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Phosphatidylcholine: Function and Detection

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Phosphatidylcholine (PC) consists of a glycerol group, a fatty acid group, a phosphate group
and choline. The fatty acid groups often include palmitic acid, stearic acid, oleic acid, linoleic
acid, linolenic acid, and arachidonic acid.

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Function and application of phosphatidylcholine

PC not only provides essential phosphorus for human growth and development, but also is a
major source of choline and essential fatty acids. PC also contains hydrophilic phospholipid
groups and lipophilic fatty acid groups, which are typical amphiphilic compounds with good
emulsification function. PC has high medical value in medicine, and can prevent and treat
high blood lipids, high cholesterol and fatty liver, and plays an important role in protecting cell
membranes, anti-oxidation and anti-aging. In addition, it is also widely used in chemical
production, light industry, and food industry.

Applications in the pharmaceutical industry

PC promotes the binding of cholesterol and protein molecules into a complex that is present
in the blood, which reduces lipid-like infiltration of the blood vessel wall and inhibits the
development of atherosclerosis. PC is also involved in the biosynthesis of the essential
amino acid methionine and some other amino acids in the body, as well as promoting better
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PC has a choline component. Choline has an affinity for fat, which allows fat to be
transported from the liver through the blood in the form of phospholipids, thus preventing the
formation of fatty liver. It also has the effects of anti-liver fat peroxidation, reducing alcohol-
induced apoptosis of hepatocytes, regulating the activity of Corvus cells, reducing the
cytotoxicity of tumor necrosis factor and enhancing the protection of hepatocytes by
interleukin 22.

Applications in blood lipids regulation

PC has significant therapeutic effects on high blood lipids and high cholesterol, and can
prevent and treat atherosclerosis. It can emulsify and decompose fats and oils, improve
blood circulation, remove peroxides, lower cholesterol and neutral fat content in blood,
reduce the retention time of fats in the inner wall of blood vessels, promote the dissipation of
atherosclerotic plaques, and prevent the intima thickening caused by cholesterol.

Applications in brain development and protection

PC releases acetylcholine in the body, a neurotransmitter that plays an important role in the
learning and memory process. PC also contains polyene fatty acids, such as linoleic acid
(DHA), which are the main components of ceruloplasmin in synaptosomal membranes,
regulate the electrical activity of synapse formation, promote synapse formation, and
facilitate the development of neurological functions in the brain. Therefore, PC plays a key
role in brain development, enhances memory, and helps to reduce and alleviate symptoms of
Alzheimer's disease, neurological dysfunction, energy loss, and fatigue.

Detection of phosphatidylcholine

Thin-layer chromatography

The separation of phospholipid fractions is achieved by varying the magnitude of the force
between each component of phospholipids in the spreading agent and the adsorbent on the
thin-layer plate, which results in different Rf values. The quantification of each phospholipid
species can be done by calculating the integral value using a thin-layer quantitative scanner. x
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The separation is carried out by HPLC with a UV detector for detection. Due to the presence
of functional groups such as C=C, -C=O-, mono-NH2 and phosphate groups in lecithin, each
component has strong UV absorption at 200 ~ 214 nm.

Liquid chromatography-mass spectrometry (LC-MS)

Mass spectrometry is often used in combination with high-performance liquid

chromatography and gas chromatography to analyze the molecular mass and molecular
structure of PCs. The two techniques can complement each other, combining the advantages
of each with the advantages of high sensitivity, high separation and high selectivity in the
analysis process. The system is also equipped with functions such as spectral control, which
makes the analysis process of samples easier and more accurate.

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