TX Elevated LDL Cholesterol

statinsmalloraldrugs athcitrantelyareinhibitorm
BempedoicAcid oral
MOA 1InhibitHMGCoAreductase inhibits
cholesterol synthesis
2 Increaseexpression of LDLR 99 Nexletol
cholesterolmetabolism
MOA 1 InhibitsATPcitratelyases
dddLDL LIVLDL PHDL I cholesterolsynthesis
Rosuvastatin dawn Atorrastatin 2 MLDLR

Highdose door40mg prodrug by

activated acylCoA
Highdose doorsong synthase 1 in theliver
1stlinedrugforboth
primarysecondary
metabolized
in urine
by UGT267 excreted
prevention of
atherosclerotic
on Inhibit OATPBil B
combo tx w resins or
ezetimibe AE Auricacid in plasma t riskofgout
lenkopenia upperrespinfectionmuscle
AE Glupsethyperglycemia spasms
Pravamstatinm
Lovastatin r lactone statins inhibitHMG CoAreductase
whichisin skeletalmuscle and
Pitorastatin simvastatin
prod hepatocytes NoAcsul 1in skeletal
Mt'd'emfontopicppyedoicacid
activation
AE Myopathy 11 rhabdomyolysis rare buttoxic
dosedependentAE's Cl pravastatin simvastatin

Cl Hypersensitivity tostatinsacute liverfailure Ezetimibe zetialmoral

decompensated cirrhosis
P MOA selectivelyinhibits intestinal
absorption reabsorption of cholesterol
ElefederesterAntweed bybindingtowpath
MOA 1 binds to bileacidin GI tract
pexcretion ofbileacidandcholesterol peskamatibodies
2 I cholesterol PLDLR 47hrdegrade
usuallyinhibits
MOA InhibitPcskg LCDRdegradation
TX combow statins antitoxicagents
a cholesterol metabolism
forcardiacglycosideshyperlipidemia Groperexpression
in pregnantwomenbilemalabsorption
caused diarrhea Tx Forptswhocan'tusestatins
AE injectionsite rn myalgiaantibody
AE constipationandbloating AVLDL With development
absorption AlirocumabsubQ EvolocumabshbQ

Colestipol Colesevelam cholestyramine Poskasynthesisinhibitorum

Inclisiran lequio subQ
take withfood MOA degradesmRNA forPaka d
all oraldrugs plska ALDLRexpression
AE injectionsiterunsarthralgia bronchitis
TX whocan'tdonolesterol w
 I
TX Elevated VLDL Triglyceride

Fibratesmt Omega 3 Polyunsaturated

MOA ITG synth PTGmetabAvenuecholesterol FattyAlidsCPUFAly

transport
PLPLMBoxofFFAAApo Ay Icosapent Ethyl
TX trisk ofacutepancreatitis MOA unclear thepatic production
pts w severe Pta and Aclearance ofTG
AE rare Glpbimsrash TX diabetics Or ASCVDpts
Cl hepaticrenaldysfunction gallbladderdisease 4TGover150 t lifestylchange
cholesterolrelatedgallstoneformation Mafibableepynigpheral
edema
if used with ezetimibes bothwhite
salt Acholesterol saturatedbite
Pgallstones
Gemfibrozil Fenobibrate

AE aserum
rhabdomyolysis
1119th
ifused with
cogently

Tx Elevated LDL and VLDL

NicotinicAcidiniacing

Niacin
MOA D Nsynthesis and Aclearance of
VLDL
2 d Lp a onlydrugthatdoes
butnobenefits againstCVD
3 WapoA 1 clearance APA
AE Flush PGEzandPapa anddyspepsia
4Highpose Gldistress liverdystuncetc
Cl Hepatic dysfunction activepepticulcer
diabetes
 Anti Thrombotic overview

Anti Platelets
Goal preventrecurrence ofarterialthrombosis
Cl bleeding ptswithbleedinghe

1Inhibitormoral MRehtrayalinhibitousy
cox
Aspirin MOA blockADPmediated coagulation can't
MOA irreversiblybindsto cox 1 bindto Glycoprotein1lb that prevents
Cox 1 activation
TX 1 for pump again
recuwant
CUD events AE bleeding dyspnea Ticagrelor cangrelor
AE Gl ulcers bleeding
Cl bleeding
clopidogrel platy prasugretCEffient
whpetinghladhibitort irreversible irreversible
prodrugs prodrugs
Aboiximab metab cypacia Metab CYP3AdCYP2B6
irreversible
TX 1 combow aspirin TX PCI
MOA veryefficacious blockslaststep duringafterPllAcs
in platelet aggregation 2 mono if Clwlasprin
TX preventthrombosiscaused by
Pll and Acutecoronary syndrome Tisagnortal Cangnetou
reversible reversible
AE bleeding thrombocytopenia
Metab Cyp3A4 active Metab dephosphorylation
or urineandfeces
TX combow Aspirin
TX adjuncttopol for
preventAcsorstroke
ADDinhibitorand
Glycoprotein lib illa
inhibitornaivepts
 Anti Coagulants
Goal preventtreatvenousthrombosis
combo w anti platelet arterialthrombosis

Xathhibitorsy

Hindering motion.it IneianatioEEiiiya

MOAAllowsantithrombinilltogothrough
aconformationalchange bindto 4substrates of pgpandcyp3A4
active form offactorsllaandlorxa
Heparin b
Enoxaparinsh

g
MOA recombinantXa inhibits
Xa
inhibitors andtissuefactor

TX lifethreateninguncontrolled bleeding
caused byrivaroxabanandapixaban
rapidonsetofaction 2min
resume anticoagafterantidote
AE UTI pneumoniaIschemicevents
MI Stroke cardiacarrestsudden
death
osteo
Bleeding
Bleeding
Effects penesis Hit Wenvenribledinnutthrombininnibitormmw
AEforHeparin
1 osteoporosis 2 HeparinInduced BivalirudinPE ArgatrobanPE
ThrombocytopeniaHIT
activateosteoclasts MOAbindsto thrombin Factor la to inactivate
inhibitosteoblasts antibodymediated an 12,141019 and
thrombosis splatelets
Antidote Protaminesulfate
MOAbindsandinactivatesheparin
TX reverseUFAefx partiallyreverse
LMWHs

ummmm
MOA Lsynthesisofvitkdependentfactors
by
vitk reductase12,719,10proteincands
inhibiting
hhighlyboundtoplasmaalbumin ReversibleDirectThnembintnhibitorsumm
TX onlyoraldrugforvalvulardiseaseassocvenousthrombosis MOAbindstothrombin Factorla toinactivate
AE bleeding birthdefects crossesplacenta cutaneousnecrosis
1211111019and
proteinC Dabigatranoral Antidote darncizumab
Cl proteincisdeficiencyPtsw CYP2690rVkOkt 9Ytaintants prodrug
urine
elimination
Warfarinoral Antidote prothrombincomplex tx nonvalvularafib Mondal
100t bioavailable concentrates associatedstroke
1 3factor2191101 AEGlynbleeding resumedabigatran
I 2 a factor2179,10 after24hours
S R Cl renaldunno
269 C4P3A4
CYP 3 fresh frozenplasma
CYPA2 4 vitkor rF7a
slowonset
 Fibrinolytics
Rhombindhtthm
Alte
plage Antidote AminocapoicAcid
MOA Weakplasminogenactivators activate MOA bindtoplasminogenandplasmin
fibrinboundplasminogen t breakdown blockplasminfibrininteraction
formedthrombus reverseexcessivefibrinolysis

TX immediatelyopenclottedbloodvessels At renalfailure
M M
whenPa BPhastobeovertopommhg
orbypass are
unavailable
AE allergyandbleeding

Angina Drugs

Nitrate Esters
mmmm long ActingsodiumchannelBlocker
MOANOstimulatesquarryayecareto acamp hmmmm mmmm
altivatemyosinlightchainphosphatase Rahal
azine
smoothmuscle relax MOA blocklateNatcument in cardio myocyte
TX all 3Anginasbutnosurvivalbenefit INatintracellularlevels affects
Monday'sDisease headacheflushing
Nex less cast in cell
AE Acute
OrthostaticHTNsyncope
Chronic toleranceMethemoglobinemia High
doses 202carryingcapacity TX pHw bradycardia 24 Chronicstable
Cl peoplew SNPADH2.2 30501Asians hypotension
angina
OHMetabasianflush Ltxefx
pts
WNOLET
AE AQT
oral tune AQTsyndrome
Cl hepaticdye
inimitataktheaseittatibarisoggileaggognitrate
andIsosomideDinitrate
 Autonomic Drugs Antagonists
Nonselective a
Antagonist Sintagonist's
41 Aa competitivereversible
TX pheochromocytoma chronicHypertension
withBPH notfirstlinetorjustchronic
activati hypertension

in.gg
arteries andveins
pygmy gym 2 intactazreceptor
competitiveirreversible competitivereversible

Tx pheochromocytoma reversaloflocalsoft controlled

receptor
benigntumorinadrenalgland tissueanesthesia a agonist Nereleasese
normalepineratio go.no overdose Hypertensivecrisis
thmorepineratio 2050 NPLITGAHDL
duetomonoamineoxidase
cholesterol
inhibitor Maol inhibits
me
AE Hypotensiondizzinessfaintingreflextachycardia AE Hypotensiondizzinessfaintingfirstdose
syncope

Nonselective B selective B
Antagonist Antagonist
B andB2
MOA Heart Lbpand202consumption byWHR MOA Heart Lbpand202consumption byWH
andNcardiaccontractility anddcardiaccontractility
InhibitRAAS Nbp qaemajfgyffynypmm.io
inhibitRAAS Nbp
mmmm gym con gamma
Tachycardia CHF Tachycardia CHF

propranolol Nadolol Metoprolol Bisoprolol

competitivereversible competitivereversible competitivereversible
competitivereversible

TXHemangiomabright
redbirthmarkinnewborns Nebivolol
drug vasoconstricts alsoBsantagonist
competitivereversible
andbÉGF
inhibitsVEGF
andortriggers
expression

A and B
Antagonist Muscarinic Receptor
blocks a and B Bsa Antagonist
competitive reversible
doesn'tblock Atropine
x2
TX Hypertension BlocksParasympresponse
Labetalol Iv
Iv tx forhypertensive
came
antioxidant antiproliferative
d
THRAcontractilityMconduction
crisis ANOproduction velocity

TX sinusbradycardia AVblockin
MIpatients severebradycardia
andsyncopebyhyperactivecarotid
sinusreflex
 B Blockers
ummm
MOA Loademand dfrequency ofischemicevents
TX preventnitrateinduced reflextacky Monday's
1 for stableunstableangina notusedforvariant
1 Nonselective B 2 Selective B
Antagonist Antagonist
B andB2
MOA Heart Lbpanddosconsumption bywar

jj
InhibitRAAS
anddcardiaccontractility
Nbp
Mnt anddcardiaccontractility
inhibitRAAS Nbp
x mmmm y ammension anemiccondition
gamy Tachycardia CHF

unthinkable Wntillversible compttimetretersible competitive'relversible

TXHemangiomabright AE Raynaud's
redbirthmarkinnewborns
phenomenon
3 A and B
drugsvasoconstricts
bÉGF
ayyy
b04 s a and B B x
and
inhibitsVEGF
andortriggers
expression competitive reversible
doesn'tblock
apoptosis x2
TX Hypertension

irettifyishypetensive antioxidantantiproliterative
TNOproduction

cast channel Blockers

undinarinencatenanneraerre
Tx supraventricularventriculartacky
Afibflutteranginahypertension Stanglea
AE GIupsetHeartproblemsoppositetotelex
hypotensionbradycardia

Cl wolffparkinsonwhite
Verapamil Dilitiazem
metab Cyp3A4 modblockers
inhibits P glycoprotein
Cl Statins Dofettlide

Dihydropinecastchannelblockersun

MOA vasodilation Abloodsupply

TX 1 variantangina Longlasting alsosatang
HTNRaynaud'sPhenomenon La
Amlodipine Nicardipine Nrfedipine
 Inhibitors of the Renin Angiotensin system
vasoconstrictors vasodilators
sense angiotensin11 bradykininandrelatedkinins
digging endothelins anatriuretic peptides

angiotensinitproduces
cardioeffectsby
activatingATreceptor
picsips smccontraction
ATreceptors Highin
fetaltissues
a pregnantptsdon't
Yg Tareceptor
11
angiotensin constrictsefferent
arterioles blocking
pintragomenilar per to
damage glomerulus
Reninenymelnhibitormmm
AngiotensinconvertingEnzyme
MOA suppress andbang
giggypentana Inhibitors ACE
unmmunmmann
TX PrimaryHypertension notfirstline MOAinhibitACE hangitand abradykinin daldosterone
4 pregnancy renalarterystenosis Inattpilatit iisinopii ramipirito
AE Gl Headaches angioedema birthdefects capygpit
hypotensionhyperkalemia ya
shortest proding

TX 1stline MTN chronicHFwJEF AcuteMI

Bradykinin Ba Receptor Antagonist chronicrenalDisease
Wmmwurnthurn
MOA inhibitseffects Kallikreinkinin
Mayhelptype
andglucose
ildiabetesptsw insulinsensitivity
of system metabolism
blocksvasodilationvascularpermeability A constriction
Cl pregnancy renalarterystenosis
Icatibant AE Drycough Abradykinin dizziness Aviskof
angioedema
Tx acute hereditaryangioedemaALEinhibitorcausedangioedema hypotensionand hyperkalemia
d
AEnone commonamongBlack
population

watriurticeptuidentgonistereprikinghibitan
MOAinhibit
neprilyinmetabolism
RAND ABNP rangiotensin11
addARBtosurpress
needto
ofangiotensinIl valsanan
elevation

Sacubitrillwvalsartan
TXchronicHFwWEF
Cl pregnancy renalarterystenosishxofangioedema
AE angioedema rarebutseverehyperkalemiahypotension Ah9ff
losananite
j I Ifjy.tk
p1f Ij n

monththffthggysaten
raisananthiaesarginnactangiaggggarqrin
Isterygsumeteab

Bosenthano Ambrisentano TX1stline MTN chronicHFwLEF whofailAcetx

pts
diabeticneuropathy
TX pulmonaryarterialMTNPAH sinceit'scausedbyAendothelin
Cl pregnancy 4 pregnancy renalarterystenosis
AE Flushingperipheraledemachronicusecancauseliverpulms AE nodrycough hyperkalemia renalimpairment
hypotensionandangioedema
 Diuretic Agents

Carbonic Anhydrase Inhibitors LOOP Diuretics

www.mmmmw mmmm
MOA 1Actionsite Proximalconvoluted Tubule MOA 1ActionSite ThickAscendingloopofHenle
Inhibitscarbonicanhydrase inkidneys andCsf
eye BlockNatKt au pump aexcretionofCart
stopsreabsorptionofNaclinpetviaNatHtexchange MgatNacl KtHao tabsorptiontoo
Minot way th
stopsreabsorptionviacarbonicanhydrase

Acetazolamide
É epfd torsemideo
Tx Glaucoma reducesformationofHo inaqueoushumor Tx EdematousStates NonEdematousStates
andCSF up urinaryacidosisAcuteMountainsickness 1chronicHF ithmetallhemaktailpts
reducespulmonaryand
cerebraledema
fromhighaltitudeclimbing stopsnatigora
edema
stops mustbegivenwsaline
notusedasadiureticanymore G ldingforvapid
AE metabolicacidosisrenalstonesduetobasicpeelallergy 2
Actiffuttonmangidema
Since itis asulfonamide
Tolerance After3 5days sinceitpromotesnatioozexcretion
Cl Goutpts Hyperuricemia drugcompeteswuricacid
RenalDisease
Thiazide Diuretics AE HypokalemiaMetabolicAlkalosistoomuchktlost
HypomagnesemiaHyperuvicemiaallergyHyperlipidemia
Why Hyperglycemia diabetics OtotoxicityAcutekidney
injury
MOA 1ActionSite Distal tubulealsoPct
convoluted
BlocksNatcicotransponer traofnauthraot.cat
rexcretionofNacl KtHao hexuretionofcart Ktfparingpinnettlsm
Hydrochlorothiazide Chlorthalidoneo Indapamideo MOA 1Actionsite collectingTubule

TX Edematous
states nonEdematousstates i'ftp.yggeggggp.tohesemett.anhadtm'atnengetion
combotxthiazide Hypertensionallpts
loopdiuretics w Hintnormal
essential
blocksaldosteronemediated
Blom
PtGFR20 nrippinthiasis caused
of
activation Natchannel
blocksNatchanne

andosteoporosis byacastra NatKtATPaseand Atpase

directly
Diabetesinsipidusvery
aloto120
ptsdrink
thirsty f Pephrogenic

add
ADH AEimhnithamopthms AENauseavomitin
bylithium
induced
fgqgdiawneaheada
t.gg
AE HypokalemiametabolicAlkalosisHyperuriamiaallergy aghaiphrinthinkhion gym
dilutionalhyponatremiavolumecaused Tx EdemaandHen notfirstline comboto

iiiiiiiiii
Hyperaldosteronism primaryandsecondary It
Osmotic Diuretics CHE gagnon
caused born
ummmm volume
intravascular
unfinepaticannosis
MOA NotmetabolizedRintratubularosmolaritybyPosmolalityof
ClHyperkalemia summitshouldnotbeover5.57renal
19 re'tentkittitointipitanalaisintaitalitipittentemodromme
opposeactionof AE
metabolic'ieidosis
Hyperkalemia
Apatnnjjapinettingusion suspension
Antidote for Hyperkalemia patinemeno
Tx Omgforshorttermuse intracranialhematomacerebraledema nonlifethreateningcancausehypokalemia
LintraoculavP forptsneedingoccularsx preand postsx
Cl ptcannot h aveactive
bleedinganuria blockageofurinarytract dehydration
expansionofECF volumeworsenHFpulmonaryedemadehydration
AEacute
hyperkalemiahyponatremia
 Anti Hypertensive Drugs
Firstline Firstline
Diuretics

Thiazide
Dianetics toop ktsparing ACE inhibitors ARB
Diuretics Diuretics goodforptsw goodforptsw
uselowdosetowAE coumobidities
counteract coumobidities
ptswrenal
mayaplasmalipid
pavicacidinglucose
dysfunction
orche
hypokalemitefx
ofotherdiuretics
o
prils o sartans
mayaplasmalipid
spironolactone
Firstline
r u
mum m mgyygyyyy.gg cantchannel Blockers
d d
ildmod counteracts
fluid retention

tffh
Enna
NonDihydropyridines Dihydropyndines
Chlorthalidone
Hydrochlorothiazide Icatinfluxinto beastinfluxinto
cardiacmuscleSAAvnodes vascularSMC

SympatholyticAgents overampil o dipines

dilitiazem

peripherally
Tithing Arterial Vasodilators
blocking
dose
taper
A and Breceptor a agonists Hdd Minoxidil
Blockers
dilatesarterioles moa ktchannelopener
P metabacetylationfast relaxesarteriolemuscles
proprano BandBa Nonselective omethundopa
Metophotthnolo
Bi
cardiosenective agonidine TxmodsevereMTN TxsevererefractoryHin
anastobegivenwlbblockevanastobegivenwlbblocker
Nebivolol block
BisactivateBs
anda diuretic anda diuretic
pindolol block
B 3activateBa AElupus enpnematous.AE rhairgrowth
Labetalolicamedilol
A and B P likesyndrome
phenoxybenzamine Mandar
phentoalamine Mandar Nitropmssiden
rosins a chronicMTN MOA noDonorrapid
onset dintracellcastby
inducingcellmembhyperpolarization
relaxesveinslanerialespreloadwattenoad
AE cyanidetoxicity
Cl RhodanesedeficientptsLeber'sopticAtrophytobacco
Amblyopenia Renaldint

B 180 PBP 120

ag
 DRUG DRUG Interactions
CYP3A4Inhibitorsm Cyp3Adinducersm Cyp26ainhibitorsm CYP269induarsm
statins statins statins statins
Ticagnelor antiplatelet Ticagnelorlantiplatelet warfarin warfarin
Rivanexaban Rivanexaban
Apixaban Apixaban
castchannelblockers eastchannelblockers
ranolazine ranolazine

fireathibitor Daptomyeinn substrates of 0A

clopidogrel
fluconazole
statins Ytetummmm
sbempeda.cat

substratesoffgpm Wth Noth

ALS Statins Ezetimibespanticoag Ezetimibestconcof
Rivanexaban bothdrugs
Apixaban efx
dabigatran

ppy Nitrates B Blockeism

Antacids PDEsinhibitors
Ezetimibestviskof 4tadalafil Verampil Diltiazem
cholelithiasis dabigatran
sacstiminators mm
simvastatinawith
gemfibrozil dapsone
methemoglobin
ennarisk
nephrotoxic drugs

drugs w high plasma

protein binding

MOIN
Verampil Dittiazem
Ranoldzine
 DRUG DRUG Interactions

Nsaids Timethoprimmm ktsparingDiureticsm Lithium

Aliskinen
ALEinhibitors
rigginen thirstier Ekitnibitors

ARBs sacubitrillraisanan sacubitrillraisanan

Sacubitrillraisanan KtsparingDiuretics LoopDiuretics
Hipaa'demeditnetics thiazidediuretics
BBlockers

IEthibitors ARBen ktsupplementsm sulfonamide

ARB ALEInhibitors ALEinhibitors Acetazolamide CAI
Icatibant Baantagonist ktsparing Diuretics ARBs
LoopDiuretics
Sacubitrilraisanan sacubitrillraisanan
KtsparingDiuretics ktsparing Diuretics

AntihypertensiveDugswn Potentially Digoxin thhhhhhh

LoopDiuretics LoopDiuretics LoopDiuretics Eplerenonelktsparing

Mind diners thiazide dives

gym

cyclosporine Tacrolimus
ummm
sparingDiuretic
KtsparingDiuretics