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Julien, A Primer of Drug Action, 12e Chapter 7 Page 1 of 11
CHAPTER 7
MULTIPLE-CHOICE QUESTIONS
Historical Background
Pages: 236, 241, Answer: c
1. Barbiturates are in a class of drugs known as:
a. CNS stimulants.
b. sedative-anxiolytics.
c. sedative-hypnotics.
d. narcotics.
Historical Background
Page: 238, Answer: d
2. The most common cause of death when combining benzodiazepines with another CNS
depressant or alcohol is:
a. hypotension.
b. bradychardia.
c. seizures.
d. respiratory depression.
Barbiturates
Page: 242, Answer: b
5. The hypnotic action of the ultrashort-acting barbiturates is terminated by:
a. absorption.
b. redistribution.
c. degradation.
d. elimination.
Barbiturates
Page: 242, Answer: d
6. The elimination half-life of all the various barbiturates is:
a. a few minutes.
b. up to 48 hours.
c. longer than 48 hours.
d. All of the answers are correct.
Barbiturates
Page: 242, Answer: d
7. The ultrashort-acting barbiturates are ________; the longer-acting barbiturates are ________.
a. highly water soluble; highly fat soluble
b. highly fat soluble; highly fat soluble
c. highly water soluble; highly water soluble
d. highly fat soluble; moderately fat soluble
Barbiturates
Page: 242, Answer: b
8. The barbiturates:
a. suppress memory and increase REM sleep.
b. suppress memory and decrease REM sleep.
c. decrease REM sleep but do not affect memory.
d. increase REM sleep but do not affect memory.
Barbiturates
Page: 242, Answer: d
9. At nontoxic doses, barbiturates significantly affect:
a. the cardiovascular system.
b. the kidneys.
c. the gastrointestinal tract.
d. None of the answers are correct.
Barbiturates
Pages: 242–244, Answer: d
10. The reason that the use of barbiturates has declined rapidly over the years is that:
a. barbiturates are usually lethal in overdose.
b. the dosage range for the effectiveness of barbiturates is very close to its toxic range.
c. barbiturates interact dangerously with a wide range of drugs.
d. All of the answers are correct.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 3 of 11
Barbiturates
Page: 244, Answer: d
11. The treatment for overdose of barbiturates is:
a. administration of the specific antidote for barbiturates.
b. respiratory support.
c. cardiovascular support.
d. both respiratory and cardiovascular support.
Barbiturates
Page: 244, Answer: d
12. The most common symptom of withdrawal from normal clinical doses of barbiturates is:
a. hallucinations.
b. convulsions.
c. disorientation.
d. sleeplessness.
Barbiturates
Page: 244, Answer: d
13. The most common symptom(s) of withdrawal from excessively high doses of barbiturates is:
a. hallucinations.
b. convulsions.
c. disorientation.
d. All of the answers are correct.
Benzodiazepines
Page: 247, Answer: b
18. Benzodiazepines differ from one another mainly in:
a. pharmacodynamics.
b. pharmacokinetics.
c. both pharmacodynamics and pharmacokinetics.
d. neither pharmacodynamics nor pharmacokinetics.
Benzodiazepines
Page: 247, Answer: b
19. Benzodiazepines differ from one another in:
a. their basic structure.
b. their plasma half-lives.
c. their binding sites.
d. their site of action.
Benzodiazepines
Page: 249 and Table 7.3, Answer: d
20. Generally speaking, the long-acting benzodiazepines are biotransformed into ________; the
short-acting benzodiazepines are biotransformed into ________.
a. inactive products; inactive products
b. active products; active products
c. inactive products; active products
d. active products; inactive products
Benzodiazepines
Page: 249, Answer: d
21. Compared with young adults, the elderly:
a. are less sensitive to the benzodiazepines.
b. are more tolerant to the benzodiazepines.
c. more readily metabolize benzodiazepines.
d. less readily metabolize benzodiazepines.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 5 of 11
Benzodizaepines
Page: 249, Answer: b
22. As shown in the figure below, compared with the dose-response curve for young adults (curve
A), the dose-response curve for the elderly will be shifted in the direction of:
a. A.
b. B.
c. C.
d. The point cannot be predicted.
Benzodiazepines
Page: 250, Answer: a
23. Benzodiazepines ________ binding at the ________ receptor.
a. facilitate; GABA
b. facilitate; 5-HT
c. inhibit; GABA
d. inhibit; 5-HT
Benzodiazepines
Page: 250, Answer: a
24. Benzodiazepines facilitate the action of the neurotransmitter:
a. GABA.
b. ACh.
c. NE.
d. 5-HT.
Benzodiazepines
Page: 250, Answer: d
Long-term benzodiazepine use is associated with a twofold increase in:
25. a. depression.
b. bipolar disorder.
c. Parkinson’s disease.
d. dementia.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 6 of 11
Benzodiazepines
Page: 250, Answer: d
26. The brain site(s) mediating anxiety and/or panic is(are) the:
a. amygdala.
b. orbitofrontal cortex.
c. insula.
d. All of the answers are correct.
Benzodiazepines
Page: 251, Answer: d
27. Presently, the drug of choice for the treatment of chronic anxiety is:
a. benzodiazepines.
b. depressants.
c. sedatives.
d. antidepressants and atypical antipsychotics.
Benzodiazepines
Page: 251, Answer: d
28. Effects of the benzodiazepines include:
a. sedation.
b. anxiolysis.
c. muscle relaxation.
d. All of the answers are correct.
Benzodiazepines
Page: 251, Answer: d
29. The benzodiazepines are best prescribed for:
a. directly relaxing muscles.
b. alleviating depression.
c. treating chronic anxiety.
d. treating short-term anxiety.
Benzodiazepines
Pages: 251–252, Answer: d
30. Benzodiazepines may be useful for treating all of the following EXCEPT:
a. anxiety.
b. insomnia.
c. alcohol withdrawal.
d. intoxication.
Benzodiazepines
Page: 252, Answer: d
31. The drug of choice for the treatment of panic attacks is:
a. benzodiazepines.
b. depressants.
c. sedatives.
d. antidepressants.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 7 of 11
Benzodiazepines
Page: 252, Answer: d
32. Higher doses of benzodiazepines produce:
a. anxiolysis.
b. depression.
c. amnesia.
d. both anxiolysis and amnesia.
Benzodiazepines
Page: 252, Answer: d
33. Perhaps the best use of benzodiazepines is in:
a. treating epilepsy.
b. treating chronic anxiety.
c. treating panic disorder.
d. intentionally producing anterograde amnesia.
Benzodiazepines
Page: 253, Answer: d
34. Early withdrawal signs following cessation of long-term benzodiazepine use include:
a. agitation.
b. insomnia.
c. restlessness.
d. All of the answers are correct.
General Anesthetics
Page: 259, Answer: d
43. The inhaled anesthetics include:
a. morphine.
b. ketamine.
c. phenobarbital.
d. nitrous oxide.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 9 of 11
General Anesthetics
Page: 259, Answer: d
44. The most common cause of death with nitrous oxide is:
a. convulsions.
b. hypotension.
c. stroke.
d. hypoxia.
General Anesthetics
Page: 259, Answer: b
45. The major mechanism of action of the injectable anesthetics is probably:
a. perturbation of the cell membrane.
b. potentiation of GABAA-induced neurotransmission.
c. potentiation of glutamate-induced neurotransmission.
d. induction of analgesia.
Antiepileptic Drugs
Page: 265, Answer: b
49. The major mechanism of action of the antiepileptics is:
a. blockade of voltage-dependent sodium channels.
b. enhanced GABA-mediated inhibition of neural activity.
c. blockade of GABA receptors.
d. enhanced glutamate-mediated neurotransmission.
Julien, A Primer of Drug Action, 12e Chapter 7 Page 10 of 11
Antiepileptic Drugs
Page: 266, Answer: d
50. At the cellular level, the novel antiepileptic agent Vimpat (lacosamide) affects:
a. K+ channel activation.
b. K+ channel inactivation.
c. Na+ channel activation.
d. Na+ channel inactivation.
Historical Background
Page: 238, Answer: False
51. Benzodiazepines are a form of barbiturates.
Barbiturates
Page: 242, Answer: False
55. REM sleep is unaffected by barbiturates.
Barbiturates
Page: 244, Answer: True
56. Barbiturates can, paradoxically, induce a state of aggression.
Barbiturates
Page: 244, Answer: True
57. The therapeutic-to-toxic range for barbiturates is very narrow.
Barbiturates
Page: 244, Answer: False
58. Drowsiness is a common, but not inevitable, consequence of barbiturate usage.
Barbiturates
Page: 244, Answer: False
59. Fortunately, there are specific antidotes to barbiturates overdose.
60. The nonbarbiturate sedatives act like, but do not structurally resemble, the barbiturates.
Benzodiazepines
Page: 249, Answer: True
61. A number of benzodiazepines are biotransformed into active metabolites.
Benzodiazepines
Page: 251, Answer: False
62. Benzodiazepines are the treatment of choice for chronic anxiety.
Benzodiazepines
Page: 253, Answer: True
63. A major side effect of the benzodiazepines is amnesia.
Benzodiazepines
Page: 254, Answer: False
64. The benzodiazepines reduce anxiety, and benzodiazepine blockers produce anxiety.