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1-s2.0-S1932227519300904
1-s2.0-S1932227519300904
1-s2.0-S1932227519300904
Obes e P at i en t
a, b
Surangama Sharma, MD *, Lovkesh Arora, MD
KEYWORDS
Obesity Anesthesia for morbidly obese Pathophysiology of obesity
Preoperative evaluation in obese Ambulatory surgery in obese patients
Intraoperative management of obese patients Postoperative care of obese patients
KEY POINTS
Obesity is a serious and expensive health care issue, associated with a proinflammatory
state, affecting multiple organ systems, prevalent in almost 40% of the US population.
Body mass index (BMI), comorbidities, and metabolic health (better predicted by waist-
hip ratio, waist circumference, total body fat) play a major role in risk stratification.
Patients with clinical signs of obesity hypoventilation syndrome, undergoing moderate- to
high-risk procedures, should be evaluated for global cardiac function.
Ambulatory surgery in supermorbid obese patient with (BMI >50 kg/m2) is not recommen-
ded as per Society of Ambulatory Anesthesia Consensus guidelines, because of potential
need for overnight admission and inpatient monitoring.
A multimodal, opioid-sparing approach to analgesia should be used for all patients, for
better recovery profile, including early discharge.
INTRODUCTION
a
Department of Anesthesia, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 6417-
JCP, Iowa City, IA 52242, USA; b Department of Anesthesia, University of Iowa Hospitals and
Clinics, 200 Hawkins Drive, 6413-JCP, Iowa City, IA 52242, USA
* Corresponding author.
E-mail address: surangama-sharma@uiowa.edu
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198 Sharma & Arora
Table 1
World Health Organization classification of obesity
Adapted from World Health Organization (WHO) Regional Office for Europe. Body mass index –
BMI. Available at: http://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-
healthy-lifestyle/body-mass-index-bmi. Accessed May 6 2019; with permission.
PATHOPHYSIOLOGY
Metabolic Syndrome
Accumulation of visceral fat, and the proinflammatory and immune activation state
that accompanies it, is associated with insulin resistance and T2DM.4
In simple terms, risk factors causing cardiovascular diseases and diabetes are
grouped together as metabolic syndrome. The presence of any 3 of the 5 listed risk
factors constitutes a diagnosis of metabolic syndrome, and obesity is one of the major
risk factors.5 The diagnosis of metabolic syndrome is associated with a higher risk of
morbidity after surgery.
Cardiovascular
Cardiovascular diseases are more prevalent in obese patients than the patient popu-
lation with a normal weight in the same age group. In an attempt to adapt to the excess
body mass and increasing metabolic demands, almost one-third of patients with long-
standing obesity develop structural and functional changes that lead to obesity car-
diomyopathy.4,6 An increase in intravascular blood volume as well as an increase in
cardiac output (mostly from an increase in stroke volume, even though heart rate re-
mains normal) is noted. The increase in stroke volume leads to an increase in left ven-
tricular load and dilation, compensatory left ventricular hypertrophy, and subsequent
left ventricular failure.6
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Anesthesia for the Morbidly Obese Patient 199
Hypertension
Obesity and hypertension are directly proportional. The cause of hypertension in the
setting of obesity and metabolic syndrome is multifaceted, resulting from interaction
between genetic factors, insulin resistance, sodium retention, activation of the sympa-
thetic nervous system as well as the activation of the renin-angiotensin-aldosterone
axis.4,7
Arrhythmias
Arrhythmias in the obese may be precipitated by hypoxemia, nodal dysfunction from
left atrial and ventricular enlargement and fatty infiltration into the conduction system,
electrolyte disturbances from diuretic therapy, an increase in plasma catecholamines,
and hypercarbia. Multiple studies have demonstrated an increased risk of arrhyth-
mias, especially atrial fibrillation,3,4,8,9 which results in markedly increased risk of sud-
den cardiac death. Obesity also makes individuals prone to prolonged QT interval.3,10
Respiratory
Obesity is inversely related to respiratory function, primarily causing restrictive
physiology, from decreased airway compliance, and visceral fat, causing diaphrag-
matic restriction.11,12 Lung volumes decrease in obese patients, including total lung
capacity, functional residual capacity (FRC) and expiratory reserve volume, forced
vital capacity (FVC), and forced expiratory volume in 1 second (FEV1); the FEV1/FVC
ratio is usually preserved.12,13 Obesity is associated with increased work of breath-
ing as a consequence of increased airways resistance and reduced respiratory sys-
tem compliance.13 Airway resistance is increased, from the increase in pleural
pressure that results from the weight of the chest wall.11 Chest wall compliance
is reduced, possibly from the added pressure from chest wall and intraabdominal
adipose tissue. Lung compliance is reduced as well, from increased pulmonary
blood volume and early airways closure.14 Breathing at low volumes increases
airway resistance with expiratory flow limitation and gas trapping owing to early
airway closure and subsequent generation of intrinsic positive end-expiratory pres-
sure (PEEP), or auto-PEEP.15 The presence of auto-PEEP further increases the
work of breathing, which is already elevated because of reduced compliance.
Above changes in lung mechanics, impair the capacity of obese patients to tolerate
apneic episodes with early onset oxygen desaturation.13,16 At baseline, ventilation-
perfusion mismatch is present in the obese, with preserved perfusion to the bases
and diminished ventilation to those areas from atelectasis. Exercise capacity is
reduced in obesity because of increased work of breathing and cardiovascular
compromise. The changes in lung function, including auto-PEEP, are more severe
when the patient moves from the upright to the supine posture.11
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200 Sharma & Arora
right ventricular dysfunction, and eventually, failure.4 Some patients with severe
obesity develop OHS, characterized by alveolar hypoventilation (PaCO2 > 45 mm Hg)
unexplained by other disorders.18 Obese patients have a reduction in airway caliber
leading to an increase in airway resistance with impairment of pharyngeal dilator ac-
tivity and an increased risk of airway collapse.17,19
Asthma
Beuther and Sutherland20 demonstrated that obesity increased the likelihood of
asthma twice as much as individuals with a BMI < 25. Altered airway smooth mus-
cle contractility leading to increased airway responsiveness and the chronic, low-
grade inflammatory state associated with obesity were linked to higher incidence.4
Obese patients are more likely to respond poorly to inhaled corticosteroids and
long-acting b-agonists. Good response to bronchodilators rules it as true
asthma rather than obesity related. In 50%, obesity-related asthma is reversible
with weight loss.3
Pulmonary hypertension
Obese patients have multiple risk factors for developing pulmonary hypertension like
OSA, OHS, left heart dysfunction, and chronic pulmonary thromboembolism.4
Endocrine
Diabetes mellitus
Individuals with a BMI 40 are 7 times more likely to have diabetes compared with
individuals with a normal BMI.4,21
Liver Disease
Risk factors for metabolic syndrome (abdominal obesity, insulin resistance) are also
risk factors for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
(NASH). Fatty infiltration can progress to NASH once inflammatory changes are super-
imposed. In about one-fifth of these patients, NASH can progress to cirrhosis, placing
them at increased risk of developing hepatocellular cancer, portal hypertension, asci-
tes, and liver failure.22
Venous Thromboembolism
Prothrombotic state increases the risk of venous thromboembolism in obese
patients.
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Anesthesia for the Morbidly Obese Patient 201
with patients with normal BMI, although outcomes were worse for underweight or
morbidly obese patients.24,25 Therefore, other than BMI, comorbidities and metabolic
health (better predicted by waist-to-hip ratio, waist circumference, total body fat) play
a major role in risk stratification. To maximize patient safety, a multidisciplinary team
approach is advisable for major surgeries, including consultation with an anesthesiol-
ogist preoperatively.26
Hypertension
Poorly controlled hypertension is associated with labile blood pressure (BP) (exag-
gerated response to noxious stimuli and severe hypotension on induction), during
general anesthesia and increases in cardiac, neurologic, and renal complications.
No clear guidelines exist, and a case-by-case approach is the best. Elective, high-
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202 Sharma & Arora
Table 2
Summary of the principal components analysis, varimax rotation
Factor
Loadingsa
Snoring
1. (STOP Q1). Do you snore loudly (louder than talking or loud enough to 0.596
be heard through dosed doors)?
a. Yes
b. No
2. (Berlin Q1). Do you snore? 0.747
a. Yes
b. No
c. Don’t know
3. (Berlin Q2). Your snoring is: 0.825
a. Slightly louder than breathing
b. As loud as talking
c. Louder than talking
d. Very loud–can be heard n adjacent rooms
4. (Berlin Q3). How often do you snore? 0.795
a. Nearly every day
b. 3–4 times a week
c. 1–2 times a week
d. 1–2 times a month
e. Never or nearly never
5. (Berlin Q4). Has your snoring ever bothered other people? 0.404
a. Yes
b. No
c. Don’t know
Tiredness during daytime
6. (STOP Q2). Do you often feel tired, fatigued, or sleepy during daytime? 0.674
a. Yes
b. No
7. (Berlin Q6). How often do you feel tired or fatigued after your sleep? 0.805
a. Nearly every day
b. 3–4 times a week
c. 1–2 times a week
d. 1–2 times a month
e. Never or nearly never
8. (Berlin Q7). During your waking time, do you feel tired, fatigued, or not 0.743
up to par?
a. Nearly every day
b. 3–4 times a week
c. 1–2 times a week
d. 1–2 times a month
e. Never or nearly never
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Anesthesia for the Morbidly Obese Patient 203
Table 2
(continued )
Factor
Loadingsa
Stop breathing during sleep
11. (Berlin Q5). Has anyone noticed that you quit breathing during your 0.644
sleep?
a. Nearly every day
b. 3–4 times a week
c. 1–2 times a week
d. 1–2 times a month
e. Never or nearly never
12. (STOP Q4). Has anyone observed you stop breathing during your sleep? 0.606
a. Yes
b. No
High blood pressure
13. (Berlin Q10). Do you have high blood pressure? 0.947
a. Yes
b. No
c. Don’t know
14. (STOP Q3). Do you have or are you being treated for high blood 0.945
pressure?
a. Yes
b. No
Questions with low factor loading for all four factors
9. (Berlin Q8). Have you ever nodded off or fallen asleep while driving a
vehicle?
a. Yes
b. No
10. (Berlin Q9). How often does nodding off or fating asleep while driving
a vehicle occurs?
a. Nearly every day
b. 3–4 times a week
c. 1–2 times a week
d. 1–2 times a month
e. Never or nearly never
a
Factor loadings are correlations between the original questions and their factors. Factor loadings
greater than 0.30 in absolute value are considered to be significant.
From Chung F, Yegneswaran B, Liao P, et al. STOP questionnaire: a tool to screen patients for
obstructive sleep apnea. Anesthesiology 2008;108(5):816; with permission.
Cardiovascular Disease
The American Heart Association Scientific Advisory on Cardiovascular Evaluation and
Management of Severely Obese Patients Undergoing Surgery recommends that
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204 Sharma & Arora
severely obese patients with at least 1 risk factor for Coronary Heart Disease (dia-
betes, smoking, hypertension, or hyperlipidemia) or poor exercise tolerance should
have a 12-lead electrocardiogram and chest radiograph before surgery,35 because
their cardiac symptoms can easily be masked by obesity-related issues. Preoperative
cardiac evaluation and management, otherwise, are similar to patients with normal
BMI.
Diabetes Mellitus
T2DM is strongly associated with obesity. Patients with poorly controlled diabetes are
more likely to have wound infections, acute renal failure, and postoperative leaks.36 A
target hemoglobin A1c (HbA1c) value of 6.5% to 7.0% or less perioperatively is recom-
mended, although an HgbA1c of 7% to 8% can be considered in patients with exten-
sive comorbid conditions or difficult to control diabetes.37
Airway Assessment
Airway assessment should be an integral part of preanesthetic evaluation, irrespective
of the type of anesthesia. Obese patients desaturate more quickly during apnea (eg,
during attempts at securing the airway). Obesity and an increase in neck circumfer-
ence are risk factors for difficulty with mask ventilation, supraglottic airway (SGA)
ventilation, and video laryngoscopy.38
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Anesthesia for the Morbidly Obese Patient 205
Type of Anesthetic
Whenever feasible, regional anesthesia is advocated over general anesthesia in
obese, especially with patients with OSA, to avoid the potential airway and respiratory
problems. Neuraxial anesthesia and peripheral nerve blocks offer the advantages of
improved postoperative pain control, reduced use of opioids for postoperative anal-
gesia, and consequently, decreased potential for drug-induced respiratory depres-
sion. Peripheral nerve blocks with ultrasound guidance appear to be safe in obese
patients, with relatively high block success rates, in experienced hands. However,
obesity may make peripheral nerve block more difficult to perform and may be asso-
ciated with higher block failure rates.41 Obesity may be a risk factor for catheter-
related infection. In a large retrospective analysis, obesity was an independent risk
factor for peripheral but not neuraxial catheter-related infections.42 Neuraxial medica-
tion should be given incrementally whenever possible, to avoid excessively high
blockade; the same dose of spinal and epidural local anesthetics can spread to higher
levels in obese compared with normal weight patients. If sedation is considered in
conjunction with regional anesthesia, it should be kept to a minimum.3 General anes-
thesia, as a backup plan, should always be considered and consent provided for,
given an unsuccessful or failed regional block. General anesthesia may be the first
choice given the type of procedure (laparoscopy/thoracotomy and so forth), longer-
duration prone positioning cases, or procedures whereby controlled ventilation is
warranted.
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206 Sharma & Arora
morphine, hydromorphone), using IBW as the initial dose and titrating to effect is
advisable. Neuromuscular blocking agents, including rocuronium, cisatracurium,
and vecuronium, are hydrophilic and distributed primarily within the central compart-
ment. Lean body mass is a suitable dosing scalar. For suxamethonium, administration
should be based on consideration of TBW, because of both an increase in plasma
pseudocholinesterase and an extracellular volume in obese patients.44 For neostig-
mine, studies have shown no significant difference in recovery to a train of 4 ratio of
0.7 in obese versus nonobese patients after a standard dose. However, full recovery
to a train of 4 ratio of 0.9 was prolonged in obese patients.45 Sugammadex is a reversal
agent that acts by binding steroidal nondepolarizing neuromuscular blockers to its
lipophilic core. Dosing of sugammadex is based on the number of posttetanic twitches
or time from administration. Dosing recommendations from the manufacturer are
based on TBW.43
Intraoperative Management
Monitoring
Use of a noninvasive BP cuff may be challenging. Appropriately sized large adult BP
cuffs and unconventional sites like the forearm might be beneficial. Invasive BP moni-
toring may be needed for critically ill, extensive, or longer-duration procedures. An
appropriately sized angiocatheter with longer cannulas and ultrasound might be
needed, because venous access is more difficult in this population, making intrave-
nous line insertion difficult.
Positioning
Studies have demonstrated an increased risk of nerve injury in the obese surgical pop-
ulation.46 Prone position and steep Trendelenburg positions are especially technically
challenging, with decreased lung volume in the Trendelenburg position, and airway
and face edema in dependent areas in both. Caution should be excised with adequate
gel padding, keeping eyes, nose, ears, and other pressure points free, minimizing risks
of complications.
Premedication
Anxiolytics can be titrated for desired effect, without causing respiratory compromise.
Aspiration prevention using antacids (sodium citrate), gastric stimulants (metoclopra-
mide), or H2 blockers may be used, if the patient is also at higher risk for aspiration
related to other comorbidities.47
Airway management
Obese patients are more likely to require intubation rather than an SGA, because they
are more likely to require controlled ventilation to prevent hypoventilation during spon-
taneous respiration and an SGA may not maintain a seal at the higher airway pressures
needed in obese patients. No specific criteria for the use of an SGA in obese patients
have been established. However, a decision should be made for individual patients
taking into consideration grade and distribution of obesity, type and length of surgery,
and patient position to determine when its use is appropriate. When SGAs are used,
second-generation devices designed for controlled ventilation, which allow for higher
seal pressures and provide a gastric port, are frequently used.48 Intubation may be
more challenging in obese patients. Awake intubation is prudent when there is
concern for both difficult intubation and difficult mask ventilation. Appropriate posi-
tioning with ramping (a stack of blankets or a preformed ramp can be used to elevate
the patient’s upper body and head with the goal of horizontal alignment between the
external auditory meatus and the sternal notch), availability of backup airway
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Anesthesia for the Morbidly Obese Patient 207
Induction
Preoxygenation in the reverse Trendelenburg position in the obese, to improve FRC by
decreasing pressure from abdomen and upward shift of the diaphragm, is advisable.49
The safe apnea time should be maximized by using 100% oxygen at a flow rate high
enough to prevent rebreathing (approximately 2 times the minute ventilation), aiming
for an end-tidal concentration of oxygen greater than 90%. Preoxygenation with
manually applied PEEP, or the use of noninvasive ventilation (NIV), will improve
oxygenation in obese patients, if tolerated.50 Passive apneic oxygenation using nasal
cannula during laryngoscopy can prolong the time to desaturation during airway man-
agement.51 Succinylcholine can be used for standard intubation or rapid sequence in-
duction, with availability of sugammadex; an intubating dose of rocuronium is another
safe option. Mask ventilation is usually difficult, so, optimal positioning should be
used, and use of an oral airway, a 2-handed approach, or a Laryngeal Mask Airway
(LMA) should be considered if needed for ventilation.
Anesthetic agents
The choice of induction agent used for an obese patient is the same as for a normal
weight patient, although doses may need to be modified, as discussed in the section
"Pharmacology in the Obese". Anesthesia can be maintained with either an inhaled
anesthetic agent or a total intravenous anesthesia.
Ventilation
When patients are managed with spontaneous respiration (with either an LMA or an
endotracheal tube), minute ventilation and end-tidal CO2 should be closely moni-
tored to assure adequate ventilation. Continuous positive airway pressure (CPAP)
during spontaneous respiration should be used to improve oxygenation. When pa-
tients are unable to maintain enough volume, ventilation should be assisted or
controlled. A protective ventilation strategy is reasonable to maintain oxygenation
and normocapnia, and to avoid lung damage. Lung protective strategy consists
of low tidal volumes, low levels of oxygen (as tolerated), PEEP, and recruitment ma-
neuvers.52,53 Recruitment maneuvers should not be performed unless patients are
hemodynamically stable and euvolemic, because these maneuvers may lead to a
transient decrease in preload.
Fluid management
Clinical judgment based on available measures of volume status and tissue perfusion
should be used to guide fluid administration. Fluid therapy guided by stroke volume
variation can be used as well.54
Extubation
The head-up position is ideal to improve oxygenation and decrease work of breathing,
and standard extubation criteria should be followed. Airway swelling and edema
complicate an already challenging intubation. Therefore, emergency airway equip-
ment and personnel to assist in airway management must be available to manage po-
tential difficulties.
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208 Sharma & Arora
Analgesia
A multimodal, opioid-sparing approach to analgesia should be used for all patients.
The use of potent nonsteroidal anti-inflammatory analgesics, such as ketorolac, or
acetaminophen with local anesthetic wound infiltration, is beneficial. Other agents
that may be used include ketamine, alpha-2 agonists (eg, clonidine and dexmedeto-
midine), magnesium, systemic lidocaine, and antiepileptic drugs (pregabalin and
gabapentin). A multimodal strategy reduces postoperative opioid use and gives a bet-
ter recovery profile, including decreased sedation and postoperative nausea and
vomiting.56
POSTOPERATIVE CARE
Obese patients in the postanesthesia care unit (PACU) are prone to respiratory
and ventilatory compromise. Obese patients are at greater risk for hypoxia in the
postoperative period, so careful attention should be paid to maintaining
adequate oxygenation by administration of oxygen, titrated to keep oxygen satu-
ration at greater than 90% (by face mask or nasal cannula) and positioning the pa-
tient in head up (sitting or semisitting). The use of incentive spirometry or chest
physiotherapy postoperatively improves pulmonary function and decreases com-
plications. Administration of CPAP or other forms of NIV in patients with preoper-
ative use, or with hypoxia unresponsive to incentive spirometry, significantly
improves ventilation. An arterial blood-gas test may be used to assess hypoventi-
lation in patients who are unable to maintain oxygen saturation despite supplemen-
tation and with altered sensorium. Hypoventilation owing to sedative medication
should be ruled out; pharmacologic reversal of benzodiazepines or opioids may
be used as clinically indicated. Often simply arousing a drowsy patient with a
reminder to breathe deeply is sufficient, but this may need to be repeated
frequently. When upper airway obstruction occurs, an oropharyngeal airway (if
the patient is sedated), a nasopharyngeal airway, or both, may open the airway
and permit adequate ventilation. When these maneuvers are insufficient, it is
reasonable to assist these patients with NIV, which may keep them from requiring
reintubation.
Discharge
Oxygen saturation on room air should return to preoperative baseline, and
patients should have continuous pulse oximetry in the PACU until they have
demonstrated that they can maintain adequate oxygenation when left unstimu-
lated. Patients who cannot maintain adequate oxygenation when left undisturbed
should not be discharged from the hospital but should be sent to the floor and
monitored.57
SUMMARY
Obese patients have a unique set of physiologic and pharmacologic changes; under-
standing them makes caring for this subset of patients safer. Meticulous planning and
interaction between surgical and anesthetic teams increase the probability of suc-
cessful and satisfactory outcomes for the patient.
DISCLOSURE
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Anesthesia for the Morbidly Obese Patient 209
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Anesthesia for the Morbidly Obese Patient 211
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