精神科藥物常見藥物及劑量範圍

台北榮總精神部 李正達 111.8.23

常見抗憂鬱藥物 [商品名(成人抗鬱藥物口服劑量範圍)]
 TCA 類藥物：amitriptyline[Tryptanol(50-100mg/day)]，
imipramine[Tofranil(50-150mg/day)]，doxepin[Sinequan 及 Doxepin(75-
300mg/day)]
 MAOI 類藥物：phenelzine[Nardil(45-90mg/day)]，可逆性 MAO-A 抑制劑
moclobemide[Aurorix(150-600mg/day)]
 SSRI 類藥物：fluoxetine[Prozac(20-80mg/day)]，citalopram[Cipram(20-
40mg/day)]，sertraline[Zoloft(50-200mg/day)]，escitalopram[Lexapro(10-
20mg/day)]，paroxetine[Seroxat(20-50mg/day)]，fluvoxamine[Luvox(50-
300mg/day)]
 SNRI 類藥物：venlafaxine[Efexor(75-375mg/day)]，
duloxetine[Cymbalta(30-120mg/day)]，milnacipran[Ixel(50-100mg/day)]
 NDRI 類藥物：bupropion[Wellbutrin(150-450mg/day)]
 NaSSA 類藥物：mirtazapine[Remeron(15-45mg/day)]
 SARI 類藥物: trazodone [Mesyrel(200-300mg/day)]
 Melatonin 類藥物：agomelatine[Valdoxan(25-50mg/day)]
 Serotonin 調控類藥物：vortioxetine[Brintellix(10-20mg/day)]
 Glutamate 類藥物：esketamine[Spravato(56-84mg/time)]
常見二代抗精神病藥物[商品名(成人抗精神病藥物口服劑量範圍)]
 Done 類 SDA (serotonin-dopamine antagonists)
risperidone [Risperdal (2-6 mg/day); Risperdal Consta 長效針劑 (25-
50mg/Q2W)]，paliperidone [Invega (6-18 mg/day); Invega Sustenna 長效針劑
(78-234 mg/QM); Invega Trinza 長效針劑 (273-819 mg/Q3M)]，
ziprasidone[Geodon (80-160 mg/day)]，lurasidone [Latuda (20-160 mg/day)]
 Pine 類 SDA (又稱 MARTA, multi-acting receptor antagonists)
quetiapine [Seroquel (400-800 mg/day)]，olanzapine [Zyprexa (5-20 mg/day)]，
asenapine [Saphris (10-20 mg/day)]，clozapine [Clozaril (300-450 mg/day)]
 多巴胺部份促效劑(dopamine partial agonist)
aripiprazole [Abilify (10-20mg/day); Abilify Maintena 長效針劑(300-
400mg/QM)]; cariprazine [Vraylar (1.5-6mg/day)]
 特定第二型及第三型多巴胺拮抗劑
amisulpride [Solian (400-800mg/day)]
 血清素-多巴胺功能調節劑
brexpiprazole [Rexulti (2-4 mg/day)], lurasidone [Latuda (40-160 mg/day)]

CHENG-TA LI 李正達 1
 鎮靜安眠及抗焦慮藥物[商品名(成人抗精神病藥物口服劑量範圍)]
 苯二氮平 BZD 類
1. 短效(半衰期<8-10 小時)
brotizolam [Lendormin (0.125-0.25 mg/day)], midazolam [Dormicum (7.5-15
mg/day)], triazolam [Halcion (0.125-0.5 mg/day)]
2. 中效(10-24 小時)
alprazolam [Xanax (0.5-10 mg/day)], bromazepam [Lexotan (1.5-12 mg/day)],
estazolam [Eurodin (1-2 mg/day)], lorazepam [Ativan (1-10 mg/day)], oxazepam
[Alepam (15-120 mg/day)]
3. 長效(>24 小時)
chlordiazepoxide [Librium (10-150 mg/day)], clonazepam [Rivotril (0.5-10
mg/day)], diazepam [Valium (2-40 mg/day)], flunitrazepam [Modipanol (1-4
mg/day)], flurazepam [Dalmadorm (15-30 mg/day)]
 非 BZD 類的抗焦慮藥物
1. 抗憂鬱劑: 如 SSRI 類、SNRI 類、SARI 類(細節見相關段落)
2. buspirone [Buspar (10-40 mg/day)]
3. propranolol [Inderal (10-40 mg/day)]
 Z 藥物安眠藥
zaleplon [Sonata (5-10 mg/day)], zolpidem [Stilnox (5-10 mg/day)], zolpiclone
[Imovane (3.75-7.5 mg/day)]
 食慾素接受器拮抗劑類安眠藥
sulvorexant [Belsomra (10-20 mg/day)], lemborexant [Dayvigo (5-10 mg/day)]
 抗組織胺類安眠藥
chlorpheniramine [Chlorpheniramine (5-40 mg/day)], diphenhydramine [Benamine
(50-100 mg/day)], hydroxyzine [Vistaril (50-100 mg/day)]

情緒穩定劑 [商品名(成人抗精神病藥物口服劑量範圍)]
 lithium [Ligilin (600-1200 mg/day)]
 valproate [Depakine (1000-2500 mg/day)]
 carbamazepine [Tegretol (600-1200 mg/day)]
 lamotrigine [50-200 mg/day]

CHENG-TA LI 李正達 2