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EDITORS IN CHIEF
David L. Andrews is Professor of Chemical Physics at the University of East Anglia, located in the
cathedral city of Norwich in the United Kingdom. He heads a well-established research group
pursuing the development and applications of fundamental, photon-based theory for widely
ranging photonic and nanoscale processes, encompassing molecular chirality, multiphoton spec-
troscopy, nonlinear optics, quantum optics, energy transfer, optical nanomanipulation, inter-
molecular interactions, structured light and optical vortices. His current tally of research
publications approaches 400 papers, alongside twenty books: he is the author of a widely adopted
textbook on Lasers in Chemistry, edited volumes including Structured Light and its Applications,
another on the Angular Momentum of Light, and he is co-author of an Introduction to Photon
Science and Technology. The other main pillar of Andrews’s career is conference organisation; he
has instigated and championed numerous conferences, including the Nanophotonics conference at
Photonics Europe, which has now become the largest of its kind. He enjoys travel and is a widely
known speaker, who has given invited lectures in twenty different countries around the world.
Andrews is a Fellow of the Royal Society of Chemistry, the Institute of Physics, the Optical Society
of America, and SPIE – the international optics and photonics society.
Professor Rob Lipson received his Ph.D. in Physics in 1985 from the University of Toronto, and
did post-doctoral work in the Spectroscopy group at the National Research Council of Canada.
He was a faculty member in the Department of Chemistry at Western University from 1986
until 2010; serving as departmental Chair from 2000 to 2005, and Director of the Western
Institute for Nanomaterials Science from 2004-2009. He joined the University of Victoria as
Professor of Chemistry and Dean of Science in 2010, and was reappointed for a second term as
Dean in 2015. Externally, Dr. Lipson served as Senior Editor of the Canadian Journal of
Chemistry (2004-12). He was a former member and Chair of the NSERC Chemistry Grant
Selection Committee 026 (2004-06), and a member of the NSERC E. W. R. Steacie Fellowship
Committee (2008-10). He is currently in his second term as a member of the federal Tri-Council
Panel for the Responsible Conduct of Research. Dr. Lipson has published extensively in the
fields of laser spectroscopy, photonics materials and applications related to interference litho-
graphy, and analytical technique development for MALDI mass spectrometry. He is a Fellow of
the Chemical Institute of Canada.
Thomas Nann is an experienced teacher and researcher in the area of Nanoscience and tech-
nology. In 1997, he completed a PhD in Physical Chemistry (Electrochemistry) and started
working with nanomaterials shortly afterwards. He held teaching, research and leadership
positions at the Universities of Freiburg (Germany), East Anglia (UK), South Australia, and
Wellington (New Zealand). Thomas’s research focusses on the wet-chemical synthesis of various
nanomaterials and their application in the areas of energy and health. His electrochemical roots
and nanomaterials expertise come together in his research on photovoltaic and photocatalytic
systems, as well as different types of batteries. In the nanomedicine area, he is mainly interested
in using nanoparticles as contrast agents and markers. Thomas is passionate about teaching and
leading students and researchers to undertake excellent research with real-world impact.
vii
VOLUME EDITORS
Duncan H Gregory is the WestCHEM chair of Inorganic Materials, University of Glasgow having
previously been an EPSRC Advanced Fellow, Lecturer and Reader in Materials Chemistry at the
University of Nottingham. He is currently a Visiting Professor at Kyushu University and was Vice
President of the Royal Society of Chemistry (RSC) Materials Chemistry Division from 2009-
2014. He is the author of more than 150 papers, patents and book chapters and his research
interests focus on the synthesis and characterization of new solids including sustainable energy
materials (e.g. Li batteries, fuel storage, thermoelectrics), inorganic nanomaterials and the solid-
state chemistry of carbides, hydrides, nitrides and chalcogenides. His research also embraces the
sustainable production of materials including the microwave synthesis and processing of solids.
He won the inaugural RSC Sustainable Energy Award in 2009, is the founding Editor-in-Chief
of Inorganics and is an Associate Editor of Materials for Renewable and Sustainable Energy.
Professor Richard Tilley is the Director of Electron Microscope Unit and a Professor in
Chemistry at UNSW. His research is focused on the solution synthesis of nanoparticles and
quantum dots for applications ranging from catalysis to biomedical imaging. He graduated with
a Masters of Chemistry from Oxford University and did his PhD in the Department of
Chemistry, University of Cambridge. He was then a Postdoctoral Fellow for two years at the
Toshiba basic R&D Center, Japan followed by 10 years as an academic at Victoria University of
Wellington.
Renee Goreham completed a PhD in 2014 at the University of South Australia on the topic of
NanoBiotechnology. Since completion, she has held post-doctoral positions at Flinders Uni-
versity, University of South Australian, and Victoria University of Wellington. Recently, she was
accepted a permanent lecturing position at Victoria University of Wellington in physical
chemistry. Her research niche uses nanotechnology for biomedical applications. With two main
areas of interest; (1) using nanosized extracellular vesicles (EVs) for detection of disease or as
drug delivery agents and (2) metal nanoclusters stabilised by biomolecules (such as DNA and
protein).
Satoshi Kawata has been a Professor of Applied Physics at Osaka University since 1993 and a
Chief Scientist at RIKEN since 2001. He is now the Professor Emeritus of Osaka University and
the Honorary Scientist of RIKEN. He has developed a number of unconventional advanced
methods in optical microscopy, photolithography, and spectroscopy, including two-photon 3D
nano-fabrication based on polymerization, 3D optical data-storage with two-photon photo-
isomerization, tip-enhanced near-field Raman scattering microscopy, plasmonic 3D color
holography, and evanescent-field optical force. He is a Fellow of OSA, SPIE, IOP, and JSAP. He
served as the president of the Japan Society of Applied Physics and the Spectroscopic Society of
Japan and the Editor of Optics Communications. He has published B 500 research papers
(Web of Science), and authored and/or edited more than 30 books.
ix
x Volume Editors
David S. Bradshaw is an honorary research associate at the University of East Anglia in the UK. He
graduated twice from the same university, first receiving a Master’s degree in chemical physics
(which included a year at the University of Western Ontario, London, Canada) and then a PhD in
theoretical chemical physics. Overall, David has co-written over 80 research papers, all based on
molecular quantum electrodynamics. In addition, he has co-authored two books: one on optical
nanomanipulation and the other on nanophotonics. His long running research interests include
resonance energy transfer, optical binding and nonlinear optics. David is a Member of both the
Institute of Physics and the Royal Society of Chemistry.
LIST OF CONTRIBUTORS TO VOLUME 1
xi
xii List of Contributors to Volume 1
VOLUME 1
xiii
xiv Contents of all Volumes
VOLUME 2
VOLUME 3
VOLUME 4
VOLUME 5
Volume 1: Nanomaterials
This volume considers the huge scope that now exists for inorganic, organic and hybrid nanomaterials. Since the publication
of the previous edition of Comprehensive Nanoscience and Nanotechnology, the breadth of known nanomaterials has expanded –
most notably perhaps in the burgeoning scientific field of two-dimensional materials – and our understanding of the growth,
structure, functionality and performance of nanomaterials has flourished with it. In nanomaterials science, the underpinning
chemistry and physics of materials at the nanoscale combines with growth and deposition towards the unique approaches to
device fabrication that characterise engineering in the nanometer regime. The applications of nanomaterials, both potential
and realised, have also proliferated as our grasp of new properties and phenomena improves. The importance of dimen-
sionality in structure and properties has helped redefine the limits of nanomaterials performance. The topics in this volume
are interwoven with this theme of dimensionality and illustrate the ranges of materials behaviour and phenomena that
depend upon this fundamental variable.
A consideration of nanomaterials of the lowest dimensionality - zero-dimensional nanoparticles - begins this volume in
Chapter 1.01. The chapter adopts a chemistry-oriented viewpoint to describe the parameters and mechanisms behind nanoparticle
formation and growth processes. The chapter emphasises how a physical understanding of the thermodynamics and kinetics of the
nucleation and growth phenomena are vital in the subsequent, more practical choices of synthesis technique and conditions.
Building on the underlying principles discussed above, the following chapter (Chapter 1.02) discusses wet-chemical synthesis and
characterization of 0D nanoparticles, with a strong emphasis on IIB/VI semiconductors. Manna et al. survey all the relevant
synthesis methods, including potentially scalable approaches such as continuous flow synthesis or thermospray methods. This
chapter is concluded with a comprehensive discussion on the most important characterisation methods.
In extending the discussion of nanoparticles to the noble metals, Toropov and Vartanyan present a comprehensive discourse on
the optical properties that distinguish these metal species (Chapter 1.03). Both top-down and bottom-up approaches are relevant
to the synthesis of noble metal nanoparticles and issues of purification, monodispersity and the stability of optical spectra are
central in the most appropriate choice of synthetic route and conditions. Such requirements are significant in the context of many
unique applications including sensors, surface-enhanced Raman scattering and transparent conductive electrodes. Magnetic
nanoparticles also have great potential for both new and commercially-important applications. Their proliferation as contrast
agents for magnetic resonance imaging illustrates the impact that such materials are already having in modern society. Mørup et al.
(Chapter 1.04) describe the properties of these materials in detail, highlighting underpinning phenomena such as super-
paramagnetism, magnetic fluctuations and magnetic anisotropy. This chapter concludes with a discussion of some of the key
applications of magnetic nanocrystals from data storage to medical uses and considers also their occurrences in nature. Arguably
the next level of complexity is then to combine and link the magnetic properties of metallic nanoparticles with semi-conductivity
to produce nanoparticles of ferromagnetic semiconductors that could typically be deposited as a thin film. This is the topic covered
in Chapter 1.05, where Hai introduces the concept of spintronics and the roles of nanostructured doped III-V and Group VI
semiconductors towards achieving this goal. The chapter discusses the practicalities of fabrication while also considering phe-
nomena such as the tunnelling magnetoresistance effect (TME) and how it might be controlled. A variety of III-V and Gp VI
materials are considered in more detail and it is demonstrated how the choice of dopant (for example Fe vs Mn) can have a
profound influence on properties and performance.
Building on the fundamentals and examples introduced in the previous chapters, Parak et al. (Chapter 1.06) describe the
increasingly influential area of core-shell nanoparticles and introduce the methods for the - often epitaxial - growth of
inorganic shells onto nanocrystals. The primary focus is on nanomaterials with semiconductor cores and how both chemical
and physical properties of this core can be modified by the presence (and activity) of the shell. Such a construction can lead to
so-called quantum dot-quantum well (QDQW) regimes in which the 0D behaviour of the core is complemented by the 1D
behaviour of the shell. The chapter concludes by considering lattice mismatch of core and shell and how shape control can be
exerted.
The emphasis changes gradually from 0D to 1D nano-objects in the immediately following chapters and there is perhaps
no better system in which to observe this evolution than carbon. Chapters 1.07, 1.08 and 1.09 consider Fullerenes,
nanotubes and nanotube superstructures respectively and it is possible to follow how these structures and superstructures
are derived from C 60 and closely-related building blocks. Chapter 1.07 establishes the basics of fullerenes before presenting
detailed information on the processes involved in their chemical functionalisation, expounding on the synthetic organic
chemistry that permits increasingly complex molecular entities to be constructed and leading to the concept of molecular
wires. The natural dimensional progression from Fullerenes is to carbon nanotubes and Chapter 1.08 explains how the
unique molecular crystal structure of single walled carbon nanotubes (SWCNTs) accounts for their electronic structure.
Moreover, Bepete and Coleman demonstrate how the intrinsic electronic and vibrational properties are manifested in the
spectra of nanotubes. Spectroscopy, combined with electron microscopy, provides a powerful means to verify the purity
and functionalisation of SWCNTs as well as providing information on defects, size and chirality. Controlling the
xvii
xviii Preface
interactions of nanotubes with other nanoparticular species is key in extending structure and functionality beyond the
tubes themselves, opening further applications in microelectronics, sensing, catalysis and energy storage and conversion.
Rance and Khlobystov articulate the incredible extent of interactions available in assembling nanoparticle-carbon nano-
tube (NP-CNT) superstructures (Chapter 1.09). The potential of such a choice of strength and directionality of interaction
is undeniable but the authors are very clear about the challenges that remain in terms of superstructure control. They also
rightly highlight the health (cytotoxicity) issues that must be considered as such materials are developed further.
One dimensional (1D) inorganic nanostructures are introduced in Chapter 1.10 with examples of inorganic nanotubes.
Remskar first underscores the parallels with carbon nanotubes before going on to emphasise that despite some structural simi-
larities, the growth mechanisms of inorganic nanotubes are profoundly different from those of CNTs. Further, the extent of
compositional diversity afforded by drawing on elements from across the periodic table, gives rise to a wide range of contrasting
properties with possible applications as lubricants, inert reaction vessels or drug delivery systems. The theme of anisotropic 1D
inorganic nanomaterials is developed further in Chapter 1.11, where Zitoun et al. discuss how sensors can be fabricated from
either metallic or semiconducting nanowires. Vapour-liquid-solid (VLS) and solution-liquid-solid (SLS) phase synthesis
approaches are pivotal in the preparation of inorganic nanowires for devices where sensing can originate from a host of different
chemical and physical functionalities from thermal conductivity through optical properties to electrochemical activity to name
only three. Response time, extreme sensitivity and manufacturability can be issues that will need to be addressed as materials and
devices become more sophisticated. Electrospinning is one technique that might enable a progression from lab- to plant-scale
nanomaterial production. In Chapter 1.12, Willerth elaborates on this increasingly popular technique in which an electrical field is
applied to a polymer solution as it is discharged from a nozzle. The ensuing stream of charged liquid divides as it is repelled by the
applied voltage yielding polymeric fibres. Such fibres can be fashioned into three-dimensional scaffolds, for example, with
applications in filtration, regenerative medicine and energy storage. There is also the prospect of manufacturing increasingly
advanced functional and “smart” textiles.
As one moves from 1D to 2D materials, inevitably one is confronted with one of the major scientific breakthroughs of the
last several decades. Bazylewski and Fanchini provide a comprehensive overview of the graphene phenomenon in
Chapter 1.13. The authors describe the origin and fundamentals of its existence prior to presenting the essential aspects of its
isolation and fabrication. The unique electronic structure, vibrational structure and transport properties that have made
graphene the exciting discovery that it is are explained in detail before a selection of the most important applications are
appraised. The authors highlight how the many theoretical predictions of the properties and applications of the archetypal 2D
nanomaterial are one-by-one beginning to be realised. In the wake of the discovery of graphene, the emergence of inorganic
2D materials has by no means been unnoticed. In Chapter 1.14 the accent is on perhaps the largest family of 2D inorganics,
the transition metal dichalcogenides (TMDs). The electronic properties of TMDs can vary with composition and crystal
structure, but many are semiconducting with similar carrier mobilities to silicon. The particular subject of this chapter is the
exotic optical properties of 2D TMDs and especially the capacity for nonlinear photonics. Ultimately, the prospects for
development of concepts such as quantum photonics and the combination of TMDs with metasurfaces are assessed. Another
rapidly emerging family of 2D inorganic nanomaterials are the MXenes which are vying with TMDs as the most flexible in
terms of composition and multifunctionality. Chakraborty, Das and Saha-Dasgupta collate the various compositional and
structural groupings of MXenes in Chapter 1.15 and offer a full account of their electronic, magnetic and mechanical
properties. They also evaluate the prospects for MXene heterostructures (with graphene or TMDs), which to date are largely
the topic only of theoretical studies. Superconductivity and energy storage are just two interesting possibilities in terms of
properties and applications for further exploration.
Chapter 1.16 amalgamates concepts of 3D and 0D nanomaterials in its discussion of nanoconfinement of essentially isolated
species within three dimensional mesoporous frameworks. Soler-Illia et al. first introduce mesoporous materials and continue by
summarising the means by which they can be synthesised and their internal structures modified. The processes of nanocon-
finement and nanocomposite formation are illustrated with several examples relating especially to catalysis and adsorbing,
stabilising, releasing and delivering drugs. The chapter emphasises that nanoconfined systems can be regarded as much more than
simply high surface area solids and adsorbed species. Chapter 1.17 considers a completely different set of applications, showing
how the properties of thermoelectric materials can be enhanced hugely by processes of nanostructuring. Nanoscale thermoelectrics
can benefit from the full range of dimensional variation from nanoparticles, through nanowires to superlattices. As Kleinke et al.
convey in the chapter, most tellingly, all the best-performing, most efficient thermoelectric materials (with figures of merit, ZT 4 2) are
nanomaterials. Four prototypical thermoelectric systems are presented to elucidate how chemical and physical methods of size
reduction and control can impact electronic and thermal transport. Finally, Up-converting nanomaterials have a huge potential for
applications in both the physical and life sciences (for example. bioimaging, cancer therapy and electro-optics). Dominated by 0D
nanoparticles, but also embracing 1D and core-shell approaches, the preparation of luminescent up-converting nanomaterials is not
straightforward. Wang and Liu (Chapter 1.18) give a comprehensive overview of synthesis methods and applications of f-block
element doped nanophosphors. Surface modification and functionalisation is crucial in the continued development of new
upconversion nanomaterials.
This volume contains a wealth of exciting examples that reflect the dynamism associated with current nanomaterials research.
As one probes deeper into concepts of structure and properties at the nanoscale, more and more field-defining revelations continue
to materialise. Coupled with the implementation of progressively more imaginative and ingenious synthesis techniques, the
Preface xix
chances of discovering new nanomaterials and with them, new phenomena, increases. I am very grateful to the all the expert
authors who have contributed to this volume and succeeded in communicating the vitality of this fast-moving area.
Duncan H. Gregory
University of Glasgow, Glasgow, United Kingdom
FOREWORD
Eight years have elapsed since the publication of the first edition of this Comprehensive, a forerunner to the present set of volumes.
It is interesting to observe how, over this period, the whole field of nanoscience and its associated technologies have undergone
both a remarkable and substantial growth and consolidation. The early days are now but a distant memory when the very term
‘nanoscience’ was viewed more as a buzzword than a reality, and gendered some degree of scepticism – perhaps even derision in
some quarters. As nanoscience has developed and grown, its increasing maturity has enabled a range of new technologies to reach
the marketplace, while at the research level newer topics continue to emerge, as well as a deeper understanding of the fundamental
underpinnings of the field.
It is therefore with great enthusiasm that we accepted the invitation to work with Elsevier to capture afresh the new state of the
art. In each volume, the majority of the content is entirely new, or it has been substantially updated, and we have ourselves learned
a great deal of new science in the course of soliciting contributions and putting the content together. In this endeavour we have
also been joined by an eminent team of Volume Editors whose tireless work has, more than anything, ensured the integrity and
success of this project. We gladly acknowledge our debt to them.
As with the first edition, each chapter aims to provide an amenable point of entry for scientists, engineers and specialist
technologists, covering key developments in a scholarly, readable, and critical discourse. Once again it has been a delight to find,
among the continually escalating numbers in nanoscience and nanotechnology, so many highly esteemed authors willing to
contribute suitably broad and incisive material. Full credit goes to these individuals. We also record our sincere thanks and
appreciation for the skills and professionalism of numerous Elsevier staff - especially Ruth Ireland and Claire Byrne, who have
been involved in this project with us since its inception.
David L. Andrews
Norwich, United Kingdom
Robert H. Lipson
Victoria, Canada
Thomas Nann
Newcastle, Australia
xxi
1.01 Physical Chemistry of Nanoparticle Syntheses☆
Geoffry Laufersky, Victoria University of Wellington, Wellington, New Zealand and The MacDiarmid Institute for Advanced Materials
and Nanotechnology, Wellington, New Zealand
Thomas Nann, University of Newcastle, Newcastle, Australia and The MacDiarmid Institute for Advanced Materials and
Nanotechnology, Wellington, New Zealand
r 2019 Elsevier B.V. All rights reserved.
The synthesis of nanoparticles differs significantly from typical wet-chemical synthesis methods. In many chemical reactions, the
reagents are mixed or dissolved in a solvent and then reacted until equilibrium is reached. As a result, the product is usually the
thermodynamically most stable one. Nanoparticles are small objects with large surface to volume ratios. The free energy
(or Gibbs energy) of a surface is simply the product of its surface area s and its surface tension g:
GS ¼ sg ð1Þ
Since both s and g are positive values, the change in free energy when creating a surface is positive too. This means that creating
a large surface – what we do when we synthesize nanoparticles – is thermodynamically unfavorable. For example, a simple
reaction system that leads to a crystalline solid would try to minimize its free energy by reducing the surface contribution of the
resulting products, which would inevitably lead to large crystals.
There are two basic principles that can be used when synthesizing nanoparticles: strictly kinetically driven reactions and
syntheses that use thermodynamically stable templates. The former are primarily used for the preparation of inorganic nano-
particles, while the latter see use in the formation of both organic and inorganic nanoparticles. In the following sections, we will
investigate the physical chemistry of nanoparticle nucleation and growth, which are fundamental to kinetically driven reaction
schemes. While templated growth processes are extremely useful given their high degrees of reproducibility, the reaction mechanics
are vastly varied and different from the ones presented here. As such, the interested reader is directed toward several excellent
reviews for discussions of those methods [1–3].
☆
Change History: All previous sections, figures, and equations have been removed. New sections outlining the theory and experimental evidence for nano-
particle nucleation and growth mechanism have been added. These sections are supported by 41 new equations and 18 new images.
This is an update of N. Vukmirović, L.-W. Wang, 1.07 - Quantum Dots: Theory, Editor(s): David L. Andrews, Gregory D. Scholes, Gary P. Wiederrecht,
Comprehensive Nanoscience and Technology, Academic Press, 2011, Volume 1, Pages 189-217.
Fig. 1 Diagram of the formation of monomers of a binary compound AB from precursor sources and their assembly into a particle.
AB is formed from the assembly of subunits of AB. In order to keep things simple, we assume that we synthesize spherical
nanoparticles (this assumption is not far-fetched, because a sphere is the geometrical shape with the minimum surface to volume
ratio, which is, as established above, thermodynamically favorable). A sphere with the radius r has a surface area of s ¼ 4pr2. Thus,
when we form a spherical nucleus from molecular or ionic reagents, we will change the surface free energy DGS by
DGS ¼ 4pr 2 g ð2Þ
which is a positive value.
Then, the free energy for a bulk solid is comprised of the product of the volume of the object, v, and its lattice energy (in case of
a crystal). Comparing this to the free energy of an equimolar solution of fully dissolved crystal monomers, Gsol, will give us the
change in free energy imparted by crystal formation. However, this view is too simplistic, because lattice energies are usually
measured and calculated per mol (as opposed to per volume) and do not include non-crystalline solids. A general formula for the
volume free energy then includes an element that represents the free energy of formation of a “unit” volume element dGV*:
GV ¼ v dGV ð3Þ
The presence of meconic acid or morphine in the urine can only be positively
determined by elaborate chemical analysis. In cases of doubt the urine should be
submitted to a competent analyst. To make sure that opium or its derivatives are not
being taken, the feces must also be examined.
Chloral Hydrate.
The dose taken by victims of the chloral habit varies greatly. Thirty or
forty grains daily is a moderate amount. Not rarely this quantity is
repeated twice or oftener within the space of twenty-four hours. The
tolerance after a time exhibited by the organism for enormous doses
of alcohol and opium is not established, as a rule, in regard to
chloral. The victim of the latter after a little time discovers the
average dose required to produce narcotic effects, and, while he
may vary it within limits, he is liable to acute toxic effects if it be
greatly exceeded. Death from such excesses is not uncommon.
It has been claimed upon evidence that does not appear to the writer
adequate that chloral sometimes acts upon the sexual system as an
aphrodisiac, sometimes as the reverse. More or less complete
impairment of sexual power and appetite is the rule in individuals
addicted to great excesses in narcotics of all kinds. Menstruation is
not arrested by chloral as by morphine, nor does it necessarily cause
sterility in the female.
Paraldehyde.
Cocaine, within the short time that has elapsed since its introduction
into therapeutics, has unquestionably been largely abused, both
within the ranks of the profession and among the people. Highly
sensational accounts of the disastrous effects resulting from its
habitual use in excessive doses have appeared in the newspapers
and in certain of the medical journals. No case of this kind has fallen
under the observation of the writer, and it would appear premature to
formulate definite conclusions concerning the effects of cocaine
upon the data thus far available.
Treatment.