Krebs Cycle

F-
Feet
¥⇐o-b→
NADPGHOH
° -K Succinyl CoA (Gliomas)
Isocitrate - KG Histone Demethylase
a
I.C.D.H (Cofactor)
CH ° CH ° (Decarboxylation) 4 COd

• ooo ooo Bo
2 CO2 6 NADH
:
••
••

Glucose 2-OH-Gluterate
C 2+
NADH 2 CO2 2 FADH y

: 2 NADH 2 ATP (S.P.)

2 ATP

(2) Pyruvate

Isocitrate
-
2 CO2
Citrate ( - KG)
•
2 NADH Ketogluterate -

:*
* :*
1 2 3 5 6

:*
:*
4

:*
+

Acetyl CoA 1 2 3 4 5 6
2 NAD+ 2 NADH +
+
+
C 2+ 1 2 3 4 5

CoA-SH
'
!
" RAT POISON Isocitrate 2
• "Flouroacetate"
Aconitase NAD+ - KG
D.H. D.H.
Citrate -
Synthase
om om om ie
2 NADH CoA
E E E - - - - + - +
2ADP
AT NA Cit Suc AD
P DH rat ciny P
e l Co
ATP ADP 2 ATP GTP Succinyl CoA
PDH COMPLEX (OAA) A Substrate

.
1 2 3 4

2 NADH Phosphorylation Pi + GDP

2 CoA-SH ÷;
" ""

(Leiomyoma)

A
Fumerase (Uterine Smooth Muscle)
2 NAD+ (Kidneys)
2 FADH 2 FAD

B•
Malate %FB.BE?BH:. HO
Succinate
M.D.H
a

Succinyl CoA
• Furmarate Pheochromocytoma
Synthatase
go
Succinate
D.H.

Go-go
or a a

Metabolism The Krebs Cycle Gi

,
÷