Name 01) Adult DS-TB Regimen (56-70Kg)

Composition 2RHZE(150/75/400/275)/4RH(150/75)

Medicines
Total Duration
4-FDC RHZE (150/75/400/275)
2 (months)
150mg+75mg+400mg+275mg Film Film
2-FDC RH (150/75) 150mg+75mg coated tablet(s)
coated
4 (months)
tablet(s)

Name 02) Pediatric DS-TB Regimen (12-15kg)

Composition 2E(100)RHZ(75/50/150)/4RH(75/50)

Medicines
Total Duration
2-FDC RH (75/50) 75mg+50mg Dispersible tablet(s) 4 (months)
3-FDC RHZ (75/50/150) 75mg+50mg+150mg
2 (months)
Dispersible tablet(s)
Ethambutol 100mg Film coated tablet(s) 2 (months)

Name 03) Longer MDR with resistance to one group A medicine with Bdq (

Composition 1Bdq(100)Cfz(100)Cs(250)Dlm(50)Lfx(250)/6Bdq(100)Cfz(100)Cs(25

Medicines
Total Duration
Delamanid 50mg Film coated tablet(s) 0 (months), 24 (weeks)
Cycloserine 250mg Capsule(s) 12 (months), 24 (weeks)
Clofazimine 100mg Capsule(s) 12 (months), 24 (weeks)
Levofloxacin 250mg Film coated tablet(s) 12 (months), 24 (weeks)
Bedaquiline 100mg Film uncoated tablet(s) 0 (months), 24 (weeks)

Name 04) Longer MDR with resistance to one group A medicine without B

Composition 6Cfz(100)Cs(250)Dlm(50)Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(25
Composition 6Cfz(100)Cs(250)Dlm(50)Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(25

Medicines
Total Duration
Linezolid 600mg Film coated tablet(s) 18 (months)
Delamanid 50mg Film coated tablet(s) 6 (months)
Cycloserine 250mg Capsule(s) 18 (months)
Clofazimine 100mg Capsule(s) 18 (months)
Levofloxacin 250mg Film coated tablet(s) 18 (months)

Name 05) Longer MDR with resistance to one group B medicine with Bdq (

Composition 1Bdq(100)Cfz(100)Lfx(250)Lzd(600)/6Bdq(100)Cfz(100)Lfx(250)Lzd

Medicines
Linezolid 600mg Film coated tablet(s)
Clofazimine 100mg Capsule(s)
Levofloxacin 250mg Film coated tablet(s)
Bedaquiline 100mg Film uncoated tablet(s)
Total Duration
12 (months), 24 (weeks)
12 (months), 24 (weeks)
12 (months), 24 (weeks)
0 (months), 24 (weeks)

Name 06) Longer MDR with resistance to two group A medicines without B

Composition 6Cfz(100)Cs(250)Dlm(50)Lzd(600)Z(400)/12Cfz(100)Cs(250)Lzd(600

Medicines
Total Duration
Linezolid 600mg Film coated tablet(s) 18 (months)
Delamanid 50mg Film coated tablet(s) 6 (months)
Pyrazinamide 400mg Film uncoated tablet(s) 18 (months)
Cycloserine 250mg Capsule(s) 18 (months)
Clofazimine 100mg Capsule(s) 18 (months)

Name 07) Shorter MDR fully oral with Bdq and Lfx (56-70kg)

Composition 1Bdq(100)Cfz(100)E(400)Eto(250)H(300)Lfx(250)Z(400)/6Bdq(100)C
 Medicines
Total Duration
Isoniazid 300mg Film uncoated tablet(s) 0 (months), 24 (weeks)
Ethambutol 400mg Film coated tablet(s) 5 (months), 24 (weeks)
Ethionamide 250mg Film coated tablet(s) 0 (months), 24 (weeks)
Pyrazinamide 400mg Film uncoated tablet(s) 5 (months), 24 (weeks)
Clofazimine 100mg Capsule(s) 5 (months), 24 (weeks)
Levofloxacin 250mg Film coated tablet(s) 5 (months), 24 (weeks)
Bedaquiline 100mg Film uncoated tablet(s) 0 (months), 24 (weeks)

Name 08) Shorter MDR fully oral with Bdq and Mfx (56-70kg)

Composition 1Bdq(100)Cfz(100)E(400)Eto(250)H(300)Mfx(400)Z(400)/6Bdq(100)C

Medicines
Total Duration
Isoniazid 300mg Film uncoated tablet(s) 0 (months), 24 (weeks)
Moxifloxacin 400mg Film coated tablet(s) 5 (months), 24 (weeks)
Ethambutol 400mg Film coated tablet(s) 5 (months), 24 (weeks)
Ethionamide 250mg Film coated tablet(s) 0 (months), 24 (weeks)
Pyrazinamide 400mg Film uncoated tablet(s) 5 (months), 24 (weeks)
Clofazimine 100mg Capsule(s) 5 (months), 24 (weeks)
Bedaquiline 100mg Film uncoated tablet(s) 0 (months), 24 (weeks)

Name 09) Shorter MDR with Am (56-70kg)

Composition 4Am(500/2)Cfz(100)E(400)H(300)Mfx(400)Pto(250)S&N-5/21Gx1.5Z

Medicines
Total Duration
Isoniazid 300mg Film uncoated tablet(s) 4 (months)
Moxifloxacin 400mg Film coated tablet(s) 9 (months)
Protionamide 250mg Film coated tablet(s) 4 (months)
Ethambutol 400mg Film coated tablet(s) 9 (months)
Pyrazinamide 400mg Film uncoated tablet(s) 9 (months)
Amikacin 500mg/2ml Solution for injection 4 (months)
Syring and needle-5/21G (auto-disabling) 5ml, 21G 4 (months)
Clofazimine 100mg Capsule(s) 9 (months)
Name
Composition
Medicines
Linezolid 600mg Film coated tablet(s)
Pretomanid 200mg Film coated tablet(s)
Bedaquiline 100mg Film uncoated tablet(s)
Name
Composition
Medicines
Clofazimine 50mg Dispersible tablet(s)
Levofloxacin 100mg Dispersible tablet(s)
Bedaquiline 20mg Film uncoated tablet(s)
Isoniazid 100mg Dispersible tablet(s)
Pyrazinamide 150mg Dispersible tablet(s)
Ethionamide 125mg Dispersible tablet(s)
Ethambutol 100mg Dispersible tablet(s)
Name
Composition
Medicines
Clofazimine 50mg Dispersible tablet(s)
Ethionamide 125mg Dispersible tablet(s)
Linezolid 150mg Dispersible tablet(s)
Cycloserine 125mg Capsule(s)
10) BPaL (56-70 Kg)
1Bdq(100)Lzd(600)Pa (200mg)/6Bdq(100)Lzd(600)Pa (200mg)
Total Duration
0 (months), 24 (weeks)
0 (months), 24 (weeks)
0 (months), 24 (weeks)
11) Pediatric: DR-TB Fully oral STR (16-25kg)
1Bdq(20)Cfz(50)E(100)Eto(125)H(100)Lfx(100)Z(150)/6Bdq(20)Cfz(
Total Duration
5 (months), 24 (weeks)
5 (months), 24 (weeks)
0 (months), 24 (weeks)
0 (months), 24 (weeks)
5 (months), 24 (weeks)
0 (months), 24 (weeks)
5 (months), 24 (weeks)
12) Pediatric: DR-TB LTR FQ resistant (0-10kg)
6Cfz(50)Cs(125)Eto(125)Lzd(150)/12Cfz(50)Cs(125)Lzd(150)
Total Duration
18 (months)
6 (months)
18 (months)
18 (months)
Name 13) Pediatric: DR-TB LTR FQ resistant (11-15kg)

Composition 6Cfz(50)Cs(125)Dlm(25)Eto(125)Lzd(150)/12Cfz(50)Cs(125)Lzd(150

Medicines
Total Duration
Clofazimine 50mg Dispersible tablet(s) 18 (months)
Delamanid 25mg Film coated tablet(s) 6 (months)
Ethionamide 125mg Dispersible tablet(s) 6 (months)
Linezolid 150mg Dispersible tablet(s) 18 (months)
Cycloserine 125mg Capsule(s) 18 (months)

Name 14) Pediatric: DR-TB LTR FQ resistant (16-25kg)

Composition 1Bdq(20)Cfz(50)Cs(125)Dlm(25)Lzd(150)/6Bdq(20)Cfz(50)Cs(125)D

Medicines
Clofazimine 50mg Dispersible tablet(s)
Bedaquiline 20mg Film uncoated tablet(s)
Delamanid 25mg Film coated tablet(s)
Linezolid 150mg Dispersible tablet(s)
Cycloserine 125mg Capsule(s)
Total Duration
12 (months), 24 (weeks)
0 (months), 24 (weeks)
0 (months), 24 (weeks)
12 (months), 24 (weeks)
12 (months), 24 (weeks)

Name 15) Pediatric: DR-TB LTR FQ sensitive (0-10kg)

Composition 6Cfz(50)Cs(125)Eto(125)Lfx(100)Lzd(150)/12Cfz(50)Cs(125)Lfx(100

Medicines
Total Duration
Clofazimine 50mg Dispersible tablet(s) 18 (months)
Levofloxacin 100mg Dispersible tablet(s) 18 (months)
Ethionamide 125mg Dispersible tablet(s) 6 (months)
Linezolid 150mg Dispersible tablet(s) 18 (months)
Cycloserine 125mg Capsule(s) 18 (months)
Name 16) Pediatric: DR-TB LTR FQ sensitive (11-15kg)

Composition 6Cfz(50)Cs(125)Dlm(25)Lfx(100)Lzd(150)/12Cfz(50)Cs(125)Lfx(100)

Medicines
Total Duration
Clofazimine 50mg Dispersible tablet(s) 18 (months)
Levofloxacin 100mg Dispersible tablet(s) 18 (months)
Delamanid 25mg Film coated tablet(s) 6 (months)
Linezolid 150mg Dispersible tablet(s) 18 (months)
Cycloserine 125mg Capsule(s) 18 (months)

Name 17) Pediatric: DR-TB LTR FQ sensitive (16-25kg)

Composition 1Bdq(20)Cfz(50)Cs(125)Lfx(100)Lzd(150)/6Bdq(20)Cfz(50)Cs(125)L

Medicines
Total Duration
Clofazimine 50mg Dispersible tablet(s) 12 (months), 24 (weeks)
Levofloxacin 100mg Dispersible tablet(s) 12 (months), 24 (weeks)
Bedaquiline 20mg Film uncoated tablet(s) 0 (months), 24 (weeks)
Linezolid 150mg Dispersible tablet(s) 12 (months), 24 (weeks)
Cycloserine 125mg Capsule(s) 12 (months), 24 (weeks)

Name 18) LTBI therapy 3HP (56-70kg)

Composition 33HP(300/300)/0

Medicines
Total Duration
Isoniazide/Rifapentine 300+300mg Film coated
0 (months), 12 (weeks)
tablet(s)

Name 19) LTBI therapy 3HR (56-70kg)

Composition 3H(300)R(300)/0
Composition 3H(300)R(300)/0

Medicines
Total Duration
Isoniazid 300mg Film uncoated tablet(s) 3 (months)
Rifampicin 300mg Film coated tablet(s) 3 (months)

Name 20) LTBI therapy 6H (56-70kg)

Composition 6H(300)/0

Medicines
Total Duration
Isoniazid 300mg Film uncoated tablet(s) 6 (months)

Name 21) Pediatric: LTBI therapy 3HR (12-15kg)

Composition 3RH(75/50)/0

Medicines
Total Duration
2-FDC RH (75/50) 75mg+50mg Dispersible tablet(s) 3 (months)

Name 22) Pediatric: LTBI therapy 6H (12-15kg)

Composition 6H(100)/0

Medicines
Total Duration
Isoniazid 100mg Dispersible tablet(s) 6 (months)

Name 23) Longer MDR with Bdq (56-70kg)

Composition 1Bdq(100)Cfz(100)Cs(250)Lfx(250)Lzd(600)/6Bdq(100)Cfz(100)Cs(2
Composition
Medicines
Linezolid 600mg Film coated tablet(s)
Cycloserine 250mg Capsule(s)
Clofazimine 100mg Capsule(s)
Levofloxacin 250mg Film coated tablet(s)
Bedaquiline 100mg Film uncoated tablet(s)
1Bdq(100)Cfz(100)Cs(250)Lfx(250)Lzd(600)/6Bdq(100)Cfz(100)Cs(2
Total Duration
12 (months), 24 (weeks)
12 (months), 24 (weeks)
12 (months), 24 (weeks)
12 (months), 24 (weeks)
0 (months), 24 (weeks)
 (56-70Kg)

RH(150/75)

Units per Day X Days per Week

Phase 1 Phase 2
2 (months) 4 (months)
4x7 -
- 4x7

men (12-15kg)

RH(75/50)

Units per Day X Days per Week

Phase 1 Phase 2
2 (months) 4 (months)
- 3x7
3x7 -
3x7 -

stance to one group A medicine with Bdq (56-70kg)

Dlm(50)Lfx(250)/6Bdq(100)Cfz(100)Cs(250)Dlm(50)Lfx(250)/12Cfz(100)Cs(250)Lfx(250)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 12 (months)
4x7 4x7 -
3x7 3x7 3x7
1x7 1x7 1x7
4x7 4x7 4x7
4x7 2x3 -

stance to one group A medicine without Bdq (56-70kg)

Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(250)Lzd(600)
Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(250)Lzd(600)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x7 1x7
4x7 -
3x7 3x7
1x7 1x7
4x7 4x7

stance to one group B medicine with Bdq (56-70kg)

)Lzd(600)/6Bdq(100)Cfz(100)Lfx(250)Lzd(600)/12Cfz(100)Lfx(250)Lzd(600)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 12 (months)
1x7 1x7 1x7
1x7 1x7 1x7
4x7 4x7 4x7
4x7 2x3 -

stance to two group A medicines without Bdq (56-70kg)

Lzd(600)Z(400)/12Cfz(100)Cs(250)Lzd(600)Z(400)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x7 1x7
4x7 -
4x7 4x7
3x7 3x7
1x7 1x7

l with Bdq and Lfx (56-70kg)

Eto(250)H(300)Lfx(250)Z(400)/6Bdq(100)Cfz(100)E(400)Eto(250)H(300)Lfx(250)Z(400)/5Cfz(100)E(400)Lfx(250)Z(400)
 Units per Day X Days per Week
Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 5 (months)
3x7 3x7 -
3x7 3x7 3x7
3x7 3x7 -
4x7 4x7 4x7
1x7 1x7 1x7
4x7 4x7 4x7
4x7 2x3 -

l with Bdq and Mfx (56-70kg)

Eto(250)H(300)Mfx(400)Z(400)/6Bdq(100)Cfz(100)E(400)Eto(250)H(300)Mfx(400)Z(400)/5Cfz(100)E(400)Mfx(400)Z(400)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 5 (months)
3x7 3x7 -
1x7 1x7 1x7
3x7 3x7 3x7
3x7 3x7 -
4x7 4x7 4x7
1x7 1x7 1x7
4x7 2x3 -

(56-70kg)

H(300)Mfx(400)Pto(250)S&N-5/21Gx1.5Z(400)/5Cfz(100)E(400)Mfx(400)Z(400)

Units per Day X Days per Week

Phase 1 Phase 2
4 (months) 5 (months)
2x7 -
1x7 1x7
3x7 -
3x7 3x7
4x7 4x7
2x7 -
1x7 -
1x7 1x7
mg)/6Bdq(100)Lzd(600)Pa (200mg)

Units per Day X Days per Week

Phase 1 Phase 2
0 (months), 2 (weeks) 0 (months), 22 (weeks)
2x7 2x7
1x7 1x7
4x7 2x3

y oral STR (16-25kg)

(125)H(100)Lfx(100)Z(150)/6Bdq(20)Cfz(50)E(100)Eto(125)H(100)Lfx(100)Z(150)/5Cfz(50)E(100)Lfx(100)Z(150)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 5 (months)
2x7 2x7 2x7
4x7 4x7 4x7
10 x 7 5x3 -
3x7 3x7 -
4x7 4x7 4x7
3x7 3x7 -
4x7 4x7 4x7

FQ resistant (0-10kg)

zd(150)/12Cfz(50)Cs(125)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x4 1x4
1x7 -
1x7 1x7
1x7 1x7
FQ resistant (11-15kg)

o(125)Lzd(150)/12Cfz(50)Cs(125)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x7 1x7
2x7 -
2x7 -
1x7 1x7
2x7 2x7

FQ resistant (16-25kg)

m(25)Lzd(150)/6Bdq(20)Cfz(50)Cs(125)Dlm(25)Lzd(150)/12Cfz(50)Cs(125)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 12 (months)
1x7 1x7 1x7
10 x 7 5x3 -
2x7 2x7 -
2x7 2x7 2x7
3x7 3x7 3x7

FQ sensitive (0-10kg)

fx(100)Lzd(150)/12Cfz(50)Cs(125)Lfx(100)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x4 1x4
2x7 2x7
1x7 -
1x7 1x7
1x7 1x7
FQ sensitive (11-15kg)

x(100)Lzd(150)/12Cfz(50)Cs(125)Lfx(100)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2
6 (months) 12 (months)
1x7 1x7
3x7 3x7
2x7 -
1x7 1x7
2x7 2x7

FQ sensitive (16-25kg)

x(100)Lzd(150)/6Bdq(20)Cfz(50)Cs(125)Lfx(100)Lzd(150)/12Cfz(50)Cs(125)Lfx(100)Lzd(150)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 12 (months)
1x7 1x7 1x7
4x7 4x7 4x7
10 x 7 5x3 -
1x7 1x7 1x7
3x7 3x7 3x7

-70kg)

Units per Day X Days per Week

Phase 1
0 (months), 12 (weeks)
3x1

-70kg)
 Units per Day X Days per Week
Phase 1
3 (months)
1x7
2x7

0kg)

Units per Day X Days per Week

Phase 1
6 (months)
1x7

py 3HR (12-15kg)

Units per Day X Days per Week

Phase 1
3 (months)
3x7

py 6H (12-15kg)

Units per Day X Days per Week

Phase 1
6 (months)
2x7

(56-70kg)

Lfx(250)Lzd(600)/6Bdq(100)Cfz(100)Cs(250)Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(250)Lzd(600)
Lfx(250)Lzd(600)/6Bdq(100)Cfz(100)Cs(250)Lfx(250)Lzd(600)/12Cfz(100)Cs(250)Lfx(250)Lzd(600)

Units per Day X Days per Week

Phase 1 Phase 2 Phase 3
0 (months), 2 (weeks) 0 (months), 22 (weeks) 12 (months)
1x7 1x7 1x7
3x7 3x7 3x7
1x7 1x7 1x7
4x7 4x7 4x7
4x7 2x3 -