Hypothalamus

Thyroid Hormone
Paraventricular
nucleus

T.S.H.
t.r.h.
= Tyrosine
Thyrotropes Ant.pit.

Thyroglobulin
THYROID SYNTHESIS
DIT DIT MIT DIT

STEPS
DIT + DIT = T4
TRH Release from Hypothalamus Iodination Thyroxine
MIT + DIT = T3
Triiodothyronine
Anterior pituitary to release TSH T4 + T3
Thyroid Hormone
TSH stimulates Follicular cells to
synthesize T.G.B. Iodide oxidation

Active d r i n
pen
Iodide trapping Transport

s i s
yto
Oxidation of Iodide (T.P.O.) En d o c

THYROID
Iodination of Tyrosine A.A. GLAND lysosomal enzymes

Couple DIT’s & MIT’s Iodide

[I]

Endocytosis of T.G.B. with T3 + T4

Lysosomal enzymes cleave T3 + T4 out of T.G.B.
Exocytosis of T3 + T4 into blood plasma

Endocrinology | Synthesis of Thyroid Hormone