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5131128, 10:52 M ‘CASIR20_PT613TIMediciral Chemisty I_2023
CA4/R20_PT613T/Medicinal Chemistry
I_2023
Total points Qe
‘The respondent's email (bp20.0312@gnipst.ac.in) was recorded on submission of this
form
ROLL *
186012002102
NAME *
Sudipta Santra
Y_ Which of the following contains 16 membered lactone ring? * wn
O Spiramycin
© Josamycin
© Rokitamycin
©@ Allofthese v
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Y Whyare sulfa drugs selectively toxic? * m
© Human cells don't need folic acid.
© Bacterial cells don't need folic acid
© Humans obtain folic acid from their food and don't have to synthesize it v
© Folic acid kills bacteria
Y_ Which of the following co-enzyme is required for conversion of Glycine to 1/1
serine?
© N10-Formyl FAH4
© NS5,N10- Methyle FAH4 v
© N5-Formyl FAH4
© None of these
X_ Which of the following statement is false? on
© pHofurineis 6
©@ ka of sulfonamide derivative is 10.4 x
© Sulfonamides can cause crystalluria
© More of Sulfonamides remain in ionised form in urine
Correct answer
©@ More of Sulfonamides remain in ionised form in urine
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X-_ In tetracycline, in which of the following position double bond is present? * 0/1
© Between C4a and CS
© Between C5a and C6
©@ Between C11 andC11a x
© Between C11a and C12
Correct answer
@ Between C11 and C12
VY _Insolid phase peptide synthesis, the amino acid is directly attachedto “1/1
the solid support.
O Tne
@ False v
XX Macrolide antibiotics inhibits * on
© aminoacy! transferase x
© peptidyl transferase
© nucleotidyl transferase
© Allofthese
Correct answer
© peptidy! transferase
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X__ Which of the following is a pyrimidine analogue? *
n
© Acyclovir
© Gancyclovir x
© Mdoxuridine
CO Allofthese
No correct answers
Y Which of the following bond cannot be formed by Acyclovir because of 1/1
absence of -OH group at C-3' position?
© 34 Glycosidic linkage
© Phosphodiester bond v
© 3-4’ Phosphodiester bond
© 3'5'Glycosidic linkage
Whats the role of F at C-6 of Quinolone derivative? * m
©@ Increases activity against Gram negative v
© Increases activity against Gram positive cocci
© Increases activity against Gram positive bacilli
© None of these
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Which of the following is an naphthaquinone derivative having antimalarial 1/1
effect?
© amodiaquine
O Primaquine
©@ Atovaquone
© Meftoquine
Malaria is transmitted through the bite of an infected w
© Male anopheles mosquito
© Female anopheles mosquito
© Male aedes mosquito
CO Female aedes mosquito
The function of DCI in solid phase Peptide synthesis is as * 7a
© Acatalyst
CO Astarting material
© Coupling reagent
© Halogenating agent
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Y Merozoites invade which of the following cell? m
© Erythrocyte v
O Leucocyte
© neuron
O None of these
X_ Which of the following do not have 2-deoxystreptamine? * on
© Kanamycin
CO Streptomycin
© Paromomycin x
© Gentamycin
Correct answer
©@ Streptomycin
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X_ Which of the following statement/s is/are false for Amphtericin B? on
interacts with fungal cholesterol
It interacts with fungal ergosterol x
Itis amphoteric in nature
Admixture with lipid carrier helps in antifungal activity x
Correct answer
It interacts with fungal cholesterol
X_ Which of the following enzyme is present in both bacteria and human 0/1
being?
© Dihydropteroate synthase x
© Dihydrofolate synthase
© Dihydrofolate reductase
CO Allofthese
Correct answer
© Dihydrofolate reductase
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VY Which one of the following is a spiro compound? (1) ”
©@ Griseofulvin v
© Natamycin
CO Nystatin
O Miconazole
Y = Prontosil was — wi
An antibacterial compound
Adye v
An antimicrobial agent
None of these
omen Ome)
x
Which of the following are true for Naftifine? on
It interferes with epoxidation of squalene catalyzed by squalene epoxidase
Itis an allylamine antifungal agents v
It is an azole antifungal agent
It has no activity against ringworm of the scalp x
Correct answer
It interferes with epoxidation of squalene catalyzed by squalene epoxidase
It is an allylamine antifungal agents
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Y_ Which of the following contains 15 membered lactone ring? * ”
© Erythromycin
© Azithromycin v
© Clarithromycin
© None of these
Y Which of the following a chemical characteristic/s of second generation *1/1
Quinolones?
© 3-carboxylicacidgroup
© Abasic piperazino functionality attached at 7-position
© Forms Zwitterion
©@ Allofthese v
Y_ Which type/s of ring/s are present in the Penicillin? m
© Pyrolle ring
© Imidazol ring and thiazolidine ring
© BHactam ring and thiazolidine ring v
© Bactam ring and pyrolle ring
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YY Which of the following statement is false for Desosamine? * Ww
Dimethyl amino group is present at C-3 of Desosamine
OH group is attached at C-2 position of Desosamine
Methyl group is attached at C-5 position
@©ooo
Desosamine is attached at C3 position of the lactone ring v
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