Recommended MCQs - 237 Questions - Principles of

Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 1. Question 5.
Who was the first to use statistical analysis and Among the given pea plant traits identify the odd one
mathematical logics for solving biological problems?
(1) Violet flower
(1) Francis crick
(2) Yellow seed
(2) Gregor Mendel
(3) Yellow pod
(3) Hugo de vries
(4) Axial flower position
(4) W. Bateson

Question 6.
Question 2.
Mendel was born in
Gregor Mendel is known for
(1) 19th century.
(1) Species concept
(2) 18th century.
(2) Hybridisation experiments
(3) Discovery of chromosomes (3) 17th century.

(4) Experiments on maize plant (4) 20th century.

Question 3. Question 7.
The total number of pure lines prepared by Mendel for Our ancestors knew about the inheritance of characters
his hybridization experinent in garden pea plant for seven and variations because-
characters were
(1) They selectively breed plants and animals and
1. 7 selected for organisms that possessed desirable
characters.
2. 14
(2) They introduced mutations
3. 2
(3) They performed natural hybridisation
4. 22
(4) All of the above

Question 4.
Question 8.
How many pairs of contrasting traits studied by Mendel
were related to pod? Mendel's work on Pisum sativum shows that
(1) 1 1. Alleles show blending inheritance
(2) 2 2. F1 resembled either of the two parents
(3) 3 3. In a dissimilar pair of factors, members of the pair are
codominant
(4) 4
4. Genotype of F tall plant can be determined by cross
2

with recessive parent

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Question 9. Question 12.

Among the following characters, which one was not Mendel published his work on inheritance of characters
considered by Mendel in his experiments on pea? in 1865 but it remained unrecognised till 1900 because :-
(1) Stem - Tall or Dwarf (a) He could not provide any physical proof for the
existence of factors
(2) Trichomes - Glandular or Non-glandular (b) His concept of factors as stable, discrete units that
(3) Seed - Green or Yellow controlled the expression of traits did not find acceptance
from the contemporaries
(4) Pod - Inflated or Constricted (c) Mendel's approach of using mathematics to explain
biological phenomena was totally old
(d) Communication was not easy (as it is now)
Question 10. 1. (a), (b) & (c) are correct
In his classic experiments on pea plants, Mendel did not 2. (c) & (d) are correct
use
3. (a), (b) & (d) are correct
(1) seed colour
4. Only (a) is correct
(2) pod length
(3) seed shape
(4) flower position Question 13.
Which of the following is a recessive trait for a character
choosen by Mendel in garden pea?
Question 11. (1) Violet flower color
What was the most significant conclusion that Gregor (2) Yellow pod color
Mendel drew from his experiments with pea plants?
(3) Axial flower position
(1) There is considerable genetic variation in garden
peas. (4) Tall stem height

(2) Traits are inherited in discrete units, and are not the
results of ʺblending.ʺ
Question 14.
(3) Genes are composed of DNA.
Which of the following traits shows expression in only
(4) An organism that is homozygous for many recessive homozygous condition?
traits is at a disadvantage.
1. Yellow seed
2. Inflated pod
3. Axial flower
4. Wrinkled seed

Question 15.
Which of the following does not contribute to Mendel’s
success?
(1) Large sampling size
(2) Statistical analysis
(3) Performed experiments on single variety of pea
(4) Performed experiments on successive generations
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Question 16. Question 20.

What could be the genotype of a garden pea plant that Which of the following is not true for the Law of
expresses tall trait of height? Dominance given by Mendel?
1. Characters are controlled by discrete units called
1. TD factors.
2. Tt 2. Factors occur in pairs.
3. Td 3. In a dissimilar pair of factors one member of the pair
4. tt dominates the other.
4. The alleles show blending at the time of fertilization

Question 17.
Genes which code for a pair of contrasting traits or Question 21.
slightly different forms of the same gene are known as: If the offspring is aa, what possible combination of
1.Alleles parental genotype would have produced these progenies?
2. Loci
3. Cistrons (1) AA and aa
4. Introns (2) Aa and AA
(3) aa and AA

Question 18. (4) Aa and Aa

In 1900 Mendel’s work was rediscovered by:

(1) Korana, Nirenberg and Mathei Question 22.
(2) de Vries,Correns and von Tschermak A pea plant parent having violet-coloured flowers with
(3) Avery, McCleod and McCarty unknown genotype was crossed with a plant having
white-coloured flowers. In the progeny, 50% were white.
(4) Watson, Crick and Wilkins The genotypic constitution of the parent having violet-
coloured flowers was
(1) homozygous
Question 19.
(2) merozygous
The pure line round seeded pea plant was crossed with
wrinkled seeded pea plant. The F1 generation is ____ and (3) heterozygous
it can be explained by _____. (respectively) (4) hemizygous
1. Wrinkled : Law of segregation
2. Round : law of dominance
Question 23.
3. Round : Condominance
Types of gametes produced by a homozygous parent
4. Wrinkled : Law of dominance
(1) many
(2) single type
(3) depends upon number of genes
(4) depends upon number of chromosomes

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Question 24. Question 29.

If 'A' represents the dominant gene and 'a' represents its “Filial 1 progeny” refers to
recessive allele, which of the following would be the
most likely result in the first generation offspring when (1) First pure breed
Aa is crossed with aa ? (2) First offspring
(1) All will exhibit dominant phenotype. (3) First hybrid generation
(2) All will exhibit recessive phenotype. (4) Second hybrid generation
(3) Dominant and recessive phenotypes will be 50%
each.
(4) Dominant phenotype will be 75%. Question 30.
Which of the following is a monohybrid?
(1) TT
Question 25.
(2) tt
An organism with two different alleles is:
(3) Tt
1. Homozygous for that trait
2. Homologous for the allele (4) None
3. Heterozygous for the trait
4. Heterologious for the allele
Question 31.
How many laws of Mendel are based on monohybrid
Question 26. cross?
The F2 genotypic ratio of a monohybrid cross is: (1) 1
1. 1 : 1
2. 3 : 1 (2) 2
3. 1 : 2 : 1
(3) 3
3. 9 : 7
(4) 4

Question 27.
Question 32.
The F1 progeny in monohybrid crosses by Mendel
resembled: Indentify the incorrect statement:
1. The parent exhibiting dominant trait completely (1) Tall plant produce gametes by meiosis and the dwarf
plants by mitosis.
2. The parent exhibiting recessive trait completely
(2) Only one allele is transmitted to a gamete.
3. The parent exhibiting dominant trait partly
(3) The segregation of alleles is a random process.
4. The parent exhibiting recessive trait partly
(4) Gametes will always be pure for the trait.

Question 28.
Genotypic and phenotypic ratios of monohybrid cross are
(1) 3:1 and 1:2:1
(2) 1:2:1 and 3:1
(3) 1:2:1 and 1:2:1
(4) 3:1 and 3:1
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Question 33. Question 37.

Trait expressed in F1 generation is If F2 dwarf plants were self-pollinated then the genotype
of F3 & F4 plants is
(1) Parental
(1) TT and Tt
(2) Recessive
(2) tt and tt
(3) Dominant
(3) tt and Tt
(4) Recombinant
(4) Tt and Tt

Question 34.
Question 38.
Which of the following traits in the garden pea plant
would express itself only in homozygous condition? If a homozygous red flowered plant is crossed with a
homozygous white flowered plant and red colour allele
1. Violet flower color is completely dominat over white colour allele, the
2. Terminal flower position offspring would be

3. Green pod color (1) half red-flowered

4. Yellow seed color (2) all red-flowred

(3) half white-flowered
(4) half pink- flowered.
Question 35.
In a monohybrid cross F1 progeny resemble neither of
the parents. What would be true in this case? Question 39.
1. The parental traits would not appear in any of the F2 - An organism with two copies of the same allele is:
progenies
(1) Homozygous for that trait
2. The F2 phenotypic ratio will be different from the F2
(2) Homologous for the allele
genotypic ratio
(3) Heterozygous for that trait
3. It could be a case of incomplete dominance
(4) Heterologous for the allele
4. The F2 phenotypic ratio will be similar to any
Mendelian monohybrid cross
Question 40.

Question 36. A tall true breeding garden pea plant is crossed with a
dwarf true breeding garden pea plant. When the F1 plants
A cross between tall and dwarf plant was performed and were selfed the resulting genotypes were in the ratio of
120 offspring were produced in which 90 plants were tall
and 30 were dwarf. Find out the genotype of their (1) 1 : 2 : 1 :: Tall heterozygous : tall homozygous :
parents. Dwarf
(1) Tt and TT (2) 3 : 1 :: Tall : Dwarf
(2) Tt and Tt (3) 3 : 1 :: Dwarf : Tall
(3) TT and tt (4) 1 : 2 : 1 :: Tall homozygous : Tall heterogygous :
Dwarf
(4) tt and tt

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Question 41. Question 45.

In Mendel’s experiments, the contrasting traits did not A heterozygous plant produces:
show any blending in: 1. Only one kind of gamete
1. F stage
1

2. F stage 2. Two kinds of gametes each having one allele with

2

3. Both F and F stages equal proportion.

1 2

4. The statement is false as blending was seen at all 3. Two kinds of gametes each having two alleles with
stages equal proportion.
4. Two kinds of gametes each having one allele with one
allele occurring in more gametes than the other.
Question 42.
In pea plants, yellow seeds are dominant to green. If
heterozygous yellow seeded plant is crossed with a green Question 46.
seeded plant, what ratio of yellow and green plants would
you expect in F1 generation ? Which one of the following Mendelian trait controlling
unit is expressed in homozygous condition only?
(1) 50 : 50
1. Axial flower
(2) 9 : 1
2. Yellow seed
(3) 1 : 3
3. Yellow pod
(4) 3 : 1
4. Smooth seed

Question 43.
Question 47.
Monohybrid cross can be defined as
What is the ratio of a typical monohybrid test cross?
(1) Cross between plants differing in one chromosome
(1) 2 : 1
(2) Cross between plants differing in one character only
(2) 3 : 1
(3) Cross between plants differing in two traits
(3) 1: 2 : 1
(4) All of the above
(4) 1 : 1

Question 44.
Question 48.
Read the following statements (A-D) :
In two pea plants having red (dominant) coloured flowers
(A) Autosomal recessive trait can't be transmitted from with unknown genotypes are crossed, 75% of the flowers
normal parents to the offspring are red and 25% are white. The genotypic constitution of
(B) In mendelian cross, blending of alleles are observed the parents having red coloured flowers will be
at F1 generation
(1) both homozygous
(C) Dominance is not an autonomous feature of gene or
gene product (2) one homozygous and other heterozygous
(D) Dominance is not universal
(3) both heterozygous
Find which are only correct statements?
(4) both hemizygous
1. A & D
2. C & D
3. A, B & D
4. All are correct
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Question 49. Question 53.

A genetic cross between homozygous individuals but What will be the ratio of homozygous dominant,
with different alleles for a single gene of interest is called homozygous recessive and pure heterozygous traits in F2
as: generation in pea plant is
1. A reciprocal cross
(1) 1 : 1 : 8
2. Monohybrid cross
(2) 2 : 3 : 2
3. Dihybrid cross
(3) 1 : 1 : 2
4. Test cross
(4) 2 : 2 : 6

Question 50.
Question 54.
Which of the given traits of pea selected by Mendel
during the hybridization experiment on pea can be A cross was performed between pea plants P1 (violet
expressed in both homozygous as well as heterozygous flower) and P2 (white flower). If obtained progeny
conditions? showed ratio of 1 (violet) : 1 (white) , then determine the
genotype of P1.
(1) Round seed
(1) Homozygous recessive
(2) Green seed
(2) Heterozygous
(3) White flower
(3) Homozygous dominant
(4) Terminal flower
(4) Can’t be determined

Question 51.
Question 55.
Mating of an organism to a double recessive in order to
determine whether it is homozygous or heterozygous for Select the correct statement
a character under consideration is called 1. Chemical characterization of transforming principle by
(1) reciprocal cross Watson

(2) test cross 2. Test cross helps to determine the genotype of a

dominant plant of F 2

(3) dihybrid cross

3. ‘Coupling and Repulsion’ hypothesis proposed by
(4) back cross Morgan
4. Haemophilia is an X-linked dominant trait.

Question 52.
A common test to find the genotype or hybrid is by :
(1) crossing of one F2 progeny with male parent

(2) crossing of one F2 progeny with female parent

(3) studying the sexual behaviour of F1 progenies

(4) crossing of one F1 progeny with recessive parent

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Question 56. Question 59.

When a violet flower of unknown genotype is crossed Which one of the following cannot be explained on the
with white flower, the progenies are violet and basis of Mendel's Law of Dominance?
white in equal proportion. Then read the following
statements : (1) The discrete unit controlling a particular character is
called a factor
(i) This is called test cross.
(ii) Unknown flower is homozygous (2) Out of one pair of factors one is dominant, and the
(iii) Unknown flower is heterozygous other is recessive
(iv) This test used to determine the phenotype of the (3) Alleles do not show any blendings and both the
plant at F2 characters recover as such in F2 generation.
(v) In test cross, violet or white flower is crossed with the
recessive parent instead of self-crossing. (4) Factors occur in pairs
Select the incorrect statement.
1. iii, iv, v Question 60.
2. ii, iv What is the means of segregation in Law of segregation?
3. i, ii, v (1) Allelic separation
4. ii, iv, v (2) Chromosomal separation
(3) Crossing over
Question 57. (4) Linkage
A graphical representation to calculate the probability of
all possible genotypes of offspring in a genetic cross is
called as: Question 61.
1. Forked line diagram
2. Punnett square Law of segregation can be proved with
3. Pedigree chart 1. The presence of dominant genotype in F 2

4. Idiogram
2. The presence of recessive genotype in F 1

3. The presence of recessive homozygous in F 2

Question 58. 4. The presence of a heterozygous individual in F

Select the correct statement:
2

1. Franklin Stahl coined the term "linkage".

2. Punnett square was developed by a British scientist. Question 62.
3. Spliceosomes take part in translation.
4. Transduction was discovered by S. Altman. What percent of 'ab' type of gamete produced by a pea
plant of genotype AaBb?
1. 25%
2. 50%
3. 75%
4. 100%

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Question 63. Question 67.

In Mendel's experiments with garden pea, round seed
shape (RR) was dominant over wrinkled seeds (rr),
Yellow cotyledon (YY) was dominant over green
cotyledon (yy). What are the expected phenotypes in the
F2 generation of the cross RRYY x rryy ?
In a test cross involving F1 dihybrid flies, more parental-
type offspring were produced than the recombinant type
offspring. This indicates
(1) chromosomes failed to separate during meiosis

(1) Only round seeds with green cotyledons (2) the two genes are linked and present on the same
chromosome
(2) Only wrinkled with yellow cotyledons
(3) both of the characters are controlled by more than one
(3) Only wrinkled seeds with green cotyledons gene
(4) Round seeds with yellow cotyledons and wrinkled (4) the two genes are located on two different
seeds with yellow cotyledons. chromosomes

Question 64. Question 68.

In a plant, red fruit (R) dominant over yellow fruit (r) and
tallness (T) is dominant over shortness (t). If a plant with
RRTT genotype is crossed with a plant that is rrtt. Then
(1) 25% will be tall with red fruit
(2) 50% will be tall with red fruit
(3) 75% will be tall with red fruit
(4) All of the offspring will be tall with red fruits
‘When two pairs of traits are combined in a hybrid,
segregation of one pair of characters is independent of
the other pair of characters’. This is the statement of:
1. Law of Dominance
2. Law of segregation
3. Law of Independent Assortment
4. Law of Linkage

Question 65.
Question 69.
Which one of the following trait is only expressed in the
presence of identical allele? An individual with AaBb genotype is producing four
types of gametes as AB, aB, Ab and ab by meiosis. If the
1. Yellow seed frequency of these gametes is 25% each then, it explains
2. Inflated pod 1. Incomplete linkage
3. Green pod 2. Mutations
4. Green seed 3. Independent assortment
4. Complete linkage
Question 66.
If the female has three boys in her first three pregnancy. Question 70.
What are the chances of getting female child this time?
Law of Independent Assortment is not applicable to
(1) 25%
(1) Linked genes
(2) 50%
(2) Genes on different chromosomes
(3) 75%
(3) Distantly located gene
(4) 20%
(4) both (2) and (3)

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Question 71. Question 75.

What is probability of homozygous individuals for both What does Blending inheritance refers to?
characters in F generation of a dihybrid cross?
2
(1) Mixed characters in an offspring
1. 1/2
(2) Dominant character
2. 3/4
(3) Recessive character
3. 1/3
(4) Dominant & recessive character
4. 1/4

Question 76.
Question 72.
Presence of more than two alleles for a gene is known as
1. Polygenic inheritance
When Mendel self hybridized F1 progeny of a dihybrid
cross between pure Yellow Round seeded plants and 2. Multiple allelism
Green Wrinkled plants, he observed that yellow and 3. Co-dominance
green colour segregated in a ratio of:
4. Incomplete dominance
(1) 1 : 1
(2) 3 : 1
(3) 9 : 3 : 3 : 1 Question 77.

(4) 1 : 2 : 1 In the case of co-dominance, the F1 generation

resembles:
(1) Dominant parent
Question 73. (2) Recessive parent
Incomplete dominance is present in (3) Both the parents
(1) Snapdragon flower (4) None of the parents
(2) Dog flower
(3) Antirrhinum flower
Question 78.
(4) All of the above
In human ABO group system ________ different alleles
allow the possibility of _______ different types of
genotypes in population.
Question 74.
1. 3, 4
What is the F2 phenotypic ratio in cases of incomplete
dominance? 2. 2, 4
1. 1 : 1 3. 3, 6
2. 3 : 1 4. 6, 3
3. 1 : 2 : 1
4. 1 : 1

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Question 79. Question 82.

Which of the following terms best describes when the In Antirrhinum (Snapdragon), a red flower was crossed
phenotype of the heterozygote differs from the with a white flower and in F generation, pink flowers
1

phenotypes of both homozygotes? were obtained. When pink flowers were selfed, the F 2

generation showed white, red and pink flowers. Choose

(1) Incomplete dominance the incorrect statement from the following:
(2) Multiple alleles 1. Law of Segregation does not apply in this experiment
(3) Codominance 2. This experiment does not follow the Principle of
(4) Epistasis Dominance
3. Pink colour in F is due to incomplete dominance
1

4. Ratio of F is 1/4(red):2/4(pink):1/4(white)
Question 80. 2

The unmodified (functioning) allele which represents the

original phenotype is the (a) allele and the modified Question 83.
allele is (b) the (c) allele. F2 generation in a Mendelian cross showed that both
1. (a) Recessive, (b) generally, (c) dominant genotypic and phenotypic ratios are same as 1:2:1. It
represents a case of
2. (a) dominant, (b) always, (c) recessive
(1) codominance
3. (a) dominant, (b) generally, (c) recessive
(2) dihybrid cross
4. (a) recessive, (b) always, (c) dominant
(3) monohybrid cross with complete dominance
(4) monohybird cross the incomplete dominance
Question 81.
A pure tall - red flower plant was crossed with dwarf -
white-flowered plant. In F , all were tall with pink Question 84.
1

flowers. What is the percentage probability of getting red Which of the following characteristics represent
and pink-flowered plants respectively? 'Inheritance of blood groups' in humans?
1. 25% and 50% a. Dominance
2. 50% and 25% b. Co-dominance
3. Zero and 75% c. Multiple dominance
4. Zero and 50% d. Incomplete dominance
e. Polygenic inheritance
1. b, c and e
2. a, b and c
3. b, d and e
4. a, c and e

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Question 85. Question 88.

In antirrhinum two plants with pink flowers were
hybridized. The F1 plants produced red, pink and white
flowers in the proportion of 1 red, 2 pink and 1 white.
What could be the genotype of the two plants used for
hybridization ? Red flower colour is determined by RR,
and White by rr genes -
ABO blood groups in humans are controlled by the gene
I. It has three alleles — IA, IB and i. Since there are three
different alleles, six different genotypes are possible.
How many phenotypes can occur?
(1) Three

1. RR (2) One

2. Rr (3) Four

3. rr (4) Two

4. rrrr
Question 89.

Question 86. To study whether a gene exhibits multiple allelism or not

one must study:
A man with blood group ‘A’ marries a woman with blood 1. An individual
group ‘B’. If their child has blood group ‘O’ then what 2. A population
could be their genotype? 3. A species
4. With concentration
1. Both are homozygous
2. Man is homozygous while woman is heterozygous
3. Both are heterozygous Question 90.

4. Man is heterozygous while woman is homozygous
Question 87.
If two persons 'AB' blood group marry and have
sufficiently large number of children, these children
could be classified as 'A' blood group : 'AB' blood group :
'B' blood group in 1 : 2 : 1 ratio. Modern technique of
protein electrophoresis reveals presence of both 'A' and
'B' type proteins in 'AB' blood group individuals. This is
an example of
(1) codominance
(2) incomplete dominance
(3) partial dominance
In case of starch synthesis in pea seeds [controlled by B
gene], BB homozygotes produce large and round starch
grains; bb homozygotes produce smaller and wrinkled
starch grains and Heterozygotes produce round seeds of
intermediate size. What can be inferred from this
observation?
(1) The gene B mutates at a faster rate.
(2) The gene B is easily influenced by the environment
(3) Dominance is not an autonomous feature of a gene or
the product that it has information for
(4) Some genes do not follow the law of segregation.
Question 91.

(4) complete dominance What can be the blood groups of progeny whose father
and mother are of AB and O blood group respectively?
1. A and B only
2. AB only
3. All except O
4. A, B, AB and O

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Question 92. Question 96.

In a marriage between male with blood group A and If size of strach grains in pea is considered as phenotype,
female with blood group B, the progeny had either blood Bb alleles show
group AB or B. What could be the possible genotype of
parents? 1. Dominance
2. Codominance
1. IA i (Male) ; IB IB (Female)
3. Incomplete dominance
2. IA IA (Male) ; IB IB (Female)
4. Pleiotropism
3. IA IA (Male) ; IB i (Female)

4. IA i (Male) ; IB i(Female)
Question 97.
What is correct for AB blood group system?
Question 93. a. The effect of both alleles of a gene is equally
The phenotype of an individual may be affected if the expressed.
modified allele produces b. Produces an intermediate phenotypic effect.
A. The normal/less efficient enzyme c. The blending of both alleles occurs.
B. No enzyme at all d. There is no intermediate phenotypic effect.
C. A non-functional enzyme 1. a, c, d
1. Only A is correct 2. a, b, c
2. Only C & A are correct 3. a, d
3. Only B is correct 4. b. c
4. B & C are correct

Question 98.
Question 94. Blood group antigens are:
ABO blood groups are controlled by which gene 1. Carbohydrates present in plasma
2. Carbohydrates present on the surface of RBCs
(1) a 3. Plasma proteins
4. Proteins present on the surface of RBCs
(2) I
(3) b
(4) All of the above Question 99.
Both the alleles produce their effect in
1. Heterozygous B blood group
Question 95.
2. Sickle cell hemoglobin
In ABO blood grouping how many genotypes show co-
dominance? 3. Snapdragon flower color
(1) 1 4. Cucurbits fruit color
(2) 2
(3) 3
(4) 4

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Question 100. Question 103.

Match the terms in Column I with their description in
Column II and choose the correct option. Match column-I with column-II.

Column-I Column-II

Multiple Phenylketonuria in
(a) (i)
alleles humans

Blood groups in
(b) Polygenes (ii)
humans

(c) Pleiotropy (iii) Skin color in human

1. a-ii, b-i, c-iii

2. a-ii, b-iii, c-i
3. a-iii, b-ii, c-i
4. a-i, b-iii, c-ii

1. A-2 B-3 C-4 D-1 Question 104.

2. A-4 B-1 C-2 D-3
3. A-4 B-3 C-1 D-2 Ability of a gene to have multiple phenotypic effects is
4. A-2 B-1 C-4 D-3 known as
1. Co-dominance
2. Pleiotropy
3. Multiple allelism
Question 101.
4. Incomplete dominance
A pleiotropic gene
a. is expressed only in primitive plants
b. is a genet envolved during Pliocene Question 105.

c. controls a trait only in combination 'Nith another gene The best example for pleiotropy is:-

d. control multiple traits in an individual 1. Skin color

2. Phenylketonuria
3. Colour Blindness
4. ABO Blood group
Question 102.
Which one of the following pairs of features is a good
example of polygenic inheritance?
(1) Human height and skin colour
(2) ABO blood group in humans and flower colour of
Mirabilis jalapa
(3) Hair pigment of mouse and tongue rolling in humans
(4) Human eye colour and sickle cell anaemia
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Question 106. Question 109.

How many of the following statements is/are correct for a Which of the following is least probable?
polygenic inheritance?
(1) Female child with Sickle cell anaemia
(1) They show uniformity.
(2) Male child with haemophilia
(2) Controlled by three or more genes
(3) Carrier female for haemophilia
(3) It is not influenced by the environment.
(4) Female child with haemophilia
(4) In polygenic inheritance phenotype reflects the
contribution of dominant allele only.
Options : Question 110.
1. 1 and 2 A colour blind girl is rare because she will be born only
when
2. 2, 3 and 4
(1) Her mother and maternal grand father were colour
3. 1, 3 and 4 blind
4. only 2 (2) Her father and maternal grand father were colour
blind
(3) Her mother is colour blind and father has normal
Question 107. vision
In pea, the gene that controls starch synthesis shows all (4) Parents have normal vision but grand parents were
of the following except colour blind.
1. Dominance
2. Incomplete dominance
Question 111.
3. Multiple allelism
A female whose father was colorblind marries and
4. Pleiotropy normal male whose father was also colorblind. What is
the probablility that their daughter will be colorblind?
1. 0 %
2. 25 %
Question 108.
3. 50 %
One of the genes present exclusively on the X-
chromosome in humans is concerned with 4. 75 %

(1) baldness
(2) red-green colour blindness Question 112.
(3) facial hair/moustaches in males Gynaecomastia refers to
(d) night blindness (1) Masculine development in females
(2) Development of breasts in males
(3) Development of female characters in male
(4) Reduced breasts in the female

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Question 113. Question 116.

All are X-linked traits, except T. H. Morgan worked on the fruit fly, Drosophila
melanogaster . Which of the following is not an
1. Colourblindness advantage of this fly?
2. Haemophilia 1. They could be grown on simple synthetic medium in
the laboratory.
3. Deficiency of glucose-6-phosphate dehydrogenase 2. They complete their life cycle in about two years, and
4. Hypertrichosis a single mating could produce a large number of progeny
flies.
3. There was a clear differentiation of the sexes – the
male and female flies are easily distinguishable.
4. It has many types of hereditary variations that can be
seen with low power microscopes.
Question 114.
Who rediscovered Mendel’s laws?
(1) de Vries Question 117.
(2) Correns Pairing and separation of a pair of chromosomes would
lead to segregation of a pair of factors they carried. This
(3) Von Tschermak conclusion was drawn by
(4) all of these (1) Walter Sutton
(2) Theodore Boveri
Question 115. (3) both (1) and (2)
Which of the following statements are correct regarding (4) Thomas Hunt Morgan
Chromosomal basis of sex determination?
(i) The mechanism of sex determination in insects is of
XO type. Question 118.
(ii) XX insect is female while XO insect is male. Among human males _______ chromosome is present
but its counterpart is _____ and called ______
(iii) The X chromosome is called sex chromosome chromosome.
because it was involved in sex determination.
(1) Y, bigger, Z
(iv) Grasshopper has XY type of sex determination.
(2) X, smaller, Z
(v) Man has XX type of sex determination.
(3) X, smaller, Y
(1) (iv), (v)
(4) Z, bigger, X
(2) (i), (ii), (iii), (iv), (v)
(3) (i), (ii), (iii)
(4) (i), (iv), (v) Question 119.
Who noticed that the behaviour of chromosomes is
parallel to the behaviour of genes?
1. Temin and Baltimore
2. Correns and Tschermak
3. Beadle and Tatum
4. Sutton and Boveri

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Question 120. Question 123.

Chromosomal theory of inheritance is a combination of
(1) Knowledge of chromosomal segregation with
Mendelian principle
(2) Knowledge of Dihybridcross with motion of
chromosome
(3) Knowledge of Law of dominance with chromosomal
appearance
(4) Knowledge of classical genetics with modern
molecular biology
Which of the following statement is correct?
(1) Mendel’s work remained unrecognised till 1920.
(2) Mendel’s work suggested that factors were discrete
units.
(3) Mendel provided physical proof of the existence of
factors.
(4) He used geographical approaches to solve the
problems of biology.

Question 124.
Question 121.
Consider the following statement and find out the
Morgan worked with the tiny fruit flies - Drosophila incorrect one:
melanogaster, which were suitable for genetical studies,
as (1) Advancement in Microscopy made the study of
chromosomal behaviour possible.
a. They could be grown on simple medium
(2) The two alleles of a gene pair are located on
b. They complete their life cycle in about two weeks homologous site on homologous chromosomes.
c. Single mating could produce a large number of (3) Experimental verification of chromosomal theory of
progeny flies Inheritance was done by T. H. Morgan et. Al.
d. No clear cut sexual dimorphism is found (4) Morgan Chose Drosophila as an experimental animal
because it has variations that can be seen with high
1. Only d is incorrect power of microscope.
2. Both a and d are incorrect
3. Only b is correct
Question 125.
4. Both c and d are incorrect
Which of the following pairs is wrongly matched?
1. Dog flower – Incomplete dominance
Question 122. 2. Non-Disjunction – Aneuploidy
The initial studies for sex determination were done over 3. Linkage – Morgan
(1) Plants 4. Sutton and Boveri – Recombination and Linkage
(2) Insects
(3) Humans
Question 126.
(4) Hen
Experiment verification of the chromosomal theory of
inheritance was given by
1. Sutton and Boveri
2. Thomas Hunt Morgan
3. de Vries
4. Mendal

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Question 127. Question 131.

The chromosome movement during meiosis have been The figure below shows the chromosome segregation
worked out during germ cells formation with four stages labelled as
(A), (B), (C) and (D). Select the right option giving all
(1) 1900 the four stages correctly identified
(2) 1902
(3) 1911
(4) 1930

Question 128.
Sutton combined Cytological observation on meiotic cell
division and Mendel's concept on inheritance 1. (A) Interphase (B) Metaphase-l
to propose. (C) Telophase-l (D) Anaphase-ll
1. Laws of inheritance 2. (A) G 1 (B) G 2

(C) Anaphase-l (D) Anaphase-ll

2. Chromosomal theory of inheritance
3. (A) G 1
(B) G 2
3. Law of segregation (C) Metaphase-l (D) Anaphase-l
4. Law of sex determination 4. (A) G (B) G
1 2

(C) Anaphase-l (D) Metaphase-ll

Question 129.
When the two genes in a dihybrid cross are situated on
the same chromosome:
1. The proportion of parental gene combinations was
much higher than the non-parental type.
2. The proportion of parental gene combinations was
much lesser than the non-parental type.
3. The proportion of parental gene combinations was
equal to the non-parental type.
4. Only recombinants are formed.

Question 130.
The two alleles of a gene pair are located on:
1. Homologous sites on homologous chromosomes
2. Heterologous sites on homologous chromosomes
3. Homologous sites on heterologous chromosomes
4. Heterologous sites on heretologous chromosomes

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Question 132. Question 135.

Which of the following is a non-parental type of progeny Select the correct statement from the ones given below
obtained by Morgan while carrying out a dihybrid cross? with respect to dihybrid cross.
(1) Tightly linked genes on the same chromosome show
higher recombinations
(2) Genes far apart on the same chromosome show very
few recombinations
1.
(3) Genes loosely linked on the same chromosome show
similar recombinations as the tightly linked ones
(4) Tightly linked genes on the same chromosome show
very few recombinations.
2.

Question 136.
Linkage was described by Morgan in Drosophila. Which
of the following combinations are correct?
3.
(i) He hybridised yellow bodied, white-eyed females to
brown-bodied, red eyed males and then intercrossed their
F1

(ii) The ratio of F2 generation is same as that of 9:3:3:1 in

4. this cross.
(iii) The parental combinations are observed more than
recombinants.
Question 133. (iv) According to Morgan Linkage was observed due to
When Morgan hybridised yellow-bodied, white-eyed chemical association of genes.
females to brown-bodied, red-eyed males and (v) All the genes present on same chromosomes have
intercrossed their F1 progeny, the F2 ratio deviated very same efficiency to link.
significantly from the 9:3:3:1 ratio. this can be attributed
(1) (ii), (iv), (v)
to the fact that:
(2) (i), (iii)
(1) The genes are located on X and Y chromosomes
(3) (i), (iii), (v)
(2) Fruit fly has abnormal chromosomes
(4) (i) and (iv)
(3) The genes are located on the X chromosome
(4) The genes exhibit incomplete dominance

Question 134.
The term "linkage" was coined by :-
1. TH Morgan
2. T Boveri
3. G Mendel
4. W Sulton

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 Recommended MCQs - 237 Questions - Principles of
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Question 137.
Which of the following are correct regarding linked
genes?
I. are locaed near each other on the same chromosome.
II. violate the law of independent assortment
III. segregate together during meiosis
(1) Only I and II
(2) Only I and III
(3) Only II and III
(4) I, II, III
Question 138.
Morgan and his group observed when the two genes in a
dihybrid cross were situated on the same chromosome,
the proportion of parental gene combinations were much
higher than the non-parental type, this is due to
1. Independent assortment
2. Linkage
3. Crossing over
4. Competence
Question 139.
Which one of the following statement is incorrect?
1. Sturtevant used the frequency of recombination
between gene pairs on the same chromosome as a
measure of the distance between genes
2. Sutton and Boveri argued that the pairing and
separation of a pair of chromosomes would lead to the
segregation of a pair of factors they carried.
3. Y-linked genes are holandric
4. 7 : 1 : 1 : 7 as linkage ratio in case of dihybrid test
cross means that there are 8 parental and 8 recombinant
plants
Question 140.
What is incorrect for genetic maps?
1. Alfred Sturtevant prepared it for the first time using
monohybrid test cross
2. It is a measure of the distance between genes present
on the same chromosome
3. Stronger the linkage lesser is the distance between two
genes
4. It was extensively used in the case of the Human
Genome Sequencing Project
Question 141.
Genes for which of the following characters in
Drosophila were found to be very tightly linked by
Morgan?
1. Eye colour and wing size
2. Body colour and wing size
3. Wing colour and eye colour
4. Body colour and eye colour
Question 142.
Choose the correct statement about recombination and
linkage
1. Complete linkage results in higher non-parental gene
combinations than parental type
2. Recombination results in the generation of parental
gene combinations
3. Genetic maps are constructed by using the frequency
of recombination between gene pairs
4. T.H. Morgan constructed the first chromosome map
Question 143.
Today ________ are extensively used as a _______ point
in the sequencing of whole genome
(1) Pedigree charts, conclusive
(2) Genetic maps, starting
(3) Pedigree charts, starting
(4) Genetic maps, conclusive
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Question 144. Question 147.

The frequency of recombination between gene pairs on
the same chromosome as a measure of the distance
between genes was explained by: A couple has a daughter. What is the probability that their
next child will be a daughter?
1. Sutton Boveri
(1) 0 %
2. T.H. Morgan
(2) 25 %
3. Gregor J. Mendel
(3) 50 %
4. Alfred Sturtevant
(4) 100 %

Question 145.
Question 148.
Observe the sex determination in the following:-
I. Human males = XY Sex of progeny is determined by female parent in
II. Female hen = ZW 1. Drosophila
III. Male Drosophila = XY
IV. Male grasshopper = XO 2. Bird
V. Male birds = ZZ 3. Human
Male heterogamety = A
Female heterogamety = B 4. Grasshopper
Male homogamety = C
Which of the following combination is correct?
Question 149.
1. A–I, III, IV, B–II, C–V
Heterogametes are produced by
2. A–II, IV, B–I, C–III
1. Human female
3. A–II, IV, B–I, C–II
2. Female grasshopper
4. A–III, IV, B–II, C–I
3. Female Drosophila
4. Female bird
Question 146.
It is unfortunate that in our society women are blamed for
producing female children and have been ostracised and Question 150.
ill-treated because:
A woman receives her X chromosomes from:
1. The sex is determined by the type of sperm fertilizing
the egg 1. Her mother only
2. The sex is determined by the type of egg fertilizing the
sperm 2. Her father only
3. The sex is determined by the hormones produced by 3. Both her mother and father
the fetus
4. The sex is determined by the God’s will 4. Mitochondria of mother only

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Question 151. Question 153.

50% of the male gametes have only autosomes and the Choose correct option w.r.t. given figure for
rest 50% have both autosomes and one sex chromosomes determination of sex by chromosomal differences.
in
1. Grasshopper
2. Drosophila
3. Birds
4. Butterflies

Question 152.
During his observation of spermatogenesis in a few
insects, Henking found that a nuclear structure was
received by 50 % of the sperms. What did he call this
structure?
1. b after spermatogenesis forms only one type of
gametes
1. X – body
2. b & c represents same sex
2. Y – body
3. a, d are heterogametic
3. X – chromosome
4. Sex determination in d is similar to grasshopper
4. Y – chromosome

Question 154.
Which of the following is developed by parthenogenesis:
A.Drones
B.Queen Honey bee
C.Worker honey bee
D.Both B and C

Question 155.
Find incorrect match
1. Polygenic inheritance – Spread across of gradient.
2. Pleiotropy – Single gene multiple phenotype.
3. X body of henking – One each in sperm.
4. Pedigree analysis – Mendelian trait.

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Question 156. Question 160.

Morgan observed tight linkage in Drosophila with only
1.3 percent recombination for
The number of autosomes in a human egg would be:
1. White eye and yellow body
(1) 22
2. Normal wing and yellow body
(2) 23
3. White eye and miniature wing
(3) 1
4. Yellow body and miniature wing
(4) 2

Question 157.
Question 161.
Morgan coined the term recombination to describe
Males produce two types of gametes in
1. Physical association of genes on a chromosome
1. Butterflies
2. Generation of new traits by mutation
2. Birds
3. Linkage of two genes on different chromosomes
3. Drosophila
4. Generation of non-parental gene combinations
4. Moth

Question 158.
Question 162.
Which of the following pair is wrongly matched?
In humans, the mechanism of sex determination is:
1. Factors - Discrete units
(1) XX – XY; male heterogamety
2. Multiple alleles - ABO blood group
(2) XX – XY; female heterogamety
3. Female Drosophila - Heterogametic
(3) XX – XO; male heterogamety
4. Inborn error - Phenylketonuria
(4) XX – XO; female heterogamety

Question 159.
Question 163.
Which of the following statement is correct with respect
to human sex determination? Which of the following matches is wrong?

(1) The genetic makeup of egg determines the sex of (1) Birds- ZZ(male)- ZW(female)
child. (2) Drosophila- XY(male)- XX(female)
(2) Female produces two types of ovums and males (3) Humans- XY (male), XX (female)
produce only one type of sperm.
(4) Cockroach- - XZ(male)- ZZ(female)
(3) Each pregnancy has more probability of male child
than of female.
(4) Out of 23 pairs of chromosomes, 22 are same both in
males and females.

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Question 164. Question 168.

In which of the following male heterogamety is not Sex determination in Honey bee depends upon-
observed?
(1) Number of sets of chromosomes present in parents
(1) Insects
(2) Number of sets of chromosomes present in progenies
(2) Birds
(3) Number of sets of genes present in parents
(3) Humans
(4) Number of sets of genes present in progenies
(4) (1) and (2)

Question 169.
Question 165.
Read the following four statements (A-D)
Which of the following is correct ?
A. The characters never blend in heterozygous
(1) Henking discovered the small Y-chromosome. condition.
(2) Drosophila also shows XX-XY sex determination like B. Change in a single base pair of DNA does not cause
human. mutation.
(3) Birds have ZZ-ZW sex determination, where females C. Cancer cells commonly show chromosomal
are ZZ and males are ZW. aberrations.
(4) Grasshoppers show XX-XY sex determination. D. In chicken, sex chromosomes in males are ZW and in
females are ZZ.
How many of the above statements is/are right?
Question 166.
1. Two
What is wrong with respect to sex determination in honey
bee? 2. Three

(1) Unfertilized egg develops as a male by means of 3. Four

parthenogenesis. 4. One
(2) Union of sperm and egg develops as a female
(3) All workers and males will have 16 chromosomes
while queen will have 32 chromosomes. Question 170.

(4) Males produce sperms by mitosis. Males are heterogametic and females are homogametic in
1. Human beings and birds
2. Fruit fly and butter fly
Question 167.
3. Grasshopper and cockroach
Select the incorrect statement.
4. Birds and silkworm
1. Human males have one of their sex-chromosome
much shorter than the other.
2. Male fruit fly is heterogametic.
3. In male grasshoppers, 50% of sperms have no sex-
chromosome.
4. In domesticated fowls, sex of progeny depends on the
type of sperm rather than egg.

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Question 171. Question 175.

What is the special characteristic feature of haplodiploid Study the pedigree chart given below to identify the
sex determination? disorder
(1) Males produce sperms by mitosis
(2) Number of sets of chromosomes present in progenies
will decide their sex
(3) Workers will have diploid set of chromosomes.
(4) Drones will have haploid set of chromosome.

(1) Sickle cell anaemia

Question 172.
(2) Haemophilia
In pedigree analysis, the symbol for affected male is
(3) Myotonic dystrophy
(4) Phenylketonuria
1.

2. Question 176.
What does the given pedigree chart shows?

3.

4.

Question 173.
(1) Sex-linked recessive trait
In the pedigree analysis, the meaning of the symbol
(2) Sex-linked dominant trait
is (3) Inheritance of Sickle cell anaemia
1. Still birth (4) Inheritance of autosomal dominant trait
2. Dizygotic twin
3. Mating between relatives
Question 177.
4. Sex unspecified
The family pedigree of Queen Victoria shows a number
of haemophilic descendants as she was:
1. Affected by the disease
Question 174. 2. Carrier for the disease
Pedigree analysis is not utilized to trace 3. Did not carry the allele for hemopihilia
4. Was not a queen
(1) Specific trait
(2) Sex ratio
(3) Disease
(4) Abnormality

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Question 178. Question 180.

Study the given pedigree chart and choose the correct Study the pedigree chart of a family showing the
statement inheritance of myotonic dystrophy.

1. The trait under study is dominant.

2. Both parents are homozygous.
3. The trait can be X-linked recessive disease
haemophilia.
4. The trait depicted is autosomal recessive like cystic
fibrosis. The trait under study is
(1) dominant X-linked

Question 179. (2) recessive X-linked

The trait shown in the given pedigree chart is most likely (3) autosomal dominant
a/an: (4) recessive Y-linked.

Question 181.
In the given pedigree chart select the correct statement:

1. Autosomal recessive trait

2. Autosomal dominant trait
3. Sex linked recessive trait
4. Sex linked dominant trait
(1) A & B are twins
(2) A is younger than B
(3) B is younger than A
(4) Can’t determine the age of A & B

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Question 182. Question 186.

The disease inheritance pattern exemplified in the given
pedigree analysis can be :
In sickle cell anaemia, the mutant haemoglobin molecule
undergoes
(1) Polymerisation under low oxygen tension causing that
changes the shape of the RBC to sickle like structure
(2) Depolymerisation under low oxygen tension causing
that changes the shape of the RBC to sickle like structure
(3) Denaturation under high oxygen tension causing that
changes the shape of the RBC to sickle like structure

1. Hemophilia (4) Denaturation

2. Red green colour blindness

3. Phenyl ketonuria Question 187.
4. Polydactyly A normal woman, whose father had colour blindness,
married a normal man. What is the chance of occurrence
of colour blindness in the progeny?
Question 183. 1. 25%
The point mutation leading to sickle cell anaemia occurs: 2. 50%
3. 100%
1. at sixth position in the beta chain of haemoglobin
2. at sixth position in the alpha chain of haemoglobin 4. 74%
3. at sixth position in the beta chain of myoglobin
4. at sixth position in the alpha chain of myoglobin
Question 188.
Which of the following genotypes could cause Sickle cell
Question 184. anaemia?
(1) Hbˢ + Hbᴬ
The point mutation in sickle cell anaemia leads to a (2) Hbᴬ+ Hbᴬ
change in codon. Identify the correct change:
(3) Hbˢ + Hbˢ
(1) UGA to UAA
(4) Both ‘A’ and ‘C’.
(2) GUG to GAG
(3) GAG to GUG
(4) UAA to UGA

Question 185.
Sickle cell anaemia results from.
1. A chromosomal aberration
2. Non disjunction of autosome
3. A point mutation
4. Blood transfusion reaction
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Question 189. Question 190.

In the given below figure what does (a) and (b) represent Given below is the initial amino acids of the beta chain of
a hemoglobin molecule. What will be true about this
hemoglobin molecule ?

1. GAG, Glumatic acid 1. The RBCs carrying this molecule will undergo sickling
2. GUG, Valine at high oxygen tension

3. GAG, Valine 2. The RBCs carrying this molecules will undergo

sickling at low oxygen tension
4. GUG, Glumatic acid
3. There will be a quantitative decrease in the synthesis
of this molecule
4. This is normal beta chain of the hemoglobin molecule

Question 191.
In a person suffering from sickle-cell anaemia, the
template strand of sickle-cell Hb(s) gene has a specific
nitrogenous base sequence that codes for valine amino
acid. The base sequence on template strand is
1. 5’-CAC-3’
2. 5’-GAG-3’
3. 3’-CAG-5’
4. 3’-CAC-5’

Question 192.
In which of the following one may observe variation in
DNA?
(1) Fragmentation
(2) Budding
(3) Amitosis
(4) mutation
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Question 193. Question 197.

Two phenotypically normal individuals have an affected Which of the following is not a hereditary disease?
child. What can we conclude about the parents?
1. Haemophilia.
1. they both carried the diesease allele
2. Cretinism.
2. they are not the parents of the child
3. Cystic fibrosis.
3. they are affected
4. Thalassemia.
4. no conclusions can be drawn

Question 198.
Question 194.
Mendelian disorders are mainly determined by:
All the following are examples of Mendelian disorders 1. Alteration or mutation in a single gene.
except: 2. Chromosomal gross structural changes.
3. Recombination between linked genes.
1. Hemophilia 4. Jumping genes
2. Sickle cell anemia
3. Phenylketonuria
Question 199.
4. Down's syndrome
In cases of Phenylketonuria:

Question 195. 1. The affected individual lacks an enzyme that converts

the amino acid tyrosine into phenylalanine.
In Phenylketonuria,
I. Phenylpyruvic acid and other derivatives are 2. The affected individual makes an enzyme that converts
accumulated in brain resulting in mental retardation. the amino acid tyrosine into phenylalanine.
II. These are also excreted through urine because of its 3. The affected individual makes an enzyme that converts
poor absorption by kidney. the amino acid phenylalanine into tyrosine.
1. Only I is correct
2. Only II is correct 4. The affected individual lacks an enzyme that converts
3. Both are correct the amino acid phenylalanine into tyrosine.
4. Both are incorrect

Question 200.
Question 196.
How many diseases in the list given below are Mendelian
Which one of the following traits are controlled by genes disorders?
located on the differential part of X-chromosome?
1. Porcupine skin and epidermolysis bullosa
2. Beard in man and milk glands in female
3. Color blindness and hemophilia
4. Color blindness and cystic fibrosis 1. Four
2. Five
3. Six
4. Seven

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Question 201. Question 204.

Match each item in Column I with one item in Column II Which of the following amino acid substitution in the
and chose your answer from the codes given below: beta chain of the haemoglobin molecule leads to the
development of sickle cell anaemia?
Column I Column II 1. Arginine by tyrosine 2. Tyrosine by
phenylalanine
Disorder Feature 3. Valine by Glutamic acid 4. Glutamic acid by
Valine
(i) Rudimentary ovaries
(ii) Gynecomastia
Question 205.
(iii) Trisomy 21
I. Phenylketonuria The incorrect statement with regard to haemophilia is
(iv) Lack of enzyme
II. Sickle Cell anemia PAH (1) it is a sex-linked disease
III. Down's Syndrome (v) Lack of tyrosinase (2) it is a recessive disease
IV. Turner's Syndrome (vi) Mutation GAG to (3) it is a dominant disease
GUG (4) a single protein involved in the clotting of blood
(vii) Mutation GUG to effected
GAG

Question 206.
1. I - v; II - vii; III - iii; IV - i The genetic disease that transfer from a phenotypically
normal but carrier female to only some of the male
2. I - iv; II - vi; III - iii; IV - i progenies. The disease is
3. I - v; II - vi; III - iii; IV - ii 1. Autosomal dominant
4. I - v; II - vi; III - iii; IV - i 2. Autosomal recessive
3. Sex-linked dominant
Question 202. 4. Sex-linked recessive
Cystic fibrosis, Myotonic dystrophy and Thalassemia are
1. Chromosomal disorders Question 207.
2. Autosomal recessive disorders What is incorrect for Hemophilia?
3. Mendelian disorders 1. In this disease, a single protein that is a part of the
4. Autosomal dominant disorders cascade of proteins involved in the clotting of blood is
affected.
2. In an affected indlvidual a simple cut will result in
Question 203. non-stop bleeding.

Queen Victoria of England was : 3. The heterozygous female (carrier) for haemophilia
may transmit the disease to sons.
1. Haemophilic carrier
4. The possibility of a female becoming a haemophilic is
2. Colour blind extremely rare because mother of such a female has to be
hemophilic and the father should be a carrier.
3. AIDS patients
4. Deaf

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 Recommended MCQs - 237 Questions - Principles of
Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 208. Question 212.

Choose odd one out w.r.t. chromosomal disorder Alpha Thalassemia is controlled by ------- on
chromosome number----
1. Down's syndrome
2. Klinefelter's syndrome (1) Linked gene, 11

3. Turner's syndrome (2) Linked gene, 16

4. Thalassemia (3) Unlinked gene, 11

(4) Unlinked gene, 16

Question 209.
Question 213.

Thalesemia is inherited as a/an ____________ condition. Find the correct match-

(1) Autosomal recessive a. Alpha Thalassemia- 11th chromosome

(2) Autosomal dominant b. Beta chromosome- 16th chromosome’
c. Alpha Thalassemia- linked genes
(3) Sex linked recessive d. Thalassemia- Qualitative trait
(4) Sexlinked dominant

Question 214.
Question 210. Thalassemia and sickle-cell anaemia are caused due to a
How sickle cell anaemia is different from Thalassemia? problem in globin molecule synthesis. Select the correct
statement.
(1) Being autosomal recessive
(1) Both are due to a qualitative defect in globin chain
(2) Being a blood disease synthesis
(3) Being a qualitative disorder (2) Both are due to a quantitative defect globin chain
synthesis
(4) Involvement of mutation
(3) Thalassemia is due to less synthesis of globin
molecules
Question 211. (4) Sickle-cells anaemia is due to a quantitative problem
of globin molecules
The genes which are involved in alpha Thalassemia are--
-- and ----- while in beta thalassemia are----.

(1) HBA1, HBB, HBA2

(2) HBB1 HBB2 HBA
(3) HBB1 HBA HBB2
(4) HBA1 HBA2 HBB

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 Recommended MCQs - 237 Questions - Principles of
Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 215. Question 218.

How many of the following statements are correct? A cell at telophase stage is observed by a student in a
(1) Phenyl ketonuria leads to mental retardness. brought from the field. He tells his teacher that this cell is
(2) Thalassemia is quantitative where as sickle-cell not like other cells at telophase stage. There is no
anaemia is qualitative. formation of cell plate and thus the cell is containing
(3) Possibility of female becoming haemophilic is more number of chromosomes as compared to other
extramely rare. dividing cells. This would result in
(4) 8% of male & 0.4% of females are haemophilic.
1. polyploidy
Options
2. somaclonal variation
1. All
3. polyteny
2. 3
4. aneuploidy
3. 2
4. 1
Question 219.
If a man consists of an extra copy of chromosome
Question 216. number 18, then the condition is known as
Furrowed tongue and partially open mouth are (1) Monosomy
characteristics of
(2) Trisomy
(1) Edward’s syndrome
(3) Nullisomy
(2) Turner’s syndrome
(4) Polyploidy
(3) Down’s syndrome
(4) Klinefelter’s syndrome.
Question 220.
Myotonic dystrophy is
Question 217.
(1) Autosomal recessive trait
All are the characteristics of an individual from trisomy
of chromosome 21, except (2) Autosomal dominant trait

1. Short stature (3) X- linkeddominant trait

2. Gynaecomastia (4) X- linked recessive trait

3. Palm crease
4. Furrowed tongue Question 221.
Which of the following is not a feature of Down's
Syndrome?
1. It is caused by a non-disjunction in an autosome
2. The affected individual has trisomy of chromosome 21
3. The aflected individual has a characteristic simian
palmar crease
4. The mental development of affected individual is
normal

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 Recommended MCQs - 237 Questions - Principles of
Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 222. Question 226.

Monosomy means: Which of the following would not be a feature seen in a
1. Lack of one pair of chromosomes patient with the following karyotype?
2. Lack of one of any one pair of chromosome
3. Presence of an extra chromosome
4. Presence of an extra set of chromosomes

Question 223.
Aneuploidy results from :
1. Point mutations
2. Gross structural changes in chromosomes
3. Failure of cytokinesis after telophase stage of cell
division
1. Many loops on fingertips
4. Failure of segregation of chromatids during cell 2. Congenital heart disease
division 3. Big and wrinkled tongue
4. Mucus clogging of airways

Question 224.
Question 227.
Down’s syndrome was first described in the year
Consider the following statements:
(1) 1962
I. People affected by phenylketonuria are unable to
(2) 1866 convert tyrosine to phenylalanine.
II. Alzheimer’s disease results from accumulation of
(3) 1856 amyloid protein plaques in the brain.
(4) 1863 III. Klinefelter’s and Turner’s syndromes are the result of
nondisjunction of the sex chromosomes in either of
sexes.
Which of the above statements are true?
Question 225. 1. I and II only 2. I and III only
A person with Down syndrome will show all the given 3. II and III only 4. I, II, and III
symptoms except
1. Many loops on finger tips.
2. Flat back of head Question 228.
3. Big and wrinkled tongue Chromosome component in the person affected from
4. Narrow round face Klinefelter syndrome will be
1. 44 + XX
2. 44 + XXY
3. 44 + XY
4. 44 + XO

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 Recommended MCQs - 237 Questions - Principles of
Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 229. Question 232.

In humans karyotype of 47, XXY leads to Which of the following occurs due to monosomy of sex
chromosome?
(1) Klinefelter’s syndrome
(1) Down's syndrome
(2) Turner’s syndrome
(2) Turner's syndrome
(3) Down’s syndrome
(3) Haemophilia
(4) Edward’s syndrome
(4) Sickle cell anaemia

Question 230.
Question 233.
n
Which of the following statements are correct?
Column I Column II (i) Polyploidy is caused due to failure of cytokinesis after
telophase.
i. Down’s a. Broad palm with (ii) polyploidy results into increase in number of
syndrome characteristic palm crease autosomes

ii. Klinefelter’s (iii) Turner’s syndrome is an example of polyploidy

b. Gynaecomastia
syndrome (iv) polyploidy results into an increase in a whole set of
chromosomes
iii. Turner’s (1) (i) and (ii)
c. rudimentary ovaries
syndrome
(2) (i) and (iii)
d. XO (3) (ii) and (iii)
(4) (i) and (iv)
e. XXY

f. physical development is
Question 234.
retarded.
Match the following
Choose the correct match: Column-l Column-ll
(1) i-c,d; ii-b,e,f; iii-a a. Haemophilia i. Rudimentary ovaries
(2) i-e,c; ii-b,f; iii-a,d b. Sickle cell anaemia ii. X-linked recessive
(3) i-a; ii-b,e,f; iii-c,d c. Turner's syndrome iii. Gynaecosmastia
(4) i-a,c; ii-d,e; iii-b,d d. Klinefelter's iv. Autosomal recessive
syndrom
a. a(ii), b(iv), c(i), d(iii)
Question 231.
b. a(ii), b(iv), c(iii), d(i)
A human female with turner's syndrome
c. a(iv), b(ii), c(i), d(iii)
(1) has 45 chromosomes with XO
d. a(iv), b(i), c(ii), d(iii)
(2) has one additional X-chromosome
(3) exhibits male characters
(4) is able to produce children with normal husband

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 Recommended MCQs - 237 Questions - Principles of
Inheritance & Variation Contact Number: 9667591930 / 8527521718

Question 235. Question 237.

Match the items of Column - I with Column - II : If we change the position of genes on chromosomes it
will be included in
Column-I Column-II 1. Gene mutation
2. Chromosomal mutation
XX-XO method of Turner's
(a) (i) 3. Polyploidy
sex determination syndrome
4. Transversion mutation
XX-XY method of Female
(b) (ii)
sex Determination heterogametic

(c) Karyotype-45 (iii) Grasshopper

(d)
ZW-ZZ method of
(iv)
Female CLICK HERE to get
Sex Determination homogametic
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Select the correct option from the following: days of ANY NEETprep
1. (a) - (ii), (b)- (iv), (c)- (i), (d)-(iii)
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3. (a) - (iii), (b)- (iv), (c)- (i), (d)-(ii)
4. (a) - (iv), (b)- (ii), (c)- (i), (d)-(iii)

Question 236.
Match the column correctly
Column l Column ll
a. Phenylketonuria i. Autosomal trisomy
associated with mongolism
b. Down's syndrome ii. Gynaecomastia
c. Klinefelter's syndrome iii. Autosomal recessive
trait associated with mental retardation
d. Turner's syndrome iv. Sterile females with
rudimentary ovaries
1. a(iii), b(i), c(iv), d(ii)
2. a(ii), b(iii), c(i), d(iv)
3. a(ii), b(i), c(iii), d(iv)
4. a(iii), b(i), c(ii), d(iv)

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