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FIRST YEAR SIA Q BANKS, EXAM ORIENTED PDFS,

TEXT BOOKS
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 PAPER CODE: MB2019101
KAI-OJI NARAHNA RAO UNIVERSITY OF SCIENCES
ARANGAI. TELANGANASTATE- 506002
MBBS FIRST WAR EXAMINATIONS:NOVEMBER. 2023
BIOCHEMISTRY (New Regulation)
PAPER —1
Time: Ilours Max Marks: 100
Note: Answeralt gucsuons
diagramswhenever KNRUHS -2022 I pencillanydart
Colourpencil

Multiple Choice Questions: lox 1-10

Anomenc carbon atom of fructose is in

a) I g carbon atom _b) carbonatom
c) Penultimate carbon atom d) None of the above
2. All the following are unsaturated fatty acids except
-a) Propionicacid b) Linoleicacid
c) Linolcnicacid d) Arachidonicacid
3. During glycogen breakdown, the action of glycogen phosphorylase produces
a) Glucose -6-phosphate •b) Glucose-I-phosphate

c) Fructose- 6-phosphate d) None of the above

4. The key enzyme in the pathway of cholesterolbiosynthesisis
a) HMG COA b) HMGCoA1yase

-c) HMG COA reductase d) Mevalonate kinase

5. Components of the electron transport chain are arranged in order of

. a) Decreasing redox potential b) Increasing redox potential

c) Positive redox potential to negative d) None of the above

redox potential
6. Enzymes act by reducing the
@medi circle
-a) Activation energy b) Heat energy

c) Binding energy d) All of the above

7. Increased levels of lactate dehydrogenase (LDH) can be observed in

a) Myocardial infarction . b) Haemolytic anaemia

c) Lcukaemia •s d) All of the above

 fluid mosau-•model or membrane Includes
a) Cholesterol molecules in the b)
Membrane proteins are fixed
membrane Increase stability of and cannot move
membrane
c) Membranecontatns bimolecular d) Permeabilityof drugs across
leaflet of l'Ptds cell membrane ts dependent on
their solubility in water
9. Mobility of particles during electrophoresis is based on all
the followtng
factors. except
a) Current voltage and ampere Quality of supporting media
c) Ph of buffet medium d) Solubility of particle protein
10. The power house of the cell is
a) Nucleus b) Cell membrane
, c) Mitochondria d) Lysosomes

Essey/Long Answer Questions: 2 x 15=30

41. Whatarc t.ipoproteins.ClassifyLipoproteins.Explainthe transportof TAG (Tri Acyl
glycertdes) in the body. Discuss the clinical significance of LDL and HDL. Add a note on
dyslipidaernias.
$2. What is Glycogen. How is Glycogen broken down in the body. Explain the hormonal
regulation of the pathway. Write about glycogen storage disorders.

ShortAnswerQuestions: @medi circle 7 x 6-42

13. What are the different types of enzyme inhibition. Explatn about competitive inhibition with
two examples of its thetapeutic significance.
J.4. Write about inhibitors and uncouplers of electron transport chain.
Justify Physician role in Health Care System.
J6. Enzyme profile in liver diseases,and write abouttheir clinical significance.
F. Describe the sources. daily requirement and functions of Vitamin C.
Descnbe the regulation of calcium homeostasis.
J'. Define BMR, what is its normal value, and what are all the factors affecting BMR

Very Short Answer Questions: 6 x 3-18

Write about classification of lipids with suitable examples.
Principle and applications of Enzyme Linked Immunosorbent Assay (ELISA).
—22.Antioxidant Vitamins.
.23. Describe about transport systems with examples,
-24. Essential Fatty acids.
'8. Compare and Contrast Kwashiorkor and Marasmus.
 PAPER CODE: MB2019102
KALO.JINARAYANARAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL,TELANGANASTATE- 506002
MBBSFIRST VEAREXAMINATIONS:
NOVEMBER,2023
BIOCHEMISTRY (New Regulation)
PAPER — 11
Time:3 Ilours Max Marks: 100
Note; Answer all questions
Draw diagrams whenevernceessary With Black Ball point pen '11Bpencil "any dark
Colour pencil

MultipleChoiceQuestions: 10 x 1-10
1. Peptidebond is
a) Singlebondin character b) Doublebondin character
c) Partialdoublebond in character d) Triplebond in character
2. Duringurea cycle, the twonitrogenatomsare derivedfrom
a) Ammoniaand Arginine b) AmmoniaandAsparticacid
c) BothfromAmmonia d) Ammoniaand Ornithine
3. The sourcesOfoxalicacidin urineare
a) Ornithineand citrulline b) Oxalosuecinateand formicacid
c) Oxaloacetateand asparticacid d) Ascorbicacidand Glycine
4. Elevatedhomoeysteinelevels are associatedwith a risk of
a) Bronchiectasis b) Nephrotie
c) Coronaryarterydisease d) Diabetesmellitus
5. RegardingDNA structurewhichis not correct.
a) Two strands arc covalently b) Two strands are antiparallel
bonded
c) Strands have polarity. d) Strands are complementaryto
eachother
6. Whicho t n 1i s is not associatedwith hyperuricemia.
a) Multiplemyeloma b) Xanthinuri*'
c) Psoriasis d) Polycythemiavera
7. Sickle cell anaemia occursdue to
a) Silentmutation b) Mis-sensemutation
c) Nonsensemutation d) Frameshiftmutation
8. Whichof the followingrenal functionaltests are used to measure the
GlomemlarFiltrationRate(GFR)
a) Clearancetests. b) Urineconcentrationtests
c) Urine dilutiontests d) Urine acidificationtests
9. Which is an anticancerdrug.
a) Zidovudine b) 6-mercaptopuri»e
c) Allopurinol d) Acyclovir
 10. Okazaki fragments occur on the
a) Leadingstrand b) Lagging strand
c) Double helical DNA strand d) All the above
Essay/ Long Answer Questions: 2 x 15-30
A 15-year-old boy complained of swelling and pain in the distal phalangeal
joints. Blood investigations showed the following results. On diagnosing
the pathology, the physician decided to treat patient with allopurinol.
a. What is your probable diagnosis in the above patient.
b. Write tlle synthesis of Uric Acid.
c. Whatis the normal uric acid level.
d. What are other blood investigations would you suggest.
e. Commenton the serum uric acid level and explain the cause of pain in
joints.
f. Writethe ways for loweringserumuric acid level. 0)
g. What is the biochemical explanation for the treatment given in the
above patient.
. Describe the steps of catabolism of Phenylalanine and Tyrosine. Indicate
the inborn errors of metabolism. What are the Biomedically important
compounds derived from tyrosine. (8+5+2)
ShortAnswerQuestions: 7 x 6=42
Medi Circle
13. Namc the enzymes measured to assess liver functions. Discuss the clinical
significance of Alanine transaminase and Alkaline phosphatase in assessing
liver ['unction.
. Discuss the Watson and Crick model ofDNA. Add a note on different forms
CDNA.
. Write on the classification of Acid-base disorders in the body and also
ention the compensatorymechanismsfor each type.
. ustify the statement "Physician is a lifelong learner".
Describethe formation ofbilirubin. Name the different types of jaundice.
J What are tumour markers. Discuss the clinical utility Ofany three tumour
markers,
Write about structure, classification and functions of immunoglobulins.
Very Short Answer Questions: 6 x 3=18
Orotic aciduria.
List the thyroid function tests. Mention the laboratory findings in a case
of
ypothyroidism.
What is Polymerase Chain Reaction (PCR). Mention two clinical
applications of PCR technique.
23. Importance of cytochrome P450 in detoxification.
What is foetal haemoglobin. How does its structure differ from
adult
haemoglobin and explain how it is useful to the foetus.
. ACTH.