and access is either
primary cause of death (30% of all deaths) in Malaysia for the
delayed, or in many cases, not available at all. This mismatch
past 35 years, over and above communicable infections and
of need vs. demand is due predominantly to limitations or
cancers. Heart attacks or ST-Elevation Myocardial Infarctions
constraints of bed- or CCU-availability, lack of available
(STEMI) are increasingly common and represent a serious
expert personnel, accustomed non-cardiologist physician-
cause of death in Malaysia, particularly in the major urban
decision bias, or perceived higher costs at private centers.
areas. Cardiovascular Diseases (CVD) accounted for 244,472
Therefore, for the capital city of Kuala Lumpur despite its
admissions or 7.44% of total admissions to Malaysia’s public
and private hospitals in 2012. In 2012, CVD accounted for higher GDP, there are not enough concerted efforts to organize
some 25.1% of all deaths among hospital admissions in the a coordinated response to address this issue of delay in access
to this lifesaving procedure.
country.17
So how can we achieve or perform better for STEMI Suboptimal Choice of Fibrinolytic Therapy: Of course, there
management? STEMI is best treated with early and timely is still a place for fibrinolytic therapy based on our curent CPG
primary angioplasty to re-open clogged-up heart arteries, to guidelines for STEMI. But this should not be the default first
help save and preserve heart muscle and function. PPCI has choice.21 Used as default first line therapy, many patients who
been shown to save more lives. Unfortunately because of could have been better treated with primary angioplasty, would
be denied this preferred mode of therapy. While also beneficial associated with unaffordable higher costs. Thus, most heart
when compared to no treatment at all, fibrinolytic therapy has attack patients are either self-referred or are preferentially
been shown to be inferior to primary angioplasty in short and channeled to ‘cheaper’ public hospitals and facilities by
long term results, in residual morbidity outcomes and even default. This is also true when ambulance services are called
deaths.22 Survival data suggest that primary angioplasty upon for emergency transfer. These default transfers have been
reduces by half the one-year mortality rate that which is known to cause great strains on the limited resources of these
achievable with fibrinolytic therapy, and that return to work heavily subsidized public centers, and result in bottlenecks of
and life functionality, quality of life is also superior. Cost- delayed or suboptimal care. Thus, we also need to address this
effectiveness measures also favor primary angioplasty in terms issue of engaging emergency and ambulance services as well
of longer-term costs of therapy and economic loss analysis.23 as primary care practitioners to enlighten them that we now
have a more concerted and integrated approach to optimum
According to our NCVD database, as many as 7-10 percent of STEMI therapy, regardless of costs.
heart attack patients in Malaysia still perish within the first 7
days of hospitalization (the rate for best global standards is So what can be done about the costing issue?
now around 5%); with the 30-day mortality rate ranging from
11-14 percent. The first year mortality rate averages 15-18 The Rationale of Bridging the Private-Public Gap
percent.15 These do not reflect the best practices achievable Is this current public-private dichotomy of care, and lack of
elsewhere, unfortunately. coordinated access viable or sustainable? Or can this be
mitigated? In West Jakarta, Indonesia, there is now an ongoing
Perhaps it is time to enact a pradgim shift in our dichotomous coordinated project (both public and private facilities) that
approach to treating STEMI for Malaysians. Could we not integrates all PCI-capable centers to engage in the best
establish and coordinate a program to help educate, facilitate optiumum treatment for STEMI.26
access, transfer as well as to integrate the various facilities to
ensure that as many people as possible with heart attacks can One suggestion for us here in Malaysia, is to set up a not-for
achieve this goal of timely access and therapy at the lowest profit but self-funding private-public financed corporation/
costs and best utilization of current resources, as best as consortium to develop a working cost-effective model and
possible? It is certainly doable if some common vision and integrated proposition to the health authorities. But we also
mission can be established to realize this win-win strategy for need buy-ins from healthcare payers (insurers, third party
all, especially for all our patients. payers, employer-health schemes, public sector health cost
allocation) on how to develop and execute a comprehensive
A Greater Kuala Lumpur Area/Klang Valley STEMI PPCI seamless system to ensure the best care for heart attack patients
Project? i.e. coordinated transfer of patients, providing well-trained
We could pilot this project to include all of Greater Kuala personnel, consistent and routine access to coordinated
Lumpur area or the Klang Valley, which has the metropolitan pathways, i.e. organizing cathlabs (cardiac catheterization
population of about 6.9 million, as of 2010. laboratories) to operate 24/7 for acute PCI, seamless structural
admission/registration mechanisms and integrated approaches
Costs of therapy: Since costs has always been a bugbear in including reimbursement models for timely primary
health access, we need to resolve this issue once and for all. angioplasty. The goal is for this improved system to be rolled
Treating a heart attack in the Klang Valley by primary out for action within a year or as soon as possible.
angioplasty costs approximately MYR 30,000 for a daytime
procedure with a single stent, standard medications, and a Social Impact Bonds: Possible Financing Model
routine uncomplicated hospital stay of 3-4 days.24 Care Recently there have been some touted new models of joint
requiring coronary artery bypass surgery (CABG) or during Public-Private Financing Initiatives, not just based on for-profit
off-office hours emergency setting can cost up to twice or three ventures, but also for social causes. This came about when
times as much, with an additional cost of MYR 8-10,000 per Corporate Social Responsibility (CSR) and grant giving are
additional stent used. Medical treatment of heart attacks using seen as one-off contributions that often do not see committed
fibrinolytic therapy costs an average of MYR 12,000 for the or measurable outcomes. So how about creating possible
acute hospital stay of 3-4 days, if the cheaper streptokinase is higher-risk “Pay for Success” joint venture models to help
used, MYR 16,000 for tenectaplase. However, because of bring about more accountability and measureable results?27
expected increased rates of recurrent events and complications
utilizing the fibrinolytic method, the overall total economic
costs are estimated to be 4 to 5 times the total cost of primary
angioplasty in the longer term, per incident STEMI.

Based on the (estimated) expected 1,750 heart attack patients


per year, the cost for optimal care via primary angioplasty for
in-hospital costs alone in the Greater KL area would be MYR
60 million.25 If we include logistics, transfers and other
complication costs, this could add conservatively another MYR
10 million. We estimate that the full one year integrated
program would cost around MYR 70 million for the Klang
Valley alone.

Logistics/Costs Access issues: So how do we address the


This began as an experimental model at Peterborough UK to
issues of cost and logistics, to facilitate that as many heart
help reduce the rate of ex-inmate recidivism in 2010, (via a £5
attack patients can gain timely access to preferred PPCI?
million fund from individual investors and Charities) and since
then has spread globally quite successfully.28 UK now has 14
First we must change people’s mindsets! More often than not,
public and payer preconceptions are that private healthcare are Social Impact Bond (SIB) Programs. The rationale is to have a
win-win approach at achieving targeted goals and measureable
outcomes, through unlocking private investments for social • Ultimately the benefits of early and best treatment of heart
outcomes (where governments would not have otherwise attacks for the patients would be manifest, as this will
funded, or whose priorities are elsewhere), using private risk translate into better longer-term outcomes, a healthier
investment ventures and government guarantees for above more productive population, as well as incurring lower
average returns on investment for success.29 total economic costs.

Although SIB programs have been used more for social


engineering initiatives, there are now SIBs for achieving better Proposals on Capital Needs and Other Resources
health outcomes too. The Fresno’s SIB Program30 for reducing
asthma in the community started in 2013 and is now another • Set up a holding corporation that will be the overall
success story that is leading to more such programs in the coordinating body to plan, obtain funding and liaise with
USA. In fact a Social Impact Bond Act is being proposed in the all the participating stakeholders, which will include the
USA, starting with a USD 300 million grant.31 Ministry of Health Malaysia, to include its public tertiary
hospitals with primary angioplasty amenities, academic
Using this SIB model it is possible to seriously consider medical centers and all private medical centers with
making this PPCI for STEMI work for all, at least until the similar capabilities within the greater Kuala Lumpur area
government feels the need and the urgency to totally finance (Klang Valley).
the costs of this best-practices program. As can be seen in the • Obtain a start-up fund with initial operating costs target of
model below, costs can actually be saved from the public MYR 10 million, to kick start the program, (from a
purse.27 seeding fund from the Ministry of Health from its annual
budget?) We should be able to achieve MYR 70 million
from other targeted sources for the initial first year with
coordinated, integrated and careful budgeting and
planning.
• From our Malaysian hospital utilization data,32 it is
suggested that some 70% of patients choose the public
sector hospitals because of cost considerations. This means
that the public purse would be brought to bear to
reimburse this program if this is shown to be true. But
because there are only 5 public/academic hospitals capable
of providing primary PCI, this will severely overload the
services of these hospitals. From our estimate of 1,750
heart attacks in the Klang Valley per year, some 1,225 or
some 3 to 4 patients would be presenting to these public
Source: Social Finance US centers every day! Therefore, this would be quite taxing on
these already short-handed resources!
• Disburse and distribute these heart attacks patients to the
Target Goals nearest available facility! This way we can spread these
• Ultimately the aim is to offer a sustainable timely, patients more widely and evenly so that every provider
coordinated, seamless and universal (‘all-comers’) access facility be they academic or private or public center, can
for the best current treatment of heart attacks that would cope and provide the necessary services of primary PCI in
benefit the 7 million population of the Greater Kuala as timely and expedient a manner as possible! That is why
Lumpur/Klang Valley. we need to take out the equation of reimbursement
• To achieve this, a reorganized (mixed) payment or consideration, and institute a mechanism to ensure that this
reimbursement model to help realize this goal will be is possible. When evenly distributed, the 17 centers would
made acceptable to the payers and stakeholdders for this each see an average of 105 patients a year, or one patient
healthcare initiative, i.e. this would include health in every 3 days. This then, should not be a burden to
insurance companies, other third party payers (TPP), and existing cardiac catheterization laboratory practices.
the Ministry of Health Malaysia. • Source funding or re-insurance from third party payers
• We must establish a cost-efficient structure for the more such as health insurers, managed care organizations,
systematic allocation of resources for both manpower and employer based health benefit managers.
facilities, as well as a re-definition of its policy goals with • Engage in a win-win dialogue with all private hospital
reference to this targeted niche area of healthcare. CEOs and practicing cardiologists to buy into this
• We can launch a Social Impact Bond initiative with program, with discussion on how to implement a case-mix
measurable targets to draw in investors both from funding mechanism on primary PCI for heart attacks, and
individuals as well as from charities and other corporate to come up with a per patient quantum of cost that is
players with CSR programs. acceptable. DRGs and global budgets per ailment comes to
• This will serve as a pilot template to roll-out nation-wide mind.
to improve the consistent delivery of better evidence-based • Tap into how to utilize ‘Social and Welfare contribution”
healthcare of heart attacks for Malaysians. (corporate social responsibility, CSR) funds (quantum to
be derived from Private Healthcare facilities by law)33 to
cater to other less endowed patients who do not have any
Value proposition for all: insurance or who may not be able to pay out of pocket, i.e.
so as to make this program all inclusive to benefit the
• This will enhance and raise the profile of the Health poorer patients among the public, in as wide an area as
Ministry as a policymaking and service provider possible. We must ensure that no one patient with a heart
• More if not all healthcare providers including cardiologists attack is turned away for lack of funding or reimbursement
would be engaged in this national exercise and duty of plans.
universal access to best care for STEMI
• Ensure transparency and clarity of purpose of being a non- • Lack of funding or commitment for agreed reimbursement
profit program, i.e. strive to keep the administrative costs plans most likely to involve DRGs or case-mix quanta of
of such a coordinated program to below 5-10% of the total disbursement.
costs. • Lack of support from the public sector to allow
• Engage all ambulance and emergency operators to engagement with the private sector especially with regards
coordinate how to transfer and deliver patients with heart to distributing and sharing patients or fund disbursement.
attacks to as expedient and quickly a manner as possible to • Lack of ministerial support to institute a mandatory
the nearest available resource facility. program of social welfare contribution or CSR funding
• Roll out a media blitz campaign to the public and also to from private healthcare facilities.
primary care physicians and clinics on how to implement • By utilizing the Social Impact Bond model of financing it
this program, with direct and timely referral to all is possible to mitigate against losses, but careful attention
participating facilities for primary angioplasty. to performance indicators, measureable indexes and costs
• Design and manage a comprehensive information and controls to prevent overruns are critical.
technology system to document and coordinate this • The actual number of heart attacks may be more than
program. We understand that there are some medical estimated, this could increase the overall costs for the
device companies with such programs that could be program a few fold, but the plan remains achievable based
purchased or sponsored with win-win initiatives and on a per pax reimbursement protocol with government
collaboration, e.g. Medtronics Inc. Hence the need to build guarantees and public purse disbursement and allocation.
smart partnerships with these companies on a shared • Ultimately the overall cost of health care cost caused by
benefit platform.34 heart attacks would be lower with better quality of life and
• Work with certain pharmaceutical companies to ensure survival without or with lower major adverse
that all patients receive the necessary anti-clotting (dual cardiovascular complications (MACCs).
antiplatelet therapy, DAPT) medications for a stipulated
minimum period 6 months to one year) for the best Conclusion
effects/outcomes to be realized following primary
angioplasty. Some of the newer antiplatelet agents are It is time for our cardiac fraternity to take the lead in
expensive and these can be negotiated with their establishing the best care strategy for our heart attack (STEMI)
manufacturers to agree on a minimum base price to benefit patients. We can make our heart care world class and at par
all patients.35 with the best outcomes, not just for a few privileged able-to-
• Involve and enlist our entire cardiology fraternity of pay patients, but for all. Let’s help realize this one niche aspect
Malaysia to support this program i.e. our National Heart of offering universal access for all, for the best (optimum)
Association of Malaysia (NHAM). Ensure that every one management of STEMI, and set an example of possible
of our cardiology fellows and members participate in healthcare excellence in this country, as we march toward
making this program a success. 2020!
• Take lead to organize and ensure adequate and continuous
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goal for all heart attack patients based on common good Monday  April7,  2014.  
principles. http://www.themalaymailonline.com/malaysia/article/think-­‐tank-­‐
spells-­‐out-­‐regressive-­‐hit-­‐in-­‐gst.  
                                                                                                                                                                                                                                                                                                                                                                                                                                           
13 32
 Jameela  Zainuddin,  Noryati  Yusof@Atan.  Malaysia  National  Health    Safurah  Jaafar,  Kamaliah  Mohd  Noh,  Khairiyah  Abdul  Mutatlib,  et  
Accounts  Health  Expenditure  Report  2007-­‐2012.   al.  (Ed.  Judith  Heath)  Malaysia  Health  System  Review.  Health  Systems  
www.moh.gov.my/.../554756755a584a6961585268626939515a5735 in  Transition  Vol.  3  No.  1,  2013;.  WHO  2012  
33
6c  Accessed  15  May  2015.    Private  HealthCare  Facilities  and  Services  Act  1998  (Act  586),  Part  
14
 The  Star:  Almost  3  million  treated  at  1Malaysia  clinics.  The  Star   XVII,  Article  105,  1-­‐4;  and  Private  Healthcare  Facilities  and  Services  
newspaper  website;,  Accessed  on  28  November  2011.  Available  at:   Regulations  [P.U.  (A)  138/2006],  Article  430,  1-­‐3  and  Article  431.  
34
http://thestar.com.my/news/story.asp?file=/2011/11/28/nation/996  Medtronics  Inc,  Global  Lumen  Initiative  
35
4890&sec=nation.    Pharma  Companies  that  produce  these  DAPT  e.g.  clopidogrel,  
15
 WA  Wan  Ahmad,  KH  Sim  (Eds.)  Annual  Report  of  the  NCVD-­‐PCI   ticagrelor  and  prasugrel  are  Sanofi,  AstraZeneca,  Eli  Lilly,  Winthrop,  
Registry,  2007-­‐2009.  NHAM,  CRC,  Ministry  of  Health  Malaysia,  Kuala   Sandoz,  Ranbaxy-­‐SunPharma,  Apotex.  
36
Lumpur,  Malaysia,  National  Cardiovascular  Disease  Database,  April    Jiri  Knot,  Petr  Widimsky,  William  Wijns,  et  al.  on  behalf  of  the  
2011.   “Stent  for  Life”  Initiative.  How  to  set  up  an  effective  national  primary  
16
 Invasive  Cardiovascular  Laboratories  in  Government  and  Private   angioplasty  network:  lessons  learned  from  five  European  countries.  
sector.  In  National  Heart  Association  of  Malaysia:  A  Heartfelt   EuroIntervention  2009;5:299-­‐309.  
37
Journey:  Celebrtaing  35  years.  Eds.  David  KL  Quek,  Robaayah  Z.    Bilkova  DM,  Motovska  Z,  Prochazka  B  et  al.  Transportation  to  
NHAM,  Kuala  Lumpur  2014,  pp161-­‐162   Primary  PCI,  compared  with  on-­‐site  fibrinolysis,  as  a  strong  
17
 Ministry  of  Health  Malaysia.  Health  Facts  2013.  Health  Informatics   independent  predictor  of  functional  status  after  myocardial  
Centre,  Planning  Division,  Kuala  Lumpur.  MOH/S/RAN?53.13  (TR)  July   infarction:  5-­‐year  follow-­‐up  of  the  PRAGUE-­‐2  trial.  Eur  Heart  J:  Acute  
2013.   Cardiovasc  Care;  Epub  ahead  of  print.  
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 Van  de  Werf  F,  Bax  J,  Betriu  A,  et  al.  Management  of  acute    Widimsky  P,  Bilkova  D,  Penicka  M,  et  al  for  the  PRAGUE  Study  
myocardial  infarction  in  patients  presenting  with  persistent  ST-­‐ Group  Investigators.  Long  term  outcomes  of  patients  with  acute  
segment  elevation:  the  Task  Force  on  the  Management  of  ST-­‐ myocardial  infarction  presenting  to  hospitals  without  catheterization  
Segment  Elevation  Acute  Myocardial  Infarction  of  the  European   laboratory  and  randomized  to  immediate  thrombolysis  or  
Society  of  Cardiology.  Eur  Heart  J  2008;29:2909-­‐2945.   interhospital  transport  for  primary  percutaneous  coronary  
19
 Stenestrand  U,  Lindback  J,  Wallentin  L.  Long-­‐term  outcome  of   intervention:  5-­‐years  follow-­‐up  of  the  PRAGUE-­‐2  trial.  Eur  Heart  J  
primary  percutaneous  coronary  intervention  vs  prehospital  and  in-­‐ 2007;28:679-­‐684.  
hospital  thrombolysis  for  patients  with  ST-­‐elevation  myocardial  
infarction.  JAMA  2006;296:1749-­‐1756.  
20
 Jennifer  Gomez.  Health  Ministry’s  budget  cut  will  not  affect  patient  
care,  says  minister.  The  Malaysian  Insider.  April  30,  2015.  
http://www.themalaysianinsider.com/malaysia/article/health-­‐
ministrys-­‐budget-­‐cut-­‐will-­‐not-­‐affect-­‐patient-­‐care-­‐says-­‐
minister#sthash.Dat0zJre.dpuf  
21
 NHAM,  AMM  &  MOH.  Clinical  Practice  Guidelines  for  acute  
th
management  of  STEMI,  3  Edition,  2014,  Kuala  Lumpur.  
MOH/P/PAK/276.14  (GU)  
22
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primary  angioplasty  versus  immediate  thrombolysis  in  acute  
myocardial  infarction:  a  meta-­‐analysis.  Circulation  2003;108:1809-­‐
1814.  
23
 Fazel  R,  Krumholz  HM,  Bates  ER  et  al.,  for  the  National  Registry  of  
Myocardial  Infarction  (NRMI)  Investigators.  Choice  of  reperfusion  
strategy  at  hospitals  with  primary  percutaneous  coronary  
intervention:  a  National  Registry  of  Myocardial  Infarction  Analysis.  
Circulation  2009;120:2455-­‐2461.  
24
 Hospital  cost  estimates  based  on  a  Klang  Valley  private  hospital:  
PPCI  STEMi  MYR  30,000;  CABG  (uncomplicated)  MYR  60,000.  
25
 Number  of  STEMi  estimated  from  NCVD  database  at  250  per  
100,000  population  oer  year.  For  the  nearly  7  million  in  the  Klang  
Valley,  this  would  be  1,750.  
26
 iSTEMI:  Indonesian  STEMI  Network  for  West  Jakarta  Program,  in  
collaboration  with  Medtronics  Global  STEMI  Initiative.  
www.isic.or.id/pages/istemi  
27
 Jon  Hartley.  Social  Impact  Bonds  are  going  mainstream.  Forbes,  
Sept  15,  2014.  http://onforb.es/10QyT4r.  
28
 Emma  Disley,  Jennifer  Rubin,  RAND  Europe.  Phase  2  report  from  
the  payment  by  results  Social  Impact  Bond  pilot  at  HMP  
Peterborough.  Ministry  of  Justice  Analytical  Series,  UK.  2014  
29
 Toby  Eccles,  creator-­‐founder  of  Social  Finance  and  SIB  model.  
http://www.socialfinance.org.uk/about-­‐us/board-­‐and-­‐team/  
30
 The  California  Endowment  Awards  Grant  to  Social  Finance  and  
Collective  Health.  Social  Finance  press  release,  March  25,  2015,  on  
the  Nonprofit  Finance  Fund  website,  
http://payforsuccess,org/sites/default/files/fresno_asthma_demonst
ration_project_press_release.pdf,  accessed  May  2015.  
31
 Social  Impact  Bond  Act.  
http://toddyoung.house.gov/uploads/Social%20Impact%20Bond%20
Act.pdf  

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