The table in the image provides an analysis of creatinine levels under different conditions and

treatments. Here’s a comprehensive discussion:

- **Normal Control**: The baseline creatinine level is **1.79±0.2**. This serves as the control
value for comparison with treated groups.

- **200mg/kg Extract**: Treatment with 200mg/kg of an extract resulted in a negligible increase

in creatinine levels to **1.82±0.1**. The change is not statistically significant (p<0.05), indicating
that this dosage does not substantially affect creatinine levels.

- **400mg/kg Extract**: A higher dosage of 400mg/kg extract significantly reduced creatinine

levels to **0.63±0.1**, a **64.80% reduction**. This is statistically significant (p<0.05),
suggesting that this treatment is effective in lowering creatinine levels.

- **300mg/kg TAA**: Treatment with 300mg/kg of TAA increased creatinine levels to

**1.85±0.01**, a change of **-3.351%**. This increase is highly significant (p<0.01), indicating
that TAA at this dosage negatively impacts creatinine levels, potentially reflecting kidney stress
or damage.

The data suggests that while a moderate extract dosage does not alter creatinine levels, a higher dosage
can significantly reduce them, and TAA treatment at 300mg/kg is detrimental to creatinine clearance,
possibly indicating kidney function impairment. The statistical significance values provide a measure of
confidence in these results.

Source: Conversation with Bing, 5/17/2024

(1) https://scienceon.kisti.re.kr/srch/selectPORSrchReport.do?cn=TRKO201100015619.
https://scienceon.kisti.re.kr/srch/selectPORSrchReport.do?cn=TRKO201100015619.

(2) www.google.com/patents/WO2001012196A1?cl=en.
http://www.google.com/patents/WO2001012196A1?cl=en.

(3) https://www.pnas.org/doi/10.1073/pnas.1521018113.
https://www.pnas.org/doi/10.1073/pnas.1521018113.

(4) https://www.natap.org/2005/EACS/eacs_22.htm. https://www.natap.org/2005/EACS/eacs_22.htm.

(5) https://www.semanticscholar.org/paper/Stability-of-calcium-folinate-(Teva)-in....
https://www.semanticscholar.org/paper/Stability-of-calcium-folinate-(Teva)-in-concentrate-Karbownik-
Sza%C5%82ek/5907b81b73fe85ca4dd919b131caed0717006341/figure/0.