PHARMACEUTICS

QUESTION PAPER (I- Internal Theory Exam)

Name of the Examination: M.Pharmacy I-Year I-Sem Batch: Regulations:
Subject: ABPPK Date: --------- Duration: 2 Hrs. Max. marks: 25M

SNo. Question BT CO
I. Answer all questions 5*2=10M
1 Define the concept of bioequivalence and its importance in generic drug II 1
development.
2 What is the role of complexation in improving the bioavailability of I 1
poorly soluble drugs.
3 Propose scenarios where the apparent volume of distribution may be VI 2
altered and how it impacts drug distribution in the body.
4 Compare and contrast non-invasive methods for estimating IV 2
pharmacokinetic parameters, with a focus on salivary and urinary
samples.
5 Differentiate between zero-order and first-order rate constants in drug II 3
absorption.
II. Answer any three questions 3*5=15M
1 Perform an Invitro-Invivo Correlation analysis and interpret the levels of IV 1
correlation.
2 Evaluate the importance of formulation design in achieving the desired V 1
bioavailability for specific drug classes.
3 Calculate and interpret the half-life of a drug under different III 2
administration conditions (intravenous infusion, multiple dose injections).
4 Define the concept of clearance in pharmacokinetics, distinguishing II 2
between organ clearance and total clearance.
5 Evaluate the merits and limitations of different experimental study models V 3
of absorption: in silico, in vitro, in situ, and in vivo.