7th Sem Que Paper

QP Code: 721006 Reg. No.
Seventh Semester B. Pharm Degree Regular Examinations

October 2021
Instrumental Methods of Analysis
(2017 Scheme)
Time: 3 Hours Max. Marks: 75
Answer all questions to the point neatly and legibly " Do not leave any blank pages between
answers " Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together "Leave sufficient space between answers
Draw diagrams wherever necessary
Essays (2x10=20)
1. Explain the different vibrational modes of molecules. With a neat diagram explain
the instrumentation of IR spectrophotometer.
2. Discuss the different pumping device, flow control system, sample port and
columns employed in HPLC.
Short Notes (7x5=35)
3. Describe the construction of hollow cathode lamp used in atomic absorption
spectroscopy.
4. Describe the construction and working of a photo multiplier tube.
5. What is the chromatography media used in gel filtration. What are the
considerations when choosing a gel filtration chromatography media.
6. Explain how affinity chromatography helps in quantification and analysis of
proteins.
7. Discuss the underlying principle of capillary electrophoresis.
8. Outline the various steps in the preparation of TLC plates in the laboratory.
9. Explain the mechanism of ion exchange as applied to chromatography.
Answer Briefly (10x2=20)
10.Retention time and retention volume.
11.Distinguish between isocratic and gradient elution.
12.Distinguish between hypso chromic and hyper chromic shift.
13.Quenching of fluorescence
14.What are the grades of paper used in Paper Chromatography.
15.List out four gases commonly used as carrier gas in Gas Chromatography.
16. Distinguish between group frequency region and finger print region.
17.State Beer-Lambert's Law.
18.List out four sources of radiation useful for UV Specroscopy.
19.List out the four electronic transitions.
Seventh Semester B. Pharm Degree Supplementary Examinations
February 2022
(2017 Scheme)
answers" Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together Leave sufficient space between answers
Essays (2x10=20)
1. Explain the principle of fluorimetry using Jablonskis diagram, explain the various
deactivation processes. Explain the applications of fluorimetry.
2. Explain the construction and working of gas chromatography with a neat
diagram.
3. Explain the different types of electronic transitions encountered in UV
spectroscopy.
4. What is "Electrophoresis " Chromophore "Auxochrome
Bathochromic shift "Hypsochromic shift
5. Explain the construction and working of a GOLAY Cell.
6. Explain the principle behind flame photometry.
7. Explain the term height equivalent of a theoretical plate.
8. Explain the principle, stationary and mobile phases of gel filtration
chromatography.
9. Explain the principle and applications of affinity chromatography.
10. Give two examples of cation exchange resins and two examples of anion
exchange resins.
11.How willyou distinguish between primary and secondary amines on an IR
spectrum.
12. Give two applications of ion exchange chromatography.
13. In an IR spectrum what is the finger print region.
14.lsocratic elution.
15.Reverse phase chromatography.
16.Isoelectric focusing.
17. Give two methods of identifying the separated spots in paper chromatography.
18.Compare TLC and HPTLC on particle size parameter and thickness of stationary
phase.
19. Methods for preparing TLC plates
********
QP Code: 721006 Reg. No....
Seventh Semester B. Pharm Degree Special Supplementary
Examinations July 2022
(2017 Scheme)
Answer allparts of a single question together "Leave sufficient space between answers
Essays (2x10=20)
1. Explain Beer-Lambert's law. Derive the Beer-Lambert's equation and explain the
deviations.
2. With the help of a schematic diagram, explain the instrumentation of HPLC. Add
a note on detectors used in HPLC.

3. Explain the different types of spectral shifts observed in UV - visible
spectroscopy.
4. Classify sampling techniques in IR spectroscopy. How to prepare solid samples
by pressed pellet technique to obtain IR spectrum.
5. Enlist and explain with example the qualitative applications of UV spectroscopy.
6. What is programmed tenperature gas chromatography. Write its principle and
advantages.
7. Why high pressure pumps are important in HPLC. Explain the working of
reciprocating pump.
8. Define and classify chromatography. Explain the mechanisms of separation in
chromatography.
9. Differentiate between free boundary electrophoresis and zone electrophoresis.
Write the procedure and applications of paper electrophoresis.
10.Define quenching of fluorescence.
11.Differentiate between Hyperchromic and hypochromic effect using UV Spectra.
12.Why photomultiplier tube is considered as the most sensitive detector in UV
spectroscopy.
13.What is the finger print region of IR Spectrum.
14.Any two applications of gel filtration chromatography.
15.What are the factors affecting the Chromatographic column efficiency.
16.Explain how softening of hard water could be achieved by using "lon exchange
chromatography
17.What is two dimensional development in TLC. Explain its importance.
18.Explain with examples the specific and non-specific detection techniques in TLC.
19.Differentiate between normal phase and reversed phase hromatography.
t***k****t*********
Seventh Semester B. Pharm Degree Regular/Supplenmentary
Examinations February 2023
(2017 Scheme)
answers Indicate the question number correctly for the answer in the margin space
Essays (2x10=20)
1. With the help of aray diagram, explain the instrumentation requirements of UV
spectrophotometer. Discuss the working of Photomultiplier tube in detail.
2. Define and dlassify Chromatography. With the help of van-Deemter equation and
van-Deemter plot, discuss the factors influencing the efficiency of separation.
3. Explain simultaneous equation method of multicomponent analysis.
4. With the help of neat and labelled diagram, write a note on Golay detector used
in IR spectroscopy.
5. Explain the construction and working of Hollow Cathode Lamp with the
help of a neat diagram.
6. Discuss the steps involved in Paper chromatography. Discuss the importance of
Chamber saturation in paper chromatograpy.
7. Discuss the mechanism of ion exchange chromatography. DiscuSs the
applications of ion exchange chromatography.
8. Explain the construction and working of thermal conductivity detector in GC.
9. What is the principle of Electrophoresis. Explain the factors in electrophoresis.
Write the procedure and applications of paper electrophoresis.
10.Differentiate between Bathochromic and hypsochromic shifts with the help of UV
Spectra.
11.What isQuenching. List the factors responsible for quenching of fluorescence.
12.What are the ideal properties of a UV detector.
13.Why enission wavelength is always longer than absorpion wavelength.
14.Write the formulae and explain how the Number of Theoretical plate can be
determined from a chromatogram
15.Why activation of chromatographic plate is important in adsorption TLC
16.Explain the principle of affinity chromatography.
17.Differentiate between Isocratic elution and gradient elution in HPLC.
18.Write briefly on carrier gases used in GC.
19.Explain the working of "Rotary sample valveloop injection" used for sample
injection in HPLC.
June 2023
(2017 Scheme)
answers " Indicate the question number corectly for the answer in the margin space
Essays (2x10=20)
1. Explain the construction and working of a double beam UV spectrophotometer
with the help of a neat diagram.
2. Explain the principle behind IR spectroscopy and the different stretching and
bending ibrations.
3. Briefly explain what are the factors that affect intensity of fluorescence.
4. Explain the principle and types of resins employed in ion exchange
chromatography.
5. Explain on the stationary and mobile phases used in gel chromatography.
6. Explain any two types of burners used in Flame Photometry.
7. What are the types of columns used in gas-liquid chromatography.
8. Explain the instrumentation setup of HPTLC.
9. Explain zone electrophoresis.
10.In fluorescence what is intersystem crossing.
11.Explain Isobestic point.
12.Explain flame atomizers.
13.Explain derivatization in Gas chromatography.
14. Give four examples of detectors used in gas-iquid chromatography.
15. Column efficiency.
16.Distinguish between guard column and analytical column.
17.State four applications of HPLC.
18. Mention two methods of detecting spots on a TLC plate.
19.What is the role of a ultrasonicator in HPLC.
*******t**********
QP Code: 722006 Reg. No..
October 2021
Industrial Pharmacy
(2017 Scheme)
Answer allparts of a single question together Leave sufficient space between answers
Essays (2x10=20)
1. Discuss the role of Central Drug Standard Control Organization in controlling the
drug distribution in India and write its organization and responsibilities.
2. Describe different types of hazards and their prevention in the Pharmaceutical
Companies.
3. Write briefly about platform technology.
4. Discuss the WHO guidelines for Technology Transfer (TT).
5. Discuss the Non-Clinical drug development.
6. Describe the plant location and layout of Pharma Industry.
7. What are the responsibilities of regulatory affairs personnel.
8. Discuss the practical aspects and problems of commercialization.
9. Responsibilities of TT agencies.
10.What is critical equipment variable.
11.Applications of quality risk management.
12.Different phases of clinical trials.
13. What are bioequivalence experimental study design,
14.Define NDA
15.Accident records
16.Define COPP
17.Structure of CTD
18.What are the critical manufacturing steps direct compression of tablet dosage
forms
19.What are the objectives of pilot plant scale up techniques
February 2022
Industrial Pharmacy
(2017 Scheme)
Answer all questions to the point neatiy and legibly " Do not leave any blank pages between
Answer all parts of asingle question together "Leave sufficient space between answers
Essays (2x10=20)
1. Write a note on the historical overview of regulatory affairs, regulatory authorities
and their role & responsibilities in controlling the introduction of newer drug
molecules.
2. Discuss the plant location and layout and other requirements for starting a
Pharma Industry.
3. Discuss the chemical hazards and their prevention.
4. Explain in detail about SUPAC guidelines.
5. Granularity of TT Process.
6. Describe briefly about platform technology.
7. What are the regulatory requirements and approval procedures for New drugs in
India
8. What are the role of TBSE in Technology transfer.
9. What are the responsibilities of CDSCO.
10.What are the unit operations involved in pilot plant scale up of solid dosage forms
11.Define Technology transfer.
12. Different phases of clinical trials.
13.What are innovation and invention.
14.Different types of licensing agreement
15.Define regulatory authority.
16.Briefly Explain TIFAC.
17.Briefly Explain COPP.
18.Steps of drug development process.
19.What is the structure of CTD
Seventh Semester B. Pharm Degree Special Supplementary
Industrial Pharmacy
(2017 Scheme)
Essays (2x10=20)
1. Explain general consideration and significance of personnel requirements, space
requirement of pilot plant scale up techniques.
2. Explain in detail about WHO guidelines for technology transfer.
3. Explain the regulatory requirement for non-clinical drug development.
4. Describe the factors influencing the location of the pharmaceutical industry.
5. Explain approved regulatory bodies and agencies.
6. Explain detail about Common Technical Document (CTD).
7. Mention some important consideration to platform technology.
8. Introduction and historical overview of regulatory affairs.
9. Explain APCTT and BCIL.
10.What are accident records.
11.What is NDA.
12.Write the importance of risk management principles.

13. Define transfer of technology.
14.What are fire hazards and electrical hazards.
15.What are regulatory requirements and approval procedure for new drugs.
16. Significance of SUPAC guidelines.
17.Differentiate between process layout and product layout.
18.List out the responsibility of regulatory affairs professionals.
19.Define commercialization.
Seventh Semester B. Pharm Degree Regular/Supplementary
Industrial Pharmacy
(2017 Scheme)
Essays (2x10=20)
1. Explain technology transfer protocol and quality risk management in technology
development and also process involved in technology transfer from R and D to
production.
2. Explain the general consideration of pilot plant scale up techniques for the
development of liquid orals forms with relevant documentation.
3. Explain any two hazards and their industrial safety measures.
4. Explain SUPAC guidelines.
5. Explain organization and responsibilities of CDSCo.
6. What are confidentiality agreements and MoUs.
7. Explain the granularity of TT process involved in technology development and
transfer.
8. Explain Data presentation for FDA submissions.
9. Explain Certificate of Pharmaceutical Product (COPP).
10.List out the major utility and service systems used in pharma industry.
11.Importance of Investigators Brochure ((B) and NDA.
12.Define TIFAC and TBSE.
13.What are regulatory requirements and approval procedure for new drug.
14.List out the different modules of CTD.
15.What are general consideration of Investigational New Drug (IND) application.
16. Format of COPP.
17.Define technology transfer protocol.
18.Define accident records.
19.What are the steps involved in scale up process.
***********t******
June 2023
Industrial Pharmacy
Time: 3 Hours
(2017 Scheme) Max. Marks: 75
Answer all questions to the point neatly and. Do not leave any blank pages between
Answer allparts ofa single question together "Leave sufficient space between answers
Essays (2x10=20)
1. Describe the steps involved in the pilot plant scale up techniques for the
development of semisolid dosage forms with relevant documentation
2. Discuss the WHO guidelines followed for Technology Transfer in the introduction
of drug product for marketing.
3. SUPAC guidelines.
4. Discuss the responsibilities of State Licensing authority.
5. Quality risk management.
6. Describe briefly about platform technology.
7. Investigator's Brochure.
8. Discuss the regulatory requirements for drug approval.
9. Plant location and layout of a pharmaceutical industry.
10.Types of hazards.
11.What is CTD (common technical document).
12.Different phases of clinical trials.
13.TT agencies in India.
14.Explain INDA.
15.Organization of CDSCO.
16. Define Validation.
17.Define overages.
18.Confidentiality agreement in technology of transfer.
19.What are the contents of NDA application.
October 2021
Pharmacy Practice
(2017 Scheme)
Essays (2x10=20)
1. Explain the different methods adopted to dispense drugs to inpatient.
2. Explain Pharmacokinetic drug interactions with examples.
3. Management of Tuberculosis.
4. Explain the tests associated with liver function.
5. Rational use of Antibiotics
6. Steps be followed to add or delete a drug to the Hospital Formulary.
7. Define an adverse drug reaction and classify it with suitable examples.
8. Explain the need for conducting patient medication history interview.
9. Factors to be considered during Therapeutic Drug Monitoring.
10.Draw a typical layout of community pharmacy.
11.Role of proton pump inhibitors in the management of peptic ulcer disease.
12.Composition of pharmacy and therapeutic committee.
13.Drawa typical organizational structure of a hospital.
14.What are the responsibilities of a hospital pharmacist.
15.Scope of clinical Pharmacy.
16.Pharmaceutical care.
17. Dispensing of proprietary products in community pharmacy.
18.Enlist any four causes of patient medication non-adherence.
19.Different types of materials to be stocked in a community pharmacy set up.
February 2022
Pharmacy Practice
(2017 Scheme)
Essays (2x10=20)
1. Define Hospital Formulary and explain its contents in detail.
2. Define on adverse drug reaction and describe the various causality assessment
scales used to measuring it.
3. Management of Hypertension.
4. What are the different abnormal constituents of urine and explain the various
tests used to detect the same.
5. Rational use of Injections.
6. Explain the functions of a hospital pharmacist.
7. Define patient counselling and explain the various steps involved in patient
COunselling.
8. Explain the role of pharmacists in ward round participation.
9. Explain the role of P.T.C. in ensuring safe use of drugs in hospital.
10.What are the different records be maintained in a community pharmacy.
11.Enlist the different methods of procurement of drugs in a drug store.
12.Write the different indications of therapeutic drug monitoring.
13.Write the different sources of drug information.
14.Explain the non-pharmacological management of asthma.
15.Automatic stop order reglation in hospital pharmacy services.
16.Explain the importance of taking medication history from a patient.
17.Write any two pharmacodynamic drug interactions with examples.
18.Write the different modes of non-verbal communication.
19. Re-order level in inventory control.
QP Code: 723006 Reg. No...
Seventh Semester B. Pharm Degree SpecialSupplementary

Pharmacy Practice
(2017 Scheme)
Answer all parts of asingle question together "Leave sufficient space between answers
Essays (2x10=20)
1. Describe location, layout and staff requirement for a Hospital Pharmacy.
2. Define and dassify adverse drug reactions. Explain the mechanism of Type A
reaction ith example.
3. Management of Myocardial Infarction.
4. Explain the various hematological tests used to measure the abnormal
Constituents of blood.
5. Rational use of over the counter drugs.
6. Explain unit dose drug dispensing system and complete floor stock systenm for in
patients.
7. Explain the various sources of drug information services.
8. Define therapeutic drug monitoring and need for therapeutic drug monitoring.
9. Functions of pharmacy and therapeutic committee.
10.Legal requirements to be followed for establishing a drug store.
11.Advantages and disadvantages of ABCanalysis.
12. Non-pharmacological management of epilepsy.
13.Methods used for analysis of drug expenditure.
14.Write any four communication skills required for a pharmacist.
15.Procedure adopted by PTC to prepare a list of emergency drugs.
16.Factors that influence non adherence to medication.
17.Differentiate between drug list and hospital formulary.
18.Write any four functions of a hospital.
19. Drawa medication interview form to collect patient details.
t ******t
Pharmacy Practice
(2017 Scheme)
Essays (2x10=20)
1. Explain the importance of drug distribution techniques and discuss in detail albout
unit dose drug distribution method ina hospital.
2. Define adverse drug reaction. Discuss in detail on its management along
with its reporting and classification.
3. Steps involved in pharmaceutical care planning.
4. Explain the management of hypertension.
5. Roles and responsibilities of pharmacy and therapeutic committee.
6. Different methods of inventory control in pharmacy.
7. Liver function tests associated with cholestatic liver disease.
8. Explain rational use of antibiotics.
9. Requirements for poison information centre.
10.Mention the responsibilities of hospital pharmacist.
11.Write the key functions of hospitals.
12.Define therapeutic drug monitoring.
13.Addition and deletion of drug from hospital formulary.
14.Steps in patient counseling.
15.Write the various drug information resources.
16. Mention different types of ward round participation.
17.What is medication chart review.
18. Define the term buffer stock/safety stock.
19. Mention the common systems for arranging medicines in the shelves.
t***t****t*********
June 2023
Pharmacy Practice
(2017 Scheme)
Essays (2x10=20)
1. Discuss the design and legal requirements for community pharmacy
management.
2. Define medication adherence. Explain the reasons of non-adherence and what
are the roles of a pharmacist in monitoring and improving medication adherence.
3. Storage and dispensing of controlled drugs.
4. Roles and responsibilities of community pharmacist.
5. Significance of verbal and nonverbal communication during patient counselling.
6. Explain the management of peptic ulcer.
7. Guidelines for patient medication history interview.
8. Applications of ABC and VED analysis.
9. Role of purchasing agent in drug procurement.
10. Classify the various types of hospitals.
11.Write about various drug distribution methods a hospital.
12. What are the various registers to be maintained in a community pharmacy.
13. Mention the various reasons for ordering for therapeutic drug monitoring.
14. Define patient counseling.
15. Write the examples of primary drug information sources.
16.Enumerate the classes of drugs used in bronchial asthma.
17. Mention types of ward round participation.
18.Enumerate pulmonary function tests.
19.Write the equaion for estimating the reorder quantity.
++++t
October 2021
Novel Drug Delivery Systems
(2017 Scheme)
Answer all parts of a single question together " Leave sufficient space between answers
Essays (2x10=20)
1. Explain the approaches involved in design of controlled release formulations
2. Discuss the various approaches for Gastroretentive drug delivery
3. Describe ideal drug candidates for pulmonary drug delivery
4. Explain Ocuserts
5. Explain the principles of mucoadhesion
6. Mention the advantages of targeted drug delivery systems
7. List the disadvantages of Implantable systems
8. Highlight the significance of biodegradable polymers with suitable examples
9. Explain microencapsulation by coacervation technique
10.Differentiate between microspheres and microcapsules
11.List any four examples for mucoadhesive polymers
12.Explain on dry powder inhalers
13.Outline four challenges involved in ocular drug delivery
14.Identify transmucosal permeation routes
15. Differentiate between controlled and sustained drug delivery
16.What are monoclonal antibodies
17.What are Nasal Sprays
18.What are osmotic drug delivery systems
19.Mention the applications of niosomes
February 2022
(2017 Scheme)
Essays (2x10=20)
1. Discuss the approaches for targeted drug delivery with suitable examples
2. Discuss the basic components of trans dermal drug delivery systemns
3. Describe ideal drug candidates for liposomal drug delivery
4. Discuss microencapsulation by air suspension technique with diagram
5. Classify and outine the salient features of ophthalmic inserts
6. Outline principle and components of osmotic drug delivery system with suitable
diagram
7. ldentify the uses of polymers in pharmaceutical industry
8. Highlight the importance of Nasal route of drug delivery
9. List pharmaceutical applications of microencapsulation
10. Mention the applications of monoclonal antibodies
11.Distinguish between liposomes and niosomes
12. List four examples for controlled release polymers
13.Differentiate biodegradable and non-biodegradable polymers
14.List the physical approaches for permeation enhancement in trans dermal drug
delivery systems
15.Menion disadvantages of controlled release drug delivery systems
16.Describe gastroadhesive systems
17.Explain on nebulizers
18.Outline mechanism of transmucosal permeability
19.Define diffusion controlled drug delivery systems
QP Code: 724006 Reg. No..
Seventh Semester B. Pharm Degree SpecialSupplementary
(2017 Scheme)
answers" Indicate the question number correctly for the answer the margin space
Essays (2x10=20)
1. Explain the formulation approaches for Transdermal delivery systems. Add a
note on the basic components of TDDS
2. Discuss methods of microencapsulation
3. Describe ideal drug candidates for buccal drug delivery
4. Discuss the concept of Monoclonal antibodies
5. Explain the concept of osmotic pump
6. Explain diffusion and dissolution-controlled systems citing suitable examples
7. Describe any two theories of mucoadhesion
8. Briefly outine the method of preparation of liposomes
9. What do you mean by Floating drug delivery systems
10.List the approaches for targeted drug delivery
11.Mention the applications of nanoparticles
12. Metered dose inhaler
13. Give any four examples of permeation enhancers used in transdermal drug
delivery
14.What are the major components of niosomes
15.Explain intra ocular barriers
16. Give two examples each for biodegradable and non-biodegradable polymers
17.Highlight the importance of pulmonary drug delivery
18. List four desirable properties of polymers for pharmaceutical use
19.Write about ideal drug candidates for controlled drug delivery
ttt
(2017 Scheme)
" Answer all questions to the point neatly and legibly " Do not leave any blank pages between
Essays (2x10=20)
1. Classify approaches to design controlled release dosage forms. Explain the
principle involved in the design of dosage form using ion exchange resins (5+5)
2. Discuss the formulation aspects in the development of buccal patches citing
suitable examples
3. Explain the basic components of transdermal patches
4. Importance of polymers in formulation development
5. Explain in-situ ocular delivery systerns
6. Discuss formulation criteria for pulmonary route of drug administration
7. Differentiate between liposomes and niosomes
8. Discuss the limitations of conventional ocular delivery systems
9. Explain any three theories of mucoadhesion
10.Define repeat action tablets with examples
11.Write the merits and demerits of transdermal patches
12. Mention two examples each of hydrophilic and hydrophobic polymers
13.Enlist ideal features of permeation enhancers with examples
14.What are implants. Give example
15. Classify types of nasal formulations
16.Enlist the applications of microencapsulation
17.Mention the applications of nanoparticles.
18.Write the scope of targeted drug delivery
19.Enlist physico-chemical factors affecting selection of drug candidate
*****t tttt tt******t

June 2023
(2017 Scheme)
Essays (2x10=20)
1. Mention the need for gastro retentive drug delivery systems. Explain the
methodology of floating drug delivery system with suitable examples (4+6)
2. Mention the limitations of conventional ocular preparations. Discuss the
importance of ocular inserts (4+6)
3. Discuss on pharmaceutical applications of polymers
4. Merits and demerits of microspheres
5. Explain the factors affecting drug permeation across mucosal membrane
6. Monoclonal antibodies
7. Elaborate the recent developments on the concept of nanotechnology in
pharmaceuticals
8. Explain controlled release delivery system based on the principle of diffusion
mechanism
9. Smart polymers with examples
10.Recall the use of penetrants and crosslinking agent in trans dermal drug delivery
system.
11.Mention the applications of dry powder inhalers.
12.Write the merits and demerits of buccal drug delivery system
13.Differentiate biodegradable and non-biodegradable polymers with examples
14.Enlist biological factors affecting selection of drug candidate
15. Differentiate microsphere and nanoparticles
16.Write the mechanism of osmotic drug delivery system
17.Mention the applications of nanoparticles
18.Mention the main components of liposome formulation
19. Name any two categories of marketed transdermal patches with examples
ttttt tt t*****

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QP Code: 721006 Reg. No.

Seventh Semester B. Pharm Degree Regular Examinations

Short Notes (7x5=35)

12.Write the importance of risk management principles.

Seventh Semester B. Pharm Degree SpecialSupplementary

Seventh Semester B. Pharm Degree Supplementary Examinations

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