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Aphasia

Huykien Le; Mickey Y. Lui.

Author Information

Last Update: August 30, 2021.

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Continuing Education Activity


Aphasia is an impairment of language caused by damage to the language area of the brain,
primarily Broca and Wernicke areas. Injury to the brain can be caused by various disease
processes such as cerebrovascular accident (CVA), traumatic brain injury (TBI), brain mass,
or neurodegenerative diseases. Patients can develop symptoms that include difficulties
articulating words or sentences, deficits of comprehension, or both. This activity highlights
the evaluation and treatment of aphasia and outlines the role of the interprofessional team in
the care of patients with this condition.
Objectives:
 Identify the pathophysiology of aphasia.
 Outline the typical presentation of each aphasia syndrome.
 Explain the management options available for aphasia.
 Describe interprofessional team strategies for improving care coordination and
communication to advance the care of patients with aphasia and improve outcomes.
Access free multiple choice questions on this topic.
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Introduction
Aphasia is an impairment to comprehension or formulation of language caused by damage to
the cortical center for language. It can be caused by many different brain diseases and
disorders; however, cerebrovascular accident (CVA) is the most common reason for a person
to develop aphasia. The symptoms of aphasia can range from mild impairment to complete
loss of any fundamental components of language such as semantic, grammar, phonology,
morphology, and syntax.
The function of language is the ability to express and comprehend spoken and written words.
The language area of the brain is typically located in the dominant hemisphere. These
structures include Wernicke area, Broca area, and arcuate fasciculus.[1] The Wernicke area is
located at the posterior end of the superior temporal gyrus. Its function is to process visual
and auditory information, and it is the center for comprehension and planning of words.
Broca area is located in the inferior frontal area and is the center for motor execution of
speech and sentence formation.[2] Arcuate fasciculus is the neural pathway connecting
Wernicke area to the Broca area.
Specific aphasia syndromes are dependent on the location of the lesion in the brain.[3] In
fluent aphasia, the patient can speak in sentences that sound like normal speech, but some of
the words are made-up words or have some sounds that are not correct. People with non-
fluent aphasia struggle to get words out, omit words, and speak in very short sentences.
Specific non-fluent aphasia syndromes include Broca, transcortical motor, mixed
transcortical, and global. Fluent aphasia syndromes include Wernicke, transcortical sensory,
conduction, and anomic.
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Etiology
Aphasia is most commonly seen in patients who have had a cerebrovascular accident but can
be seen in neurodegenerative diseases (Alzheimer disease, frontotemporal lobar degeneration,
etc.), vascular dementia, brain tumor, or traumatic brain injury.
Aphasia is not secondary to damage to motor or sensory function. It is not a result of
peripheral motor or sensory difficulties including paralysis affecting the speech muscles or
general hearing impairment.
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Epidemiology
According to the National Institute on Deafness and Other Communication Disorders
(NIDCD), in the United States, there are 180,000 new aphasia cases a year, and 1 of every
272 Americans are affected with aphasia. Approximately one-third of the cases are attributed
to cerebrovascular accidents.[4] The most common type is global aphasia.[5] There is an
equal incidence of aphasia caused by CVA between men and women.[6] However, the
incidence is age-dependent. Those younger than 65 years old have a 15% chance of being
affected compared to those older than 85 years old and have a 43% chance of developing the
condition.[7] 25% to 40% of stroke survivors develop aphasia due to damage to the language-
processing regions of the brain.
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Pathophysiology
Aphasia is caused by lesions to the language areas of the brain, which are typically located in
the dominant hemisphere. For the majority of the population, the dominant hemisphere is on
the left side.[8] These areas are Wernicke area, Broca area, and arcuate fasciculus. The most
common cause of aphasia is due to CVA. CVA occurs when the blood supply to a certain part
of the brain is greatly diminished or stopped due to an ischemic event (i.e., embolism or
thrombosis) or from a hemorrhagic event (i.e., intracerebral hemorrhage, subarachnoid
hemorrhage). In some cases, aphasia can be caused by damage to subcortical structures deep
within the left hemisphere, including the internal and external capsules, the thalamus, and the
caudate nucleus.[9]
In addition, aphasia can be caused by progressive deterioration of brain tissue such as
Alzheimer, Pick disease, vascular dementia, some forms of Parkinson disease, or from direct
physical injuries, as seen in traumatic brain injury. Other causes of injuries to language areas
can include infection and mass effects from brain tumors.[10]
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History and Physical


There are many different types of aphasia syndromes with signs and symptoms that may
overlap with each other. A clinician with the insight to differentiate and recognize the
differences in each type of aphasia can carefully formulate an individualized treatment plan.
Wernicke Aphasia (Receptive)
 The lesion is located in the Wernicke area (Brodmann area 22), which is the center for
comprehension and planning of words.[11][12] Although patients are unable to
understand written and/or spoken words, their speech remains fluent. At the same
time, however, their speech is meaningless and can include paraphasia, both
phonemic and semantics, neologism, and jargon. Phonemic paraphasia involves words
that sound alike (i.e., sap and map), while semantics paraphasia pertains to words that
relate to each other (i.e., sofa for couch). Neologisms are made-up words. Jargon is a
string of made-up words in combination with real words that do not make sense
together in context. These patients are unaware of their errors and do not recognize
that their speech lacks meaning.
o Example:
 Examiner: Hi, how are you doing today?
 Patient: I’m happy, are you pretty.
 Examiner: What are you doing today?
 Patient: We stayed with the water today.
Broca Aphasia (Expressive)
 The lesion is located in the Broca area, which is the center for the motor part of
speech and sentence formation.[12] Patients are unable to formulate grammatically
correct spoken and written language properly. Although their speech is non-fluent and
lacks words with grammatical significance such as prepositions and articles, patients
are able to include important content words such as nouns, verbs, and some
adjectives. Therefore, patients are usually able to convey the message that they are
trying to express.
o Example:
 Examiner: Hi, Mr. Smith, when did you graduate college?
 Patient: I was umm… 7 years… ago
 Examiner: What did you use to do?
 Patient: well… work… um… work… on desk… uh… marketing…
very good…
Conduction Aphasia
 The lesion is located at the arcuate fasciculus, which is the neural pathway connecting
the Wernicke area to the Broca area.[1] Patients have difficulties or are unable to
repeat what is spoken to them. They recognize their paraphasic errors and try to
correct them.
o Example:
 Examiner: Please repeat after me; boy.
 Patient: Boy.
 Examiner: Seventy-nine.
 Patient: Ninety-seven…no… seventy sine… seventy-nice
Transcortical Sensory Aphasia
 The lesion is located around Wernicke area, however, sparing Wernicke area and
isolating it. Patients have an inability to comprehend but can repeat with fluent
speech. At the same time, patients display the presence of semantic paraphasia.
Transcortical Motor Aphasia
 The lesion is located around Broca area, however, sparing Broca area and isolating it.
Patients have a non-fluent speech but are able to repeat long, complex phrases.
Patients tend to remain silent but may speak with 1 to 2 words.
Mixed Transcortical Aphasia
 The lesion is located around Wernicke area, Broca area, and arcuate fasciculus, but
these areas are spared and are isolated. Patients would have severe speaking and
comprehension impairment; however, they can repeat long, complex sentences.
Global Aphasia
 Lesions vary in size and location but tend to follow the left middle cerebral artery
distribution. This is the most severe form of aphasia. Patients can only produce a few
recognizable words and have little to no understanding of written or spoken language.
Patients are unable to read or write.
Anomia
 The lesion is at the angular gyrus and is the mildest form of aphasia. Patients have
difficulties with word finding.
Related Behaviors
 Self-repairs are disruptions in fluent speech resulting from mis-attempts to repair
erred production of speech.
 Speech disfluencies include repetitions and prolongations at the phonemic, syllable,
and word level with pathological frequency.
 Preserved and automatic language are when some language or language sequences
that were utilized frequently prior to onset are still produced with more ease.
 Struggle in non-fluent aphasias is a severe inc
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Evaluation
Patients with aphasia usually are evaluated with computed tomography (CT) without contrast
initially if a CVA is suspected, and subsequently, a magnetic resonance imaging (MRI) to
identify the precise location of the lesion. Then they are evaluated by speech/language
pathologists to assess and help identify areas of language deficit. Several formal exams are
used to identify aphasia, such as the Boston diagnostic aphasia exam and Western aphasia
battery. Boston diagnostic aphasia exam provides a severity rating from slight to severe. The
Western aphasia battery helps assess if the patient is aphasic, and if so, determines the type
and severity. Furthermore, it provides a baseline and should be repeated to trend
improvements, all the while identifying strengths and weaknesses.
For the evaluation of aphasia, three parts of language assessments are used to distinguish the
different types of aphasia syndromes. This includes fluency of speech, comprehension, and
repetition. Fluency of speech entails a typical speech rate, intact syntactic ability, and
effortless speech output. Comprehension is the patient's ability to understand written and
spoken words. Finally, repetition is the patient's ability to repeat written or spoken words.
Fluent Aphasia Syndromes
 Wernicke- fluent, impaired comprehension, unable to repeat
 Transcortical sensory- fluent, impaired comprehension, able to repeat
 Conduction- fluent, intact comprehension, unable to repeat
 Anomic- fluent, intact comprehension, able to repeat
Non-fluent Aphasia Syndromes
 Broca- non-fluent, intact comprehension, unable to repeat
 Transcortical motor- non-fluent, intact comprehension, able to repeat
 Mixed transcortical- non-fluent, impaired comprehension, able to repeat
 Global- non-fluent, impaired comprehension, unable to repeat
A cognitive neuropsychological approach attempts to identify the key language skills that are
not functioning properly. These are called modules. A patient may have difficulty with just
one module, or with a number of modules.
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Treatment / Management
The initial treatment of aphasia is dependent on its cause. Immediate management follows the
ABCs of critical care: airway, breathing, and circulation. In patients with acute CVA, patients
may receive intravenous thrombolytic therapy with tissue plasminogen activator (tPA), intra-
arterial mechanical thrombectomy, or carotid endarterectomy.[13] Surgical decompression is
used for patients with hemorrhagic CVA, TBI, or brain tumors. If the cause is due to an
infection, initiation of steroids, antivirals, or antibiotics may be indicated.
While there is no standardized treatment, the primary goal is for patients to regain their
greatest level of independence. To achieve this goal, the patient’s physical comorbidities,
mental health, and deficits need to be addressed and properly managed. In addition, caregiver
education and social support greatly impact a patient’s recovery outcome.
Patients suffering from aphasia have difficulties communicating their wants and needs. Some
patients with aphasia are cognizant of their deficit and situation, which can be frustrating and
may lead to severe depression and lack of participation in therapy. Therefore, early diagnosis
of depression is instrumental in treating the aphasic patient. The patient will require
emotional support from family, friends, and/or spiritual leaders. Referral to a psychiatrist,
neuropsychologist, and/or psychologist for evaluation and management may be indicated. In
addition, the treatment of depression includes pharmacological management.[14] First-line
medications include selective serotonin reuptake inhibitors (SSRIs), as well as tricyclic
antidepressants (TCAs). However, SSRIs are generally preferred due to lower side effect
profiles.
Patients will be evaluated by speech-language pathologists to determine their strengths and
weaknesses to individually customize a treatment plan. However, it has been shown that
patients have better improvement with short, intense treatment sessions compared to longer
but less intense treatment sessions.[15] Patients will be provided with different compensatory
strategies, also known as augmentative and alternative communication (AAC). These
strategies can include providing patients with a whiteboard, pen, and paper for writing,
photos of common items for identification, or more advanced devices, such as tablets with
common phrases or pictures.
Patients with non-fluent aphasias, such as Broca aphasia, have impaired fluency when it
comes to sentence generation but tend to have intact singing abilities. Melodic intonation
therapy (MIT) utilizes melody and rhythm to improve a patient’s fluency. The theory behind
MIT is to utilize the undamaged non-dominant hemisphere that is responsible for intoning
and reduce the use of the dominant hemisphere. MIT can only be used in patients with intact
auditory comprehension.[16]
Advances in neuroimaging technology now can appreciate the activation of the language
areas of the brain, allowing for further advances in aphasia research and treatment.[4]
[17] Studies on transcranial stimulation by direct electrical current (TES) and transcranial
magnetic stimulation (TMS) have shown promising results.[18] Along with therapy, there has
been an improvement in word-finding, function, and activity outcomes.[19] It should be
noted that using neuroimaging to isolate optimal stimulation sites for the use of TES is
expensive and time-consuming; therefore, it is currently more applicable in research rather
than clinical treatment. Stimulation of ancillary systems is easier and has shown to be
promising.[20] Studies on pharmacological therapy have yielded mixed results and tend to
coincide with the treatment of CVAs. Drug therapies have included dopaminergic agents, and
catecholaminergic agents can facilitate neural plasticity and recovery but require further
research.[21]
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Differential Diagnosis
Aphasia can present insidiously or acutely and is caused by several disease processes that
need to be ruled out such as CVA, brain tumor, brain hemorrhage, traumatic brain injury
(TBI), and dementia due to toxin, infection, or vascular.
Other differential diagnoses to consider include:
 Altered mental status from encephalopathy or delirium
 Dysphonia
 Dysarthria
 Apraxia of speech
 Cognitive-communication disorder
 Deafness
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Prognosis
Recovery of aphasia varies depending on the type, severity, cause, motivation of the patients,
etc.[22] Most improvement can be seen two to three months after onset and tends to peak at
six months, with recovery rates drastically decreasing thereafter. Broca aphasia has better
recovery when compared to global aphasia, and global aphasia has better recovery compared
to Wernicke aphasia.[23]
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Complications
Patients suffering from aphasia, who were once educated and literate, are now unable to
communicate their basic wants and needs. Many have intact awareness of their deficit and
may become frustrated, even violent. They may feel that they have lost control of their life
and feel isolated, which will lead to severe depression.[24] In addition, many will suffer from
other deficits seen in CVA, TBI, etc., such as the loss of mobility, ability to perform activities
of daily living, or potentially be bedridden. Patients may be incontinent of bowel or bladder
and unable to communicate whether they have urinated or defecated. This will increase the
likelihood of infections or pressure ulcers. They may have pain that is undertreated. In
summary, complications of aphasia are related or dependent ultimately on the underlying
cause.
Many patients with aphasia often have co-occurring non-linguistic cognitive deficits. This
often involves attention and working memory. This can involve the verbal domain as well as
the visuospatial domain.[25]
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Consultations
 Physiatrist (physical medicine and rehabilitation)
 Psychiatrist
 Neurologist
 Speech-language pathologist
 Neuropsychologist
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Deterrence and Patient Education


The most common cause of aphasia is CVA, and patients should be educated on correcting
modifiable risk factors that may lead to a CVA. The most important modifiable risk factor is
hypertension. Patients should follow various guidelines, such as the American College of
Cardiology (ACC) or the Joint National Committee (JNC-7, 8), to keep their blood pressure
under control.[26] Patients with atrial fibrillation should be on anticoagulation based on CAD
VASC2 Score, and those with diabetes need their blood sugar controlled.[27] Patients should
be encouraged to quit smoking. Ultimately, patient education depends on the underlying
cause.
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Pearls and Other Issues


It is important to understand that patients with aphasia have an impairment of language due to
injury from the brain and not a cognitive deficit. When communicating with patients with
aphasia, speak clearly, and use simple and short sentences. Another technique is repeating or
writing down keywords. Also, allow patients time to talk and finish their thoughts and avoid
correcting their speech.
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Enhancing Healthcare Team Outcomes


Aphasia is caused by different disease processes and consists of many syndromes. Because of
this, it is easily misdiagnosed. The initial challenge of diagnosing aphasia is that patients are
unable to communicate to provide an adequate history for diagnosis. This may require a
history from family members or friends, which can be unreliable or unavailable. Therefore,
the healthcare professional needs to be familiar with the signs and symptoms of aphasia.
Initially, patients will present to primary care or emergency clinicians. The ability to
recognize aphasia can aid in the diagnosis of its underlining cause. For example, patients with
an acute stroke can initially present with aphasia and can be misdiagnosed as delirium.
Aphasia has many underlining causes and requires an interprofessional team that includes a
physiatrist, psychiatrist, neurologist, speech-language pathologist, and neuropsychologist to
manage comorbidities and deficits.[15] Interprofessional team members need to know how to
properly communicate and interact with aphasic patients to avoid frustration and encourage
patient participation.
The speech-language pathologist plays a vital role in identifying the type of aphasia
syndrome and formulate an individualized rehabilitation regimen with the assistance of the
physiatrist. Depending on the patient’s comorbidities, other specialists are required. Patients
who suffered from a stroke may have cardiac, pulmonary, renal, or integumentary issues
requiring a cardiologist, pulmonologist, nephrologist, and wound care clinician. Physical
therapists and occupational therapists will be a part of the interprofessional team to treat
physical deficits and aid in aphasia treatment. Patients with neurodegenerative disease will
require a neurologist, while patients with an infectious cause require infectious disease
specialists.
Patients with aphasia will likely suffer from depression and require support from healthcare
professionals such as a neuropsychologist, psychologist, and psychiatrist. Patients will also
require social support. Family members, friends, and/or religious leaders will require
extensive education to assist patients in their recovery process.
There is no specific protocol in treating patients with aphasia. The treatment and
rehabilitation regimen is highly individualized and requires an extensive interprofessional
team. Proper consultation of specialists and education of family members and friends is
required to optimize patient treatment and allow patients to regain their greatest level of
independence.

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