Non-migraine specific

- Analgesics NSAIDS – Naproxen, Aspirin, Ibuprofen

- Antiemetics: Prochlorperazine
- Opioids in severe cases after failure of other options

Migraine Specific
5-HT1 receptor Agonists

- Triptans
- Dihydroergotamine

Serotonin agonists act as vasoconstrictors or inhibit the release of Pro-inflammatory

neuropeptides from the Trigeminal n

Triptans effective on 70% of patients

- Sumatriptan given intranasally, orally, and subcutaneously

Dihydroergotamine – most effective when given in early stages of migraine

- Most common side effect is nausea

- Contraindicated in
Pregnancy
Peripheral vascular disease
Cornonary artery disease

Prophylaxis

Attack occurs 2 or more/ month

- Beta Blockers – Propronol and metoprolol

- Calcium channel blockers – Verabamil
- Tricyclic antidepressants – Amitriptyline
Antiepileptic drugs

First Generation

- Benzodiazepines and Barbiturates are GABA- agonists

Diazepam and Lorazepam are used for myoclonic, partial, and generalied tonic clonic
seizures

Diazepam is the Preferred for STATUS EPILEPTICUS

Phenobarbitol used last thing for status epilepticus due to its inducing effect of CYp450
cognitive impairment and sedation effect

Carbamazepine and Phenytoin are sodium blockers

Phenytoin small amount can lead to toxicity (most BS. Ataxia, Gingival hyperplasia blab la)

Valproic acid is TERATOGENIC

GABApentin for geraric grp partial seizure and neurpathic pain

Second Generation

- Lamotrigine interferes with the glutamate release via blocking ca and sodium channels

Side effect – Rash and Hypersensitivity reactions

- Topiramate interferes with the glutamate as it blocks the sodium channels

Side effects – RENAL stones - parasthesia – Weight loss