Muscle relaxants

Classification:

1- By central action:
 Methocarbamol
 Tizanidine
 Cyclobenzaprine
 Chlorzoxazone
 Baclofen
 Dantronello
2- Peripheral action:

Not depolarizing

 Rocuronium
 Mivacurio
 Vecuronium
 Pancuronium
 Atracurium
 Cisatracurium

Depolarizing:

 Succinylcholine

Mechanism of action of neuromuscular blockers

Pharmacokinetics of muscle relaxants
The description of the relationship of an administered dose and its levels in the
blood over time define this concept. The speed of disappearance of a muscle
relaxant from the plasma is characterized by a rapid initial phase, followed by a
slower one. Distribution in tissues is the cause of the initial phase, while excretion
is the cause of the second.

Peripheral action muscle relaxants

Succinyl choline depolarizing blockers

- Administer intravenously
- Dose 0.5 to 1 mg/kg
- Once administered, its biotransformation begins
- 10% of the dose reaches biophase
- Few data on its pharmacokinetics

Pharmacodynamics of muscle relaxants

The clinical pharmacodynamics of these drugs is determined by measuring the

speed of action of the neuromuscular blockade and its duration. This is measured
by monitoring the abductor pollicis muscle. The electrical stimulus should be
monophasic and rectangular with an optimal duration of 0.2 to 0.3 ms

Health education

- Ask or observe if the patient is elderly, have cardiac disorders, arrhythmias,

heart failure or recent myocardial infarction, patients who consume alcohol,
administer with care or if it is risky, explain to the patient that muscle
relaxant cannot be administered.
- In patients who are pregnant, do not administer muscle relaxants, so ask
them if they are pregnant.
- Say if you use muscle relaxants, avoid operating machinery or vehicles.
- Explain that after administering it, you may experience a sore throat, back
spasms, unconsciousness, confusion, depending on where the anesthesia
is administered, explain.

Bibliography:

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%20documentos/Downloads/13126019_S300_es%20(2).pdf

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