Estudos

http://aformulabr.com.br/qrcode/ttafv01.pdf
 TRIBULLUS TERRESTRIS
Afrodisíaco natural

DESCRIÇÃO

Obtido dos frutos secos de Tribullus terrestris (Zygophyllaceae) composto por esteroides, flavonoides, alcaloides e
saponinas. Em países do leste europeu têm sido usado como estimulante da produção de testosterona.

MECANISMO DE AÇÃO
O Tribullus terrestris provoca vaso dilatação na região genital, o que pode explicar os seus efeitos sobre a área.
Pode aumentar ainda a contagem de espermatozoides, bem como a sua motilidade, podendo, ser um auxiliar no
tratamento da infertilidade. Em mulheres, diminui os sintomas da frigidez sexual, aumentando a libido e reduzindo os
sintomas da menopausa. Ao aumentar as concentrações plasmáticas de testosterona aumenta também produção de
músculo como efeito anabólico. A testosterona é vital porque desempenha vários papéis essenciais no nosso
organismo, em especial a síntese de massa muscular e como consequência o ganho de força. Durante um esforço, o
Tribullus terrestris permite atuar contra o cansaço preservando os níveis de catecolaminas (noradrenalina e
dopamina) que estimulam o cérebro.

INDICAÇÕES

 Desordens do trato gênito-urinário;

 Aumentar libido;
 Impotência;
 Aumento da massa muscular em atletas;
 Estimular o sistema imune e a ovulação;
 Reduzir os sintomas da menopausa.

DOSE USUAL
Recomendação de 250 a 1500mg de Tribullus terrestris ao dia, às refeições, via oral.

SUGESTÃO DE FÓRMULA

Aumento dos níveis de testosterona

Tribullus terrestris................................. 250 a 500mg
Crisina................................................................ 250mg
Tribullus terrestris E. Seco............................. 250mg
Excipiente Qsp.............................................. 1 cápsula
Modo de uso: 1 cápsula 3 vezes ao dia, antes das
refeições. Modo de uso: 1 cápsula 2 vezes ao dia.

PRINCIPAIS REFERÊNCIAS

BATISTUZZO, J. A O; ITAYA, M.; ETO, Y. Formulário Médico-Farmacêutico. 4 ed. São Paulo: Pharmabooks, 2011.

Fitoterapia – VadeMecum de Prescripción – Plantas medicinales – 3º ed. 1999.

 TRIBULLUS TERRESTRIS
ESTUDOS CLÍNICOS

Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats.

Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried
fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods:
Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect
of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and
sperm count were carried out. Twenty-eight-day oral toxicity studies were carried out to evaluate the long-term effects
of the LAET administration on different body systems. Results: A dose-dependent improvement in sexual behavior
was observed with the LAET treatment as characterized by an increase in mount frequency, intromission frequency,
and penile erection index, as well as a decrease in mount latency, intromission latency, and ejaculatory latency. The
enhancement of sexual behavior was more prominent on chronic administration of LAET. Chronic administration of
LAET produced a significant increase in serum testosterone levels with no significant effect on the sperm count. No
overt body system dysfunctions were observed in 28-day oral toxicity study. Conclusions: Findings of the present
study validate the traditional use of T. terrestris as a sexual enhancer in the management of sexual dysfunction in
males.

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Antimicrobial activity of organic and aqueous extracts from fruits, leaves and roots of Tribulus terrestris L., an Iraqi
medicinal plant used as urinary anti-infective in folk medicine, was examined against 11 species of pathogenic and
non-pathogenic microorganisms: Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Corynebacterium
diphtheriae, Escherichia coli, Proteus vulgaris, Serratia marcescens, Salmonella typhimurium, Klebsiella pneumoniae,
Pseudomonas aeruginosa and Candida albicans using microdilution method in 96 multiwell microtiter plates. All the
extracts from the different parts of the plant showed antimicrobial activity against most tested microorganisms. The
most active extract against both Gram-negative and Gram-positive bacteria was ethanol extract from the fruits with a
minimal inhibitory concentration (MIC) value of 0.15 mg/ml against B. subtilis, B. cereus, P. vulgaris and C.
diphtheriae. In addition, the same extract from the same plant part demonstrated the strongest antifungal activity
against C. albicans with an MIC value of 0.15 mg/ml.

The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an
evaluation using primates, rabbit and rat.
Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the
management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7.5, 15 and
30 mg/kg, in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10mg/kg of TT extract
orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate
(10mg/kg, subcutaneously; biweekly for 8 weeks) or TT orally (5mg/kg daily for 8 weeks). Blood samples were
analyzed for testosterone (T), dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate (DHEAS) levels using
radioimmunoassay. In primates, the increases in T (52%), DHT (31%) and DHEAS (29%) at 7.5mg/kg were
statistically significant. In rabbits, both T and DHT were increased compared to control, however, only the increases in
DHT (by 30% and 32% at 5 and 10mg/kg) were statistically significant. In castrated rats, increases in T levels by 51%
and 25% were observed with T and TT extract respectively that were statistically significant. TT increases some of the
sex hormones, possibly due to the presence of protodioscin in the extract. TT may be useful in mild to moderate cases
of ED.
Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds.

The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when
our laboratory described the existence of natural anxiolytic flavonoids. The first of these was chrysin (5,7-
dihydroxyflavone), followed by apigenin (5,7,4'-trihydroxyflavone) and flavone itself. Semisynthetic derivatives of
flavone obtained by introducing halogens, nitro groups or both in its molecule, give rise to high affinity ligands for the
benzodiazepine receptor, active in-vivo; 6,3'-dinitroflavone, for example, is an anxiolytic drug 30 times more potent
than diazepam. The data collected in this paper make clear that some natural flavonoids are CNS-active molecules
and that the chemical modification of the flavone nucleus dramatically increases their anxiolytic potency.

Inhibition of xanthine oxidase by flavonoids.

Various dietary flavonoids were evaluated in vitro for their inhibitory effect on xanthine oxidase, which has been
implicated in oxidative injury to tissue by ischemia-reperfusion. Xanthine oxidase activity was determined by directly
measuring uric acid formation by HPLC. The structure-activity relationship revealed that the planar flavones and
flavonols with a 7-hydroxyl group such as chrysin, luteolin, kaempferol, quercetin, myricetin, and isorhamnetin
inhibited xanthine oxidase activity at low concentrations (IC50 values from 0.40 to 5.02 microM) in a mixed-type mode,
while the nonplanar flavonoids, isoflavones and anthocyanidins were less inhibitory. These results suggest that certain
flavonoids might suppress in vivo the formation of active oxygen species and urate by xanthine oxidase.

REFERÊNCIAS
SINGH S.; NAIR V.; GUPTA Y.K. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats. Department
of Pharmacology. V.3 nº1 p.7-43, Jan 2012. Disponível em: http://www.ncbi.nlm.nih.gov/pubmed/22368416>. Acesso em: 23 de Fev. de 2015.

AL-BAYATI F.A.; AL-MOLA H. F. Antibacterial and antifungal activities of different parts of Tibullus terrestris L. growing in Iraq. Journal of
Zhejiang University SCIENCE B. V. 9, nº 2, p. 154-159, Fev. de 2008. Disponivel em: < http://link.springer.com/article/10.1631/jzus.B0720251>.
Acesso em: 23 de fev. de 2015.

GAUTHAMAN K.; GANESAN A.P. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction – an
evaluation using primates, rabbit and rat. Phytomedicine. V.15, I. 1–2, p. 44 – 54, 25 January 2008. Disponível em: <
http://www.sciencedirect.com/science/article/pii/S0944711307002838>. Acesso em: 25 de fev. de 2015.

PALADINI A.C.; MARDER M.; VIOLA H.; WOLFMAN C.; WASOWSKI C.; MEDINA J.H. Flavonoids and the central nervous system: from
forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol. V.51 nº5 p.519-26, May 1999. Disponível em:<
http://www.ncbi.nlm.nih.gov/pubmed/10411210>. Acesso em: 03 de Março de 2015, às 12:06.

NAGAO A.; SEKI M.; KOBAYASHI H. Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem. V. 63 nº10 p.1787-90, Oct. 1999.
Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/10671036>. Acesso em: 03 de Março de 2015, às 12:11.