6.

SUMMARY

In this work an attempt is made to design Pravastatin mucoadhesive buccal drug

delivery system containing an Anti hyperlipidamic drug. The main objective of the
present research work was to formulate a buccal delivery system of Pravastatin which
can bypass the hepatic first pass metabolism and enhance the bioavailability.

Mucoadhesive buccal tablets were prepared by direct compression method of

Pravastatin and different polymers like carbopol 940p, HPMC K4M, and NaCMC in
different ratios.

Stability studies of the selected formulation was carried out to determine

the effect of formulation additives on the stability of the drug and also to determine the
physical stability of the formulation. The stability studies were carried out at 40°C/75%
RH for 90days. There was no significant change in the physical property and weight
variation, hardness, thickness, friability, swelling studies, surface pH, in vitro drug
release studies, in vitro mucoadhesion strength drug content during the study period.

From the above the results formulation F5 was found to be best formulation for
the mucoadhesive buccal delivery of Pravastatin that complied with all the parameters.

Pravastatin mucoadhesive buccal tablets could be formulated using the drug,

Carbopol 940p and HPMC K4M, Na CMC with their proportions. It can be seen that by
increasing the concentration of Carbopol 940p and decreased concentration of Na CMC
in the formulation, the drug release rate from the tablets was found to be Increased. and
with the concentration mucoadhesive strength was also increased. But when the
concentration of HPMC K4M increased and Carbopol decreased the drug release rate
was found to be decreased.

From the formulations F5, F6, F7 and F8 the formulation F5 was selected as
optimized formulation because it showed maximum release and the other properties
such as swelling index was also low, mucoadhesion force shown good.

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Jangaon Institute of Pharmaceutical Sciences