ICLE’S Motilal Jhunjhunwala College of Arts, Science & Commerce, Vashi

SYBT Semester - III 2020 Subject: Biotechnology

Paper- Immunology USBT- 303 Unit -1

Multiple choice questions

1 Which of the following is not a part of the lymphatic system?

Bone marrow
Liver
Thymus and spleen
Tonsils

2 The epidermal layer of the skin is composed of epithelial cells called

a. keratinocytes
b. Keratids
c. Oocytes
d. Neither of these

3 Hematopoietic stem cell is

a. multipotent
b. pluripotent
c. Both (a) and (b)
d. Neither (a) nor (b)

4 Appropriate microenvironments for the development and maturation of

lymphocytes.

a. The Spleen
b. The second ary lymphoid organs
c. The primary lymphoid organs
d. Neither of these

5 Lymphocytes possess the attributes of

a. diversity
b. specificity
c. memory
d. All of these

6 leukocytes, - T lymphocytes, secrete various protein molecules called

a. cytokines.
b. Amines
c. Lymphocytes
d. Neither of these
7 Basophils are nonphagocytic granulocytes that release pharmacologically
active substances that play a major role in

Hematopoesis
Phagocytosis
Allergic responses.
Complement response

8 Myeloid stem cells generate progenitors of

red blood cells
white blood cells
platelets
All of these

9 In humans, hematopoiesis, the formation and development of red and white

blood cells, begins in the during the first weeks of development.
Liver
embryonic yolk sac
Kidney
Bone marrow

10 The proteins and glycoproteins that compose the complement system are
synthesized mainly by.
Histiocytes
liver hepatocytes
Osteocytes
Neither of these

11 The resulting increase in the number of circulating neutrophils is called

leukocytosis
Leukopnia
Both (a) and (b)
Neither (a) nor (b)

12 In bone marrow, HSCs grow and mature on a meshwork that support the
growth and differentiation of hematopoietic cells

stromal cells
Stromatal cells
Both (a) and (b)
Neither (a) nor (b)
13 Dendritic cells have the major function of

the presentation of antigen to TH cells

Attaching antibodies
Killing the host cells
Neither of these

14 The Bone Marrow provides site for hematopoietic stem cells to self-renew and
differentiate into
Complement proteins
Lymph nodes
Spleen cells
Myeloid cells and B Lymphocytes

15 The ability of any stem cell to self-renew and differentiate depends on the
structural organization and cellular function of specialized anatomic
microenvironments known as
stem cell niches
Stem cell notches
Both (a) and (b)
Neither (a) nor (b)

16 ' refers to a system of factors that occur in serum and are activated by antigen-
antibody interaction and subsequently mediate a number of biologically
significant consequences.

Complement
Component
Albumin
Globulin

17 Versatile cells that both generate bone and control the differentiation of HSCs
are

Kupffer’s cells
Osteoblasts
Hepatocytes
Lymphocytes

18 Activated macrophages express higher levels of class II MHC molecules,

allowing them to function more effectively as

Antigenic cells
Antigen-presenting cells
Both (a) and (b)
 Neither (a) nor (b)

19 Immature T cells, known as

Monocytes
Macrocytes
Thymocytes
Neither of these

20 Lymph nodes and the spleen are

Primary lymphoid organs
secondary lymphoid organs
Tertiary lymphoid organs
Tertiary lymphoid organs

21 All immune cells that travel through tissues, blood, and lymph nodes are
guided by small molecules known as.

chemokines
Amines
Both (a) and (b)
Neither (a) nor (b)

22 The paracortex is traversed by a web of processes that arise from stromal cells
called
Cyst
fibroblast reticular cells (FRCs).
Both (a) and (b)
Neither (a) nor (b)

23 A follicle without a germinal center is referred to as

a primary follicle
a secondary follicle
Germinal epithelium
Neither of these

24 A somewhat less organized system of secondary lymphoid tissue are

collectively referred to as
mucosa-associated lymphoid tissue (MALT),
Primary lymphoid follicles
Secondary lymphoid follicles
Neither of these

25 Both neutrophils and eosinophils are

 phagocytic
Non phagocytic
Both (a) and (b)
Neither (a) nor (b)

26 Movement of circulating neutrophils into tissues, called

extravasation
Extraction
Transportation
Neither of these

27 The group of proteins that assist in eliminating foreign pathogens and in

promoting the resulting inflammatory reaction are
complement
Albumin
Globulin
Neither of these

28 Mature thymocytes, which express only CD4 or CD8 and are referred to as
leave the thymus as they entered: via the blood vessels of the corticomedullary
junction.

single negative (SN),

Double negative (DN)
single positive (SP)
double positive (DP)

29 The T-cell receptor (TCR) does not recognize free antigen but recognizes
antigen that is bound to particular classes of self-molecules, encoded by genes
within the

Major histone complex

major histocompatibility complex (MHC).
Both (a) and (b)
Neither (a) nor (b)

30 Fusion of the pseudopodia encloses the Ag within a membrane-bounded

structure called a
Monosome
Lysosome
phagosome
Neither of these

31 Activated phagocytes produce a number of reactive oxygen intermediates

 (ROIs) and reactive nitrogen intermediates that have

Chemical activity
Lysosomal activity
potent antimicrobial activity.
Neither of these

32 The process by which particulate antigens are rendered more susceptible to

phagocytosis is
Inhibition
Actvation
Opsonization
Neither of these

33 Macrophages are attracted by and move towards a variety of substances

generated in an immune response by a process called
Chemotaxis
Homeostasis
Hematopoesis
Neither of these

34 Stromal cells include, , fibroblasts, and.

fat cells
endothelial cells
macrophages
All of these

35 Macrophage located in the lungs are called

Histiocytes
Oocytes
Alveolar macrophages
Neither of these

36 Interaction of small lymphocytes with antigen, in the presence of certain

cytokines induces these cells to enter the cell cycle by progressing from G0
into
G2 phase
M phase
G1 phase
S phase

37 In the classical pathway, the antibody activated the C1 complex consisting of

C1q, C1r & C1s subunit. Which of the following subunit binds to the
antibody
 C1q
C1r
C1s
All of the above

38 Which of the following component of complement proteins enhances

inflammation (anaphylatoxin)?

C3a
C5a
Both (a) and (b)
Neither (a) nor (b)

39 Lymphoblasts proliferate and differentiate into.

effector cells
memory cells
Both (a) and (b)
Neither (a) nor (b)

40 Mature B cells synthesize and display membrane-bound immunoglobulins,

which serve as.

Mast cell receptors

Neutrophil receptors
Antigen receptors
Neither of these

41 Germinal centers are substructures that facilitate the generation of B cells with

increased receptor affinities

decreased receptor affinities
Both (a) and (b)
Neither (a) nor (b)

42 The tonsils are found in

Lingual location
at the sides of the back of the mouth
pharyngeal
All of these

43 Activation of C3 without prior participation of C142 is known as

Classical pathway
'alternative pathway'.
 Lectin pathway
Neither of these

44 Free macrophages travel by movement throughout the tissues.

amoeboid
Gliding
Sliding
Neither of these

45 Activated macrophages secrete cytokine that has a variety of effects and is

cytotoxic for some tumor cells

Chemokines
tumor necrosis factor
Both (a) and (b)
Neither (a) nor (b)

46 A number of proteins are secreted by activated macrophages, these include

interleukin 1 (IL-1)
TNF-α
Both (a) and (b)
Neither (a) nor (b)

47 Activated macrophages secrete cytokines that stimulate

Organogenesis
hematopoiesis
Both (a) and (b)
Neither (a) nor (b)

48 Macrophages in the kidney are called

Mesangial cells
Microglial cells
Osteoclasts
Osteoblasts

49 NK cells express CD16, a membrane receptor for Fc region, they can attach to
these antibodies and destroy the targeted cells. This is an example of a process
known as

Exravasation
Attraction
antibody-dependent cell mediated cytotoxicity (ADCC).
 Neither of these

50 The ratio of CD4+ and CD8+ in normal human peripheral blood is

approximately
2:1
1:2
1:3
1:5

51 In oxygn dependant killing, as the lysosome fuses with the phagosome, the
activity of myeloperoxidase produces
hypochlorite and chloride ions
Nitrous oxide
Nitric oxide
Neither of these

52 Activated macrophages exhibit

greater phagocytic activity

an increased ability to kill ingested microbes
increased secretion of inflammatory mediators
All of these

53 Macrophages are dispersed throughout the body. Some take up residence in

particular tissues, becoming
fixed macrophages
Mobile macrophages
Wandering macrophages
Neither of these

54 The cells that have characteristics of both T cells and NK cells are

NK1-T cells
NK cells
NP cells
NV cells

55 Secondary lymphoid organs –

MALT
CALT
Spleen and lymph nodes
Thymus and bone marrow
56 T cells expressing CD8, a dimeric membrane glycoprotein, are restricted to
recognition of antigen bound to

Class I MHC molecules

Class II MHC molecules
Class III MHC molecules
Neither of these

57 T cells that express the membrane glycoprotein molecule CD4 are restricted to
recognizing antigen bound to

Class I MHC molecules

Class II MHC molecules
Class III MHC molecules
Neither of these

58 The T-cell receptor (TCR) does not recognize.

Bound antigen
Free antigen
Both (a) and (b)
Neither (a) nor (b)

59 B and T lymphocytes that have not interacted with antigen and are resting cells
in the G0 phase of the cell cycle are called

Native cells
Naïve cells
Hematopoetic cells
Prime cells

60 Mature B cells synthesize and display membrane-bound immunoglobulins,

which serve as
Antigen receptors
Antibody receptors
Natural killer cells
Neither of these

61 A group of proteins that assist in eliminating foreign pathogens and in

promoting the resulting inflammatory reactions are
The hematopoetic proteins
The complement proteins
Platelets
Neither of these

62 A multipotent stem cell differentiates either to a

 common lymphoid progenitor cell
common myeloid progenitor cell
Both (a) and (b)
Neither (a) nor (b)

63 All blood cells arise from a type of cell called the

Granulocytic cells
Natural killer cells
Platelets
Hematopoietic stem cell (HSC).

64 The B cell divides repeatedly and differentiates over a 4- to 5-day period,

generating a population of
memory cells
plasma cells
Both (a) and (b)
Neither (a) nor (b)

65 is its major site of maturation in a number of mammalian species, including

humans and mice.

Bone marrow
Thymus
Both (a) and (b)
Neither (a) nor (b)

66 Granulocytic cells that contain multilobed nucleus are

Basophils
Eosinophils
Neutrophils
Native cells

67 Kupffer cells are present in

Connective tissues
Liver
Kidney
Bone

68 Stromal cells influence the differentiation of hematopoietic stem cells by

providing a
Nutritional environment
Hematopoetic macronvironment
Hematopoietic-inducing microenvironment
Neither of these
69 Different lineages of lymphocytes express membrane molecules that are
recognized by particular monoclonal antibodies these are grouped together as
a

Cluster of differentiation (CD)

Cluster of demarcation (CD)
Both (a) and (b)
Neither (a) nor (b)

70 Memory cells look like small lymphocytes but can be distinguished from naive
cells by the presence or absence of

Fc fraction
Antigens
Cell membrane molecules
Neither of these

71 Effector cells function in many ways to

eliminate antigen
Bind to the antibody
Both (a) and (b)
Neither (a) nor (b)

72 Which of the following cells of the immune system do not perform

phagocytosis?
Macrophage
Neutrophil
Eosinophil
Basophil

73 T cells that express the membrane glycoprotein molecule CD4 are restricted to
recognizing antigen bound to

Class I MHC molecules

Class II MHC molecules
Non MHC molecules
Neither of these

74 The cells that have a higher cytoplasm:nucleus ratio and more organellar
complexity than small lymphocytes
Lymphoclast
Monocytes
lymphoblasts
Neither of these
75 Primary lymphoid organs –
MALT
CALT
Spleen and lymphnodes
Thymus and bone marrow