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Download Pharmacotherapeutics for Nurse Practitioner Prescribers 3rd Edition Moser Woo Test Bank all chapters
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Chapter 8: Pharmacogenomics
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 6. Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to
prescribing warfarin.
A. True
B. False
____ 7. Pharmacogenetic testing is required by the Food and Drug Administration (FDA) prior to
prescribing:
A. Erythromycin
B. Digoxin
C. Cetuximab
D. Rifampin
____ 8. Carbamazepine has a Black Box warning recommending testing for the HLA-B*1502 allele in
patients with Asian ancestry prior to starting therapy due to:
A. Decreased effectiveness of carbamazepine in treating seizures in Asian patients
with the HLA-B*1502 allele
B. Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
C. Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502
allele
D. Patients who have the HLA-B*1502 allele being more likely to have a resistance to
carbamazepine
____ 9. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the
body may lead to:
A. Decreased effectiveness of irinotecan in the treatment of cancer
B. Increased adverse drug reactions, such as neutropenia
C. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
D. Increased concerns for irinotecan being carcinogenic
____ 10. Patients who have a poor metabolism phenotype will have:
A. Slowed metabolism of a prodrug into an active drug, leading to accumulation of
prodrug
B. Accumulation of inactive metabolites of drugs
C. A need for increased dosages of medications
D. Increased elimination of an active drug
MULTIPLE CHOICE
1. ANS: D PTS: 1
2. ANS: B PTS: 1
3. ANS: C PTS: 1
4. ANS: D PTS: 1
5. ANS: B PTS: 1
6. ANS: B PTS: 1
7. ANS: C PTS: 1
8. ANS: C PTS: 1
9. ANS: B PTS: 1
10. ANS: A PTS: 1
11. ANS: B PTS: 1
12. ANS: C PTS: 1
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