2 4 1 o 2

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ea letamel

n
a medication ue te Tat
nNd to_mpderatu pain AA h

pae Mame
OH

h-hydsesphel)
hananud

NH- C CR

Used A anipyotii, druug to- 9eclues. bocdy

temp in CaAe e highgeue
Ledo Neak analAesite geduea nRilL
tp mocloratL painheach toothacha-)_
Syrthosi e baracotamoby-Con uentianal
method
Boot/a MathodL

Steb) Niration e phanel uing ndtrating nixt

(HNO H,So is an9
oloctophUlc aromati Zubatitdhon ua
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OH

RNOt HoSH
NO
Phene
NO
b-Aidaphene (O- N -
Majer) phenol
stabla-cduu itp nueoarB pesoud)
steam distlllation OeA Miner
sterieall Les stabe
hindood te inia
eleCula-
R-onding
( )me AteAicqy
hindec.

hsed to Aobaat p-Nitiophono b

HPLC o teomdatelLcttie

ztab h) Raductión-ek NOto amunw NH

MAinguducing
O aget AuLh-as LSn tRCL
Na BH NH,OHg usng Rone Mù in

OH

e- (n tH C)/NaBHy
ZRoney N +R O

NOg NH
-NiHtuepharoL) -Qdne-ehonal )
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t t )NLcleophilie addReac oR p-aminephona

uith acti anhydide CCHCol, O

h - poosenLe q 3edlium actato The N ato

e M dA mar ueleothli Han-Oatolon
hencs th &00ch eccu nut NRg 9oup
oH

CCHa
H2Coo{uh-|

t t -NH- -CH

TCHaUoH:
auobacks e} Conentional mathad
1 pencandtage actonmecenermy caleulatad fo
COnuentiondl method ialmost A36
scomaining ate htactd as hast_pclut
Pareatarmet
a nthais otCouen uess
LHoLAche Calania athod
idize ct az henol authaLctia-
anhydudo and HE as CotelyAt thi LAut
gh-atom congm
2th Phensl Aacta huh aretieanhydrtde in
hrussnco G HE(stAong acid )-t ian exa
TTE
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shl oxima in aádimedium CECoot und

Beckmann Rea9coang.ement Jo- poaouco
ubtitiude amide Beckmann- Roaeorongou
o abeueBetoime gluesaacutamal

BecRmann
Koasvatment
-CH CCCooH)_
N-OH iuvoacai NH-CC
aid

CKetexime (Posraotamol
Atom- economy CalLe Latod hothis qoes kuth
iabout 58:}

tGan ehaniealu
g e ehoica u one that poguudes highn
peumanie ond unctienal Kwhil bair
uoe onuonMentoll
benirn thsOughu

Greenchemiea lA aaa 2LoAúend u ehenmidalu

enating hamu ha>ardeuis
subtences-
Som hLmale
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Gaen2oluents

Zolwetts play uasp imeeotand rolain

os ehhemeal Jeach
The s nb any zaluerct nahich-is enAld d
a s geenAolent uay eac Tha solo
o aey Beluect is Limitd ta-spei{l
applleation

ai)hlote H0)ALcehal
Tonic iauids e ngt m i t wolatile 0
Oompeund

em o 6u1k and Q18 atpr paesswu wotaL

beeomes Aupr itical i e Ne-hydrogan
benddis peLeset haue-the abilit ta
dimelue osaanii Asluenta ike patan
euomatics

ehlorinaied subatanceso

uL Acetote dained_uem CoIn uLed ins

aina and Coatings n in duutecies
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QGeonue
BisdieAl an ênuron metod nd
S e juel tibe Co Sc SupoiticalY
used as bleuing agert ntthe uina
Qu hazadous chendcal
een Oidat

reon axidarct Lke Ozen kmno d o

REC + hFenstead of CECs eduas Oeens

dopletion.
)Green cheomistklbiedtaadable d
ackaging o oad
6)Zeelitei uied as eatalyatinnmanuatuing
bulk chomcal

EnuironMenta Impoc/henoia ogaa enehai

Rodura aminonn and braduut mha i

Plert and animals uhte leu haam. Hotsi
chemieal nthe eninonmett
lauspcbntol f glabal Wanina , 0zu
dapletion and tonation
e o landlhul spaiall haapsd ous O
landh