Subject: QUALITY CONTROL I and II

General Instructions: Choose the letter of the best answer

1. The synonym of 0.1N Bromine solution.

A.) Koettsdorfer solution D.) All of these

B.) Kjeldahl solution E.) None of these
C.) Koppeschaar’s solution

2. An oxidizing agent electrons.

A.) Gains D.) Receives

B.) Loses E.) Shares
C.) Donates

3. It pertains to a reaction with acid and a base resulting to the formation of salt
and water.

A) Neutralization D.) Oxidation

B.) Complexation E.) Reduction
C.) Precipitation

4. Indicator used in ceric sulfate titrations

A.) Ferrous phenanthroline D.) Potassium permanganate

B.) Ferric alum E.)Phenolphthalein
C.) Eosin Y

5. The theoretical point at which the added titrant is chemically equivalent to the
analyte in the sample.

A.) Stoichiometric point D.) Both A and B

B.) End point E. Both A and C
C.) Equivalence point

6. A method of analysis which involves the determination of a solution of known

concentration required to react with a given amount of substance to be analyzed:

A.) Gravimetric analysis D.) Both A and B

B.) Titrimetric analysis E.) Both B and C
C.) Volumetric analysis

7. The following are the reasons of using the disodium form of EDTA in preparing
standard solutions of EDTA except:

A.) Less Soluble in water D.) All of these

B.) Non hygroscopic E.)None of these
C.) Very stable

8. The weight of a substance that is chemically equivalent to one milliliter of a

standard solution.

A.) Gram-equivalent weight D.) Gram-milliequivalent weight

B.) Milliequivalent weight E.) Millimole
C.) Titer value

9. It refers to the direct or residual analysisof acids using standard basics solutions:
A.) Kjeldahl method D.) Compleximetry
B.Acidimetry E.) Precipitimetry
C.) Alkalimetry

10. Inaccurate measurements resulting from not reading at proper eye level:

A.) Color blind D.) Parallax

B.) Double vision E.) None of these
C.) Thermal after-effect

11. A permanent change in volume with volumetric apparatus caused by heat or hot
solutions.

A.) Parallax D.) All of these

B.) Color Blind E.) None of these
C.) Thermal after-effect

12. What is the method of analysis involved in the essay of sodium hydroxide?

A.) Direct Acidimetry D.) Direct compleximetry

B.) Direct alkalimetry E.) Direct permanganometry
C.) Direct precipitimetry

13. It is the point at which titration process is stopped.

A.) Equivalence point D.) Both A and C

B.) End point E.) Both B and C
C.) Stoichiometric point

14. What is the method of analysis involved in the essay of aspirin capsules?

A.) Residual acidimetry D.) Residual precipitimetry

B.) Residual alkalimetry E.) Residual permanganometry

15. Which of the following is/are the way/s of faciliating the digestion of nitrogen to
ammonium sulfate?

A.) Addition of potassium sulfate D.) Use of copper sulfate

B.) Use of selenium E.) All of these
C.) Addition of anhydrous sodium sulfate

16. The indicator used when titrating weak acid with a strong base:

A.) Ferric alum D.) Ferroin

B.) Methyl red E.) Dichloroflouroscein
C.) Phenolphthalein

17. What is the allowable quantity of moisture in nonaqueous titration?

A.) Less than 5.0 % D.) Less than 0.005 %

B.) Less than 0.5 % E.) Less than 0.0005 %
C.) Less than 0.05 %

18. What is the commonly employed titrant in nonaqueous acidimetry?

A.) Hydrochloric acid D.) Sulfuric acid

B.) Bromic acid E.) Nitric acid
C.) Perchloric acid
 19. The indicator used when titrating weak base with a strong acid:

A.) Methyl orange D.) Methyl red

B.) Methyl yellow E.) Methylene red
C.) Methylene blue

20. It refers to the analysis of metal ions:

A.) Precipitation D.) Complexation

B.) Neutralization E.) Oxidation
C.) Reduction

21. Ferric ammonium sulfate , an indicator used in precipitimetry, is

commonly known as

A.) DCF D.) Ferroin

B.) Eosin Y E.) TEE
C.) Ferric alum

22. Which of the following indicator/s is/are used when titrating a strong with
a strong alkali?

A.) Methyl red D.) All of these

B.) Phenolphtalein E.) None of these
C.) Methyl orange

23. A water-soluble vitamin used as a masking agent:

A.) Vitamin A D.) Vitamin D

B.) Vitamin B E.) Vitamin E
C.) Vitamin C

24 The following are examples of adsorption indicators in precipitimetry

except:

A.) Tetrabromophenolphthalein ethyl ester D.) Dichloroflourescein

B.) Hydroxynaphthol blue E.) None of these
C.) Eosin Y.

25.What type of analysis involves a change in the valence of the reacting

substances?

A.) Complexation D.) Precipitation

B.) Oxidation-reduction E.) Recombination
C.) Neutralization

26. What is the purpose of using mixed indicators in some titrations?

A.) Shapen up the color change D.) All of these

B.) Speed up the reaction E.) None of these
C.) Enhance the solubility of the analyte

27. A solid substance of known purity used in preparing standard solutions:

A.) Primary standard D.) Titrand

B.) Analyte E.) Titrant
C.) Secondary standard
28 . What is the indicator used in iodimetry and iodometry?

A.) Phenolphthalein D.) Starch

B.) Ferric alum E.) Potassium permanganate
C.) Hydroxynapthol blue

29. What is the analyte being assayed in iodometry?

A.) Oxidizing agents D.) Basic agents

B.) Acidic agents E.) Reducing agents
C.) Metallic agents

30. Which of the following theory explains the actions of indicators?

A.) Physicchemical theory D.) All of these

B.) Organic theory E.) None of these
C.) Colloidal theory

31. It refers to the analysis of a metal in the presence of another metal:

A.) Chelation D.) Cerimetry

B.) Masking E.) Digestion
C.) Complexation

32. The following are ways of forming the equivalent precipitate in

gravimetric analysis except:

A.) Precipitation D.) All of these

B.) Ignition E.) None of these

33.What is the precipitate form of sulfate following gravimetric ?

A.) Sodium sulfate D.) Magnesium sulfate

B.) Potassium sulfate E.) Calcium sulfate
C.) Barium sulfate

34. What is the precipitating form of sulfate following gravimetry?

A.) Sliver nitrate D.) Hydrogen sulfide

B.) Magnesia mixture E.) Sodium phosphate

35. Which of the following is the chemical reaction involved in titrmetric

analysis?

A.) Neutralization D.) Oxidation-reduction

B.) Precipitation E.) All of the above
C.) Complexation

36. What is the most suitable solvent for the extraction of resins and
resinous materials

A.) Absolute alcohol D.) 80 % Ethanol

B.) Ether E.) N-hexamene
C.) Distilled water

37. It refers to the number of mg of KOH required tp neutralize the free acids
present in a sample:
 A.) Acid number D.) Ester number
B.) Iodine number E.) Koettsdorfer number
C.) Saponification number

38. Which is the chemical formula of Potassium biphthalate?

A.) KCI D.) KHCO3

B.) KHC8H4O4 E.) KHO
C.) K2CO3

39. The components of titrimetric analysis are following except:

A.) Analyte D.) Solvent

B.) Titrant E.) None of these
C.) Indicator

40. What is the composition of crude fiber?

A.) Saponins D.) Phyosterol

B.) Cellulose E.) Proteins
C.) Starch

41. What is the term of referring to Koettsdorfer number?

A.) Acid value D.) Hydroxyl value

B.) Iodine value E.) Ester value
C.) Saponification value

42. It refers to the method of analyzing the nitrogen content present in a

sample:

A.) Masking D.) Gravimetry

B.) Iodemetry E.) Acidimetry
C.) Kjeldahl method

43. It refers to the direct or residual analysis of bases using standard acid
solutions:

A.) Alkalimetry D.) Permanganometry

B.) Iodimetry E.) Acidimetry
C.) Cerimetry

44.) This value serves as a quantitative measure of the proportion of

unsaturated fatty acids present in a sample:

A.) Acid value D.) Hydroxyl value

B.) Ester value E.) Iodine value
C.) Saponification value

45. Type of oils whose iodine number is more than 120:

A.) Drying oils D.) All of these

B.) Semidrying oils E.) None of these
C.) Nondrying oils

46. It refers to the method of assaying alcohol content:

A.) Bisulfite method D.) Hydroxylamine method

B.) Kjeldahl method E.) Masking method
C.) Acetylization method
47. What is the main element present in alkaloids?

A.) Carbon D.) Nitrogen

B.) Hydrogen E.) Sulfur
C.) Oxygen

48. What is the method of titration involved in ultimate assay?

A.) Direct titration D.) All of these

B.) Indirect titration E.) None of these
C.) Residual titration

49. It refers to the nearness of a value to a target value:

A.) Accuracy D.) Error

B.) Defect E.) Any of these
C.) Precision

50.) A buret with a glass stopcock can be used for:

A.) Acids D.) Salts

B.) Bases E.) Oxidizing agents
C.) Alcohols

51. Two substances reacting upon reaching the end-point must have same :

A.) Volume D.) Weight

B.) Normality E.) % Purity
C.) Number of equivalent

52. In titrimetric analysis, the substance being analyzed is the:

A.) Indicator D.) Titrand

B.) Normality E.) Both C and D
C.) Analyte

53. The following are expressions of concentration in volumetric

solutions except:

A.) Molarity D.) Formality

B.) Normality E.) Titer
C.) Molality

54. An organic compound that changes from one color to another at a

certain pH is called:

A.) Titrand D.) Indicator

B.) Active consitituent E.) Titrant
C.) Analyte

55. A substance that has a high degree of purity and is used in direct
standardization purposes:

A.) Analyte D.) Secondary standard

B.) Primary standard E.) CP grade
56. The experimental way of determining when equivalent amounts of
reactants have reacted together is:

A.) Titration D.) All of these

B.) Masking E.) None of these
C.) Standardization

57. A concentration expression referring to the number of

milliequivalents of sclute per milliliter of solution

A.) Molality D.) Molality

B.) Normality E.) % purity
C.) Formality

58.A solution of known concentration used to standardize another

solution is

A.) Dilute solution D.)Concentrated solution

B.) Standard solution E.) Secondary standard
C.) Primary standard

59. What is the significance of controlling the temperature in

nonaqueous titrations:

A.) To avoid competition of the titrant with weak nitrogen base

B.) To prevent the volatilization of the titrant
C.) To meet the requirements of the USP in conducting non-
aqueous titrations.
D.) All of these
E.) None of these

60. Based on Arrhenius concept of non-aqueous neutralization

are weakly protophylic substances.

A.) Acids D.) Reducing agents

B.) Oxidizing agents E.) Bases
C.) Metals

61. Which titrant in nonaqueous alkalimetry produces a

gelatinous reaction product?

A.) Sodium methoxide D.) Sodium aminometheoxide

B.) Lithium methoxide E.) Sodium triphenylmethane
C.) Potassium methoxide

62. The process by which the exact concentration of a solution is

determined is.

A.) Titration D.) Direct titration

B.) Standardization E.) Residual titration
C.) Masking

63. Class of systematic error that are invariably caused by faulty and
uncalibrated instruments:

A.) Personal errors D.) Constant errors

B.) Instrumentals errors E.) Proportional errors
C.) Regeant errors
64. Silica from the soil that is left after treatment with diluted acid is the

A.) Total ash D.) Loss on drying

B.) Moisture E.) Extractive
C.) Acid-insoluble ash

65. A type of titration where the first is added in excess with the sample and
the second titrant reacts with the added excess

A.) Direct titration D.) Back titration

B.) Residual titration E.) B and D
C.) Indirect titration

66. Residual titration method under EDTA titrations is applied to which

metal ion

A.) Potassium D.) Calcium

B.) Magnesium E.) Sodium
C.) Aluminum

67. The measurement of a weak base in a non-aqueous medium of a given sample

with standard perchloric acid:

A.) Non-aqueous alkalimetry D.) Alkalimetry

B.) Acidimetry E.) Non-aqueous acidimetry
C.) Compleximetry

68. Ferric alum TS is used as indicator in volumetric precipitation analysis if the

titrant used is:

A.) Sodium Hydroxide solution D.) Hydrochloric acid solution

B.) Ammonium thiocyanate solution E.) Zinc sulfate solution
C.) EDTA solution

69. The masking agent used in the assay of Magnesium with EDTA in the
presence of Aluminum.

A.) Triethanolamine D.) Citrates

B.) Thioglycol E.) Ascorbic acid
C.) Potassium Cyanide

70. Assay of sodium is an example of assay under

A.) Cerimetry D.) Iodimetry

B.) Iodometry E.) Brominimetry
C.) Permanganometry

71. The apparatus used in assay of volatile oils in spirits:

A.) Cassia flask D.) Distillation flask

B.) Babcock bottle E.) Erlenmeyer flask
C.) Iodine flask

72. What is the color of phenolphthalein in vinegar?

A.) Purple D.) Colorless

B.) Blue E.) Pink
C.) Yellow
 73. The primary standard used in the standardization of potassium
permanganate:

A.) Potassium permanganate D.) Sodium hydroxide

B.) Sodium oxalate E.) Potassium dichromate
C.) Potassium biphthalate

74. The components of blank titration are the following except:

A.) Analyte D.) Indicator

B.) Titrant E.) None of these
C.) Solvent

75.The following are the cleansing agents for volumetric analysis

except:

A.) Sodium dichromate in sulfuric acid

B.) Synthetic detergent solution
C.) Nitric acid and hydrochloric acid
D.) Solution of trisodium phosphate
E.) None of these

76. The method of assay for sulfonamides is:

A.) Kjeldahl method D.) Trimetric analysis

B.) Diazotization method E.) Volumetric analysis
C.) Gravimetric method

77. A water content determination method that uses a xylene tube is:

A.) Karl fischer titration D.) Gravimetric method

B.) Azeotropic method E.) Electrolytic hygrometric method
C.) Dew point method

78. Adsorption indicators are used in which method of analysis

A.) Acidimetry D.) Precipitimetry

B.) Alkalimetry E.) Oxidation-reduction
C.) Compleximetry

79. The indicator used in which method of analysis

A.) Phenolphthalein D.) Starch TS

B.) Hydroxynaphthol blue E.) Potassium permanganate
C.) Eosin Y

80. Specific gravity refers to the ratio of the volume of oil to thst of an equal
volume of pure water when both are determined at 25C. The official
method for determining specific gravity is:

A.) Pycnometer D.) Both A and B

B.) Westphal balance E.) All of these
C.) Hydrometer

81. It refers to a molecule that provides a group for attachment to metals

A.) Chelate D.) All of these

B.) Complex E.) None of these
C.) Ligand
82. A process wherein the sample is made to liberate iodine, which is then titrated
with a standard solution of sodium thiosulfate:

A.) Cerimetry D.) All of these

B.) Iodimetry E.) Iodometry
C.) Diazotization method

83. Malic Acid present in cherry juice may be determined by:

A.) Direct permanganometry D.) Iodimetry

B.) Indirect permanganometry E.) Iodometry
C.) Residual permanganometry

84. The Kjeldahl method of analysis used to determine which analyte?

A.) Moisture content D.) Cellulose

B.) Nitrogen content E.) Fat content
C.) Sulfonamides

85. The iodine value of oils is a quantitative measure of

A.) Cellulose D.) Nitrogen content

B.) Unsaturated fatty acids E.) Water content
C.) Free fatty acids

86. The number of mg of KOH needed to neutralize the free acids and
saponify the esters in 1 g fat or oil

A.) Acid Value D.) Hydroxyl value

B.) Ester value E.) Iodine value
C.) Saponification.

87. Analysis where the constituents of a sample are separated and then the
product are weighed:

A.) Gasometry D.) Volumetric analysis

B.) Titrimetry E.) Diazotization method
C.) Gravimetry

88. It refers to the number of milligrams of potassium hydroxide required to

neutralize the acetic , acid obtained by the saponification of 1 gram of
acetylated fatty acid.

A.) Acid value D.) Acetyl value

B.) Saponification value E.) Ester value
C.) Hydroxyl value

89. A type of analysis that identifies the amount of a single chemical specie in a
given sample:

A.) Classical method of analysis D.) Volumetric analysis

B.) Ultimate assay E.) Proximate assay
C.) Instrumental assay

90. EDTA is considered as a/an ligand

A.) Unidentate D.) Octadentate

B.) Tridentate E.) Pentadentate
C.) Hexadentate
91. It is present in Koppeschaar’s solution:

A.) Bromine D.) Flourine

B.) Chlorine E.) None of these
C.) Iodine

92. A means of facilitating the digestion of nitrogen to ammonium sulfate by

interaction with anhydrous sodium sulfate or potassium sulfate:

A.) Use of catalysts D.) All of these

B.) Digestion with sulfuric acid E.) None of these
C.) Gunning method

93. The temperature for ignition described as dull red heat is

A.) 500-550oC D.) 1000-1200oC

B.) 550-700oC E.) 1200-1600oC
C.) 800-1000oC

94.Acetylization method of analysis in volatile oils is used to determine

A.) Aldehydes D.) Ketones

B.) Phenols E.) Alcohols
C.) Acids

95. The valence number of Mn in KMnO4 is:

A.) +1 D.) +7
B.) +3 E.) +9
C.) +5

96. The alkaloidal test solution “mercuric potassium iodine TS” is also
known as :

A.) Valser’s reagent B.) Dragendorff’s reagent

B.) Mayer’s reagent C.) None of these
C.) Wagner’s reagent

97. Determine the iodine value of a sample of olive oil weighing 0.2100 g if
24.15 mL and 12.00 mL of 0.1100 N sodium thiosulfate solution which are
required for the blank and residual titrations respectively.

A.) 80.5 D.) 80.8

B.) 80.6 E.) 80.9
C.) 80.7

98. Which of the following physical properties is possessed by alkaloids?

I. Alkaloids combine directly with acids to form salts that are usually
soluble in water?
II. Alkaloids are liberated from aqueous solutions of their salts by alkalies
III. Alkaloids form highly insoluble precipitates with a considerable number of
reagents especially with the salts of some heavy metals

A.) I only D.) II and III

B.) I and II E.) I,II and III
C.) I and III

99. Which of the following factors does NOT affect the yield of alkaloids in
plants?
A.) Age of the plant when it was collected
B.) Season of the year when the drug was harvested
C.) Menstrum used in the extraction of the alkaloid
D.) Soil and climate in which the drug was grown
E.) Conditions when the drug was collected;dried and stored

100. The glassware that is required in the determination of iodine value of

volatile oils

A.) Cassia flask D.) Iodine flask

B.) Erlenmeyer flask E.) Distillation flask
C.) Babcock bottle

101. What is the unsaponfiable matter present in animal oils and fats?

A.) Ergosterol D.) All of these

B.) Phytosterol E.) None of these
C.) Cholesterol

102. Acid-insoluble ash is mainly composed of

A,) Organic compounds D.) Inorganic matter

B.) Silica E.) Adulterants
C.) Inorganic salts

103. Find the acid number of rosin sample weighing 1.100 g which required
28.00 mL 0.1100 N NaOH to bring about the end point.

A.) 157.0 D.) 157.3

B.) 157.1 E.) 157.4
C.) 157.2

104. The temperature equivalent 800oC is described as:

A.) White heat D.) Dull red heat

B.) Yellow red heat E.) Very dull red heat
C.) Bright red heat

105. A precipitate of AgCl weighing 0.2432 g was obtained from a 25-mL

sample of a hydrochloric acid solution. What is the % w/w HCL content of
the solution ? (Atomic weights : Ag=108,Cl=35,H=1)

A.) 0.2449% D.) 3.0707%

B.) 3.8642% E.) 2.4499%
C.) 25.8787%

106. What is the component of starch that reacts with iodine to form the
intensely blue-colored solution?

A.) Alpha-Amylose D.) Both A and B

B.) Beta-Amylose E.) Both B and C
C.) Amylopectin

107.) What weight of arsenic trioxide ( 98.73% ) would be used as a sample so that
35.00 mL of 0.1 N iodine would be needed to titrate it? (Atomic weighs :
As=175, O=16,I=126.9)
 A.) 0.1753 g D.) 0.1756 g
B.) 0.1754 g E.) 0.1757 g
C.) 0.1755 g

108. A 1.1000 g sample of sodium nitrate was dissolved in sufficient water to

make 100 mL . A 10-mL sample of the solution was added to 50.00 mL
of 0.1 N KMnO4 in the presence of sulfuric acid . The
mixture was treated with 25.00 mL of 0.0975 N oxalic acid and titrated with
4.58 mL with 0.1 N KMnO4. Calculate the % sodium nitrate in the sample .
(Atomic weighs Na=23, N=14, O=16)

A.) 80.36% D.) 80.37%

B.) 90.73% E.) 90.74%
C.) 9.47%

109. Which of the following is NOT an advantage of permanganate

titrations?

A.) Easily standardized D.) It reacts rapidly

B.) Retains its concentration over E.) Does not need an indicator
long periods of time
C.) It is stable even on boiling

110. What is the best standard to be used in the standardization of

potassium permanganate?

A.) Sodium hydroxide D.) Sodium biphthalate

B.) Sodium oxalate E.) Sodium carbonate
C.) Sodium chloride

111. The solvent for fats and fixed oils.

A.) Distilled water D.) 95% ethyl alcohol

B.) n-hexane E.) Chloroform
C.) 80% ethanol

112. A 2.00mL sample of hydrogen peroxide solution required 8.5mL of a

permanganate solution in titration. If each milliliter of the permanganate
solution is equivalent to 0.007294 g of Fe, what % w/v of hydrogen peroxide
was in the sample ? ( Atomic weights:H=1,O=16 Fe=56)

A.) 0.90% D.) 1.88%

B.) 0.94% E.) 2.00%
C.) 1.80%

113. Masking is accomplished by adjusting the pH of the titration

medium to favor the analysis of a single metal even in the
presence of other metals. Bismuth could be solely analyze of the
presence of other metals by adjusting the pH level at .

A.) pH 2 D.) pH 11
B.) pH 5 E.) pH 13
C.) pH 7
 114. A 0.2182 g sample of solution chloride was assayed by the Volhard
method using 50.00 mL of 0.0985 N silver nitrate and 11.75 mL of 0.1340
N ammonium thiocyanate . Calculate the % sodium chloride in the sample (
Atomic weights: Na=23, Cl=35)

A.) 89.00% D.) 89.06%

B.) 89.02% E.) 89.08%
C.) 89.04%

115. Which acidic solution is being added in precipitation titrations in order

to prevent the precipitation of silver as well as to prevent the hydrolysis
of ferric alum?

A.) Boric acid D.) Perchloric acid

B.) Hydrochloric acid E.) Sulfuric acid
C.) Nitric acid

116. A chemical reagent that is added in Volhard titrations to form a film

over the precipitated silver chloride particles and prevent its reaction
with ammonium thiocyanate.

A.) Triethanolamine D.) Nitric acid

B.) Nitrobenzene E.) Ferric ammonium sulfate
C.) Thioglycol

117. The end-point determination of a reaction in precipitimetry may be

determined in which of the following way/s:
I. Cessation of precipitation or appearance of turbidity
II. Use of internal indicators
III. Instrumentals methods like potentiometry

A.) I only D.) I and II

B.) II only E.) I, II, and III
C.) III only

118. A 4.0520 g sample of hydrolic acid .with specific gravity of 1.18,

required 26.25 mL of 0.0952 N sodium hydroxide in titration .What is
the % hydrochloric acid ? (Atomic weights: H=1, Cl=35, Na=23, C=12,
O=16)

A.) 2.20% D.) 2.23%

B.) 2.21% E.) 2.24%
C.) 2.22%

119. In relation to Question #118 , What is the what is the normality of

hydrochloric acid ?

A.) 32.81 N D.) 32.84 N

B.) 32.82 N E.) 32.85 N
C.) 32.85 N

120. In relation to Question #118 What is the sodium carbonate titer

of the sample ?

A.) 1.7391 g D.) 1.7394 g

B.) 1.7392 g E.) 1.7395 g
C.) 1.7393 g
 121. Calculate the magnesium oxide content of milk of magnesia 12.32 g of
which was dissolved in 50.00 mL of 0.0340 N sulfuric acid ,
producing amixture that required 24.60 mL of 1.1255 N sodium hydroxide
(Atomic weights: Mg=24,O=16)

A.) 3.88% D.) 7.79%

B.) 3.89% E.) 7.80%
C.) 3.90%

122. It refers to the nearness or closeness of the measured values with one
another

A. Accuracy D.) Defect

B.) Error E.) None of these
C.) Precission

123. If a 0.2800 g sample of sodium bicarbonate ( 96.5%) is titrated with

0.9165 N sulfuric . What volume of the acid should be required
to produce an end point? ( Atomic weights: Na=23, H=1, C=12, O=16)

A.) 3.49 mL D.) 3.52 mL

B.) 3.50 mL E.) 3.53 mL
C.) 3.51 mL

124.If the amount of indicator to be used is not specified in the assay

monograph. How much indicator should be added in the analysis?

A.) One drop D.) Four drops

B.) Two drops E.) Five drops
C.) Three drops

125. A theory explaining the reactions of indicators, which is based in

certain groupings of elements in a given compound

A.) Physicochemical theory D.) All of these

B.) Organic theory E.) None of these
C.) Colloidal theory

126. What is the color reaction of methyl red indicator in bases?

A.) Red D.) Blue

B.) Green E.) Purple
C.) Yellow

127. Which is the following is NOT a function of indicators?

A.) Determine end-points in neutralization reaction

B.) Determine the pH
C.) Indicate that a desired pH has been achieved
D.) For direct titrations, the reaction must be rapid so a sharp end point is
observed
E.) None of these

128. The following requirements must be met by any of the reactions in

titrimetric analysis,EXCEPT:
 A.) The reaction must proceed to completion by having an equilibrium
constant that is equal to or less than 108
B.) The reaction must proceed in a stoichiometric manner
C.) There must be a suitable end-point detecting device
D.) All of these
E.) None of these

129. Which of the following statements is NOT true regarding transfer or

delivery pipets?

A.) Pipets should be filled to above 1 cm above the mark

B.) Wipe off any liquid adhering to the outer surface of the pipet
C.) Filling pipets by mouth is sometimes recommended
D.) All of these
C.) None of these

130. A sample of potassium dichromate weighing 1.5650 g was assayed

iodometrically using 26.60 mL of 0.1120 N sodium thiosulfate. Each mL of
0.1 N sodium thiosulfate is equivalent to 49.03 mg of potassium dichromate What is
the % purity or the sample? (Atomic weights:K=39,Cr=52,O=16)

A.) 9.34% D.) 93.50%

B.) 93.40% E.) 94.30%
C.) 0.93%

131. Calculate the amount of caffeine extracted from coffee beans using 0.0215
g of the sample. The volume of 0.0252 N sulfuric acid added to the extract was
25.40 mL, the excess was titrated by 21.75 mL of 0.0215 N sodium hydroxide.
Each mL of 0.02 N sulfuric acid is equivalent to 3.8658 mg of caffeine.

A.) 3.26% D.) 3.29%

B.) 3.27% E.) 3.30%
C.) 3.28%

132. Type of errors that can be determined and corrected

A.) Defective D.) Both A and B

B.) Determinate error E.) Both A and C
C.) Indeterminate error

133. If a sample of beeswax is found to have an acid number of 15.50 and and
saponification value of 71.20,the ester value of the sample is:

A.) 86.70 D.) 50.00

B.) 55.70 E.) None of these
C.) 89.00

134.Given the following data for tragacanth powder. Weight of empty

crucible – 52.452 g; Weight of crucible and sample - 61.648g; Weight
of crucible with sample after drying – 60.502g; Weight of crucible and residue left
after incineration – 53.006g; What is the moisture content in grams?

A.) 1.146 g D.) 1.166 g

B.) 1.144 g E.) 1.441 g
C.) 1.164 g
135. In relation to Question # 134 ,What is the % moisture content of the
sample ?

A.) 12.64% D.) 12.54%

B.) 12.46% E.) 12.47%
C.) 12.45%

136. In relation to Question #134,what is the total ash content I grams?

A.) 0.545 g D.) 0.556 g

B.) 0.555 g E.) 0.445 g
C.) 0.554 g

137. In relation to Question #134 , what is the % total ash?

A.) 6.20% D.) 6.22%

B.) 6.02% E.) 6.92%
C.) 6.00%

138. Calculate the calcium carbonate content of a sample of chalk

weighing 0.2545 g and consuming 16.67 mL of 0.1150M of EDTA solution (
Ca=40 ,C=12 , O=16) The percentage of Calcium carbonate

A.) 75.33% D.) 37.66%

B.) 75.34% E.) 37.65%
C.) 75.30%

139. This is used for the quantitative preparation of astandard

solution

A.) Erlenmeyer flask D.) Volumetric flask

B.) Pipet E.) Beaker
C.) Graduated cylinder

140. It refers to the process of removing an appropriate number of items

A.) Inspection D.) Inspection analysis
B.) Analysis E.) Sampling inspection
C.) Sampling

141. A method that deals with the transitions between energy levels that
are generated by radiant energy after subjecting the molecules in a magnetic
field

A.) Chromatography D.) Spectrometry

B.) Polarimetry E.) Refractometry
C.) Nuclear Magnetic Resonance

142. The of a nuclei is based on the nuclei’s change and mass

A.) Spin D.) Affinity

B.) Mass E.) None of these
C.) Charge

143. A branch of electrochemistry which deals with the study and measurement of
electrode potential
A.) Polarography D.) Chromatography
B.) Potentiometry E.) Colorimetry
C.) Refractometry
144. A method of analysis based of measurement of current resulting from the electrolysis
of an electroactive species at a given electrode at a given electrode potential under
controlled conditions

A.) Chromatography D.) Potentiometry

B.) Colorimetry E.) Refractometry
C.) Polarography

145. It deals with the study of the rotatory powder of substances

A.) Spectrometry D.) Refractometry

B.) NMR E.) Polarimetry
C.) Potentiometry

146. A radiationless process when the downward transitions occur at a greater than
the upward transitions resulting to the appearance of useful NMR signals

A.) Saturation D.) Relaxation

B.) Resonance E.) Angular velocity
C.) Magnetic moment

147 It deals with the study and measurement of index of refraction of

substances in order to assess their composition purity

A.) Polarimetry D.) Refractometry

B.) Potentiometry E.) Spectrometry
C.) Polarography

148. An instrument that measures the durability of tablets to withsland shock and
abrasion during transport

A.) Spectrophotometer D.) Friabilator

B.) Refractometer E.) Coulter counter
C.) Hardness Tester

149. It is used as a reference in proton NMR and assigned a chemical shift of zero

A.) Tetramethylsilane D.) Trimethoxsilane

B.) Tetramethoxsilane E.) None of these
C.) Trimethylsilane

150. The type of chromatography where the cellulose of paper is used as the
adsorbent

A.) Column chromatography D.) Gas chromatography

B.) Paper chromatography E.) Liquid chromatography
C.) Thin layer chromatography

151. It is defined as the ratio of velocity of light in air to the velocity of light in
the medium or the ration of the sine of angle of refraction

A.) Angle of rotation D.) Optical activity

B.) Specific rotation E.) Rotatory activity
C.) Index of refraction
152. In paper chromatography,the data needed to compute the Rf value is

A.) Distance travel by solute D.) Both A and B

B.) Distance travel by the solvent E.) Both A and C
C.) Distance travel by the blank

153. In TLC, the separation takes place on a planer surface by:

A.) Differential migration D.) Relative solubility

B.) Electrostatic forces E.) Capillary action
C.) Molecular size

154. Gypsum in silica gel G is used as:

A.) Disintegrant D.) Diluent

B.) Dessicant E.) Antiadherent
C.) Binder

155. Wavelength used in all polarimetric measurements

A.) 598 nm D.) 958 nm

B.) 589 um E.) 589 nm
C.) 859 um

156. For a liquid, it is defined as the angular rotation in degrees through which
the plans of polarization of polarized monochromatic light is rotated by passage
through 1 dm or 100 mm of the liquid calculated on a basis of specific gravity of
1.0

A.) Index of refraction D.) Specific rotation

B.) Optical activity E.) Angle of refraction
C.) Angle of rotation

157. It is used in the analysis of volatile substances

A.) Column chromatography D.) Paper chromatography

B.) Liquid chromatography E.) Gas chromatography
C.) Thin layer chromatography

158. Used to measure the optial activity of liquid substances

A.) pH meter D.) Polarizing microscope

B.) Polariscope E.) Potentiometer
C.) Refractometer

159. A law stating that the power of a transmitted radiant beam decreases
exponentially as the concentration of the solution containing the absorbing
chemical species increases arithmetically

A.) Beer’s law D.) Beer-Lambert’s law

B.) Lambert’s law E.) Beer-Bouguer’s law
C.) Bouguer’s law

160. Most commonly used,highly abundant,and the most sensitive isotope in

NMR analysis
A.) C12 D.) O16
B.) H1 E.) P31
C.) N14
 161. The calcium and sodium content of the blood can be determined by:

A.) Flame spectroscopy D.) Nephelometry

B.) Turbidimetry E.) Colorimetry
C.) Chromatography

162. In microbial assay, the instrumental method used to prepare the inocolumn is:

A.) Nephelometry D.)Turbidimetry

B.) Flame photometry C.) Spectrometry
C.) IR spectroscopy

163. Acetylene and aldehyde groups present in a compound that absorbs radiant
energy are called:

A.) Active components D.) All of these

B.) Chromophore E.) None of these
C.) Inactive components

164. It is the number of complete cycles that pass a given point per second

A.) Frequency D.) Radiant energy

B.) Wavenumber E.) Spectrum
C.) Wavelength

165. A spectrophotometer differs from a colorimeter because it consist of:

A.) Prism D.) Optical scale

B.) Cell compartment E.) None of these
C.) Lamp house

166. The law related to spectrometry wherin the power of transmitted light decreases
exponentially as the thickness of the solution increases arithmetically

A.) Charles’ law D.) Boyle’s law

B.) Beer’s law E.) Henry’s law
C.) Lambert’s law

167. The instrument used to measure Na and K ions quantitatively

A.) Colorimeter D.) Flame photometer

B.) Spectrometer E.) Refractometer
C.) Spectrophotometer

168. Thiamine is assayed by:

A.) Flame spectroscopy D.) Flame photometer

B.) Spectrometer E.) Refractometer
C.) Flourometry

169. The following are optical methods of analysis except:

A.) Flame spectroscopy D.) Chromatography

B.) Colorimetry E.) Nephelometry
C.) Turbidimetry

170. A plot of absorbance against a concentration of a standard drawn in

straight line is:
 A.) Charles’ D.) Bougouer’s
B.) Lambert’s E.) Henry’s
C.) Beer’s

171. The method of assay for Vitamin B12 and calcium pantothenate is by:

A.) Flourometry D.) Nephelometry

B.) Colorimetry E.) Spectrophotometry
C.) Turbidimetry

172. In IR spectrometry water is not used as a solvent for the sample because the
water will:

A.) Absorb IR radiation D.) Both A and B

B.) Dissolve the NaCl cell holder E.) Both B and C
C.) Not dissolve the sample

173. A type of biological assay performed with microorganisms, like bacteria, yeast
and molds

A.) Bioassay D.) Fungal assay

B.) Microbial assay E.) Viral assay
C.) Bacterial assay

174. It refers to the complete wave or cycle from the peak of the next wave :

A.) Wavelength D.) All of these

B.) Frequency E.) None of these
C.) Wavenumber

175.The most commonly used matrix in pellet making

A.) Cal D.) Nal

B.) KCl E.) Csl
C.) KBr

176. USP limit for content uniformity

A.) 90-110% D.) 80-120%

B.) 95-105% E.) 97.50-102.50%
C.) 85-115%

177. A test which is determined by selecting NLT 30 tablets from each production
batch and assaying 10 tablets individually as directed in the assay of the official
compendial monograph:

A.) Content uniformity test D.) Disintegration test

B) Weight variation test E.) Friability test
C.) Dissolution test

178. Potentiometry finds application in:

A.) Biologic assay D.) Pharmacological screening

B.) pH determination E.) Toxicity testing
C.) Qualitative assay

179. Karl Fischer electrometric titration is a method used to assay samples for it
A.) Carbon content D.) Water content
B.) Nitrogen content E.) Volatile of content
 C.) Ash content

180. Colorimetric methods of analysis are absorptimetric methods that utilize

the region of the spectrum

A.) Ultraviolet D.) All of these

B.) Visible E.) None of these
C.) Infrared

181. Which of the following regions of the electromagnetic spectrum is useful in

Spectrometric analysis?

I. X-rays
II. Ultraviolet
III. Visible
IV. Infrared
V. Radio waves

A.) I only D.) I and V

B.) II,III and IV E.) II,III,IV and V
C.) III and IV

182. Which of the following is true about spectrometry?

I. A method of analysis dealing with the measurement of spectra
II. Measures the wavelength in the electromagnetic spectrum where the radiant energy
has interacted with a chemical specie
III. Measures the power of transmitted,fluorescent,reflected or emitted energy

A.) I only D.) I and III

B.) II only E.) I,II and III
C.) III only

183. It deals with the measurement of the monochromatic radiation absorbed by

chemical species

A.) Spectrophotometry D.) Nephelometry

B.) Flame photometry E.) Turbidimetry
C.) Flourometry

184. The wavelength ranging from 3 to 15 micrometers falls under which region of the
spectrum?

A.) Ultraviolet D.) Mid infrared

B.) Visible E.) Far infrared
C.) Near infrared

185.One micrometer is equivalent to:

A.) 10-2 cm D.) 10-8cm

B.) 10-4 cm E.) 10-9cm
C.) 10-7cm

186. In the formula E = hv,”h” is the

A.) Energy D.) Planck’s constant
B.) Frequency E.) Wavenumber
C.) Wavelength
187. A fundamental vibration of atoms in which the distance increases or
decreases along the bond axis:

A.) Scissoring D.) Wagging

B.) Deformation E.) Twisting
C.) Stretching

188. What microorganism is used in the microbial assay test for Vitamin B12?

A.) Lactobacillus shirota D.) Lactobacillus bifidus

B.) Lactobacillus plantarum E.) All of these
C.) Lactobacillus leichmanii

189. Which of the following is NOT true about the fingerprint region?

I. Wavelength range of 8 to 15 um
II. Gives the spectrum of a molecule as a whole
III. Energy absorption is because of the functional groups

A.) I only D.) I and II

B.) II only E.) II and III
C.) III only

190. A microbial assay for antibiotics that measures the diameter of the zones of
microbial growth inhibition in a solid nutrient medium.

A.) Cylinder plate method D.) All of these

B.) Broth dilution method E.) None of these
C.) Turbidimetric method

191.

192. The turbidimetric assay of antibiotic potency is based on the inhibitation of

microbial growth by measuring the turbidity of the bacterial suspension. The
degree of turbidity is measured in terms of:

A.) Absorbance D.) All of these

B.) Transmittance E.) None of these
C.) Concentration

193. Mull technique in IR spectroscopy is:

A.) Dissolving the solid in a suitable organic solvent D.) All of these
B.) Incorporating the solid in a pellet E.) None of these
C.) Dispersing the finely ground solid in liquid
petrolatum

194.In cylinder plate method of the microbial assay for antibiotics,the

measurements are based on the of the zone of microbial growth inhibition

A.) Radius D.) All of these

B.) Diameter E.)None of these
C.)Circumference

195.Fluorometry is the official method use in the analysis of which vitamins?

A.) Nicotinamide D.)Folic acid

 B.) Riboflavin E.) Cyanocobalamin
C.) Pyridoxine

196. The microbial assay for this compound is based on the inability of the
microorganism to synthesize the factor being assayed

A.) Antibiotics D.) Hypotensive drugs

B.) Insulin E.) Sulfonamides
C.) Vitamins

197. Turbidimetric and nephelometric methods of assay analyze what type/s

of samples?

A.) Suspension D.) Both A and B

B.) Solution E.) Both A and C

198. Vitamin B12 is also known as:

A.) Thiamine D.) Pyridoxine

B.) Riboflavin E.) Folic acid
C.) Cyanocobalamin

199. These are substances or bacterial components that cause fever or febrile
reaction

A.) Toxins D.) Exotoxins

B.) Pyrogens E.) Antigens
C.) Enzymes

200. Turbidimetry is the method use for the assay of which vitamins

A.) Tocopherol D.) Folic acid

B.) Thiamine E.) Cyanocobalamin
C.) Ascorbic Acid

201. What is the minimum number of rabbits used in Pyrogrn test?

A.) One D.) Four

B.) Two E.) Five
C.) Three

202. What biological animal is used when conducting in Pyrogen test?

A.) Dogs D.) Frogs

B.) Horses E.) Rats
C.) Rabbits

203. A spectrometric method of analysis which is used in the standardization of

bacterial incolumns in microbial assays.

A.) Spectrophotometry D.) Flame photometry

B.) Flourometry E.) Nephelometry
C.) Turbidimetry

204. A decisions to accept is made in the pyrogen test if the temperature rise in
one rabbit is:

A.) Less than 0.5oC D.) Equal or less than 0.5oC

B.) Equal to 0.5oC E.) Equal to or more than 0.5oC
C.) More than 0.5oC
205. It is the process by which a solid enters into solution.

A.) Disintegration D.) All of these

B.) Deaggregation E.) None of these
C.) Dissolution

206. A spectrometric method of analysis that measures the reflected light

passing through a turbid solution or a suspension

A.) Flourometry D.) Polarimetry

B.) Refractometry E.) Spectrophotometry
C.) Nephelometry

207. If the requirement for the pyrogen test was not met,a repeat test is a
required using additional rabbits

A.) One D.) Seven

B.) Three E.) Nine
C.) Five

208.Which is true for dissolution test?

A.) A simple and inexpensive indicator of a product’s physical activity

B.) It is a useful tool in the early stages of drug development and molecular
manipulation
C.) It serves as an approximation of the drug’s biological activity
D.) All of these
E.) None of these

209. The following are the basic components of the instrument used in NMR
studies,EXCEPT
A.) Radiofrequency transmitter D.) Prism or diffraction grating
B.) Magnet E.) Detector and recorder
C.) Method of sweeping through the spectrum

210. In the repeat test for pyrogens using a total of eight rabbits,the
requirement is met if the total rise in temperature is:

A.) Less than 3.3 Celsius D.) Equal to or less than 3.3 Celsius
B.) Equal to 3.3 Celsius E.) Equal to or more than 3.3 Celsius
C.) More than 3.3 Celsius

211. The solvent used in NMR assay must be free from

A.) Neutrons D.) Positrons

B.) Electrons E.) Negatrons
C.) Protons

212. Which of the following physicochemical properties does NOT affect

dissolution of drugs?

A.) Solubility D.) Polmorphism

B.) Particle size E.) Solid phase characteristics of the drug
C.) Method of granulation
 213. Which of the following is/are used as dissolution media when conducting the
dissolution test?

A.) Distilled water D.) All of these

B.) Simulated gastric fluid E.) None of these
C.) Simulated intestinal

214. Which among the following solvents in NMR assay?

A.) Chloroform D.) Absolute alcohol

B.) Carbon tetrachloride E.) All of these
C.) Ether

215. This is also known ain s “in-vitro” pyrogen test

A.) Rabbit test D.) Both A and CE

B.) Bacterial endotoxin test E.) Both B and
C.)LAL test

216. What is the most popular indicator electrode used in pH determination?

A.) Quinhydrone electrode D.) Calomel electrode

B.) Glass electrode E.) Standard hydrogen electrode
C.) Ag/AgCI electrode

217. Apparatus 1 in a dissolution apparatus:

A.) Basket D.) Flow-through cell

B.) Paddle E.) Paddle over disk
C.) Receprocating cylinder

218. The following are the principal objectives of chromatography, EXCEPT:

A.) Resulotion of mixtures into constituent part

B.) Compsrison of substance suspected of being identical
C.) Dilution of substance from concentraded solutions
D.) Purification of samples
E.) Quantitative separation from complex mixtures

219. What is the reference electrode used in polarography?

A.) Saturated hydrogen electrode D.) Glass electrode

B.) Quinhydrone electrode E.) Saturated calomel electrode
C.) Dropping mercury electrode

220.LAL in bacterial test is also known as

A.) Limulus amebocyte lysate D.) Limnulus amebocyte lysate

B.) Limulus amebocide lysate E.) None of these
C.) Linnaeus amebocyte lysate

221.Which of the following is NOT a principle of separation in chromatography?

A.) Absorption D.) lon-exchange

B.) Adsorption E.) Molecular exclusion
C.) Partition

222. Apparatus 2 in a dissolution tester is:

 A.) Basket D.) Flow-through cell
B.) Paddle E.) Paddle over disk
C.) Partition

223.It is the current resulting from the oxidation or reduction of electroactive

substances at the microelectrode

A.) Electric current D.) All of these

B.) Charging Current E.) None of these
C.) Faradaic current

224 What instrument is used to determine the position of the separated radioactive
components following chromatography?

A.) Painting the column D.) Spraying with colored solution

B.) Charring E.) Geiger-Muller counter
C.) Use of iodine vapors

225. LAL is an aqueous extract of the circulating amebocytes obtained from

A.) Horses D.) Mice

B.) Crab E.) Dogs
C.) Horseshoe crab

226. What is the required temperature of the dissolution media?

A.) 35oC D.) 35-39oC

B.) 37oC E.) 36-38oC
C.) 36.5-37.6oC

227. A law stating that when two immiscible solvents are in contact with each other and
a substance which is soluble in each is added ,the substance distributes itself in a way that
at equilibrium and a given temperature ,the ratio of the
concentrations of the two solutions is constant.

A.) Beer’s law D.) Stokes’s law

B.) Lambert’s law E.) Bougouer’s law
C.) Nernst’s law

228.) It is considered as the most rapid way of determining water content of

samples

A.) Gravimetric method D.) Dew point

B.) Karl fischer titration
C.) Xylene method

229. The observed result in bacterial endotoxin test is the formation of:

A.) Zone inhibition D.) Color change

B.) Transmittance E.) Acid production
C.) Gel Clot

230. A type of paper chromatography which is accomplished by allowing the

mobile phase to rise upward following capillary attraction

A.) Ascending chromatography D.) All of these

B.) Descending chromatography E.) None of these
C.) Radial chromatography

231. Which of the following is NOT a component of Karl Fischer reagent?

 A.) Pyridine D.) Sulfuric acid
B.) Iodine E.) None of these
C. Methanol

232. It refers to the ability of tablets resist chipping ,abrasion or breakage under
conditions of storage transportation and handling before usage.

A.) Thickness D.) Content uniformity

B.Disintegration E.) Weight variation
C.) Methanol

233. Which chromatographic technique is used in the separation of water-

insoluble substance like steroids?

A.) Adsorption chromatography D.) Ion-exchange chromatography

B.) Parition Chromatography
C.) Reversed-phase chromatography

234. The bacterial source of the USP References Standard for Endotoxin is:

A.) Staphylococcus aureus D.) Haemophilus influenza

B.) Strephylococcus pyogenes E.) Vibrio cholera
C.) Escherichia coli

235. A substance that rotates plane polarized light to the right is designated as

A.) Dextrorotatory D.) All of these

B.) Levorotatory E.) None of these
C.) optically active

236. Which among the chromatograpihic technique separates constituents of the

sample based on the molecular size?

A.) lon-exchange D.) Reversed-phase

B.) Partition E.) Gel-filtration
C.) Adsorption

237. A tablet hardness tester that uses a coil spring mechanism to break the tablet.

A.) Srtong- Cobb HT D.) Reversed-phase

B.) Pfizer HT E.) Schleuniger HT
C.) Erweka HT

238. Calculate the percent moisture in aminosalicylic acid if 9.00 mL of KFR ,having a
water equivalence factor of 4.10,was consumed by a 5.100g sample.

A.) 723.52% D.) 531.38%

B.) 723.53% E.) 531.39%
C.) 531.37%

239. A type of chromatography that involves the spotting of a sample of a mixture of

components at one end of an adsorbent –coated glass plate followed by passage of a
solvent through the adsorbent for the purpose of separating the
components of the sample.
 A.) Paper chromatography D.) Gas chromatography
B.) Column chomatography E.) Liquid chromatography
C.) Thin layer chromatography

240. This is the in-vivo way of determining the presence of pyrogens.

A.) Bacterial endotoxin test D.) Turbidimetric

B.) Cylinder plate method E.) None of these
C.) Rabbit test

241. The prism that is used in examining the polarized light is called the:

A.) Polarizer D.) Nicol prism

B.) Diffraction grating E.) None of these
C.) Analyzer

242. What is the best solvent system to be used in separating components of an

unknown sample?

A.) Benzene with 10% ethanol D.) Chloroform with benzene

B.) Benzene with 10%methanol E.) Choroform with 10% ether
C.) Ether with 10% ethanol

243.What is the minimum satisfactory hardness value for a compressed tablet?

A.) 2 kg D.) 4-10kg

B.) 2-3kg E.) 10kg
C.) 4 kg

244. Mikhail Tswett discovered chromatography through an experiment regarding:

A.) Proteins D.) Pigments

B.)Alkaloids E.)Carbohydrates
C.) Glycosides

245. Which of the following methods can be used in visualizing separated

components that are colorless?

A.) Charring using sulfuric acid D.) All of these

B.) Use of iodine crystals E.) None of these
C.) Examination using UV radiation

246. A tablet hardness tester that uses an air pump

A.) Schleuniger HT D.) Stokes-Monsanto HT

B.) Pfizer HT E.) Strong-Cobb HT
C.) Erweka HT
247. USP defines this method as a technique of separating molecular mixtures

A.) Filtration D.) Refractometry

B.) Chromatography E.) Potentiometry
C.) Spectrophotometry

248. The inert gas used as mobile phase in gas chromatography is referred to as:

A.) Vehicle gas D.) All of these

B.) Carrier gas E.) None of these
C.) Gas substrate

249. A hardness tester that operates on the same mechanical principle as ordinary
pliers

A.) Stokes-Monsanto HT D.) Schleuniger

B.) Pfizer HT E.) Erweka HT

250. A hardness tester that eliminates the operator variability in measuring tablet
hardness

A.) Erweka HT D.) Strong-Cobb HT

B.) Schleuniger HT E.)Stokes-Monsanto HT
C.) Pfizer HT

251. It refers to the time required by an average molecule of component to pass

from the injection point through the column to the detector

A.) Retention factor D.) Any of these

B.) Retention volume E.) None of these
C.) Retention time

252.This is also known as “crushing strength”

A.) Hardness D.) Content uniformly

B.) Thickness E.) Weight variation
C.) Friability

253. An instrument that is used to determine tablet friability

A.) Dissolution apparatus D.) Disintegration apparatus

B.) Friabilator E.) Moisture analyzer
C.) Hardness tester

254. Which is the following is NOT an advantage of HPLC?

A.) Precise D.) Ease of operation

B.) Slow separation E.) None of these
 C.) Accurate

255. It refers to the ability of a tablet to withstand abrasion in packaging,

handling,and shipping

A.) Content uniformly D.) Hardness

B.) Friability E.)Thickness
C.) Crushing strength

256. A test that exposes tablets to rolling and repeated shocks to determine the
weight loss on tables.

A.) Disintegration test D.) Friability test

B.) Hardness test E.) Dissolution test
C.) Thickness test

257. What is the prerequisite for solvents used in high pressure liquid
Chromatography?

A.) Free from protons D.) All of these

B.) HPLC grade E.) None of these
C.) Degassed

258. Which of the following can be used in measuring tablet thickness?

A.) Hardness tester D.) Dissolution apparatus

B.) Vernier caliper E.) Ruler
C.) Friabilator

259. What is the tolerable limit/allowance in thickness test for tablets?

A.) 85 to 115% D.) 92.5 to 107.5%

B.) 87.50 to 112.50% E.) 95 to 105%
C.) 90 to 110%

260. What is the number of tablets required in weight variation test?

A.) 10 tablets D.)25 tablets

B.) 15 tablets E.) 30 tablets
C.) 20 tablets

261.What are the variation limits if the computed average weight for a
bath of tablets is 100mg?

A.) 95 mg to 105 mg D.) 90 mg to 110 mg

B.) 80 mg to 120 mg E.) 85 mg to 115 mg
C.) 92.50 mg to 107.50 mg

262. Using a spectrophotometer to measure the concentration of the

sample,the following data werw obtained:

Absorbance of standard solution = 0.225

 Absorbance of sample solution = 0.214
Concentration of standard solution = 17.7 mcg

A.) 18.6 mcg D.) 16.9 mcg

B.) 19.0 mcg E.) 17.7 mcg
C.) 16.8 mcg

263. LAL test applicable in the determination of:

A.) Microorganisms D.) All of these

B.) Pyrogens E.) None of these
C.) Chemical impurities

264.

265.The amount of dissolved drug can be determined by:

A.) Friabilator D.) Moisture anayzer

B.) Dissolution tester E.) Spectrophotometer
C.) Hardness tester

266. Content uniformity is to be performer for ali tables whose active ingredients is

A.) Less than 50 mg D.) More than 50mg

B.) Less than 100 mg E.) More than 100mg
C.) 50mg to 100mg

267.Stationary phase:
I. The fixed phase in chromatography
II. A porous or ficaly divided solid or a liquid that has been coated in a thin layer on an
inert supporting material.
III. The particles should be small and homogenous so as to provide a large surface
area so that sorption of the solutes will occur frequently
and efficiently

A). I only D.) II and III

B.) II only E.) I, II and III
C.) III only

268. The initial content uniformity test is conducted using:

A.) 10 tablets D.) 25 tablets

B.) 15 tablets E.) 30 tablets
C.) 20 tablets

269. The following pharmaceutical excipients affect the disintegration of tablets ,EXCEPT:

A.) Binders D.) Disintegrants

B.) Colorants E.) Diluents
C.) Granulating agents

270. It is the universal detector used in gas chromatography since it responds to all type of
solutes.
 A.) Flame ionization detector D.) Thermoionic specific detector
B.) Thermal conductivity detector E.) Flame photometric detector
C.) Electron capture detector

271. A passing tablet friability result is a maximum weigth of NMT what % of the weight of
the tablets being tested:

A.)0.50% D.) 2.00%

B.) 1.00% E.) 2.50%
C.1.50%
272. What tablet attribute is correlated with the biological activity of the active
ingredients?

A.) Hardness D.) Disintegration

B.) Dissolution E.) Thickness
C.) Friability

273. A dector in gas chromatography which is most frequently used because it is highly
sensitive is able to detect microgram quantities of solutes and is an almost universal
detector.

A.) FID D.) TSD

B.) TCD E.) ECD
C.) NPD

274. Given a tablet thickness of 0.47 cm,what should be the acceptance range?

A.) 0.4465 to 0.4935 cm D.) 0.3525 to 0.5875 cm

B.) 0.4348 to 0. 5050 cm E.) 0.3760 to 0. 5640 cm
C.) 0.4230 to 0.5170 cm

275. A spectrometric method that measure the amount of light that that scattered by a
suspension

A.) Colorimetry D.) Flame photometry

B.) Turbidimetry E.)AAS
C.) Nephelometry

276. A modified form of the flame ionization detector that shows increased response to
compounds containing nitrogen phosphorus

A.) Thermal conductivity detector D.) Flame ionization detector

B.) Thermoionic specific detector E.) Electron capture detector
C.) Flame photometric detector

277. Microbiological assays are recommended for which of the following?

A.) Anesthetics D. Antipsychotics

 B.) Sedatives E.)Tranquilizer
C.) Antibiotics

278. A QC test that measure the time required for tablet to undergo disintegration under
specified set of conditions

A.) Dissolution test D.) Disintegration test

B.) Hardness test E.) Content uniformity test
C.) Friability test

279. What is the strongest adsorbent used in column chromatography

A.) Starch D.) Alumina

B.) Calcium carbonate E.) Charcoal
C.) Silica gel

280. In disintegration test the particles must pass through sieve#

A.)10 D.) 60
B.)20 E.) 80
C.) 40

281. The basket rack assembly is a component of which of the following instrument

A.) Hardness tester D.) Friabilator

B.) Vernier caliper E.) FTIR
C.) Disintegration apparatus

282. It refers to a chromatographic method in which the separation takes place within
a packed column.

A.) Paper chromatography D.) gas chromatography

B.) Vernier caliper E.) Thin layer chromatography
C.) Liquid chromatography

283. The temperature of the testing fluid used in disintegration must be maintained at

A.) 30 to 40 celsius D.) 36 to 38 celsius

B.) 32 to 38 celsius E.) 35 to 40 celsius
C.) 35 to 39 celsius

284. For the result of the disintegration test to be accepted using 18 samples ,the allowed
tablets that fail to disintegrateis:

A.) Zero D.) Six

B.) Two E.) Eight
C.) Four

285. Which of the following methods can be performed to removed unwanted gases of the mobile
phase used in I IPLC?

A.) Used of a vacuum D.) All of these

B.) Sonication E.) None of these
C.) Sparging with helium

286. What is the disintegration time for sublingual tablets like isoproterenol HCl CT?
 A.) 3 minutes D.) 2hours
B.) 30 minutes E.) 3 hours
C.) 1 hour

287. A test that measures the amount of time required for a given percentage of the
drug,substance in a tablet to go into a solution under a specified set of condition

A.) Friability test D.) Thickness test

B.) Dissolution test E.) Disintegration test
C.) Hardness test

288. What part of the HPLC instrument is used to contain the mobile phase?

A.) Reservoir D.) Analytical column

B.) Pump E.) Detector
C.) Injector port

289.It is the one responsible for the test and measure of materials and products

A.) Total Quality Management D.) All of these

B.) Quality Control E.) None of these
C.) Quality Assurance

290. It is the one responsible for establishing the system to ensure product quality

A.) Total Quality Management D.) All of these

B.) Quality Control E.) None of these
C.) Quality Assurance

291.It refers to the sum of all factors which contribute directly or indirectly to the safety
effectiveness and reliability of a product

A.) Safety D.) Efficancy

B.) Purity E.) All of these
C.) Quality

292. Organic volatile chemical from the process or generated during processing is an
example of what class of impurity?

A.) Organic D.) All of these

B.) Inorganic E.) None of these
C.)Solvents

293. Phase of Pharmaceutical Product Development categorized as definitive clinical

efficancy studies

A.) Phase 0 D.) Phase III

B.) Phase I E.) Phase IV
C.) Phase II

294. It is an optional component/part of the HPLC instrument which functions to saturate the
mobile phase in order to retard dissolution and to trap particulate matter thereby protecting the
main column

A.) Guard column D.) Both A and B

B.) Analytical column E.) Both A and C
C.) Precolumn
295. Which of the following is/are the application/s of quantitative

A.) Analysis and determination of the purity and quality

drugs and chemicals used in pharmacy
B.) Analysis of the chemical constituents found in the human body
whose altered concentrations during disease states serve as diagnostic aids in
the practice of medicine.
C.) Analysis of medicinal agents and their metabolites found in the biological
systems
D.) All of these
E.) None of these