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343_Hematology_Physiology_Erythropoiesis_Lifespan_&_Destruction
343_Hematology_Physiology_Erythropoiesis_Lifespan_&_Destruction
I) THE BASICS
Lifespan of RBCs 100-120 days
o As RBCs reach this time the cytoskeleton and
hemoglobin function start declining
→ So, it’s out with the old and in with the new
Cytoskeleton
Proteins in the cytoskeleton help with flexibility and
pliability to squeeze through small capillaries
o Spectrin protein Figure 1. Cut section of sinusoidal capillary
Webbed-like protein [Pearson Education]
o Ankyrin
Bind spectrin to cell membrane
o Glycophorin
o Band 3 protein 4.1 & 4.2
As RBCs getting older, it becomes less flexible and more
rigid.