Intrinsic resistance is innate or inherent antimicrobial resistance exhibited by

some bacteria
Organisms Intrinsic resistance to
All Enterobacterales Benzylpenicillin Fusidic acid Vancomycin Dalbavancin
(E.coli, Klebsiella, Teicoplanin Oritavancin
Proteus, Citrobacter, Telavancin
Enterobacter,
Salmonella, Shigella)
Macrolides Clindamycin Rifampicin Linezolid

Klebsiella Ampicillin Carbenicillin

Citrobacter diversus Amoxicillin Ticarcillin

Proteus mirabilis Tetracyclines Polymyxin B

Nitrofurantoin Colistin

Proteus vulgaris Ampicillin First generation cephalosporins Tetracycline Polymyxin B

Amoxicillin Cefuroxime Nitrofuranto Colistin
in
Salmonella Aminglycosides, first and second generation cephalosporins-not effective clinically
Shigella even if active invitro

Pseudomonas Ampicillin 1st generation cephalosporins Ertapenem Cotrimoxazole,

aeruginosa Amoxicillin 2nd generation cephalosporins Tetracycline,
Ampicillin Cefotaxime, Ceftriaxone Chloramphenicol
sulbactam
Amoxycillin
clavulanate

Acinetobacter species Ampicillin, First generation Aztreonam, Chloramphenicol,

Amoxicillin cephalosporins Ertapenem Fosfomycin
Amoxicillin Cefotaxime,
clavulanate Ceftriaxone

Burkholderia Penicillins First- and second- Macrolides Colistin,

pseudomallei generation Rifampicin aminoglycosides
cephalosporins,

All Gram positive Aztreonam, temocillin, polymyxin B/colistin and nalidixic acid.
bacteria
Enterococcus Cephalosporins Macrolides Clindamycin Aminoglycosides
Cotrimoxazole (Low-level
resistance)
Susceptibility testing is not required for these antimicrobials.

Compiled by Dr Insha Altaf Consultant Microbiology