Most common fetal viral

Herpes 5 = CMV
infection
Herpes virus Fam B
DNA virus, replicates in nucleus cells
Lymphocytes

Features Reactivation occurs by latent in mononuclear T cells

M@
immucompromisation cells

Monocytes
TORCHeS infection

Sex

Blood

Transmission Saliva

Urine

Vertical Transmission

CMV is #1 cause of mental

2nd trimester highest risk
retardation

asymptomatic in 80-90%

Blueberry Muffin
Petechial rash due to thrombocytopenia
Congenital CMV Rash

Hepatospleenomegaly

Jaundice

10-20% cases symptoms

Sensorineural deafness #1 cause of sensorineural deafness.

Cytomegalovirus Diseases
Intracranial calcifications Around
ventricles (periventricle calcification)

parenchyma

Ventriculomegaly Leads to seizures

Edema Due to heart failure

Fetal CMV Hydrops Fetalis

Spontaneous
abortion

same features as
Immunocompetent CMV adults with CMV Mononucleosis EBV differentiation (-) monospot test
mononucleosis

CMV Pneumonia
Transplant pte
Buffy Coat Culture to detect CMV in transplant pte

Blind spots

Immunocompromised CMV Flashing lights

Retinitis pizza pie retinopathy
Vision loss

typically unilateral
AIDS pte if CD4+ count is <50
unlike
Singular, deep and multiple and
Esophagitis Herpes
linear ulcerations shallow ulcerations
esophagitis
Lab Dx. inclusion Owl’s eye bodies
Colitis

Gancyclovir
Treatment
This mutation makes it resistant to
Foscarnet Used when virus has UL97 mutation
gancyclovir