6/3/24, 11:34 AM Petra Kraus | Clarkson University

Education Background
Molecular Genetics & Human Biology Ph.D. - University of Ulm, Germany

Research Interests
I have always aimed to seek medical relevance in my research since my experience in
human genetics and genetic counseling as a graduate student. I strongly believe in
stem cells and induced pluripotent cells as the future of regenerative medicine, yet
we first must understand how stem cells direct themselves to their final
differentiated state within the complex setting of any tissue or organ. Deciphering
the “communication with” and “education from” neighboring cells a stem cell and its
progeny receives during the journey to a differentiated end point is the key to
success in controlled re-differentiation of self-renewing cells for regenerative
purposes. Using state of the art genomic technologies we have identified key aspects
of the complex Gene Regulatory Network making up the axial skeleton (backbone)
and the associated intervertebral discs (IVD). This equips us with a complex network
of interactions at a gene regulatory level. Applying this knowledge to differentiate
stem cells or patient derived induced pluripotent cells will allow for the development
of safe alternatives to one of today's most common degenerative ailments, namely
IVD degeneration

Patents
U.S. Patent. 20110165570A1. Method Of Effecting De-Differentiation Of A Cell.
Issue Date: 2011-07-07

Publications
Sivakamasundari, V., P. Kraus, S. Jie, and T. Lufkin, Pax1-EGFP: New Wildtype And
Mutant EGFP Mouse Lines For Molecular And Fate Mapping Studies. Genesis,
2013: p. In Press. DOI: 10.1002/dvg.22379

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Ng, J.H., V. Kumar, M. Muratani, P. Kraus, J.C. Yeo, L.P. Yaw, K. Xue, T. Lufkin, S.
Prabhakar, and H.H. Ng, In Vivo Epigenomic Profiling of Germ Cells Reveals
Germ Cell Molecular Signatures. Developmental Cell, 2013: p. In Press. DOI:
10.1016/j.devcel.2012.12.011
Kraus, P., V. Sivakamasundari, S.L. Lim, X. Xing, L. Lipovich, and T. Lufkin, Making
sense of Dlx1 antisense. Developmental Biology, 2013: p. In Press. DOI:
10.1016/j.ydbio.2013.01.035
Sivakamasundari, V., H.Y. Chan, S.P. Yap, X. Xing, P. Kraus, and T. Lufkin, New
Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout
studies. Genesis, 2012. 50(4): p. 375-83. DOI: 10.1002/dvg.20802
Lee, W.J., P. Kraus, and T. Lufkin, Endogenous tagging of the murine
transcription factor Sox5 with hemaglutinin for functional studies. Transgenic
research, 2012. 21(2): p. 293-301. DOI: 10.1007/s11248-011-9531-9
Kraus, P., X. Xing, S.L. Lim, M.E. Fun, V. Sivakamasundari, S.P. Yap, H. Lee, R.K.
Karuturi, and T. Lufkin, Mouse strain specific gene expression differences for
Illumina microarray expression profiling in embryos. BMC Research Notes 2012.
5: p. 232. DOI: 10.1186/1756-0500-5-232
Yap, S.P., X. Xing, P. Kraus, V. Sivakamasundari, H.Y. Chan, and T. Lufkin,
Generation of mice with a novel conditional null allele of the Sox9 gene.
Biotechnology Letters, 2011. 33(8): p. 1551-8. DOI: 10.1007/s10529-011-0608-6
Chan, H.Y., V. Sivakamasundari, X. Xing, P. Kraus, S.P. Yap, P. Ng, S.L. Lim, and T.
Lufkin, Comparison of IRES and F2A-Based Locus-Specific Multicistronic
Expression in Stable Mouse Lines. PLoS ONE, 2011. 6(12): p. e28885. DOI:
10.1371/journal.pone.0028885
Kraus, P., G. Leong, V. Tan, X. Xing, J.W. Goh, S.P. Yap, and T. Lufkin, A more cost
effective and rapid high percentage germ-line transmitting chimeric mouse
generation procedure via microinjection of 2-cell, 4-cell, and 8-cell embryos with
ES and iPS cells. Genesis, 2010. 48(6): p. 394-9. DOI: 10.1002/dvg.20627
Heng, J.C., B. Feng, J. Han, J. Jiang, P. Kraus, J.H. Ng, Y.L. Orlov, M. Huss, L. Yang, T.
Lufkin, B. Lim, and H.H. Ng, The nuclear receptor Nr5a2 can replace Oct4 in the
reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 2010.
6(2): p. 167-74. DOI: 10.1016/j.stem.2009.12.009
Chia, N.Y., Y.S. Chan, B. Feng, X. Lu, Y.L. Orlov, D. Moreau, P. Kumar, L. Yang, J.
Jiang, M.S. Lau, M. Huss, B.S. Soh, P. Kraus, P. Li, T. Lufkin, B. Lim, N.D. Clarke, F.
Bard, and H.H. Ng, A genome-wide RNAi screen reveals determinants of human

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6/3/24, 11:34 AM Petra Kraus | Clarkson University

embryonic stem cell identity. Nature, 2010. 468(7321): p. 316-20. DOI:

10.1038/nature09531
Chatterjee, S., P. Kraus, and T. Lufkin, A symphony of inner ear developmental
control genes. BMC Genetics, 2010. 11: p. 68. DOI: 10.1186/1471-2156-11-68
Feng, B., J. Jiang, P. Kraus, J.H. Ng, J.C. Heng, Y.S. Chan, L.P. Yaw, W. Zhang, Y.H.
Loh, J. Han, V.B. Vega, V. Cacheux-Rataboul, B. Lim, T. Lufkin, and H.H. Ng,
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan
nuclear receptor Esrrb. Nature Cell Biology, 2009. 11(2): p. 197-203. DOI:
10.1038/ncb1827

Contact
Email: pkraus@clarkson.edu

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Clarkson Box Number: CU Box 5805

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