Tumors of the Lung

Dr. Alia Mirghani A.

• A variety of benign and malignant tumors can
arise in the lung
• 90% to 95% are carcinomas,
• 5% are bronchial carcinoids,
• and 2% to 5% are mesenchymal
• Other are miscellaneous neoplasms.
 Carcinomas of the Lung

• The most common cause of cancer mortality

worldwide, due to the carcinogenic effects of
cigarette smoke.
• The four major histologic subtypes are:
1. Adenocarcinomas (most common),
2. Squamous cell carcinoma,
3. Large cell carcinoma,
4. Small cell carcinoma.
• Each of them is clinically and genetically
distinct.
• The precursor lesions are:
➢squamous dysplasia for squamous cancer
➢and atypical adenomatous hyperplasia and
adenocarcinoma in situ for adenocarcinomas.
• Lung cancers, particularly small cell lung
carcinomas, can cause paraneoplastic
syndromes.
• Most of small cell lung carcinomas are
metastatic at presentation, best treated by
chemotherapy.
• Other carcinomas can be curable by surgery if
limited to the lung.