KARPAGAM COLLEGE OF PHARMACY

COIMBATORE - 32

VALUE ADDED COURSE MODULE - DEPARTMENT OF PHARM. CHEMISTRY

Course Title DISCONNECTION APPROACH IN ORGANIC SYNTHESIS

Course Code KCP/VAC/023 Course duration 30 h

Course Objective

This course aims to understand the oncepts and principle involved in retrosynthetic analysis; to
explore guidelines for dissection of molecules and One-Group and Two-group Disconnection approach;
to understand the types of selectivity and to study the retrosynthetic approaches for synthesis of complex
drug molecules

Course Outcome:

1 Gain a solid understanding of the fundamental concepts and principles of retrosynthetic analysis.

2 Acquire knowledge on the guidelines for dissection of molecules in retrosynthesis

34 Interpret the concepts of Functional group interconversion (FGI) and Functional group addition
FGA)

4 Aware of the types of selectivity. Regioselectivity, Stereoselectivity, Stereo-specificity and

Chemo-selectivity

5 Understand one-group and two-group disconnection approach

6 Adopt disconnection approaches for the synthesis of complex drug molecules

Module 1 Basic Principles and Guidelines (Theory) 6h

 Basic Principles: Synthons and Reagents.

 Guidelines for dissection of molecules.
 Functional group interconversion (FGI)
 Functional group addition (FGA)
Selectivity in Retro-analysis (Theory)

 Types of Selectivity in Retro-analysis

 Regioselectivity, Stereoselectivity, Stereospecificity
 Chemo-selectivity

Module 2 Disconnection approaches (Theory) 6h

 KARPAGAM COLLEGE OF PHARMACY
COIMBATORE - 32

 One-Group and Two-Group C-X Disconnections;

 One Group and Two Group C-C Disconnections
Ring synthesis (Theory)

 Strategies for synthesis of three and four membered rings

 Strategies for synthesis of five and six membered rings

Module 3 Retrosynthesis of NSAIDs (Practical) 6h

 Retrosynthetic approaches for synthesis of NSAIDs and confirmation of the by

melting point/ boiling point and TLC

Module 4 Retrosynthesis of Sulphonamides (Practical) 6h

 Retrosynthetic approaches for synthesis of Sulphonamides (Practical) and

confirmation of the product by melting point/ boiling point and TLC

Module 5 Retrosynthesis of CNS acting drugs (Practical) 6h

 Retrosynthetic approaches for synthesis of Sulphonamides (Practical) and

confirmation of the product by melting point/ boiling point and TLC