BCDA COLLEGE OF PHARMACY &

TECHNOLOGY
NAME:SUBHADIP MONDAL
4TH YEAR,7TH SEMESTER
ROLL-20101921102
REG.NO-212010201920002 OF 2021-22
PAPER-Novel Drug Delivery System
TOPIC-Niosomes
PAPER CODE-PT716B
SUBHMITTED TO- Ms. S. DAN
CA1:POWER POINT PRESENTATION
Niosomes: A
Promising Drug
Delivery System
Niosomes are novel drug carriers with great potential for
drug delivery. In this presentation, we explore how these
small vesicles can revolutionize the field of medicine.
What are Niosomes?
Niosomes are small vesicles made of nonionic surfactants that form a bilayer structure, similar to cell
membranes. They can encapsulate both hydrophilic and hydrophobic drugs for targeted delivery.

Structure Types Loading Capacity

There are two types of niosomes:
Niosomes have a bilayer Niosomes can encapsulate both
multilamellar and unilamellar.
structure that mimics cell hydrophilic and hydrophobic
Multilamellar niosomes are onion-
membranes, which provides drugs, which makes them
like structures, while unilamellar
drug stability and enhances their versatile and ideal for drug
niosomes have a single bilayer
bioavailability in the body. delivery.
structure.
Composition of
Niosomes
Niosomes can be made from various nonionic surfactants and cholesterol. The type and ratio of
surfactants used determine the size and stability of the vesicles.

1 2 3

Surfactant Cholesterol Surfactant-to-Cholesterol

Selection Content Ratio
Polyoxyethylene, Cholesterol stabilizes the The ratio affects niosome
polyoxypropylene, and niosomes by increasing size and stability, and
alkylamines are commonly rigidity and membrane ultimately, drug delivery
used. fluidity. effectiveness.
Preparation
Methods
There are multiple methods for preparing niosomes, including film hydration, reverse phase evaporation, and
dehydration-rehydration methods.

Film Hydration Dehydration-rehydration

Reverse Phase Evaporation
Method Method
Method
This is a simple and cost-effective This method involves the use of
This method involves dispersing the
method that involves making a thin organosilicate nanoparticles to
lipids in water and then evaporating
film of a surfactant mixture and dehydrate the surfactant mixture,
the organic solvent, leading to the
hydrating it to form niosomes. followed by rehydration to form
formation of niosomes.
niosomes.
Characterization
Techniques
Various techniques can be used to characterize niosomes, including electron microscopy, X-
ray diffraction, and dynamic light scattering.

Electron Microscopy X-Ray Diffraction Dynamic Light Scattering

Electron microscopy allows for
direct visualization of
niosomes, providing
information on their size,
shape, and lamellarity.
X-ray diffraction helps to
determine the crystalline or
amorphous nature of the
niosomes, which influences
their drug release properties.
Dynamic light scattering measures
the size and size distribution of
niosomes in solution, which is
important for optimizing their drug
delivery efficacy.
Applications of
Niosomes
Niosomes have several potential applications in drug delivery due to their stability and versatility.

Skin Care
Niosomes can also be used in topical creams to deliver drugs
and treat skin diseases such as acne and psoriasis.

1 2 3

Cancer Vaccine
Treatment Delivery
Niosomes can encapsulate chemotherapy drugs Niosomes can encapsulate antigens and
and improve their targeted delivery to cancer cells, adjuvants for vaccine delivery, leading to
making them more effective and reducing side improved stability and response rates.
effects.
Advantages of
Niosomes
Niosomes have several advantages over traditional drug delivery systems.

1 Biocompatibility 2 Targeted Delivery

Niosomes are biocompatible and non-toxic, Niosomes can target specific cells or tissues,
making them safe for use in the body. reducing side effects and improving drug
efficacy.

3 Drug Stabilization 4 Cost-effective

Niosomes protect drugs from degradation in Niosomes are relatively cheap and easy to
the body and improve their solubility, leading prepare, making them an attractive option for
to increased bioavailability. drug delivery.
Future Prospects of
Niosomes
The potential applications of niosomes are vast, making them an exciting area of research in drug delivery.
Future prospects include improving their targeting capabilities, enhancing drug loading capacity, and developing
more efficient production methods.

Advanced Research Molecular-Level Understanding Collaborative Efforts

Advanced research methods and
technology can lead to the
development of more effective
niosomes for drug delivery.
A better understanding of niosome
structure and interaction with drugs
can lead to more efficient drug
delivery and treatment.
Collaborative efforts between
researchers and clinicians can
accelerate the development and
translation of niosomes to clinical
use.
 Conclusions
Niosomes are a promising drug delivery system with many advantages
over traditional systems. They have broad potential applications and
future prospects, making them a focus of intense research. Further
development of niosomes can improve drug efficacy and patient
outcomes in medicine.
 Reference
NOVEL DRUG DELIVERY SYSTEMS by Dr. K. JESINDHA
BEYATRICKS Mrs. ASHWINI S. JOSHI (page-4.12)
NOVEL DRUG DELIVERY SYSTEMS by Dr. Shailesh Thanaji Prajapati,
Dr. R. Manivannan, (Prof.) Dr. Ramesh Ganpati Katedeshmukh.
NOVEL DRUG DELIVERY SYSTEMS by Dr. Aijaz A. Sheikh, Dr.
Subhash V. Deshmane Dr. Md. Rageeb Md. Usman,
Dr. Kailash R. Blyani.
https://www.slideshare.net/PrasathP13/niosomes-138582301
https://www.slideshare.net/SunealSaini/niosomes-47868697
THANK YOU