Biopharmaceutics and Pharmacokinetics

3 of 6 sets

Chapter: Absorption

201. Which of the following drug is not intended for pulmonary administration?
A. Bronchodilators
B. Antiallergics
C. NSAIDs
D. Anti-inflammatory steroids
Answer:C

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202. A drug in the concentrated injection is absorbed faster.
A. True
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B. False
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C. none a
D. all
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Answer:A c
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203. Intramuscular drug absorption is faster than intravascular.
A. True
B. False
C. none
D. all
Answer:B

204. Several factors such as the thickness of stratum corneum, presence of hair
follicles, trauma, hydration of the skin, Grooming, exposure to chemicals
determine the passive absorption of drugs from the surface of the skin to below.
A. True
B. False
C. none
D. all
Answer:A

Chapter: Drug Distribution

205. Which process involve alteration of drug distribution

A. Competitive binding
B. Reduced plasma protein level
C. Both
D. None
Answer:C

206. If drug have very small volume of distribution it is likely that the drug
A. Has short biological half life
B. Does not accumulate in various tissue and organ
C. Not bioavailable
D. will not be effective
Answer:B

207. If distribution of drug is slower than process of biotransformation and

elimination
A. It will cause high blood level of drug
B. It will cause low blood level of drug
C. Cause failure to attain diffusion equilibrium
D. None of the above
Answer:C

208. If the drug Y bind with plasma albumin with 10 times more affinity than drug
X. Which the given statement is true?
A. Apparent volume of distribution of drug X decrease
B. Free concentration of drug X in blood will be increase
C. Apparent volume of distribution of drug Y decrease
D. Toxicity of drug Y increase
Answer:B

209. The distribution of drugs into the central nervous system (brain) usually
depends on:

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 A. Aqueous diffusion
B. Lipid diffusion
C. Active transport
D. Facilitated tr
Answer:B

210. Which of the following is most likely to be associated with a high apparent
volume of distribution
A. High hepatic extraction ratio
B. Penetration across the blood:brain and blood:testes barriers
C. Extensive binding to plasma protein
D. Extensive binding to tissue constituents
Answer:D

211. The Initial distribution of drug into the tissue is determined chiefly by
A. Rate of blood flow to tissue
B. Plasma protein binding of drug
C. Affinity for tissue
D. Gastric emptying time
Answer:A

212. Transfer of drug from plasma to tissue depends on

A. Weight of tissue
B. Blood perfusion rate of tissue
C. Size of tissue
D. All of the above
Answer:B

213. A hydrophilic medicinal agent has

A. Low ability to penetrate through the cell membrane lipids
B. Easy permeation through the blood-brain barrier
C. Penetrate through membranes by means of endocytosis
D. High reabsorption in renal tubules
Answer:A

214. Biological barriers include all except:

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 A. Renal tubules
B. Cell membranes
C. Capillary walls
D. Placenta
Answer:A

215. Blood Brain Barrier is maximum permeable to

A. Na+
B. C02
C. Cl
D. K+
Answer:B

216. If a CNS drug is extensively ionized at pH of blood it will

A. Penetrate the blood brain barrier slowly
B. Penetrate the blood brain barrier rapidly
C. Not penetrate blood brain barrier
D. Be eliminated slowly
Answer:A

217. The rate of drug transport across a cell membrane by lipid diffusion depends
on all of the following except
A. Drug size (diffusion constant)
B. Surface area of absorption
C. Lipid partition coefficient
D. Density of tr
Answer:A

218. The formula to calculate half life (t1/2) is

A. 0.693 *Vd / C1
B. 0.693 *Cl / Vd
C. 0.693 / Cl * Vd
D. 0.693 / Cl
Answer:A

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219. The procedure of transporting a drug from the bloodstream to tissues is called
as
A. Absorption
B. Dissolution
C. Distribution
D. Elimination
Answer:C

220. …………..it represents the degree to which a drug is distributed in body tissue
rather than
A. Volume of distribution (YD)
B. Effect of distribution
C. Area of distribution
D. None of the above
Answer:A

221. It is defined as the distribution of a drug between plasma and the rest of the
body after oral or parenteral dosing.
A. Volume of distribution (VD)
B. Apparent volume of drug distribution
C. Phagocytosis
D. None of the above
Answer:B

222. The drugs having molecular size …………..easily cross capillary membrane.
A. <500-600d
B. < 100-200 d
C. <300-600d
D. <90M600d
Answer:A

223. The concentration of drug in blood or plasma will be comparatively in the GI

tract.
A. High
B. Low
C. Very High

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 D. Very Low
Answer:B

224. Fat is act as reservoir for……………………… Drugs

A. Highly water soluble
B. Lower lipid soluble
C. Highly lipid soluble
D. Lower lipid soluble
Answer:C

225. Displacement is significant when, the displaced drug is more than protein
bound.
A. 50%
B. 95%
C. 10%
D. 1%
Answer:B

226. ……………is located at the sertoli-sertoli cell junction.

A. Blood testis barrier
B. Blood CSF barrier
C. Blood cellular barrier
D. All of the above
Answer:A

227. The Binding Order of drug to tissue is…………………

A. Kidney > Liver > Lungs > Muscle
B. Muscle > Kidney > Lungs > Liver
C. Liver > Kidney > Lungs > Muscle
D. Liver > Lungs > Kidney > Muscle
Answer:C

228. …………………in lipophilicity increases the extend of binding.

A. Increase
B. Decrease
C. Constant

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 D. None of the above
Answer:A

229. Protein binding of drugs helps to maintain ……………for absorption of

drugs.
A. non sink condition
B. sink condition
C. pKa
D. none of the above
Answer:B

230. The loading dose of a drug is based upon the

A. time taken for complete elimination
B. percentage of drug excreted unchanged in urine
C. percentage of drug bound to plasma protein
D. apparent volume of distribution and the desired drug concentration in plasma
Answer:D

231. The volume of distribution of drugs is:

A. An expression of total body volume
B. A measure of total fluid volume
C. A relationship between the total amount of drug in the body and the concentration of the drug
in the blood
D. Proportional to bioavailability of the drug
Answer:C

232. The volume of distribution (Vd) relates:

A. Single to a daily dose of an administered drug
B. An administered dose to a body weight
C. An unchanged drug reaching the systemic circulation
D. The amount of a drug in the body to the concentration of a drug in plasma
Answer:D

233. Movement of drug across the membrane is called as

A. Symport
B. Antiport

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 C. Drug transport
D. Absorption
Answer:C

234. Which of the following is known as Tamoxifen binding site?

A. Site I
B. Site II
C. Site III
D. Site IV
Answer:D

235. Which of the following drug selectively bound to extravascular tissues?

A. Warfarin
B. Diazepam
C. Digitoxin
D. Chloroquin
Answer:D

236. Plasma Protein binding …………..the volume of distribution of drugs.

A. increases
B. decreases
C. no change
D. none of the above
Answer:B

237. Following intravenous administration, drugs are distributed fastest to:

A. the skin, kidney, and brain
B. the liver, kidney, and brain
C. the liver, adipose, and brain
D. the liver, kidney, and adipose
Answer:B

238. …………is the tight junction between sertoli cells.

A. BBB
B. placental barrier

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 C. blood-testis barrier
D. endothelial barrier
Answer:C

239. Distribution is……………..

A. irreversible process
B. dynamic equilibrium process
C. Both (a) & (b)
D. none of the above
Answer:B

240. A drug reverses plasma-protein binding is often referred as……..

A. displacer
B. solvate
C. carrier substance
D. protein hydrolysate
Answer:A

241. Primary binding site for albumin is ………………binding site.

A. Warfarin
B. Diazepam
C. Digitoxin
D. Tamoxifen
Answer:A

242. Which of the following strategies are widely used to improve or promote
transport of drug to brain?
A. Glycosylation
B. Use of Mannitol
C. Prodrug approach
D. All of the above
Answer:D

243. Acidic drug have

A. Low Vd
B. high Vd

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 C. No Vd
D. none of the above
Answer:A

244. Low molecular weight of drugs have

A. Low Vd
B. high Vd
C. No Vd
D. none of the above
Answer:B

245. Water soluble drugs have

A. Low Vd
B. high Vd
C. No Vd
D. none of the above
Answer:A

246. Lipid soluble drugs have

A. Low Vd
B. high Vd
C. No Vd
D. none of the above
Answer:B

247. Protein binding ……………the distribution of drugs.

A. Decreases
B. Increases
C. No Change
D. none of the above
Answer:A

248. Which one of the following physicochemical property is more important for
passive diffusion of drugs from the GIT?
A. Partition coefficient
B. Lipid solubility

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 C. pH of GIT fluids
D. dissolution constant
Answer:A

249. Drug permeation through BBB can be improved by………..

A. Glycosylation
B. Mannitol
C. Dihydropyridine redox system
D. all of the above
Answer:D

250. Which of the following drug diffuses readily into the brain?
A. Penicillin
B. Thiopental
C. Dopamine
D. all of the above
Answer:B

251. Drug distribution in an organ depends on…………

A. Organ size
B. Perfusion rate
C. Partition Coefficient
D. all of the above
Answer:D

252. Protein binding of acidic drugs decreased in………..

A. Trauma
B. Surgery
C. Hepatic Cirrhosis
D. Burns
Answer:A

253. Which one of the following sentences will be the actual definition of
distribution?
A. Transfer of drug from the administration dosage to surrounding fluid
B. Transfer of drug from the surrounding the fluid to the blood

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 C. Transfer of the drug from the oral cavity to the intestine
D. Reversible tr
Answer:D

254. What should be the molecular weight of the drug molecules so that they can
easily pass through the membrane?
A. 600-800 Dalton
B. 500-600 Dalton
C. 300-500 Dalton
D. 200-400 Dalton
Answer:B

255. Which type of drug cannot enter the cell membrane in the below picture?
A. Ionized drug
B. Unionized drug
C. Hydrolyzed drug
D. Unhydrated drug
Answer:A

256. Which drugs cannot pass the Capillary endothelial Barrier?

A. Molecular size less than 600 Dalton
B. Drugs bound to blood components
C. Drugs bound to a chemical moiety
D. All drugs can pass
Answer:B

257. Which of the following drug cannot pass through the plasma membrane
barrier?
A. Drug size less than 50 Dalton
B. Lipophilic drugs 50-600 Dalton
C. Polar or ionized drugs of size greater than 50 Dalton
D. Drug size more than 600 Dalton
Answer:D

258. Which cell make up the blood-brain barrier?

A. Squamous epithelium cells

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 B. Fat cells
C. Red blood cell
D. Endothelial cells
Answer:D

259. What is the name of the specialized cells that support the blood-brain barrier
tissue?
A. Astrocytes
B. Dendrites
C. Fat cells
D. Endothelial cells
Answer:A

260. Why dopamine cannot be administered for the disease Parkinsonism?

A. Don’t have a medicine
B. It is not the medicine
C. Cannot cross the blood-brain barrier
D. Forms aggregate and thus cannot cross the BBB
Answer:C

261. Which one of these is not an approach to make the drug cross the blood-brain
barrier?
A. Using permeation enhancers
B. Osmotic disruption of the blood-brain barrier
C. Use of highly lipophilic drug only
D. Use of drug carriers to cross the BBB
Answer:C

262. Which drugs can easily pass the Placental barrier?

A. Drugs having a molecular weight less than 1000 Dalton
B. Moderate to high lipid solubility
C. Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility,
analgesics, and antibiotics
D. Analgesics, antibiotics, etc
Answer:C

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263. What is the function of the blood-testis barrier?
A. Restricts the passage of drug to the testis
B. Restricts the passage of drug to sperms
C. Restricts the passage of drugs to spermatocytes
D. Restricts the passage of drugs to spermatocytes and spermatids
Answer:D

264. What is the perfusion rate?

A. The total volume of blood
B. The volume of blood that flows through the heart per unit time
C. The volume of blood that flows per unit time per unit volume of tissue
D. The volume of tissue that flows per unit time per unit area of a blood vessel
Answer:C

265. Who has more intracellular and extracellular water more in their body?
A. Aged
B. Adults Of age more than 20
C. Infants
D. Children at puberty
Answer:C

266. Who has higher fat content?

A. Adults of age above 70
B. Adults of age more than 20
C. Infants and elders
D. Children at puberty
Answer:C

267. Who has poorly developed BBB?

A. Infants
B. Adults Of age more than 20
C. Aged
D. Children at puberty
Answer:A

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268. During pregnancy, drug distribution is more. Which of the following sentences
describe the given fact better?
A. The baby needs more drug
B. The mother needs more drug due to high metabolism
C. The surface area increases in the mother’s body due to the presence of uterus, placenta, and
foetus. Thus more area for distribution of drugs
D. The growth of the uterus, placenta, and foetus increases the volume thus increasing
distribution. And even the baby forms a separate compartment for a drug to get distributed
Answer:D

269. What happens when an obese person is given with a lipophilic drug?
A. Drug aggregation will begin
B. He cannot absorb lipophilic drugs
C. High adipose tissue take up most of the lipophilic drug
D. A large amount of drug is needed as the person’s weight is more
Answer:C

270. What is the consequence of diet high in fats?

A. The patient can’t be given with acidic drugs
B. The patient can’t be given with basic drugs
C. The basic drugs will aggregate and become poisonous for him
D. The high fatty acid level affect the binding of acidic drugs
Answer:D

271. The extent to which a drug is distributed is a tissue depends upon

___________ and _____________
A. The concentration of a drug, tissue/blood partition coefficient of drug
B. Tissue volume, tissue/blood partition coefficient of drug
C. Tissue surface area, tissue/blood partition coefficient of drug
D. Blood density upon the tissue, tissue/blood partition coefficient of drug
Answer:B

272. Which one of the following has a high perfusion rate?

A. Fat
B. Muscle and skin
C. Lungs and kidney

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 D. Bone
Answer:C

273. Which one of the following has very low perfusion rate?
A. Fat and bone
B. Muscle and skin
C. Lungs and kidney
D. Liver and Heart
Answer:A

274. Infants have high albumin content.

A. True
B. False
C. none
D. all
Answer:B

275. Disease state of a patient can influence drug distribution across the body.
A. True
B. False
C. none
D. all
Answer:A

276. In meningitis and encephalitis polar antibiotics gain access to BBB which
don’t happen to a healthy person.
A. True
B. False
C. none
D. all
Answer:A

277. What reasons make tissue-drug binding important for drug distribution?
A. Increases the volume of distribution of drugs and results in localization of drug at a specific site
B. Increases the volume of distribution of drugs
C. Results in localization of drugs at a tissue specific site

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 D. Increases in absorption from the tissue due to concentration increasing
Answer:A

278. Following is the order in decreasing order of drug binding to the

extravascular tissue. Which one is the correct order?
A. Liver > kidney > muscle > lung
B. Liver > muscle > lung > kidney
C. Liver > muscle > kidney > lung
D. Liver > kidney > lung > muscle
Answer:D

279. What is the relation between halogenated hydrocarbon and liver?

A. Halogenated hydrocarbon is a drug for liver problems
B. Halogenated hydrocarbon is nutrition for liver
C. Halogenated hydrocarbon causes hepatotoxicity
D. Halogenated hydrocarbon forms the bile juices in liver
Answer:C

280. Which drugs accumulate in liver?

A. Acidic drugs like imipramine
B. Basic drugs like imipramine
C. Halogenated hydrocarbons
D. Chloroquinine
Answer:B

281. Which metals get accumulated in kidney?

A. Mercury, cadmium, lead
B. Mercury, cadmium, iron
C. Mercury, lanthanum, lead
D. Mercury, cadmium, fluoride ions
Answer:A

282. Which of the following drugs accumulate in skin?

A. Acidic drugs like imipramine
B. Basic drugs like imipramine
C. Halogenated hydrocarbons

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 D. Chloroquine
Answer:D

283. Which of the following drugs are responsible for retinopathy?

A. Acidic drugs like imipramine
B. Basic drugs like imipramine
C. Halogenated hydrocarbons
D. Chloroquinine
Answer:D

284. Which drugs deposit in hair shafts?

A. Arsenicals
B. Tetracycline
C. Halogenated hydrocarbons
D. Lipophilic drug
Answer:A

285. Which drug causes brown yellow discoloration of infant’s teeth?

A. Arsenicals
B. Tetracycline
C. Halogenated hydrocarbons
D. Lipophilic drug
Answer:B

286. Which drug accumulate in adipose tissue?

A. Arsenicals
B. Tetracycline
C. Halogenated hydrocarbons
D. Lipophilic drug
Answer:D

287. Which drugs results in distortion of double stranded DNA structure?

A. Arsenicals
B. Quinacrine
C. Halogenated hydrocarbons

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 D. Lipophilic drug
Answer:B

288. In equation X=Vd C, what does Vd denotes?

A. Density
B. Volume of blood
C. Volume of body
D. The volume of the body fluid in which the drug is getting dissolved
Answer:D

289. The amount of drug in the body is directly proportional to the concentration
of the drug in plasma.
A. True
B. False
C. none
D. all
Answer:A

290. The body water has 3 distinct compartments. Which one of these is not one of
the compartments?
A. Vascular fluid
B. Intracellular fluid
C. Extracellular fluid
D. Between the tissue layers
Answer:D

291. How can you determine the extracellular fluid volume?

A. Evans blue
B. Na+
C. D20
D. Tritiated water
Answer:B

292. How a patient’s plasma volume can be determined?

A. Evans blue
B. Na+

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 C. D20
D. Tritiated water
Answer:A

293. The total body water volume can be determined by using high molecular
weight dyes.
A. True
B. False
C. none
D. all
Answer:B

294. How will you determine the intracellular fluid volume?

A. Evans blue
B. Na+
C. Difference between total body water and ECF volume
D. Tritiated water
Answer:C

295. What will be the apparent volume of distribution of warfarin?

A. The apparent volume of distribution is less than the true volume of distribution
B. The apparent volume of distribution is more than the true volume of distribution
C. The apparent volume of distribution is equal to the true volume of distribution
D. Warfarin is not a medicine
Answer:A

296. What will bet the apparent volume of distribution of drugs which binds
selectively to extravascular tissues?
A. The apparent volume of distribution is less than the true volume of distribution
B. The apparent volume of distribution is more than the true volume of distribution
C. The apparent volume of distribution is equal to the true volume of distribution
D. The apparent volume of distribution is equal to the volume of extravascular tissues
Answer:B

297. Factors altering the binding of the drug to the blood increases the volume of
distribution of the drug and the factors that influence drug binding to the

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extravascular component decreases the volume of distribution.
A. True
B. False
C. none
D. all
Answer:A

Chapter: Protein Binding of Drugs

298. Which one of the following bonds is not generally a bond through which a
drug will bind in our body?
A. Hydrogen bond
B. Hydrophobic bond
C. Ionic bond
D. Covalent bond
Answer:D

299. Binding of drugs falls into 2 components those are _______________

A. Binding of drugs to blood components and to extravascular tissue
B. Binding of drugs to blood components and to other cells
C. Binding of drugs to cells and blood cells
D. Binding of drugs to blood components to bones and cells
Answer:A

300. Which one of the following is the correct order of the drugs binding to various
plasma protein?
A. Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins
B. Albumin > globulins > lipoproteins > alpha-1 acid glycoprotein
C. Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
D. Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein
Answer:C

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