ELITE INTERNATIONAL COLLEGE OF HEALTH 5.

Biotransformation of a medicinal
SCIENCE AND TECHNOLOGY ZARIA substance results in:

Department: Pharmacy technician a) Faster urinary excretion

b) Slower urinary excretion
Course: AUM test type b
c) Easier distribution in organism
Time: 20 minutes
d) Higher binding to membranes
1. In synergism the combined effect of
6. The term “biotransformation” includes
the drugs could be expressed as
the following:
a. 1+1>2
a) Accumulation of substances in a
b. 1+1<2
fat tissue
c. 1+1=2
b) Binding of substances with
d. 1+1=0
plasma proteins
2. In potentiation the combined effect of
c) Accumulation of substances in a
the drugs could be expressed as
tissue
a. 1+0>1
d) Process of physicochemical and
b. 1+1<2
biochemical alteration of a drug in
c. 1+1=2
the body
d. 1+1=0
7. Pharmacodynamics involves the study
3. In Antagonism the combined effect of
of following EXCEPT:
the drugs could be expressed as
a) Biological and therapeutic effects of
a. 1+1>2
drugs
b. 1+1<1
b) Absorption and distribution of drugs
c. 1+1=2
c) Mechanisms of drug action
d. 1+1=0
d) Drug interactions
4. ________ is the degree to which a
8. Tolerance develops because of:
poison can harm humans or animal
a) Diminished absorption
a. Allergen
b) Rapid excretion of a drug
b. Adverse effect
c) Both of the above
c. Toxicity
d) None of the above
d. Allergy
9. What does the term “potentiation” d. Tolerance
mean? e. All of the above
a) Cumulative ability of a drug 13. Who is the first chair of pharmacology in
USA and what year?
b) Hypersensitivity to a drug
a. Rudolph Buchheim in 1827
c) Fast tolerance developing b. Rudolph Buchheim in 1837
d) Intensive increase of drug effects c. Rudolph Buchheim in 1847
d. Rudolph Buchheim in 1879
due to their combination 14. All the following are sources of medicines
10. The term “chemical antagonism” means except
a. Plants
that:
b. Animals
a) Two drugs combine with one another c. Bacterial
d. All of the above
to form an inactive compound
e. None of the above
b) Two drugs combine with one another 15. Aspirin is a____________________source
to form a more active compound of Medicine?
a. natural
c) Two drugs combine with one another b. synthetic
to form a more water soluble c. semi synthetic
d. DNA Recombinant
compound
d) Two drugs combine with one another
to form a fatter soluble compound
11. The word “pharmacology’ comes from:
a. Latin
b. Spanish
c. Greek
d. Italian
12. Which effect may lead to toxic
reactions when a drug is taken
continuously or repeatedly?
a. Refractoriness
b. Cumulative effect
c. Tachyphylaxis