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The fluid or semifluid contents of these cysts consist usually of
sebaceous material, cholesterin, epithelial debris, etc. Sometimes it
is thick, sometimes thin—and occasionally consists almost entirely of
mucus.
It is not uncommon to find structures in ovarian dermoids closely
analogous to, or actually resembling, mammary glands. These may
be mere nipple-like processes of skin, or completely developed
mammæ, well formed, but without ducts or gland tissue, may occupy
such a cyst. These really are pseudomammæ, because they have
no ducts. Nevertheless, glandular tissue is not always absent. This
resemblance proceeds even farther, in that in some of these ovarian
mammæ changes occur analogous to those which take place in
normal breasts.
The epiblast seems to have the power of developing mammary
glands or supernumerary mammæ in many locations—in fact, upon
any part of the body surface. About the thorax they are common;
upon the abdomen they are rarely observed; and they have been
found even upon the labia.
Sweat glands are infrequent in dermoids. Teeth are quite common.
These may vary in number from two or three up to several hundred
—may be embedded in definite sockets or simply sprout from the
cyst wall. Occasionally bone material, lodging such teeth and crudely
resembling a jaw, will be found.
Dermoids containing mucous membrane are found, especially in
connection with the ovary and with the postanal gut (i. e., the original
communication between the spinal and alimentary canals).
It is curious that under these circumstances mucous membrane is
sometimes furnished with hair, as it normally is in the stomach or
other cavities of some of the lower animals. Mucous glands and
retention cysts of these glands are also found in ovarian dermoids.
This will be more readily understood if the mutability of skin and
mucous membrane be not forgotten. The transition from one to the
other is not difficult, and we find all intermediate stages between the
two extremes—if not in man, at least in animals. This will account for
the fact that skin-covered dermoid tumors are found in certain parts
of the alimentary canal, and particularly in the pharynx. These
tumors grow also from the mucous membrane of the bowel, of the
rectum, or even of the small intestine.
Sutton has made a division of dermoids into three classes:
1. Sequestration;
2. Tubulodermoids;
3. Ovarian.
1. Sequestration Dermoids.—Sequestration dermoids occur
chiefly in situations where during
embryonic life coalescence takes place between two surfaces
possessing an epiblastic covering, although sometimes this
coalescence practically occurs late in life and by implantation.
Dermoids of the trunk occur particularly where opposite halves of
the body wall coalesce—that is, in the midline of the trunk and head.
Dermoid cysts are rarely found in connection with spina bifida, and
certain tumors spoken of as spina bifida undoubtedly are dermoids.
Anteriorly dermoids occur frequently in the scrotum, and occasionally
in the testicle. At the umbilicus they are rarely found—usually as
pedunculated tumors projecting externally. In the midline of the
thorax and neck they are most common opposite the manubrium,
dropping down behind it to invade the anterior mediastinum. Near
the hyoid bone they occur relatively frequently; about the head they
are met with most commonly at the angles of the orbits—more so at
the outer than at the inner angle. Dermoid cysts are known to
oculists as growing upon the iris or springing from the conjunctiva.
About the ear they are not infrequent; in the roof of the mouth,
especially if this be incomplete, we frequently find cysts of epiblastic
origin.
Sequestration dermoid cysts are also undoubtedly found in
connection with the dura mater, in the scalp, most commonly at the
anterior fontanelle, at the root of the nose, and at the external
occipital protuberance, where they may be confounded with
sebaceous cysts or with meningoceles. In order that a dermoid of the
dura may communicate with the skin there must of course be
osseous defect.
Sequestration dermoids upon the limbs have been mostly reported
as sebaceous cysts. They are rare, and usually associated with
antecedent injury, by which epiblastic structures are driven in and
implanted in such a way that as they develop they give rise to these
peculiar tumors. These are what Sutton calls implantation dermoids.
They are found upon the fingers and elsewhere.
2. Tubulodermoids.—These are largely connected with obsolete
canals and ducts. It is a great service which
Sutton has rendered in proving, apparently beyond the possibility of
doubt, that the central canal of the nervous system is really of
intestinal origin, and may be regarded as a disused segment of the
primary alimentary canal. He has also shown how it behaves
occasionally as do other functionless ducts, and that cysts and
dermoids in connection with it are to be thus explained. He and
others have also shown the anterior as well as the posterior
communication of these canals, and the pituitary body are to be
regarded in this light as the same formation of lymphoid tissue
around an obsolete canal which we see in Luschka’s tonsil close by,
and in Luschka’s gland at the other extreme of the canal.
Fig. 72 Fig. 73
3. Teratomas.
So far the endeavor has been to limit the term dermoid to tumors
which are essentially of epiblastic formation, their location being
explained on the inclusion theory of Cohnheim. There is also a still
more complicated type of tumor, composed of tissues of both
epiblastic and mesoblastic origin, perhaps even hypoblastic. Their
consideration belongs to that department of pathology known as
teratology, which is supposed to deal especially with monsters.
Strictly speaking a teratoma refers to an irregular tumor or mass
containing tissues and fragments of viscera of a suppressed fetus
which is attached to an otherwise normal individual. Nevertheless
the term is often applied to growths which are the result of luxuriant
mesoblastic development in which neither form nor member of a
suppressed fetus is present.
The presence of supernumerary members is largely connected
with what is called dichotomy, alluding thereby to cleavage either at
the anterior or posterior end of the developing embryo. When the
whole embryonic axis divides twins may be produced, but should
cleavage be partial we may have a monster with two heads if it be
anterior, or one with three or more limbs if it be posterior. Children
born with these deformities are usually called monsters, and the
study of such cases belongs entirely to teratology. But in certain
tumors small portions of a suppressed fetus may develop, as, for
instance, from the posterior portion of the sacrum, or within the
abdomen or thorax, or upon the neck or face, which on dissection
may contain a few vertebrae or processes resembling fingers
associated perhaps with a structure resembling intestine or liver.
This should be called a teratoma. Such tumors possess for the
pathologist the greatest value. In surgery, however, they are rare,
and there are scarcely two cases alike. The question of operation will
often arise, as it does with supernumerary limbs, and each case
should be studied upon its own merits. Sometimes they are
amenable to extirpation.
Embryonal Adenosarcoma.—Embryonal adenosarcoma is a
term given to certain teratomatous
tumors peculiar to renal and adrenal structure, which present
peculiar characteristics in the mixture of elements which enter into
their composition. At various times these tumors have been called
adenoma, sarcoma, rhabdomyoma, congenital cystic kidney, etc.
They have been also likened to the thyroid. They comprise a group
of neoplasms, always congenital in origin, which usually appear early
in life, but occasionally occur in advanced adult life. One of the most
marked specimens of this kind the writer removed from a man over
fifty years of age. Most of the specimens, however, described in
literature pertain to the young. On minute examination they often
present a strange, mixed picture of voluntary muscle elements
intermingled with epithelium arranged to imitate acinous glands, with
cystic dilatations of the true kidney tissue. They often attain
enormous size, and undergo such proliferation of mesoblastic
elements as to resemble sarcoma. Their occurrence is to be
explained only on the principles of Cohnheim’s hypothesis. When the
original Wolffian body is being differentiated from the elements about
it a confusion of the same with the excretory tubular beginnings,
which are to empty into the Wolffian duct, occurs. Thus we have the
commencement of a mixed mass which presents itself as a more or
less rapidly growing tumor, in which even cartilage or other
mesoblastic structures may be met with. It is scarcely possible that
any two specimens should yield exactly the same microscopic
picture, much depending on whether one element or the other
prevail. In a few of them there may occur also a mixture of adrenal
elements. Sometimes the renal structure itself is more or less
distinct, and rides, as it were, upon the surface of the tumor; at other
times it is entirely mixed up with it. While the condition is usually
limited to one side it may be a double affection, so that the second
kidney becomes useless and the patient succumbs. The only
treatment is extirpation.
Teratomatous tumors are sometimes found hanging in the
pharynx, attached by a small pedicle, where they may be
confounded with dermoids unless carefully examined after removal.
Many instances of this type of tumor are found in animals. Here no
false sentiment will prevent complete examination and preservation
of the specimen. They are also encountered in the sacral and
coccygeal regions.
Epulis.—Epulis means any tumor growing upon the gum. The term
was formerly applied in an indistinct and too comprehensive way,
although it is still retained in literature. But pure fibromas do spring
from the fibroösseous structure of the gum and alveolar process.
They are covered with the gingival mucous membrane and seem to
spring from the periodontal membrane. They seldom attain large
size, and then only by neglect. By the pressure of such tumors teeth
may be separated and distortion of the mouth produced. They
should be promptly extirpated.
Keloid.—Keloid is a fibrous neoplasm arising mainly in cicatricial
tissue, which is essentially fibroid in structure. It is a neoplasm which
often follows the general outline of the scar in which it grows,
consists in elevation of the surface, ordinarily quite smooth,
sometimes of a delicate pink from the dilated vessels which it
contains. Keloid is the bête noir of surgeons, as it frequently
complicates and disfigures scars which have at first been
satisfactory, and since it indicates a condition which it is discouraging
to deal with, because when it is removed there is usually recurrence
of growth within a few months after cicatrization. It often occurs in
stitch-hole scars and upon the site of extensive burns, and may be
observed after puncture of the ears for ear-rings, and has also been
observed in scars left by smallpox, acne, etc. It is more prevalent in
the colored race than in the white. In negroes multiple keloid tumors
are often seen, occasionally in large numbers. Their explanation is
unknown, and it may be that some trifling injury has preceded each
individual tumor (Fig. 74).
The treatment of keloid will be considered in the chapter on the
Surgical Diseases of the Skin.
Desmoids.—This term has been applied to tumors of a certain
clinical type which arise from the fibrous structures, usually of the
abdominal wall, and produce neoplasms like the fibromas of other
parts of the body. The use of the term should be restricted to those
tumors which proceed primarily only from muscles, tendons, and
aponeuroses, or perhaps from ligamentous and periosteal tissues.
These tumors are usually single, attain sometimes considerable size,
grow slowly, rarely involve other structures, and not infrequently
develop to such an extent as to encroach upon either pelvis or the
abdomen, or both. They have been known to attain to the weight
even of ten pounds or more. They are usually more or less
encapsulated, and are firm and dense in structure. Under the
microscope they have the general appearance of cellular fibroma.
Sarcomatous elements may be met, while they occasionally undergo
cystic degeneration. Their occurrence may be explained, at least in
some instances, on the embryological theory of Cohnheim.
Fig. 75
Multiple enchondromas.