Ammonia is a waste product of protein catabolism. Ammonia is
metabolized exclusively in the liver through the urea cycle enzymes which convert ammonia into urea. Toxic build up of ammonia due to disruption of this metabolism produces neurotoxic effects. Elevated serum levels of ammonia indicate some form of liver failure.
Increased levels
. Congenital deficiency of Urea cycle enzymes
• Hepatic coma in terminal liver Cirrhosis • Acute fulminant hepatitis . Reye 's syndrome . Hepatic encephalopathy
Hyper - ammonemia may also be found with increasing dietary