GREEN

CHEMISTRY:
DESIGNING A GREEN FUTURE

RESEARCH INTEREST

Prepared by
KUNIKA SINDHWANI
 Green chemistry :
Topic: Designing A Green Future
Green Chemistry Defined As" Design Of Chemical Products And Processes To
Reduced Or Eliminate The Use And Generation Of Hazardous Substance". Green
Chemistry Is Concept Of Design That Includes Novelty Planning And Systematic
Conception. The Green Chemistry Approach Strive To Achieve Sustainability At
Molecular Level Because Of This It Is Applied To All Industries Sectors. The Field Of
Green Chemistry has Large Impact In Education, Environment And General Public .

Framework Of Green Chemistry

1. Concept Of Green Chemistry Were First Formulated At Beginning Of 1990's.
2. Paul T Anastas For the First Time In 1991 Coined term Green Chemistry .
3. Paul Called Father Of Green Chemistry.
4. In 1998 ,12 Principles Of Green Chemistry Is Established By Paul T Anastas And
John Warner.
12 Principles Of Green Chemistry Are Design Criteria
That Provide The Framework For Sustainable Design :

1. Waste Prevention
2. Atom Economy
3. Less Hazardous Chemical Synthesis
4. Designing Safer Chemicals
5. Safer Solvent
6. Design For Energy Efficiency
7. Use Of Renewable Feed Stocks
 8. Reduce Derivatives
9. Catalysis
10. Design For Degradation
11. Real Time Pollution Prevention
12. Safer Chemistry For Accident Prevention

Limitations
1. Not All Reaction Work In Absence Of Solvent .
2. Function Of Catalyst.
3. Exothermic Reaction Are Potentially Dangerous .

Review of literature:
1. Green Synthesis Interventions Of Pharmaceutical Industries For Sustainable

Development :Green Practice In Synthesis Of Drugs By Chosen On Solvent Selection, Bio

Catalyst And Regioselectivity Of Some Pharmaceutical Product At Large Industrial
Scales( Jaya Pandey, Ragini Dubey, Mohit Mishra, Mansi Sharma ,Pooja Kumari, Vikas
Rajan)1 2021 .

2. Applicability Of Green Chemistry In

Pharmaceutical Processes: Pharmaceutical
Companies Improve With Utilising Green
Chemistry By More Effective Less Toxic,
Innovative Chemistry Research And
Application Cost Benefits. Green Chemistry
Can Save Industry an estimated USD 65.5
Billion By 2020 By Reducing Manufacturing
Cost( Vivek Sharma Ceo Pharma Solution
 And Critical Care piramal Enterprises)2 2015.
3. Ultrasound For Drug Synthesis: A Green Approach : Ultrasound And Green
Solvent Is A Smart Combination. Ultrasound Is Known To Improve The Reactivity
And Kinetics Of Some Processes, Formation, Growth And Collapse Of Micro Size
Bubble. When Pressure Waves Of Adequate Intensity Propagates Through Elastic
Medium Cycles ( By Michelin Draye,gregory Chatel,romain Duwald)3 2020.
4. Greening The Pharmacy Shelves Reducing The Environmental Impact Of
Medicines Manufacture :Pharmaceutical Companies Have Switched The
Manufacturing Of Several Well Established Medicienes -including Diabetes Drug
Sitagliptin,and The Painkiller -ibuprofen(radhika Holmstrom)42022.
5. Mechano Chemistry :a Green Approach In Preparation Of Pharmaceutical Co-
Crystals. Mechano Chemistry Consider An Alternative Attractive Greener
Approach To Prepare Diverse Molecular Compounds And Synthetic Tools In
Different Field .Mechano Chemical Methods On Obtaining Of Pharmaceutical Co-
crystals (mizrain Solares,guadalupe Coyote Dotor,jose C. Franco,miriam R.
Zermano,carmen,daniel,avila)5 2021

6. Solventless Micro Extraction Techniques For Pharmaceutical Analysis: The

Greener Solution. In This, Micro Extraction Techniques Such As Solid Phase
Micro Extraction ,stir Bar Sorpit Extraction, Micro Extraction By Packed , Sorbed In
Tube Extraction Dynamics Headspace Are Very Active Area Of Research And
Application (heba M Mohammed )6.2022
 Work Plan
Research On Investigating The Use Of Natural Products As Therapeutics
Searches Botanical Herbs And Other Natural Products :

Green Industrial Processes Pharmaceutical

Ibuprofen Anti Inflammatory Drugs

☆ Conventionally Synthesis Was A 6 Step Process And Result In 60% Of Unwanted

Waste Chemical Byproduct. BHC Discovered A New Synthetic Routine With Only
Three Steps And Increase Efficiency.
☆ Chemotherapy Drug It Was Originally Made By Extracting Chemicals From Yew
Tree Bark, Process That Used A Lot Of Solvent In Addition To Killing The Tree .
The Drug Is Now Made By Growing Tree Cells In A Fermentation Vat.
☆ Carcinogen Replace With Sugar Or Starch To Make Bio Based Plastic By 2050 (it
Is Achieved)
☆ Yi Tang, Professor In Chemistry, University Of California :synthesized Simvastatin
Medicines ,treatment For High Cholesterol By Optimising Enzymes ,low Cost
,feed Stock, Cost Effective ,reduce Waste( Traditional Method Released A Great
Amount Of Toxic And Harmful Waste)
☆ But The Ultimate Challenge Is Co2 Have Petroleum Based Economic Currently,
So Does Green Chemistry Use Approaches To Make A New Ways Of Making Fuel
?Absolutely Right!
☆ Using Co2 Itself, Using Carbon Dioxide And Converting That into new Synthetic
Fuels, Not Only Gets Away From Petroleum But Also allow we To Use The Waste
Of Co2 As A Fuel. Carbon Dioxide Can Be More Than Waste. It Can Be Asset Too.
☆ Actually, Air Company Make Luxury Vodka Out Of Ethanol That Is Produced From
Carbon Dioxide . One Of The Things Right Now Is Making sustainable aviation
fuel , Out Of Alcohol. We Are Taking Carbon dioxide Out Of Atmosphere And
Using It To Fly Aeroplane ,So It Makes A Complete Circular Fuels ( Carbon neutral
fuel).
☆ Green Chemistry Is Useful In Addressing Climate Change Not, Only By Producing
New Kinds Of fuels, But Also Looking At The Entire Spectrum Of Now we
generate ,Store And Transport Our Energy. Now Looking On Our New Ways Of
Energy Storage Certainly Battery Techno But Also Storing Energy from Such As
 H2 And Green Hydrogen
☆ Solventless Reaction :
1. Dry Media Reaction Or Solid State Reaction .
2. These Reactions Are Economic, Environment Friendly ,More Efficient With More
Selectivity Compared To Reaction carried Out In solvent.
3. Reaction Are Easy To Handle And Reduce Pollution And Cheaper.Water As A
Solvent is a Safer Solvent.
4. New Solvent: Ionic Liquid, Supracritical Fluids .
5. The Reaction Which Are Carried Without Solvent Is Claisen Rearrangement.

Principle of Green
Chemistry is elimination of solvent in chemical processes or

replacement of hazardous solvent with environmental solvent .The development of

solvent free alternative processes is a best solution especially when either one of the
substances or product is liquid can be used as a solvent.
 Future :
In Recent Years, Pharmaceutical Industry Has Been Exploring The Potential Of
Green Chemistry In Drug Manufacturing .This Sector Is Responsible For Producing Life
Saving Drugs And His Potential To Make A Significant Impact On Global Sustainability
Efforts Adopting Green Chemistry Practice .Thus Implementing Green Chemistry In
Pharma Manufacturing Can Reduced In Pollution ,Improve Efficiency And Promote
Sustainability And Social Responsibility. Recent Developments Is In Adopting Green
Catalyst Enzymes Have Provided Through Advantages Of A Traditional Chemistry By
Being Able To Selected Selectivity Catalyse. The Reaction Save Cost And Time As Well
As Reducing Impurities Hazardous By Product. The Nobel Prize In Chemistry In 2018
Was Given To The Enzyme Engineering Highlighting, The Importance Of Its Role
Introducing Pollution And Environment Impact As A Demand For Sustainable Pharma
Continue To Grow Green Chemistry Important Role In The Future Of The Pharma .

Conclusion :
Green Chemistry Is A Rapidly Growing Field That Is Advancing Sustainability
Through Innovations And Applications. By Designing And Developing Sustainable
Chemical Processes Green Chemistry Is Contributing To A More Sustainable Future .As
We Continue To Face Environmental Challenges Green Chemistry Will Play An
Increasingly Important Role In Creating A More Sustainable World.

REFERENCES:
1)"Green synthesis interventions of pharmaceutical industries for sustainable
development "by Jaya Pandey,Ragini Dubey,Mohit Mishra,Pooja Kumari ,Vikas Ranjan
2021
 2)"Applicability of Green Chemistry In Pharmacetical Processes" by Vivek
Sharma CEO-Pharma solution and care piramal enterprises 2015

3)"Ultrasound for Drug Synthesis : A Green Approach" by Micheline

Draye,Gregory Chatel,Romain Duwald 2020

4)"Greening the pharmacy shelves :reducing the environmental impact of

medicines manufacture" by Radhika Holmstrom 2022

5)"Mechanochemistry :A Green Approach in the preparation of pharmaceutical

Cocrystals"by Mizrain Solares,Mirizam,Carman Myriam,Daniel Avila ,Jaran M German
2021

6)"Solventless Micro Extraction Technique for pharmaceutical Analysis:The

Greener Solution " by Heba M Mohamed 2022