CANCER NURSING: HEALTH PROMOTION, PREVENTION, AND SCREENING
CN12 Impact of diet on immune checkpoint blockade: Nurse-
directed dietary intervention
J. Malo1, M. Benlaïfaoui1, K. Diop1, M. Messaoudene1, W. Belkaid1, A. Elkrief2,
N. Blais3, M. Tehfe3, M. Florescu3, A. Al-Saleh1, A. Leblanc2, V. Marcil4, B. Routy3,
C. Richard1
1 effectively detect newly diagnosed colorectal cancer pts at-risk for malnutrition and
Centre De Recherche Du Chum - Oncology, Université de Montreal, Montreal, QC,
Canada; 2McGill University Department of Oncology, McGill University Healthcare
Centre, Montreal, QC, Canada; 3Hemato-oncology Department, CHUM - Centre Hos-
pitalier de l’Université de Montréal, Montreal, QC, Canada; 4Nutrition, Research
Centre, Sainte-Justine University Health Center, Montreal, QC, Canada
Background: Gut microbiota modulates the response to immune checkpoint blockade
(ICB) in various cancers, and diet represents the most natural and non-evasive
method to shift its composition. A recent study suggests that a high dietary fiber
intake may improve progression-free survival (PFS) of melanoma patients treated with
ICB. However, the impact of diet on patients with advanced non-small cell lung cancer
(NSCLC) has not been yet investigated. The objective of this study was to assess the
effect of diet, including fiber intake, in patients with NSCLC amenable to ICB.
Methods: Our research nurse assessed the dietary habits of 102 patients with
advanced NSCLC treated with ICB using a food frequency questionnaire (FFQ) on
dietary habits and probiotics supplementation (approved by the ethics committee).
Upon consent of each participant, answers to 47 questions included in the FFQ were
recorded, analysed using a calculation tool to estimate 30 different nutrients and
correlated with PFS.
Results: A total of 102 patients (49% men) completed the dietary survey with a
median age of 67 years and a median follow-up of 18.6 months. In contrast to
melanoma, a high fiber diet did not correlate with an improved PFS (median PFS: low
fiber¼16.0 months versus high fiber¼9.8 months, p¼0.42) in patients with NSCLC. Of
note, the group median fiber intake was 11g/day compared to 20g/day in the mel-
anoma study. Conversely, saturated fatty acids (SFA) dietary intake correlated with a
favorable outcome in advanced NSCLC patients (median PFS: low SFA¼9.1 months
versus high SFA¼17.4 months, p¼0.03). The sources of SFA were mostly from dairy
products.
Conclusions: In our study, NSCLC patients had a very low fiber diet that could explain
the absence of survival benefit. However, SFA intake correlated with longer PFS. With
the emergence of the gut microbiota in the immuno-oncology arena, providing evi-
dence-based dietary recommendations and educational tools for nurses represents an
important strategy to potentially increase ICB efficacy.
Legal entity responsible for the study: The authors.
Funding: Has not received any funding.
Disclosure: All authors have declared no conflicts of interest.
https://doi.org/10.1016/j.annonc.2022.07.324
CN13 Nutriscore: Nutritional screening in colorectal cancer
patients previous to cancer-specific treatment
R.M. Legido-Diaz1, L. Raventos1, M. Bellver2, A.R. Gonzalez2, L. Hurtos2,
I. Peiró Martínez3, L. Arribas4
1
ONCO MEDICA, ICO - Institut Català d’Oncologia - Hospital Duran i Reynals, Hospi-
talet De Llobregat, Spain; 2NUTRITION, ICO - Institut Català d’Oncologia - Hospital
Duran i Reynals, Hospitalet De Llobregat, Spain; 3Clinical Nutrition Unit, ICO - Institut
Català d’Oncologia l’Hospitalet (Hospital Duran i Reynals), Hospitalet De Llobregat,
Spain; 4Clinical Nutrition Unit, Institut Català DOncologia, Barcelona, Spain
Background: NUTRISCORE is a nutritional screening tool validated in cancer patients
(pts) in the outpatient setting, that stands out for its sensitivity, specificity and
simplicity. Our objective was to evaluate the value of the implementation of the
NUTRISCORE done by the oncology nursing team in ambulatory clinic for patients
with recently diagnosed colorectal cancer.
Methods: All pts who attended the first oncology nursing visit of the colorectal cancer
functional unit between April and November 2021 were prospectively included. The
NUTRISCORE was calculated in the initial assessment. Those pts with a score  5 were
referred to the clinical nutrition functional unit (CNFU) for a more comprehensive
nutritional assessment.
Results: 92 pts were registered (70.6% men, 29.3% women) and the mean age was
68.61 years. Nineteen pts (20.6%) were referred to CNFU, of which in 57.8% (n¼11)
the NUTRISCORE score obtained was 5. The other 8 pts with NUTRISCORE <5 were
referred based on nursing clinical criteria. Of these, 1 patient (pt) was referred due to
S1356
the high risk of intestinal obstruction, 3 pts needed to start nutritional supplemen-
tation for severe malnutrition at the CNFU visit, 1 pt started nutritional support in
anticipation of potential gastrointestinal toxicity secondary to treatment, another pt
just needed dietary recommendations for moderate malnutrition and 2 pts did not
attend to the CNFU visit.
Conclusions: Nursing clinical criteria together with NUTRISCORE, allow us to more
anticipate their nutritional needs before starting cancer-specific treatment.
Legal entity responsible for the study: R.M. Legido-Diaz and L. Raventos.
Funding: Has not received any funding.
Disclosure: All authors have declared no conflicts of interest.
https://doi.org/10.1016/j.annonc.2022.07.325
CN14 Cancer prevention awareness among Croatian AYA
population
N. Dodlek1, S. Islamcevic2, J. Milicevic3, M. Vukoje2, A. Sajnic4, S. Karabatic5,
D. Anic6, A. Perkovic3, M. Susnjara7, T. Ladenhauser8, I. Jelincic9
1
Department for Oncology, University Hospital Center Osijek, Osijek, Croatia;
2
Depertment for Pediatric Hematology and Oncology, KBC - University Hospital Centre
Zagreb, Zagreb, Croatia; 3Department for Oncology, KBC - University Hospital Centre
Zagreb, Zagreb, Croatia; 4Dept. for Respiratory Diseases Jordanovac, KBC - University
Hospital Centre Zagreb, Zagreb, Croatia; 5Dept. for Respiratory Diseases Jordanovac,
KBC Zagreb - Clinic for Lung Diseases Jordanovac, Zagreb, Croatia; 6Osijek-Baranja
County Health Center, Osijek, Croatia; 7Anestheziology, KBC - University Hospital
Centre Zagreb, Zagreb, Croatia; 8Department for Oncology, KBC Osijek - Clinical
Medical Center Osijek, Osijek, Croatia; 9Palliative Care, Faculty for Medicine and
Dental Health Osijek, Osijek, Croatia
Background: Malignant diseases are one of the leading public health problems. Yearly
in Europe, more then 35000 children and young people suffer from malignant dis-
eases, and about 6 thousand lose their life. There is increased need of raising
awerness and making an impact, especially for young people, about attitudes in
cancer prevention and screening, where nurses are most often the first point of
contact and have a key role. The aim of this study was to examine the attitudes and
knowledge of young people aged 18-32 in Croatia about cancer prevention.
Methods: This cross-sectional study was conducted via online research-designed
survey that participants have taken after electronic consent was admitted to partic-
ipate in the study. This study is conducted from February to April 2022. Survey
contained 21 question, divided in four categories: sociodemographic data, knowledge
of cancer incidence, prevention procedures and questions about prevention self-ex-
amination separately for male and female respondents.
Results: There were total of 192 respondents, age range 18-32. 16,1% respondents
are still in high school, 36,5% has completed higher education. 71,9% respondents has
undergone education about cancer prevention during high school, 21,9% in
elementary school. 65% respondents is not doing self-examination on a monthley
bases despite that 79,5% of them is educated how to do it. 45% of male respondents
are doing self-examination of testicles, 77,1% of female respondents is going to
annual cervical cancer screening test to their doctors. 62% of respondents is NOT
familiar wether their friends are doing self-examination. 80,7% knows a person
diagnosed with cancer, but more than half of the respondents stated that information
did not affect the frequency of their self-examination.
Conclusions: Study findings are of great importance for raising awareness and
impacting attitudes among young adult population in Croatia. Despite undergone
education during their elementary or high school programmes, there is increased
need in self-examination and preventional cancer screening programmes responses.
More than half of the respondents stated that they don’t know about their friends
self-examination, which means that they are still embarrassed to talk about it.
Legal entity responsible for the study: The authors.
Funding: Has not received any funding.
Disclosure: All authors have declared no conflicts of interest.
https://doi.org/10.1016/j.annonc.2022.07.326
Volume 33 - Issue S7 - 2022