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Full download College Mathematics for Business Economics Life Sciences and Social Sciences 13th Edition Barnett Test Bank all chapter 2024 pdf
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MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Find the second state matrix if the initial state is S0 = 0.3 0.7 .
A) [0.6192 0.3808]
B) [ 0.468 0.538]
C) [0.72 0.28]
D) [0.3 0.7]
Answer: B
1
4) The transition matrix for a Markov process is:
State
A B
State A 0.1 0.9 =P
B 0.3 0.7
Find P2 .
A) 0.244 0.756
0.252 0.748
B) 0.28 0.72
0.24 0.76
C) 0.72 0.28
0.36 0.64
D) 0.1 0.9
0.3 0.7
Answer: B
Find P4 .
A)
A B C D
A 0.4 0.3 0.2 0.1
P= B 0 1 0 0
C 0 0 1 0
D 0.2 0.5 0.1 0.2
B)
A B C D
A 0.18 0.47 0.29 0.06
P= B 0 1 0 0
C 0 0 1 0
D 0.12 0.66 0.16 0.06
C)
A B C D
A 0.0396 0.5942 0.3518 0.0144
P= B 0 1 0 0
C 0 0 1 0
D 0.0288 0.756 0.2044 0.0108
D)
A B C D
A 0.084 0.554 0.332 0.03
P= B 0 1 0 0
C 0 0 1 0
D 0.06 0.726 0.19 0.024
Answer: C
2
6) A B C
A 0.2 0.3 0.5
Using a graphing utility to compute powers of P = B 0.1 0.8 0.1 , find the smallest n such that the
C 0.4 0.3 0.3
corresponding entries in Pn and Pn+1 are, when rounded to 3 decimal places, equal.
A) 2
B) 3
C) 6
D) 11
Answer: D
8) 70 percent of the people in one generation who have a certain physical characteristic will pass that characteristic
on to the next generation. 40 percent of the people in one generation who do not have this characteristic will
pass it on to the next generation.
A)
0.7 0.3
0.4 0.6
B)
0.4 0.6
0.7 0.3
C)
0.3 0.7
0.6 0.4
D)
0.6 0.4
0.3 0.7
Answer: A
3
9) A new anti-gravity commuter train has been installed. It is expected that each week 90% of the riders who used
the existing system will continue to do so. Of those who traveled by car, 5% will begin to use the new
anti-gravity train. Use this information to write the transition matrix that describes this process.
T C
T
C
A) T C
T 0.90 0.05
C 0.10 0.95
B) T C
T 0.95 0.10
C 0.05 0.90
C) T C
T 0.90 0.10
C 0.05 0.95
D) T C
T 0.95 0.10
C 0.05 0.95
Answer: C
A small town has only two dry cleaners, Fast and Speedy. Fast hopes to increase its market share by conducting an
extensive advertising campaign. The initial market share for Fast was 40% and 60% for Speedy. Solve the problem.
10) Find the probability that a customer using Fast initially will use Fast for his second batch of clothes. Use the
following transition matrix.
Fast Speedy
Fast 0.61 0.39
Speedy 0.27 0.73
A) 0.73
B) 0.27
C) 0.39
D) 0.61
Answer: D
11) Find the probability that a customer using Fast initially will use Fast for his third batch of clothes. Use the
following transition matrix. Round your answer to the nearest hundredth.
Fast Speedy
Fast 0.16 0.84
Speedy 0.31 0.69
A) 0.71
B) 0.74
C) 0.28
D) 0.26
Answer: C
4
Provide an appropriate response.
12) Given the transition matrix:
A B C D A B C D
A 0.4 0.3 0.2 0.1 A 0.0396 0.5942 0.3518 0.0144
P= B 0 1 0 0 P4 = B 0 1 0 0
C 0 0 1 0 C 0 0 1 0
D 0.2 0.5 0.1 0.2 D 0.0288 0.756 0.2044 0.0108
5
15) A trailer rental company has rental and return facilities at both a north and south location in a city. Assume a
trailer must be returned to one or the other of these locations. If a trailer is rented at the north location, the
probability that it will be returned there is .6; if a trailer is rented at the south location, the probability it will be
returned there is .65. Assume the company rents all of its trailers each day and each trailer is rented (and
returned) only once a day. If the company starts with 50% of the trailers at each location, what is the expected
distribution (in percentages) the next day?
A) 47.5% of the trailers at the north location; 52.5% of the trailers at the south location
B) 37.5% of the trailers at the north location; 62.5% of the trailers at the south location
C) 52.5% of the trailers at the north location; 47.5% of the trailers at the south location
D) 62.5% of the trailers at the north location; 37.5% of the trailers at the south location
Answer: A
16) Dublin is experiencing a population movement out of the city to the suburbs. Currently 85% of the total
population live in the city with the remaining 15% living in the suburbs. It has been shown that each year 7% of
the city residents move to the suburbs, while only 1% of the suburb population move back to the city. Assuming
population remains constant for both, what percent of the total will remain in the city after 2 years. Express your
answer rounded to hundredths of a percent.
A) 31.05%
B) 26.14%
C) 73.86%
D) 79.2%
Answer: C
17) Laurinburg is experiencing a population movement out of the city to the suburbs. Currently 85% of the total
population live in the city with the remaining 15% living in the suburbs. It has been shown that each year 7% of
the city residents move to the suburbs, while only 1% of the suburb population move back to the city. Assuming
population remains constant for both, what percent of the total will remain in the city after 5 years. Express your
answer rounded to hundredths of a percent.
A) 39.72%
B) 60.28%
C) 64.44%
D) 35.56%
Answer: B
18) Fayetteville is experiencing a population movement out of the city to the suburbs. Currently 85% of the total
population live in the city with the remaining 15% living in the suburbs. It has been shown that each year 7% of
the city residents move to the suburbs, while only 1% of the suburb population move back to the city. Assuming
population remains constant for both, what percent of the total will remain in the suburbs after 5 years. Express
your answer rounded to hundredths of a percent.
A) 39.72%
B) 35.56%
C) 64.44
D) 60.28%
Answer: A
19) Decide whether or not the transition matrix is regular. Answer Yes or No.
0.3 0.7
0.9 0.1
A) Yes
B) No
Answer: A
6
20) Decide whether or not the transition matrix is regular. Answer Yes or No.
1 0 0
0 0 1
0 1 0
A) Yes
B) No
Answer: B
21) Decide whether or not the transition matrix is regular. Answer Yes or No.
0.7 0.3 0
0 0.4 0.6
1 0 0
A) Yes
B) No
Answer: A
22) Decide whether or not the transition matrix is regular. Answer Yes or No.
1 0
0.5 0.5
A) Yes
B) No
Answer: B
23) Decide whether or not the transition matrix is regular. Answer Yes or No.
0.61 0 0.39
0.47 0.53 0
0 0.24 0.76
A) Yes
B) No
Answer: A
24) Find the stationary matrix for the transition matrix P = 0.1 0.9 .
0.6 0.4
A) [0.6 0.4]
B) [0.4 0.6]
C) 0.1 0.9
0.6 0.4
D) [0.16 0.36]
Answer: B
25) Find the stationary matrix for the transition matrix P = 0.8 0.2 .
0.35 0.65
A) 0.8 0.2
0.35 0.65
B) 1 0
0 1
C) [0.6 0.4]
D) [0.636 0.364]
Answer: D
7
0.1 0.9 0
26) Find the stationary matrix for the transition matrix P = 0.3 0.4 0.3 .
0.2 0.2 0.6
1 0 0
A) 0 1 0
0 0 1
2 4 1
B) 9 9 3
C) [0.25 0.45 0.35]
9 9 9
D) 2 4 3
Answer: B
8
1 1
2 2
30) Find the limiting matrix P corresponding to the transition matrix P = 3 4 .
7 7
Round to the nearest thousandths.
A) 0.462 0.538
0.462 0.538
3 4
B) 7 7
C) [0.462 0.538]
D) [0.5 0.5]
Answer: A
32) For the transition matrix P = 0.36 0.64 find P exactly by converting P16 to fraction form.
0.20 0.80
5 16
A) 21 21
B) 0.213 0.698
0.218 0.715
C) [0.213 0.698]
5 16
21 21
D) 5 16
21 21
Answer: D
9
Solve the problem.
33) The probability that an assembly line works correctly depends on whether the line worked correctly the last
time. Find the probability that the line will work in the long run. Round your answer as appropriate.
34) Weather is classified as sunny or cloudy in a certain place. What are the long-term predictions for sunny and
cloudy days? Round numbers to the nearest thousandths.
Sunny Cloudy
Sunny 0.9 0.1
Cloudy
0.2 0.8
A) 0.667 0.333
B) 0.900 0.100
C) 0.855 0.145
D) 0.333 0.667
Answer: A
35) Rats are kept in a cage with two compartments (A and B). Rats in A move to B with probability 0.5. Rats in B
move to A with probability 0.1. Find the long-term trend for rats in each compartment. Round numbers to the
nearest thousandth.
A) 0.475 0.525
B) 0.167 0.833
C) 0.500 0.500
D) 0.833 0.167
Answer: B
10
37) The probability that an assembly line operation works correctly depends on whether it worked correctly the last
time it was used. There is a 0.91 chance that the line will work correctly if it worked correctly the time before
and a 0.68 chance that it will work correctly if it did not work correctly the time before. After setting up a
transition matrix with this information, find the long-run probability that the line will work correctly.
A) [0.883 0.883]
B) [0.117 0.883]
C) [0.883 0.117]
D) [0.802 0.198]
Answer: C
38) The probability that a car owner will become a car renter in five years is 0.03. The probability that a renter will
become an owner in five years is 0.1. Suppose the proportions in the population are 64% owners (O), 35.5%
renters (R) and .5% neither (N) with the following transition matrix.
O R N
O 0.94 0.06 0
R 0.12 0.879 0.001
N 0 32 0.68
39) According to data collected during one year in a large metropolitan community, 30% of commuters used public
transportation to get to work, and this rose by 4% the following year. This is modeled by the transition matrix
P P′
M= P 0.9 0.1
P′ 0.1 0.9
where P represents the percentage of people that use public transportation and P′ the percentage of people that
do not.
Let S0 = [0.3 0.7]. Find S1 .
A) [0.66 0.34]
B) [0.3 0.7]
C) [0.9 0.1]
D) [0.34 0.66]
Answer: D
11
40) According to data collected during one year in a large metropolitan community, 30% of commuters used public
transportation to get to work, and this rose by 4% the following year. This is modeled by the transition matrix
P P′
M = P 0.9 0.1
P′ 0.1 0.9
where P represents the percentage of people that use public transportation and P′ the percentage of people that
do not.
Let S0 = [0.3 0.7]. Find S2 .
Round your answer to the nearest thousandths.
A) [0.34 0.66]
B) [0.372 0.628]
C) [0.66 0.34]
D) [0.628 0.372]
Answer: B
41) According to data collected during one year in a large metropolitan community, 30% of commuters used public
transportation to get to work, and this rose by 4% the following year. This is modeled by the transition matrix
P P′
M = P 0.9 0.1 S0 = [0.3 0.7]
P′ 0.1 0.9
where P represents the percentage of people that use public transportation and P′ the percentage of people that
do not.
What percentage of commuters in this community will use public transportation in the long run?
A) 34%
B) 50%
C) 37.2%
D) 30%
Answer: B
42) A B C D
A 0 0 1 0
Identify the absorbing state(s) in the transition matrix P = B 0 1 0 0
C 0 1 0 0
D 0 0 0 1
A) C and D
B) A and D
C) B and D
D) A and B
Answer: C
12
43) Find all absorbing states for the transition matrix, and indicate whether or not the matrix is that of an absorbing
Markov chain.
1 2 3
1 0.9 0 0.1
2 0 1 0
3 0.6 0 0.4
A) State 2 is absorbing; matrix is not an absorbing Markov chain.
B) State 3 is absorbing; matrix is an absorbing Markov chain.
C) State 2 is absorbing; matrix is an absorbing Markov chain.
D) State 3 is absorbing; matrix is not an absorbing Markov chain.
Answer: A
44) Find all absorbing states for the transition matrix, and indicate whether or not the matrix is that of an absorbing
Markov chain.
1 2 3 4
1 0.1 0 0.1 0.8
2 0 0.1 0 0
3 0.1 0.2 0.3 0.4
4 0 0 0 1
A) State 2 and 3 are absorbing; the matrix is an absorbing Markov chain.
B) State 2 is an absorbing; the matrix is an absorbing Markov chain.
C) State 2 and 3 are absorbing; the matrix is not an absorbing Markov chain.
D) State 2 is an absorbing; the matrix is not an absorbing Markov chain.
Answer: A
45) Find a standard form for the absorbing Markov chain with the transition matrix
A B C
A 0 0 1
B 0 1 0
C 0.2 0.6 0.2
A) A B C
B 1 0 0
A 0 0 1
C 0.6 0.2 0.2
B) B A C
B 1 0 0
A 0 0 1
C 0.6 0.2 0.2
C) A B C
A 0 0 1
B 0 1 0
C 0.2 0.6 0.2
D) B A C
A 1 0 0
B 0 0 1
C 0.6 0.2 0.2
Answer: B
13
46) Find a standard form for the absorbing Markov chain with the transition matrix
A B C
1 0 0
A
1 1 1
B
3 3 3
C
0 0 1
A) A C B
1 0 0
A
0 1 0
C
1 1 1
B
3 3 3
B) A B C
1 0 0
A
0 1 0
B
1 1 1
C
3 3 3
C) A B C
A 1 0 0
B 3 3 3
C 0 0 1
D) A C B
A 1 0 0
C 0 1 0
B 3 3 3
Answer: A
14
47) Find a standard form for the absorbing Markov chain with the transition matrix
A B C D
A 1/4 1/4 1/4 1/4
B 0 1 0 0
C 1/2 0 1/2 0
D 0 0 0 1
A) B D A C
B 1 0 0 0
D 0 1 0 0
A 1/4 1/4 1/4 1/4
C 0 0 1/2 1/2
B) A B C D
B 1 0 0 0
D 0 1 0 0
A 1/4 1/4 1/4 1/4
C 0 0 1/2 1/2
C) A B C D
B 1 0 0 0
D 0 1 0 0
A 1/4 1/4 1/4 1/4
C 0 0 1/2 1/2
D) D B C A
B 1 0 0 0
D 0 1 0 0
A 1/4 1/4 1/4 1/4
C 0 0 1/2 1/2
Answer: A
15
48) Find a standard form for the absorbing Markov chain with the following transition matrix :
A B C D
A 0.4 0.2 0.1 0.3
B 0 1 0 0
C 0 0.2 0.1 0.7
D 0 0 0 1
A) B D C A
B 1 0 0 0
D 0 1 0 0
C 0.2 0.7 0.1 0
A 0.2 0.3 0.1 0.4
B) B D C A
A 1 0 0 0
B 0 1 0 0
C 0.2 0.7 0.1 0
D 0.2 0.3 0.1 0.4
C) A B C D
B 1 0 0 0
D 0 1 0 0
C 0.2 0.7 0.1 0
A 0.2 0.3 0.1 0.4
D) B D C A
B 1 0 0 0
D 0 1 0 0
C 0.2 0.7 0.1 0
A 0.3 0.2 0.4 0.1
Answer: A
16
49) A B C D
A 0.4 0.1 0.4 0.1
For the transition matrix B 0 1 0 0 , find the limiting matrix. Use fractional entries.
C 0.3 0.1 0.2 0.4
D 0 0 0 1
A) B A C D
B 0 1 0 2
3 3
A 0 1 0 0
C 1 3
0 0
4 4
D 0 0 0 1
B) A B C D
A 0 1 2
0
3 3
B 0 1 0 0
C 1 3
0 0
4 4
D 0 0 0 1
C) A B C D
1 2
0 0
A 3 3
0 1 0 0
B 1
0 0 1
C 4
3
D 4 0 0 1
D) A B C D
A 1 2
0 0
3
B 0 1 0 0
C 1 3
0 0
4 4
D 0 0 0 1
Answer: B
17
50) Find the fundamental matrix F for the absorbing Markov chain with the given matrix. Express your answer in
fraction form.
1 0 0
0 1 0
0.12 0.72 0.16
21
A) F = 25
4
B) F = 25
11
C) F = 9
25
D) F = 21
Answer: D
51) Find the fundamental matrix F for the absorbing Markov chain with the given matrix. Express your answer in
fraction form.
1 0 0
0 1 0
3 4 1
7 7 7
7
A) F = 6
7
B) F = 3
C) F = [3]
7
D) F = 4
Answer: A
52) Find the fundamental matrix F for the absorbing Markov chain with the given matrix. Express your answer in
fraction form.
1 0 0 0
1 1
0 0
2 2
0 0 1 0
1 1 1
0
4 2 4
A) 2 3
2 1
3 2
B) 1
1
2
3
1
C) 2
1 2
D) 3 1
2 2
Answer: C
18
2 1
3 3
53) Find the limiting matrix P corresponding to the transition matrix P = 1 3 .
4 4
Round to the nearest thousandths.
A) 0.528 0.472
0.354 0.646
B) [0.429 0.571]
C) 0.429 0.571
0.429 0.571
D) 1 0
0 1
Answer: C
54) Find the limiting matrix P corresponding to the transition matrix P = 0.8 0.2 .
0.1 0.9
Round to the nearest hundredths.
A) [0.875 0.125]
B) 0.45 0.55
0.28 0.72
C) 0.33 0.67
0.33 0.67
D) 0.66 0.34
0.17 0.83
Answer: C
55)
For the transition matrix , find the probability that if one starts in state B, one
19
56) A red urn contains 4 red marbles, 2 blue marbles, and 4 green marbles. A blue urn contains 2 red marbles, 2
blue marbles, and 1 green marble. A green urn contains 3 green marbles. A marble is selected from an urn, the
color is noted, and the marble is returned to the urn from which it was drawn. The next marble is drawn from
the urn whose color is the same as the marble just drawn. Thus, this is a Markov process with three states: draw
from the red urn, draw from the blue urn, or draw from the green urn.
Write the transition matrix P.
A) G B R
G 1 0 0
P = B 0.2 0.4 0.4
R 0.4 0.2 0.4
B) G B R
G 0.4 0.2 0.4
P = B 0.2 0.4 0.4
R 0.4 0.2 0.4
C) G B R
G 3 0 0
P= B 2 2 1
R 4 2 4
D) G B R
G 1 0 0
P= B 0 1 0
R 0 0 1
Answer: A
57) A red urn contains 4 red marbles, 2 blue marbles, and 4 green marbles. A blue urn contains 2 red marbles, 2
blue marbles, and 1 green marble. A green urn contains 3 green marbles. A marble is selected from an urn, the
color is noted, and the marble is returned to the urn from which it was drawn. The next marble is drawn from
the urn whose color is the same as the marble just drawn. Thus, this is a Markov process with three states: draw
from the red urn, draw from the blue urn, or draw from the green urn.
Find the limiting matrix P, if it exists, and describe the long-run behavior of this process.
A) G B R
G 1 0 0
P = B 0.2 0.4 0.4
R 0.4 0.2 0.4
B) G B R
G 1 0 0
P = B 0.2 0.4 0.4
R 1 0 0
C) G B R
G 1 0 0
P = B 0 0.1 0.4
R 1 0 0
D) GBR
G 1 0 0
P= B 1 0 0
R 1 0 0
Answer: D
20
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“Still, we must remember how singularly, of late years, the knowledge of the
introduction of cholera by persons coming from infected districts has increased, and
how very striking are the instances of this kind already recorded in several works on
influenza.
“In some cases, again, isolation or seclusion of a community, as in prisons, has given
immunity; or at least that community has not been attacked.”
The great rapidity of spread has caused even in 1918 some temporary doubt as to the
contagiousness of the disease. Thus, Zinsser wrote:
“The opinion of direct and indirect transmission from man to man is also well
supported by a detailed study of the epidemiology of individual outbreaks. In our own
experience with epidemics such as those at Chaumont, Baccarat and other places, the
suddenness with which the malady attacked large numbers of people at almost one and
the same time, caused me at first to be exceedingly skeptical of accepting transmission
by contact as the only means of conveyance. We considered food and insect transmission
as possibilities, and tried our best to find grounds for involving such agencies. But in
every case we were forced to return to the conclusion that direct and indirect contact
between men came nearest to doing justice to all observed facts.”
There have been many examples reported from personal experience to show that
influenza is transmitted from man to man. Two objections, however, have had to be met,
before this view was generally accepted. First, it has been claimed by some that the
disease spread more rapidly from an assumed focus than individuals could travel, and
second, that instances were on record of cases occurring spontaneously in isolated
communities. Yet a third argument formerly raised against the contagious character of
the disease was the claim that it broke out in mass attacks, that large numbers became ill
on the same day without the occurrence of isolated antecedent cases. The splendid work
of epidemiologists following the 1889 epidemic appears to have answered all of these
objections. Many, such as Leichtenstern, have gone into great detail on this subject. In
fact, at that time this was the question of greatest importance. Today we assume the
correctness of the hypothesis, and pass on to consideration of other subjects of more
recent development. We will, therefore, review very hurriedly some of the evidence
quoted to prove that influenza is transmitted only from man to man and only by human
intercourse.
Isolated places.—Has it ever been shown that individuals completely isolated from
communication with communities where influenza is present have, during an epidemic,
developed the disease? Leichtenstern, after a comprehensive review, concludes as
follows: “We have not a single example on record where influenza has attacked
individuals in completely isolated localities, as on mountain tops and mountain passes.
Study of this has been undertaken in Switzerland by F. Schmid. The same has been true
of ships at sea, as has been shown chiefly from the English Marine Reports. There have
been reports of influenza occurring in mid-ocean and particularly in the earlier
epidemics, but the information has been insufficient.”
Parkes at even an earlier period observed: “I cannot but consider that we require
better evidence of ships being attacked in mid-ocean. In some of the quoted instances
the ships had been at a port either known to be infected or in which influenza was really
present, although it had not become epidemic. As we are ignorant of the exact period of
incubation some men may have been infected before sailing.”
Critical investigation into stories of spontaneous infection in isolated localities such as
ships at sea and island lighthouses will quite invariably demonstrate that these popular
reports have been distortions of the actual facts. One or two examples will suffice.
Abbott records an example: “An impression having gained some credence that influenza
had appeared on board the squadron of naval vessels which sailed from Boston in
December, 1889, while on their course across the Atlantic and before their arrival in
Europe, a letter was addressed by the writer to the Bureau of Medicine and Surgery of
the United States Navy for information upon this point, to which a reply was received, as
follows:
“The ‘Chicago,’ ‘Boston,’ ‘Atlanta’ and ‘Yorktown’ left Boston December 7, 1889, for
Lisbon, Portugal. The first three arrived at Lisbon on December 21st without having
touched at any port en route. The ‘Yorktown’ arrived at that port December 23d, having,
stopped about twenty-four hours at Fayal, Azores.... Influenza first appeared on the
‘Chicago’ December 23d, on the ‘Boston’ December 28th, on the ‘Atlanta’ December
30th and on the ‘Yorktown’ December 28th.
“Influenza was prevailing in Lisbon at the date of arrival of the squadron.”
In March, 1920, the author was notified of a somewhat similar story which he
undertook to trace. The results show well the inaccuracy of verbal transmission through
several individuals. A letter was first sent to the Quarantine Officer at Portland, Maine:
“It has been reported to us that in a lighthouse just outside of Portland, Maine, there has
been a rather interesting prank played by influenza. We are told that three men and one
woman live in the lighthouse; that during the 1918 influenza epidemic the woman
contracted the disease while none of the men became sick, and that in the present
epidemic all three of the men became sick with the disease and the woman remained
well. It was claimed that they had had no communication with the mainland for some
time before the men became ill,” etc.
The reply was as follows: “I have inquired of the Light House Inspector’s office in
Portland and they know of no stations to which the terms of your inquiry would apply.
“At the Boon Island station, there are three keepers with families. At the Half Way
Rock station, there are three keepers but no woman. The Inspector does not seem to
know of any station where there are three men and one woman.”
A second letter, sent to the Inspector of Lighthouses at Portland brought corroborative
information:
“The Boon Island Light Station was stricken by this epidemic in the following manner:
The keeper, his wife and five children were all stricken, the keeper himself having had
the hardest battle, having apparently been subject to same while ashore in Portsmouth,
N. H. after provisions, supplies, etc. The 2d assistant’s wife and two children were also
stricken, but the 2d assistant, himself, and the 1st assistant keeper did not contract the
malady in spite of the fact that they were all confined on a small island working together
at the station.
“During the year 1920 none of the keepers or their families, consisting of thirteen in
number, were affected. The Halfway Rock Light Station where three keepers are
employed did not contract this malady either in the years 1918 or 1920.
“For your information I might add that during the inspection trip in the months of
January, February and March, 1920, all of the light stations in this district were visited,
and it was found that they were all enjoying good health and had not been visited by the
epidemic, with the possible exception of three stations which are located either on the
mainland or close to where the keeper or his family were able to visit the nearby cities or
towns.”
Although it has not been shown that completely isolated places have been visited by
the disease, there is abundant evidence that such places have remained influenza free as
long as the isolation has remained complete. Islands and lighthouses, which have not
been in communication with the mainland, individuals living isolated on mountain tops,
and ships at sea remained free from influenza even in the presence of a pandemic, as
long as they did not come into communication with individuals sick with the disease.
The following places remained free from influenza throughout the 1889 epidemic: the
Isle of Man, several of the islands of the West Indies, particularly the Bahamas, Granada
and St. Lucia, also the British Honduras, British Guiana, and the Seychelle Islands.
Even in 1918, when the paths of commerce reached nearly every portion of the world,
we have examples of relative immunity of isolated places. Thus we know that the
Esquimaux were attacked late in the course of the pandemic, and we have the statement
of Barthélemy who traveled in 1919 to some of the oasis towns of the Sahara Desert, and
there discovered that there had not only been no influenza up to that time, but also that
they had not even heard of the pandemic.
Another type of isolated place is the closed institution. As early as 1709, Lancisi
remarked that the prisons of the Inquisition in Rome remained free from influenza.
Twenty-one prisons in Germany in 1889–90 remained entirely free from the disease.
This was true of 39 prisons in England, some of which were in cities where the epidemic
was most extensive. Linroth, who observed this same phenomenon in Sweden, makes
the wise remark that, “the influenza conquers more easily the space of 500 to 1,000
kilometers than it does the small barrier made by a prison wall.” A convent in
Charlottenburg housing one hundred women remained entirely free during the 1889–90
epidemic.
As a rule institutions of this sort have been unable to maintain a complete quarantine
throughout the period of an epidemic, and the relative immunity has been demonstrated
more in late invasions, at a time when the restrictions have become somewhat lax. Thus,
in 1918, Winslow and Rogers, report that in an orphan asylum in New Haven,
Connecticut, which had completely escaped during the month of October when the
epidemic was at its height, one of the Sisters and the priest in charge came down with
influenza about December 15th. By the 27th of December 127 cases had occurred in the
institution within twenty-four hours, and by January 7th there had been 424 cases, with
seven deaths out of a total population of 464. The probable source of the sudden
outbreak of December 27th seems to have been the Sister first affected who, when
convalescent, resumed her duties in the kitchen, which included the inspection and
handling of the milk given out to the children.
Crowd gatherings.—Yet another phenomenon which would lead us to conclude that
human intercourse is the most potent factor in the transmission of influenza is the fact
that there is frequently a high increase in the influenza rate following crowd gatherings.
Parkes observed long ago that persons in overcrowded habitations, particularly in some
epidemics, suffered especially, and several instances are on record of a large school or a
barracks being first attacked and the disease prevailing there for some days, before it
became prevalent in the towns around.
In England, the weekly market played an important role in the spread of the disease in
1889. One frequently saw such reports as that: “The first case of influenza was a man
who went to London daily.” Or, “All the earliest cases were men going to London daily,
while their wives and families were later affected.”
In the epidemics at San Quentin Prison, it was noted that apices of incidence usually
occurred on Tuesday and Wednesday. During the first epidemic it was these days of the
second and third weeks. Stanley sees a direct connection between this fact and the fact
that every Sunday morning large groups of the men were crowded together in a
comparatively small auditorium where they saw moving pictures. On Sunday, October
20th, they sought to eliminate this source of spread by having a band concert in the open
air, but the prisoners crowded around the band and were loud in their cheers, and on the
following day there was a large increase in hospital admissions.
On November 24th after the second epidemic had apparently ceased the picture
shows were again started after having been closed for over six weeks. The following
Tuesday and Wednesday twenty-four well defined new cases were admitted to the
hospital. On Thanksgiving Day there was a field meet between the various departments
of the prison. About 200 prisoners took active part, while 1,600 prisoners were
spectators. The meet was held in the open air, but the prisoners were closely packed and
they cheered and yelled. For the three days following this celebration there were 9, 5 and
8 patients admitted respectively.
In discussing the recrudescence of influenza in Boston in November and December,
Woodward remarks as follows:
“Whether or not it may be more than a succession of coincidences it is certainly of
interest to note that the November outbreak of influenza showed itself three days after
the Peace Day celebration on November 12th, when the streets, eating places and public
conveyances were jammed with crowds; that the December epidemic began to manifest
itself after the Thanksgiving holiday, with its family re-unions and visiting; and that
reported cases mounted rapidly during the period of Christmas shopping, reaching a
maximum a week after the holiday.” That this may have been a coincidence is indicated
by the fact that, according to reports by Pearl and others this was not consistently true in
other large cities.
Dr. Meredith Davies records the case of a hostel in Wales accommodating 200
students. Infection was introduced on October 19th on the occasion of a dance attended
by some students from an infected institution in the neighborhood. Four cases occurred
on the 20th and within the short space of five days seventy-nine students out of the 200
were attacked.
Parsons found numerous similar examples in the epidemic of 1889. In 1918 it was
frequently observed that among American Soldiers in France, those troops quartered in
barracks suffered a much more rapid spread of the disease than those billetted out
among the houses of the towns.
Mass attack.—Another argument formerly raised against the contagious character
was the claim that it broke out in mass attack, and large numbers became ill on the same
day without the occurrence of isolated antecedent cases. The first cases of such epidemic
diseases as the plague and small pox became a matter of record because of the
accompanying high mortality, while in influenza, with its relatively low death rate the
record usually begins only after a comparatively large mass of individuals have been
attacked.
Watson in 1847 observed as follows: “Although the general descent of the malady is,
as I have said, very sudden and diffused, scattered cases of it, like the first droppings of a
thunder shower, have usually been remembered as having preceded it. The disorder is
most violent at the commencement of the visitation; then its severity abates; and the
epidemic is mostly over in about six weeks. Yet the morbific influence would seem to
have a longer duration. In a given place nearly all the inhabitants who are susceptible of
the distemper suffer it within that period, or become proof against its power. But
strangers, who, after that period, arrive from uninfected places have not, apparently, the
same immunity.”
Parkes in 1876 observed that, “When the disease enters a town it has occasionally
attacked numbers of the inhabitants almost simultaneously. But more frequently its
course is somewhat slower; it attacks a few families first and then in a few days rapidly
spreads; the accounts of thousands of persons being at once attacked at the onset of the
disease are chiefly taken from the older records, in which the suddenness of the
outbreak is exaggerated. Frequently, perhaps always, in a great city the outbreak is made
up by a number of localized attacks, certain streets or districts being more affected than
others, or being for a time solely affected, and in this way it successively passes to
different parts of the city. It has generally occurred in a great city before appearing in the
smaller towns and villages round it and sometimes these towns, though in the
neighborhood, have not been invaded for some weeks.
“In some cases and perhaps a large number, it breaks out after persons ill with
influenza have arrived from infected places.
“The decline in any great town is less rapid than its rise, and usually occupies from
four to six weeks, or sometimes longer.”
Detailed studies of the Munich epidemic of 1889 and numerous similar studies of the
recent epidemic, which will be referred to later, have shown a period of two or three
weeks of steadily increasing numbers of cases before the height of the epidemic was
reached.
Droplet infection and spread through inanimate objects.—The actual mode of spread
of the virus of influenza from one individual to another is unknown. The more generally
accepted explanation is that the infecting agent leaves the body through the respiratory
tract, usually in the spray of coughing or talking; contagion is by droplet infection, as is
sometimes the case in other respiratory infections. Thorne and others have called
attention to the capillary congestion of the conjunctivae very early in the disease. They
suggest that possibly the mucous membrane of the eye is the site of infection.
There has recently been considerable discussion concerning the spread of influenza
through inanimate objects.
Leichtenstern reviews the reports of 1889–93 in which influenza was supposed to
have been transmitted through wares, merchandise and other inanimate objects. He
concluded that the evidence in all of the cases cited was insufficient for conclusive proof.
Such an example was the supposed importation of the disease in goods sent from Russia
to the Grands Magazins du Louvre at Paris. In one day 100 people became ill and in a
few more 500 were sick with influenza. The explanation was that the germs had been
imported in goods sent from Russia to the store. Detailed investigation showed that this
could not have been the case because no goods had been received from Russia for a
period of three years. Another example is that of one of the two winter caretakers at the
St. Gothard Hospice. One of the two men went down into the valley where he purchased
supplies. Ten days after his return the man who had remained in the Hospice fell ill with
influenza while his comrade remained well. It was stated that influenza was introduced
into Basel by goods shipped to that place from the Magazins du Louvre in Paris. The first
case occurred in a man who had been working at unpacking these goods.
Lynch and Cumming believe that droplet infection plays but a minor role in the
spread of sputum-borne diseases, but that insanitary methods of washing dishes and
eating utensils was the chief cause for the high rates of “sputum-borne” infections both
in army and civilian life in 1918. They found that among 31,000 troops eating from
tableware which was cleaned by kitchen police, the influenza rate was 51 per 1,000,
while among 35,000 eating from mess kits which each individual washed himself the
rate was 252 per 1,000. “Eighty-four per cent. of the cases occurred among those whose
hands were contaminated by washing their own eating utensils.”
Among 17,236 employees of hotels, restaurants and department stores, who ate from
machine washed dishes, there occurred 349 cases of influenza, while among 4,175 who
ate from hand washed dishes there were 429 cases. The rate was but 20 per 1,000 in the
former, while in the latter group it reached 103 per 1,000. Here again the chances of
infection between the two groups were as one is to five.
These authors have records covering 252,186 individuals in scattered institutions in
the United States. Among those eating from machine washed dishes the rate was 108 per
1,000 while those eating from hand washed dishes suffered at the rate of 324 per 1,000.
The ratio was 1 to 3 between the two groups. Seventy-five per cent. of the cases occurred
in that group which ate from dishes not disinfected with boiling water. They do not state
the number of individuals in each of the two groups.
Lynch and Cumming claim that in the act of coughing only a few organisms are
expelled from the mouth, rarely over 1,500, and conclude that transmission by direct
contact through the air route but rarely, if ever, takes place. While about 1,500
organisms are expelled onto the floor by an act of coughing, a sterile glove wiped across
the lips may pick up nearly 2,000,000 organisms. Such organisms may be readily
transferred to inanimate objects which are handled by many people.
Hemolytic streptococci and pneumococci may be isolated with great regularity from
the hands of carriers or patients, from table ware, inanimate objects touched by these
patients, and from floor dust. Diphtheria and tubercle bacilli have been isolated from the
hands and eating utensils of patients. The average count of a large number of restaurant
dishwater specimens was 4,000,000 bacteria per c.c. The temperature of this water
averaged 43° C. and the dishes were practically never scalded. The water was often so
highly polluted, “that the dishes are more highly contaminated after they are washed
than before washing begins. The spoon or fork is often freer from organisms just after
being used by the restaurant patron than when taken from the restaurant’s polluted dish
water.”
Major John S. Billings, epidemiologist at Camp Custer, reported that one of the larger
organizations did not properly observe the regulation requiring that all mess kits and
table equipment be properly sterilized. The disease appeared early and spread unusually
rapidly in this particular organization.
In summarizing the subject of transmission through utensils, we may say that the
evidence is suggestive but inconclusive. It is possible, even probable, that this is one
mode of transmission. That it is the most important has not been proved. Lynch and
Cumming do not take into consideration that the regiments with more sanitary methods
of cleansing the dishes are apt to be those regiments with more sanitary habits
throughout their daily routine. Those restaurants using mechanical dish washers are
usually the cleaner restaurants.
Pontano in Italy is quoted by the Office International d’Hygiène Publique as having
observed in his epidemiological study that there was a constant connection between the
living conditions and the severity of the complications. Notable differences were
observed in neighboring houses according to the hygienic conditions of the various
households.
Healthy carriers and convalescents.—Leichtenstern, who apparently accepted the
Pfeiffer bacillus as the cause of influenza, did not believe that the disease could be
transmitted by healthy carriers. He based this assumption on the statement, made by
Pfeiffer, that the influenza bacillus was only found in acute influenza cases. In the past
few years it has been abundantly shown, however, that the influenza bacillus can and
does exist on the mucous membranes of healthy individuals.
The outbreak in an orphan asylum in New Haven has been previously described.
There the probable source of the sharp outbreak of December 27th seemed to be the
sister who, on convalescence, resumed her duties in the kitchen. There she inspected
and handled the milk served to the children. This suggests the possibility of infection
being propagated by convalescents and by food.
At present we do not know whether or not a patient remains infectious after the acute
symptoms have subsided; we are ignorant as to whether a convalescent patient can
transmit the disease; and we are not certain whether the organism found in healthy
carriers is virulent or not. The information at hand strongly indicates that apparently
healthy individuals may transmit the infection, but the wide distribution of the disease,
with multiple possible sources of infection for each individual, and the relative
insusceptibility of experimentally exposed individuals has made it impossible so far to
answer these questions satisfactorily.
General Manner of Spread in Individual Localities.
Having discussed the mode of propagation of influenza among individuals we will
follow the disease as it attacks one person after another in a community and study the
epidemiologic picture, drawn no longer with the individual as a unit, but with the
community as the unit.
We must here distinguish between a primary epidemic, the first wave of a progressing
pandemic, and the secondary type in which may be grouped those large or small
recurrences which light up for a period of one to three or more years after the primary
wave.
Primary type of epidemic.—One of the first important statistical studies on this
subject was that of P. Friedrich who charted the influenza morbidity in Munich between
the months of December, 1889, and February, 1890. Similar observations have been
made by Parsons, Raats, Linroth, and H. Schmid, following the 1889 epidemic.
Between the occurrence of the first known case of influenza and the time of the first
very definite increase in influenza incidence in a community, which interval may be
termed the invasion period, there is as a rule two weeks. During this period, of course,
more and more cases are occurring, but remain usually sufficiently isolated to attract no
public notice. From this point the epidemic develops very rapidly and reaches its peak,
usually within two or at most three weeks. In another two or three weeks the incidence
has fallen away nearly to normal. The epidemic period comprises from four to six weeks,
or, including the invasion period, an entire duration of six to eight weeks. This is the
picture produced in a community by a primary uncomplicated epidemic of influenza.
Greenwood well describes the salient features of a primary epidemic as “first a rapid and
quasi-symmetrical evolution, and second, a frequency closely concentrated around the
maximum.” In other words the duration is short, the rise to a peak rapid, and the
subsequent fall equally rapid. He showed that in the July and August, 1918 epidemic in
Great Britain nearly 80 per cent. of the total incidence in the localities studied was
grouped within three weeks time. His curve corresponds so well with that of the Munich
epidemic that he is able to superimpose them (Chart I). The rapid rise to a peak, almost
explosive in character, more characteristic of this disease than of any other, is to be
explained by the high degree of invasiveness of the organism, by the short period of
incubation, by the fact that many of the sick continue at their work, thus spreading the
disease, and by the non-immunity of large masses of people, together with the fact that
the transmission of a respiratory infection is accomplished much more easily than is any
other type of infection.
The author holds that the infrequency of immunity is a most important factor in the
production of this type of outbreak. The mode of transmission of influenza is the same
as that of other respiratory diseases. The infectivity is probably no greater than that of
measles, although that indeed is relatively great. The means of transmission are
presumably the same in each. Were we able to develop an immunity for influenza of as
high degree and permanence as we possess against measles, pandemics of influenza
would disappear. We wish to emphasize that the primary type of curve is a phenomenon
not peculiar to influenza, but that under certain circumstances it may be found in other
infectious diseases, and that it would be found more frequently in the other diseases if
the immunity developed against them was of as short duration as it appears to be
against influenza. If, for example, measles were to break out in a large group of
individuals, none of whom had had the disease, the type of curve would be the same. We
will produce evidence supporting our theory under another subject. Of course, other
factors such as short incubation period and unusual opportunities for spread through
mildly ill individuals play a not unimportant role.
CHART I.