Call for Chapters: Spatially Variable Genes in

Cancer: Development, Progression, and Treatment

Response

Editors
Ramya Raghavan, Sri Sathya Sai University for Human Excellence, India

Call for Chapters

Proposals Submission Deadline: July 21, 2024
Full Chapters Due: October 13, 2024
Submission Date: October 13, 2024

Introduction
Spatially variable genes in cancer refer to genes that exhibit different expression levels or
patterns across different regions or cells within a tumor. This book sheds light on the
heterogeneity within tumors, challenging the traditional one-size-fits-all approach. The chapters
will examine how spatially variable genes (SVGs) influence tumor biology and pave the way for
novel diagnostic and therapeutic approaches. Cancer-associated fibroblasts (CAFs) are a crucial
component of the tumor microenvironment (TME), playing a fundamental role in tumor
progression, metastasis, and therapy response. Identifying and characterizing SVGs can reveal
novel targets for cancer treatment. Combining spatial transcriptomics with other omics data
(genomics, proteomics) can provide a more comprehensive picture of tumor biology. The books
will be a platform to highlight research efforts towards developing integrated analysis pipelines
for personalized cancer treatment strategies.

Objective
The objective of this work is to emphasizes the potential of spatially variable genes (SVGs) for
clinical applications, bridging the gap between research and practical use in cancer treatment.
The book will integrate knowledge from various disciplines, including cancer biology, spatial
transcriptomics, synthetic biology, machine learning and clinical oncology. By combining
expertise from various fields, researchers can gain a comprehensive understanding of the
development, progression, and treatment response of spatially variable genes in cancer. This
collaboration enables the development of innovative approaches and strategies for cancer
diagnosis, prognosis, and treatment.

Target Audience
Understanding the development, progression, and treatment response of spatially variable genes
in cancer requires interdisciplinary collaboration between various fields, including biology,
medicine, genomics, and computational analysis."Spatially Variable Genes in Cancer" appeals to
a broad audience beyond the field of oncology research and medicine. By combining
fundamental knowledge with translational applications, the book will cater to a diverse audience
within the cancer research and computational biology landscape.
Recommended Topics
• The promise of spatially variable genes (SVGs) for advancing cancer research • Gene
Expression Model Incorporating Spatial Context • Clinical translation of spatial transcriptomics
for cancer diagnosis and therapy • Potential applications of spatially variable genes in
personalized medicine • Challenges and limitations in the study of spatially variable genes •
Promising research avenues: Relationship between spatially variable genes and treatment
resistance • Influence of spatially variable genes on tumor heterogeneity and clonal evolution •
Methodological standardization Spatial multi-omics technologies • Spatial Profiling Techniques
• Spatially resolved omics data • Integration with spatial omics data • Data preprocessing and
quality control • Identifying spatially variable genes (SVGs) • Method for Identifying SVGs •
Analysis of Spatial Gene Expression Data • Statistical methods for SVG detection • Visualization
of spatial expression patterns • Functional validation: cellular heterogeneity and intercellular
communication • Spatially Variable Genes as Hallmarks of Cancer, Understanding Tissue
Heterogeneity • Biomarker Discovery: Tumor initiation and progression • Disease Mechanisms:
Invasion and metastasis • Spatially Variable Genes in Angiogenesis and vasculature • Immune
response and tumor microenvironment (TME) • The mechanisms that control spatial gene
expression patterns • Spatial Correlations and Causal Relationships • SVGs as Therapeutic
Targets and Biomarkers in Cancer • Targeting SVGs for cancer treatment • Small molecule
inhibitors • Antibody-drug conjugates (ADCs) • CAR T-cell therapy • SVGs as prognostic and
predictive biomarkers • Integrating spatial transcriptomics: Response Surface Methodology •
Ethics in use of artificial intelligence and computational methods for spatial data analysis •
Limitations in Clinical translation of spatial transcriptomics for cancer diagnosis and therapy

Submission Procedure
Researchers and practitioners are invited to submit on or before July 21, 2024, a chapter
proposal of 1,000 to 2,000 words clearly explaining the mission and concerns of his or her
proposed chapter. Authors will be notified by August 4, 2024 about the status of their
proposals and sent chapter guidelines.Full chapters are expected to be submitted by October
13, 2024, and all interested authors must consult the guidelines for manuscript submissions at
https://www.igi-global.com/publish/contributor-resources/before-you-write/ prior to
submission. All submitted chapters will be reviewed on a double-anonymized review basis.
Contributors may also be requested to serve as reviewers for this project.

Note: There are no submission or acceptance fees for manuscripts submitted to this book
publication, Spatially Variable Genes in Cancer: Development, Progression, and Treatment
Response. All manuscripts are accepted based on a double-anonymized peer review editorial
process.

All proposals should be submitted through the eEditorial Discovery® online submission
manager.

Publisher
This book is scheduled to be published by IGI Global (formerly Idea Group Inc.), an
international academic publisher of the "Information Science Reference" (formerly Idea Group
Reference), "Medical Information Science Reference," "Business Science Reference," and
"Engineering Science Reference" imprints. IGI Global specializes in publishing reference books,
scholarly journals, and electronic databases featuring academic research on a variety of
innovative topic areas including, but not limited to, education, social science, medicine and
healthcare, business and management, information science and technology, engineering, public
administration, library and information science, media and communication studies, and
environmental science. For additional information regarding the publisher, please visit https://
www.igi-global.com. This publication is anticipated to be released in 2025.
Important Dates
July 21, 2024: Proposal Submission Deadline
August 4, 2024: Notification of Acceptance
October 13, 2024: Full Chapter Submission
November 24, 2024: Review Results Returned
December 22, 2024: Final Acceptance Notification
December 29, 2024: Final Chapter Submission

Inquiries
Dr. Ramya Raghavan
Sri Sathya Sai University for Human Excellence
ramya.saivrinda@gmail.com

Classifications
Computer Science and Information Technology; Life Sciences; Medicine and Healthcare;
Physical Sciences and Engineering

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