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Astudy on drug utilisation evaluation of bronchodilators using a defined daily dose method Afreen Nasir Acharya & BM Reddy College of Pharmacy, India afreenn.official@gmail.com Introduction: Drug therapy is crucial to promoting human health by increasing the quality of life and extending lifespan. A drug utilisation study is a method to assess and improve drug use. The defined daily dose (DDD) concept is a drug quantification approach. Drug utilisation, in terms of DDD, aids in converting the available volume of medications into medically relevant units, allowing estimations of the number of people exposed to a certain medicine or class of medicines. The unit DDD per 100 bed-days in a hospital context indicates the proportion of inpatients who may receive a DDD. It is a reasonably simple and affordable approach for comparing medications in the same therapeutic class. DDD in 23 FIP Pharmacy Practice Research summer meeting 2023 bronchodilators assists in discovering the consumption of prescribed drugs and analysing the drug usage pattern. As the rational burden of respiratory disease rises, so does the use ‘of medications such as bronchodilators in hospitalised patients, Such research alded in the effective management of bronchodilators in the ward. Objectives: This study aimed to assess the drug utilisation of broncho-dilating agents prescribed to patients admitted to ‘the General Medicine ward. Methods: A prospective observation study was conducted six ‘months in ESIC MC-PGIMSR, Rajajinagar, Bengaluru. A total of 216 in-patients from the General Medicine ward who were prescribed broncho-dilating agents were included in the study. Patients’ case sheets were collected, and data were entered in a self-designed date collection form. These data were entered into the MS Excel sheet. Drugs were classified according to ATC classification, and consumption of broncho- dilating agents was calculated in terms of DDD & DDD/100 bed days, and descriptive statistical analysis was performed. Results: During the study period, 216 patients were enrolled and had an average length of 9.90 hospital stay days. The highly utilised bronchodilator during the study period in the ‘general medicine ward was theophylline with 469.54 DDD/100 bed days, and its PDD:DDD was 4.35. The current study found that the total consumption of broncho-dilating ‘agents in the general medicine ward was 2696.35 DDD; and 872.91 in terms of DDD/100 bed days. Conclusions: This study concludes that the most common reason for admission was respiratory system-related complaints, and the most commonly _ prescribed bronchodilators were ipratropium bromide and salbutamol in 2 fixed-dose combination. The study found that bronchodilators were mostly prescribed as combination therapy, with 87.36% of prescriptions comprising combination therapy. The study population had a high prevalence of hypertension and diabetes melitus, with 36.57% and 33.80% of patients, respectively, being known cases, The study also found that the number of smokers and alcoholics was higher than non-smokers and non-alcoholic. Bronchodilators in a general medicine ward were classified Using ATC classification. Theophylline was the most utilised bronchodilator, with 46954 DDD/100-bed days. Total consumption was 2696.35 DDD and 872.91 DDD/100 bed days, indicating 872.91% of in-patients received 1 DDD of bronchodilator on average dally. Methylxanthines were over- utilised with a PDD:DDD ratio of 4.35 and 3.26 for theophylline and etofylline tablets, respectively. Pharmacy Education 23(5) 1 - 38

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