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SUBMISSION PREVIEW: DEVELOPMENTAL AND

NEUROLOGICAL EFFECTS OF ARSENIC ON DROSOPHILA
MELANOGASTER

Developmental and neurological effects of arsenic on Drosophila melanogaster

Submission ID: 1830926
Type of Submission: 10-Minute Presentation
Submission Status: Active

Author(s)

Jawaid Ahsan, PhD (he/him/his)

JA Organization:
Central University of South Bihar
Role:
Presenting Author

Submission Information

ESA Section:
Physiology, Biochemistry, and Toxicology

Sub Topic(s)
Behavior
Toxicology

Abstract Text
Millions of people in developing countries are affected by arsenic (As) toxicity and its prevalence. Arsenic’s
detrimental effects on humans have been amplified by an unacceptable level of exposure to food and
drinking water, the ongoing rise in industrial usage, and several other occupational conditions. Due to
increased cellular absorption and the ability to cross the blood–brain barrier (BBB), inorganic arsenic (iAs) is
extremely hazardous to living organisms in its trivalent form. Arsenic toxicity damages an organism’s tissues
and organs, resulting in skin cancer, circulatory system abnormalities, and central nervous system
disorders. A competent model system is required to investigate the acute effects of arsenic on the brain,
cognition ability, and to assess any behavioral impairment. Drosophila melanogaster (common fruit fly or
vinegar fly), with its short generation time, genomic similarities with humans, and its availability for robust
behavioral paradigms, may be considered an ideal model for studying arsenic toxicity. The present study
helps to understand the toxic effects of acute arsenic treatment on the behavior, cognition, and
development of Drosophila in a dose and time-dependent manner. We found that the exposure of fruit flies
to arsenic significantly affected their locomotor abilities, pupae size, cognitive functions, and
neurobehavioral impairment. Hence, providing a better understanding of how arsenic toxicity affects the
brain leading to acute behavioral disorders and neurological alterations, this study will lead to a better
understanding of the mechanisms.

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