Chatur et al Journal of Drug Delivery & Therapeutics.

2022; 12(4):112-115

Available online on 30.07.2022 at http://jddtonline.info

Journal of Drug Delivery and Therapeutics

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Open Access Full Text Article Research Article

Formulation and Evaluation of Polyherbal Cream

Vibhavari M. Chatur*, Nazma M. Ansari, Sanket K. Joshi, Sanjay G. Walode
Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune-19, India

Article Info: Abstract

__________________________________________
Article History:
Received 03 June 2022
Reviewed 01 July 2022
Accepted 07 July 2022
Published 30 July 2022
__________________________________________
Cite this article as:
Chatur VM, Ansari NM, Joshi SK, Walode SG,
Formulation and Evaluation of Polyherbal
Cream, Journal of Drug Delivery and
Therapeutics. 2022; 12(4):112-115
___________________________________________________________________________________________________________________
Cosmetics made from either natural or synthetic components are almost in regular use universally in
many different forms for enhancing the beauty. Azadirachta indica and Nyctanthes arbor-tristis are
medicinal plants; these plants are used traditionally from ancient years in various herbal medicinal
systems such as Ayurvedic, Homeopathic and Siddha. The dried leaves of Azadirachta indica and dried
leaves of Nyctanthes arbor-tristis have antibacterial, anti-inflammatory analgesic activity. The present
research is focused on the formulation of polyherbal cream and their evaluation by using various
evaluation parameters.
Keywords: Polyherbal cream, Neem, Night Jasmine, Fusion method, Almond oil.

DOI: http://dx.doi.org/10.22270/jddt.v12i4.5572

__________________________________________
*Address for Correspondence:
Vibhavari M. Chatur, Rasiklal M. Dhariwal
Institute of Pharmaceutical Education and
Research, Pune-19, India

INTRODUCTION Maceration was extractive technique and carried out at

Cream formulation was semisolid formulations intended for
topical application. The cream formulations were prepared by
using various herbal extracts, herbal oils, and various
excipients.
Cosmetic products are used for the protection of skin from
various endogenous and exogenous harmful agents along with
enhancing the beauty and making skin attractive.1 The only
use of cosmetic is not developing an attractive external
appearance but also achieving longevity of good health by
reducing skin disorders.2 The cosmetics which are meant for
skin care nourishes the health, texture and moisturizes the
skin. 3
Polyherbal cream is a semisolid formulation intended for
topical application. The cream formulation is prepared by
using various herbal extracts, almond oil and various
excipients. 4
Nyctanthes arbor-tristis was the oldest holistic, sacred and
traditional medicinal plant belongs to family Oleaceae. The
plant was mentioned in Vishnu Purana and having great
importance to treat varieties of diseases, especially
rheumatoid arthritis it reduces pain and inflammation 7. The
fresh leaves are collected and complete shade drying, further
powdered by using the mixer. This formed powder was passed
through the sieve. The extract was obtained by using a simple
maceration process.
roomtemperature. Powdered herbal leaves of Nyctanthes
arbor-tristis wasimmersed in alcohol and continuousshacking
byusing REMI RSB 12 mechanical shaker. After 3 d the
concentrated extract was collected and filtered.
Nyctanthes arbor-tristis is an old holistic, sacred and
traditional medicinal plant belonging to family Oleaceae. The
fresh leaves were collected and dried in shade, further
powdered by using the mixer. This formed powder was passed
through the sieve. The extract was obtained by using a simple
maceration process. 5
Almond oil has excellent emollientproperties help the skin to
balance water loss andabsorption of moisture, helps relieve
irritation, inflammation and itching, and is greatly lubricating.6
Gram flour, commonly known as Besan, has been used
extensively since the olden times for its beauty-enhancing
benefits. It mainly acts as a tonic for the skin as it helps to
clean and exfoliate it. 7
The secondary metabolites which are present in the plants
taken will support the strength, texture and integrity to skin
along with the moisturizing of skin and maintaining its
elasticity.8 Thus, the presence of herbal ingredients in skincare
formulation helps reduce the production of free radicals in the
skin and maintain for a long time.Active ingredients delays
skin aging by reducing the wrinkles, protect against UV
radiation by antioxidant property.9

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Chatur et al Journal of Drug Delivery & Therapeutics. 2022; 12(4):112-115

MATERIAL AND METHODS

a. Preparation of Extracts-
Table 1: Ingredients used for the formulation of Polyherbal Cream
Sr. No. Ingredients Chemical Constituents Process of Extraction/ Image
Collection of Raw Material
1. Almond Oil Almonds contain lipids (around Hamdard Roghan Badam
50%), proteins (around 25%) and Shirin Sweet Almond Oil®,
carbohydrates (around 20%) and 100 g
have a low moisture content and
diverse minor bioactive compounds.

2. Night Jasmine The leaves and seeds contain iridoid Maceration-

extract glycosides. The other constituents
reported from the leaves are
mannitol, beta-amyrin, beta-
sitosterol, hentriacontane, benzoic
acid, astragalin, nicotiflorin,
oleanolic acid, nyctanthic acid
friedelin and lupeol.
3. Neem leaves The chemical constituents are found
extract in the leaves of neem as nimbin,
nimbanene, 6-desacetylnimbinene,
nimbandiol, nimbolide, ascorbic
acid, n-hexacosanol and amino acid,
7-desacetyl-7-benzoylazadiradione,
7-desacetyl-7-benzoylgedunin, 17-
hydroxyazadiradione and nimbiol
4. Besan Powder 11.2% moisture, 22.5% protein,
5.2% fat, and 58.9% carbohydrate.
Maceration is an extractive
technique and carried out at
room temperature.
Powdered herbal leaves of
Nyctanthes arbor-tristis is
further immersed in alcohol
and continuous shaking by
using mechanical shaker.
After 3 days the
concentrated extract was
collected and filtered. [10]
Extraction-
Neem leaves were collected
from Local Area. Further
the leaves were shade dried
for 4 days and size reduced
using mixer grinder
converted into coarse
powder and passed through
sieve number 22. The
extraction was carried out
for 3 hrs taking 100 gms of
plant material with 500 ml
of ethanol. [11]
Fortune chana besan®

5. Bees wax Hydrocarbons (12%–16%) with a It was purchased from Loba

predominant chain length of C27– Chemie Pvt. Ltd.
C33, mainly heptacosane,
nonacosane, hentriacontane,
pentacosane and tricosane [10]; free
fatty acids (12%–14%), with a chain
length of C24–C32; free fatty
alcohols

b. Method for preparation of Polyherbal Cream-[12] 4. Add Solution1 dropwise into Solution2. When both the
phases get mixed properly, add methyl paraben as
1. Add the required quantity of Borax in sufficient amount of
preservative.
water and prepare a solution by heating on water bath.
5. The formulated Polyherbal Cream was kept aside for about
2. In the above solution, add required quantity of night
an hour in cool and dry place indirect to sunlight till it sets
jasmine, neem extract and besan powder. [Solution 1]
completely and was used after 48 hours after keeping at
3. Weigh accurately almond oil and add into beeswax room temperature for stability and analytical testing.
contained in a china dish, melt to prepare a proper
solution. [Solution 2]
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Chatur et al Journal of Drug Delivery & Therapeutics. 2022; 12(4):112-115

Table 2: Composition of Polyherbal Cream

Sr. No. Ingredients Quantity taken Role
1. Almond Oil 10mL Emollient
2. Night Jasmine extract 1mL Anti-inflammatory
3. Neem leaves extract 0.4mL Antibacterial
4. Besan Powder 1gm Rejuvenate dull skin
5. Bees wax 3.2gm Humectant
6. Borax 0.16gm Emulsifier
7. Methyl Paraben 0.02gm Preservative
8. Water 6mL Vehicle
9. Perfume (Rose water) q.s. Fragrance

thickness by placing a definite weight for a definite time. The

specified time required to separate the two slides was
measured as spreadability.
Spreadability was calculated by the following formula:
Formula-

Formulated polyherbal Cream
Evaluation of Polyherbal Cream-
The evaluation of herbal cream was following.
1. Physical evaluation- 13
Formulated herbal cream was further evaluated by using the
following physical parameters: Color, Odour, Consistency, and
state of the formulation.
a) Colour:The colour of the cream wasobserved by visual
examination.
b) Odour: The odour of cream was found to be characteristics.
c) Consistency: The formulation was examined by rubbing
cream on hand manually. The cream having smooth
consistency. Cream did not leave greasy substances on skin
surface after application.
d) State: The state of cream was examined visually. The
cream having a semisolid state.
e) pH-The pHof prepared herbal cream was measured by
using digital pH meter. The solution of cream was prepared by
using 100 ml of distilled water and set aside for 2 h.
2. Spreadability-14
Spreadability of formulated cream was measured by placing
sample in between two slides then compressed to uniform
Where,
S= Spreadability
M= Weight tide to the upper slide
L= Length of glass slide
T= Time taken to separate the slides.
3. Wash ability-
Formulation was applied on the skin and then ease extends of
washing with water was checked. 12
4. Non-irritancy test-
Herbal cream formulation was evaluated for the non-irritancy
test. Observation of the sites was done for 24 h. 15
Viscosity
Viscosity of cream was done by using Brooke field viscometer
at the temp of 25 °C using spindle no. 63 at 5rpm. Results
were shown in table 2.
Phase separation
The prepared cream was transferried in a suitable wide mouth
h contrainner. Set asidefor story age, the oil phase and
aqueous phase separationn was visualizing after 24h. R
results were shown in table 2.
5. Viscosity-
Viscosity of cream was done by using Brooke field viscometer
at the temperature of 25°C using spindle no. 63 at 5rpm. 16
6. Phase separation-
The prepared cream was transferred in a suitable wide mouth
container. Set asidefor storage, the oil phase and aqueous
phase separation were visualizing after 24h. [17

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Chatur et al Journal of Drug Delivery & Therapeutics. 2022; 12(4):112-115

RESULTS REFERENCES
Table 3: Evaluation of Polyherbal Cream 1. Saraf S, Kaur CD. Phytoconstituents as photoprotective novel
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6. Phase separation No phase separation
DISCUSSION
The present research mainly focused on the formulation and
evaluation of polyherbal cream using various evaluation
parameters.This cream formulation was o/w type of emulsion;
hence this formulation was easily washed with normal water
after application. The prepared formulation had a good
spreadability. Viscosity and pH of the cream was in range. The
polyherbal cream was non-greasy in nature and easily
removable after application. The formulation was non-irritant
and is not harmful to the skin. The prepared cream showed no
phase separation while storage.
CONCLUSION
The incorporated herbs such as the dried leaves of
Azadirachta indica and dried leaves of Nyctanthes arbor-tristis
have antibacterial, anti-inflammatory analgesic activity.
Formulation of polyherbal cream was done by Fusion method
and further evaluated by various evaluation parameters such
as physical properties, pH, Spreadability, Wash ability, non-
irritancy test, viscosity and phase separation of cream gave
quite good results. The present experimental study showed
that it is possible to develop and evaluate polyherbal cream
with herbal extract for anti-microbial activity.
Acknowledgement
The authors are thankful to SJVPM’s Rasiklal M. Dhariwal
Institute of Pharmaceutical Education and Research for
providing the facilities required for carrying out this research
work.
Conflict of Interest
We, authors declare that we have no known competing
financial interest or personal relationships that could have
appeared to influence the work reported in this paper.
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