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Front Matter 4
Copyright 6
Preface 7
In Memorium of Ted Huang, MD 8
List of Contributors 9
Video Table of Contents 17
List of Video Contributors 18
1 - A Brief History of Acute Burn Care Management 19
2 - Teamwork for Total Burn Care: Burn Centers and Multidisciplinary Burn
Teams 28
3 - Epidemiological, Demographic and Outcome Characteristics of Burns 35
4 - Prevention of Burn Injuries 51
5 - Burn Management in Disasters and Humanitarian Crises 61
6 - Care of Outpatient Burns 77
7 - Prehospital Management, Transportation, and Emergency Care 87
8 - Pathophysiology of Burn Shock and Burn Edema 96
9 - Burn Resuscitation 110
10 - Evaluation of the Burn Wound: Management Decisions 122
11 - Treatment of Infection in Burn Patients 130
12 - Operative Wound Management 155
13 - Anesthesia for Burned Patients 174
14 - The Skin Bank 205
15 - Skin Substitutes and ‘the next level’ 216
16 - The Pathophysiology of Inhalation Injury 225
17 - Diagnosis and Treatment of Inhalation Injury 239
18 - Respiratory Care 253
19 - The Systemic Inflammatory Response Syndrome 265
20 - Host Defense Antibacterial Effector Cells Influenced by Massive Burns 285
21 - Biomarkers in Burn Patient Care 299
22 - Hematology, Hemostasis, Thromboprophylaxis, and Transfusion
Medicine in Burn Patients 305
23 - Significance of the Hormonal, Adrenal, and Sympathetic Responses to
Burn Injury 323
24 - The Hepatic Response to Thermal Injury 340
25 - Importance of Mineral and Bone Metabolism after Burn 352
26 - Micronutrient Homeostasis 362
27 - Hypophosphatemia 368
28 - Nutritional Needs and Support for the Burned Patient 376
29 - Modulation of the Hypermetabolic Response after Burn Injury 392
30 - Etiology and Prevention of Multisystem Organ Failure 401
31 - Acute Renal Failure in Association with Thermal Injury 417
32 - Critical Care in the Severely Burned: Organ Support and Management
of Complications 429
33 - Burn Nursing 460
34 - Care of the Burned Pregnant Patient 470
35 - Special Considerations of Age: The Pediatric Burned Patient 480
36 - Care of Geriatric Patients 491
37 - Surgical Management of Complications of Burn Injury 498
38 - Electrical Injuries 511
39 - Cold-Induced Injury: Frostbite 520
40 - Chemical Burns 527
41 - Radiation Injuries and Vesicant Burns 534
42 - Exfoliative Diseases of the Integument and Soft Tissue Necrotizing
Infections 543
43 - Burn Injuries of the Eye 559
44 - The Burn Problem: A Pathologist’s Perspective 575
45 - Molecular and Cellular Basis of Hypertrophic Scarring 587
46 - Pathophysiology of the Burn Scar 602
47 - Burn Rehabilitation Along the Continuum of Care 615
48 - Musculoskeletal Changes Secondary to Thermal Burns 652
49 - Reconstruction of Bodily Deformities in Burn Patients: An Overview 668
50 - Reconstruction of the Head and Neck after Burns 678
51 - Management of Postburn Alopecia 702
52 - Trunk Deformity Reconstruction 710
53 - Management of Contractural Deformities Involving the Shoulder (Axilla
), Elbow, Hip, and Knee Joints in Burned Patients 722
54 - Acute and Reconstructive Care of the Burned Hand 739
55 - Management of Burn Injuries of the Perineum 760
56 - Reconstruction of Burn Deformities of the Lower Extremity 770
57 - Electrical Injury: Reconstructive Problems 778
58 - The Role of Alternative Wound Substitutes in Major Burn Wounds and
Burn Scar Resurfacing 788
59 - Aesthetic Reconstruction in Burn Patients 796
60 - Laser for Burn Scar Treatment 805
61 - The Ethical Dimension of Burn Care 813
62 - Intentional Burn Injuries 819
63 - Functional Sequelae and Disability Assessment 834
64 - Management of Pain and Other Discomforts in Burned Patients 841
65 - Psychiatric Disorders Associated With Burn Injury 868
66 - Psychosocial Recovery and Reintegration of Patients With Burn Injuries 880
Total Burn Care
Total Burn Care
FIFTH EDITION

David N. Herndon, MD, FACS

Chief of Staff and Director of Research, Shriners Hospitals for Children–Galveston,
Director of Burn Services, University of Texas Medical Branch
Jesse H. Jones Distinguished Chair in Surgery
Professor, Department of Surgery and Pediatrics
University of Texas Medical Branch
Galveston, TX, USA

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Edinburgh London New York Oxford Philadelphia St Louis Sydney 2018

© 2018, Elsevier Inc. All rights reserved.

First edition 1996

Second edition 2002
Third edition 2007
Fourth edition 2012
Fifth edition 2018

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or
mechanical, including photocopying, recording, or any information storage and retrieval system, without
permission in writing from the publisher. Details on how to seek permission, further information about the
Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance
Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).

Dr. Leopold Cancio is the US Federal employee. His work in the Chapters 3, 5 and 9 is in public domain
Chapter 45 – Molecular and Cellular Basis of Hypertrophic Scarring
Figure 45.3 – (From Desmouli è re A, who retains copyright of the image).
Figure 45.4a-f – (From Coulomb B, Inserm U970, Universit é Paris Descartes, France and Desmouli è re A who
retains copyright of the Images (unpublished data)).
Figure 45.6a-d – (From Desmouli è re A, who retains copyright of the images.) (c, d) (From Casoli P, Plastic
Surgery and Burns Unit, University Hospital of Bordeaux, France, who retains copyright of the images).
Figure 45.7 – (From Desmouli è re A, who retains copyright of the image.)

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Preface
Over the past three decades, vast improvements in survival
from severe burns have been accompanied by a progres-
sively greater understanding of the complex processes
underlying this type of trauma. Basic science, and transla-
tional and clinical discoveries have provided new opportu-
nities to advance burn care along its entire spectrum from
management of burn shock, inhalation injury, sepsis, and
hypermetabolism to scar reconstruction and rehabilitation.
These and other key aspects of care, which are the focus of
this book, share the goal of providing burn survivors more
complete recovery from burns so that they can return to
their communities as fully functioning members. All aspects
of the physiological, psychological, and emotional care of
acutely burned patients evolving through recovery, reha-
bilitation, and reintegration back into society and daily life
are reexamined in this new, fifth edition.
The objective of the fifth edition of this book remains the
same—to serve as a sophisticated instruction manual for a
variety of health care professionals less experienced in
burns. It is intended to be a resource not only for surgeons,
anesthesiologists, and residents, but also for nurses and
allied health professionals. Although this edition of the
book covers many of the same fundamental concepts and
viii
techniques as the previous edition, the chapters have been
extensively updated with new data and references to reflect
advances in care and knowledge that have arisen over the
past 5 years. In some cases, the chapters have been com-
pletely rewritten. The new edition also contains new chap-
ters dealing with the care of unique populations, as well as
newer topics in reconstruction and scarring. As before,
demonstrative color illustrations are provided throughout
the book. Moreover, many chapters are accompanied by
online PowerPoint presentations to aid group discussion, as
well as video clips to enhance understanding of complex
concepts and techniques.
This new edition would not be possible without the many
respected colleagues and friends who have volunteered
their time and worked tirelessly to produce the various
chapters. Grateful acknowledgment is also given to Elsevier
publishing staff, who have maintained a high standard in
the development and preparation of this fifth edition.
Special thanks are offered to Dr. Derek Culnan, who gra-
ciously assisted in reviewing and updating material
throughout the book, as well as to Genevieve Bitz and Dr.
Kasie Cole for editorial assistance. Finally, I wish to thank
my wife, Rose, for her invaluable support.
 In Memorium of Ted Huang, MD
Derek Culnan, MD, Genevieve Bitz, Karel D. Capek, MD, David Herndon, MD
Last year, returning with his wife from a medical mission
trip to Taiwan, Dr. Ted Huang died. On that day, we lost a
colleague; a friend; and a surgeon of unquestioned skill,
passion, and knowledge as well as a teacher unstinting in
his advice and zeal to help others. Following a career as a
leader in the fields of gender reassignment and cosmetic
surgery, Dr. Huang retired to spend the next 20 years
working to revolutionize the practice of surgical recon-
struction of pediatric burns. He left behind a legacy in
research and surgery in the papers he authored and the
surgeons he mentored that few can achieve. He was the
principal author of the previous four editions of the recon-
structive section of this book. Stepping into the OR filled
him with joy, for he was a man who truly loved and lived
his career. When a surgical fellow once asked if he could
assist, Dr. Huang responded, “I’ve been operating on burn
scars since before you were born. If I need your help, then
the patient and I both have a big problem. But, if you want,
you can come have fun with me.” We are better for having
known him, and our principal regret is that we never figured
out the recipe for his legendary bread, which, as with every-
thing, he doled out generously to family, friends, patients,
and colleagues. As he would undoubtedly have said, that’s
how the cookie crumbles. This book is a testimonial to his
humanity and skill, from those he collaborated with and
those he mentored. Thank you, Dr. Huang, for everything.
With greatest honor and humility we dedicate this book
to you.
ix
List of Contributors
Rajeev B Ahuja MS MCh DNB FICS FACS FAMS Mette M Berger MD PhD
Senior Consultant in Plastic Surgery Associate Professor, Burn Center Director, Intensive Care
Department of Plastic Surgery Service
Sir Ganga Ram Hospital Marg; University Hospital of Lausanne
Ex-Head, Department of Burns and Plastic Surgery Lausanne, Switzerland
Lok Nayak Hospital and Associated Maulana Azad
Medical College Eileen Bernal MD
New Delhi, India Resident
University of Texas Southwestern
J F Aili Low MD PhD Dallas, TX, USA
Specialist in Plastic Surgery and Surgery
Associate Professor in Plastic Surgery Genevieve H Bitz
Art Clinic Uppsala Adjunct Researcher
Uppsala, Sweden JMS Burn and Reconstructive Center
Jackson, MS, USA
Brett D. Arnoldo MD, FACS
Professor of Surgery Fredrick J Bohanon MD
Medical Director Parkland Burn Center General Surgery Resident
UT Southwestern Medical Center Department of Surgery
Dallas, TX, USA University of Texas Medical Branch
Galveston, TX, USA
Amina El Ayadi PhD
Department of Surgery Branko Bojovic MD FACS
University of Texas Medical Branch Chief of Plastic Surgery
Shriners Hospitals for Children Shriners Hospitals for Children–Boston
Galveston, TX, USA Member of the Faculty of Surgery
Harvard Medical School
Sarah E Bache MBChB PhD MRCS Ed Assistant Surgeon
Speciality Registrar in Burns and Plastic Surgery Massachusetts General Hospital
St Andrew’s Centre for Burns and Plastic Surgery Boston, MA, USA
Broomfield Hospital Chelmsford
Essex, UK Ludwik Branski MD
Assistant Professor
Juan P Barret MD PhD Department of Surgery, Division of Plastic Surgery
Head of Department University of Texas Medical Branch
Professor of Surgery Staff Surgeon
Department of Plastic Surgery and Burns Shriners Hospital for Children
University Hospital Vall d’Hebron Galveston, TX, USA
Universitat Autònoma de Barcelona
Barcelona, Spain Elisha G Brownson MD
Burn Critical Care Fellow
Robert E Barrow PhD Department of Surgery
Retired Professor of Surgery, Coordinator of Research Harborview Medical Center
University of Texas Medical Branch Seattle, WA, USA
Shriners Hospitals for Children–Galveston
Galveston, TX, USA Michael C Buffalo DNP RN CCRN (A/P) CEN CPN CPEN
ACNP ACPNP
Debra A Benjamin RN MSN Nurse Practitioner
Nursing Program Manager Department of Surgery
University of Texas Medical Branch University of Texas Medical Branch Blocker Burn Unit
Galveston, TX, USA Shriners Hospitals for Children–Galveston
Galveston, TX, USA

x
 List of Contributors xi

Janos Cambiaso-Daniel MD Gp Capt Pallab Chatterjee MS DNB (Gen Surg) DNB

Resident (Plastic Surgery)
Division of Plastic, Aesthetic and Reconstructive Surgery Sr Advisor (Surgery) & Plastic Surgeon
Department of Surgery Associate Professor (Surgery)
Medical University of Graz Command Hospital Air Force
Graz, Austria Bangalore, India

Stephanie A Campbell BSN RN CCRN Linda Chilton

Burn Program Manager Registered Nurse, Surgical Nurse Practitioner
Parkland Regional Burn Center Senior SCP (Plastics)
Parkland Health & Hospital System St Andrew’s Centre for Plastic Surgery and Burns
Dallas, TX, USA Broomfield Hospital
Chelmsford
Leopoldo C Cancio MD FACS FCCM Essex, UK
Colonel, MC, US Army
Brooke Army Medical Center Dai H Chung MD FACS FAAP
Fort Sam Houston, TX, USA Professor of Surgery
Chairman, Department of Pediatric Surgery
Karel D Capek MD Vanderbilt University Medical Center
Clinical and Research Fellow, Nashville, TN, USA
Surgical Critical Care, Burns, and Reconstruction Shriners
Hospitals for Children Kevin K Chung MD FCCM FACP
University of Texas Medical Branch Medical Director, Burn ICU
Galveston, TX, USA US Army Institute of Surgical Research
Fort Sam Houston
Kelly D Carmichael MD San Antonio, TX, USA
Associate Professor
Department of Orthopaedic Surgery and Rehabilitation Audra T Clark MD
University of Texas Medical Branch Clinical Research Fellow
Galveston, TX, USA Department of Surgery
University of Texas Southwestern Medical Ceneter
Joshua S Carson MD Dallas, TX, USA
Assistant Professor
Division of Burns, Trauma & Acute CARE Surgery Amalia Cochran MD
Department of Surgery Associate Professor
University of Florida Vice Chair of Education and Professionalism
Gainesville, FL, USA Department of Surgery
University of Utah School of Medicine
Michele Carter PhD Salt Lake City, UT, USA
Professor, Institute for the Medical Humanities
Frances C. and Courtney M. Townsend, Sr., MD Professor April Cowan OTR OTD CHT
in Medical Ethics Assistant Professor
University of Texas Medical Branch School of Health Professions
Galveston, TX USA University of Texas Medical Branch
Galveston, TX, USA
Mario M Celis MS PA-C
Department of Surgery, University of Texas Medical Robert A Cox PhD
Branch Professor
Shriners Hospitals for Children Department of Pathology
Galveston, TX, USA University of Texas Medical Branch
Galveston, TX, USA
Jiake Chai MD PhD
Professor of Burn Surgery Beretta Craft-Coffman PA-C
Department of Burn and Plastic Surgery, Burns Institute Vice President of Non-Physician Providers
of PLA Burn and Reconstructive Centers of America
The First Affiliated Hospital of PLA General Hospital Augusta, GA, USA
Beijing, China
xii List of Contributors

Derek M Culnan MD Celeste C Finnerty PhD

Burn, Plastic, and Critical Care Surgeon Associate Professor
JMS Burn and Reconstruction Center Department of Surgery
Merit Health Central Hospital University of Texas Medical Branch
Jackson, MS, USA Shriners Burns Hospital for Children
Galveston, TX, USA
Moayad Dannoun MD
Burn Reconstruction Fellow Christian Gabriel MD
University of Texas Medical Branch The Ludwig Boltzmann Institute for Experimental and
Shriners Hospitals for Children–Galveston Clinical Traumatology
Galveston, TX, USA Austrian Cluster for Tissue Regeneration
Altenberg, Austria
Alexis Desmoulière PhD
Professor of Physiology, Faculty of Pharmacy James J Gallagher MD
University of Limoges Associate Professor
Limoges, France Department of Surgery
Weill Cornell Medical College
Matthias B Donelan MD New York, NY, USA
Chief of Staff
Shriners Hospitals for Children–Boston Nicole S Gibran
Associate Clinical Professor of Surgery Director, UW Medicine Regional Burn Center
Harvard Medical School Professor, Department of Surgery
Visiting Surgeon Harborview Medical Center
Massachusetts General Hospital Seattle, WA, USA
Boston, MA, USA
Cleon W Goodwin MD
Peter Dziewulski FFICM FRCS (Plast) Director, Burn Services
Clinical Director, Burn Service, Consultant Plastic and Western States Burn Center
Reconstructive Surgeon North Colorado Medical Center
St Andrews Centre for Plastic Surgery and Burns Greeley, CO, USA
Chelmsford, Essex, UK
Jeremy Goverman MD FACS
Naguib El-Muttardi FRCS Assistant Professor of Surgery
Consultant Plastic and Burns Surgeon Division of Burns
Department of Plastic Surgery Massachusetts General Hospital
St. Andrew’s Centre for Burns and Plastic Surgery Shriners Hospitals for Children
Chelmsford, UK Boston, MA, USA

Perenlei Enkhbaatar MD PhD Ashley N Guillory PhD

Professor, Department of Anesthesiology and Charles Assistant Professor
Robert Allen Professor in Anesthesiology, Physician Assistant Studies
The University of Texas Medical Branch University of Texas Medical Branch
Galveston, TX, USA Galveston, TX, USA

Shawn P Fagan MD Herbert L Haller MD

Chief Medical Officer Senior Surgeon
Burn & Reconstructive Centers of America UKH Linz der AUVA
Augusta, GA, USA Trauma and Burns
Linz, Austria
James A Fauerbach PhD
Associate Professor Houman K Hassanpour BA
Department of Psychiatry and Behavioral Sciences Medical Student
Johns Hopkins University School of Medicine School of Medicine
Baltimore, MD, USA University of Texas Medical Branch
Galveston, TX, USA
 List of Contributors xiii

Hal K Hawkins PhD MD Marc G Jeschke MD PhD FACS FRCSC

Professor, Department of Pathology Professor
University of Texas Medical Branch Department of Surgery, Division of Plastic Surgery and
Galveston, TX, USA Department of Immunology
University of Toronto
David N Herndon MD FACS Sunnybrook Health Sciences Centre
Chief of Staff and Director of Research, Shriners Hospitals Toronto, ON, Canada
for Children–Galveston
Director of Burn Services, University of Texas Medical Carlos Jimenez MD
Branch Associate Professor
Jesse H. Jones Distinguished Chair in Surgery Department General Surgery
Professor, Department of Surgery and Pediatrics Shriners Burn Institute
University of Texas Medical Branch; Galveston, TX, USA
Professor
Department of Surgery Andreas Jokuszies MD
University of Texas Medical Branch Consultant Surgeon for Plastic, Hand and Reconstructive
Shriners Hospitals for Children Surgery
Galveston, TX, USA Department of Plastic, Hand and Reconstructive Surgery
Burn Center
Maureen Hollyoak MBBS MMedSc FRACS Hanover Medical School
General Surgeon Hanover, Germany
Brisbane, Australia
Lars-Peter Kamolz MD MSc
Ted T Huang MD FACS (deceased) Professor and Head: Division of Plastic, Aesthetic and
Professor Reconstructive Surgery,
University of Texas Medical Branch Department of Surgery
Shriners Hospitals for Children; Medical University of Graz
Clinical Professor of Surgery Head of the Research Unit for Safety in Health
Shriners Burns Hospital Medical University of Graz;
University of Texas Medical Branch Deputy Chief Medical Officer
Galveston, TX, USA LKH- University Hospital Graz
Graz, Austria
Byron D Hughes MD
Resident, General Surgery Jennifer Kemp-Offenberg OTR
University of Texas Medical Branch Rehabilitation Services Manager
Galveston, TX, USA Shriners Hospitals for Children
Galveston, TX, USA
Gabriel Hundeshagen MD
Research Fellow, Department of Surgery Michael P Kinsky MD
University of Texas Medical Branch Professor
Galveston, TX, USA; Department of Anesthesiology
Resident, Department of Hand, Plastic and Reconstructive University of Texas Medical Branch
Surgery Galveston, TX, USA
BG Trauma and Burn Center Ludwigshafen
University of Heidelberg, Germany Gordon L. Klein MD
Professor, Department of Orthopedics
Mohamed E. Ismail Aly MSc MRCS(Ed) MD University of Texas Medical Branch
FRCSEd(Plast) Galveston, TX, USA
Consultant Plastic and Burns Surgeon
Royal Manchester Children’s Hospital and Wythenshawe Makiko Kobayashi PhD
Hospital Professor
Manchester, UK Department of Internal Medicine/Infectious Diseases
University of Texas Medical Branch
Mary Jaco RN MSN Galveston, TX, USA
Hospital Administrator
Shriners Hospitals for Children George C Kramer PhD
Galveston, TX, USA Director
Department of Anesthesiology
University of Texas Medical Branch
Galveston, TX, USA
xiv List of Contributors

Maggie J Kuhlmann-Capek MD Omar Nunez Lopez MD

Fellow, Division of Maternal Fetal Medicine General Surgery Resident
Department of Obstetrics and Gynecology Department of Surgery
University of Texas Medical Branch University of Texas Medical Branch
Galveston, TX, USA Galveston, TX, USA

Peter Kwan MD PhD Caroline Martinello MD

Assistant Professor, Department of Surgery Assistant Professor
University of Alberta Department of Anesthesiology
Edmonton, Alberta, Canada University of Arkansas for Medical Sciences
Little Rock, AR, USA
Jong O Lee MD FACS
Professor J A Jeevendra Martyn MD FCCM
Department of Surgery Professor of Anesthesia, Harvard Medical School
University of Texas Medical Branch Anesthesiologist, Massachusetts General Hospital
Shriners Hospital for Children Chief of Anesthesiology, Shriners Hospitals for Children
Galveston, TX, USA Boston, MA, USA

Kwang Chear Lee MD MSc Arthur D Mason Jr MD (Deceased)

Clinical Research Fellow, Emeritus Chief
University of Birmingham Laboratory Division
Birmingham, UK US Army Institute of Surgical Research
Brooke Army Medical Center
Jorge Leon-Villapalos MD FRCS (Plast) San Antonio, TX, USA
Consultant Plastic and Reconstructive Surgeon, Paediatric
Clinical Lead Jillian M McLaughlin MD
Department of Plastic Surgery and Burns, Chelsea and Clinical Research Fellow
Westminster Hospital Division of Plastic Surgery, Department of Surgery
London, UK University of Texas Medical Branch
Staff Surgeon, Shriners Hospital for Children
Benjamin Levi MD Galveston, TX, USA
Director, Burn/Wound and Regenerative Medicine
Laboratory Kevin H Merkley MD MBA
Associate Burn Director Interim Chair, Department of Ophthalmology
Assistant professor in Surgery University of Texas Medical Branch
University of Michigan Galveston, TX, USA
Ann Arbor, MI, USA
Walter J Meyer III MD
William C Lineaweaver MD FACS Gladys Kempner and R. Lee Kempner Professor in Child
Medical Director Psychiatry, Department of Psychiatry and Behavioral
JMS Burn and Reconstructive Center Sciences
Chief of Surgery Professor, Departments of Pediatrics and Human
Merit Health Central Hospital Biological Chemistry and Genetics
Jackson, MS, USA The University of Texas Medical Branch, Galveston, TX,
USA
Kimberly M Linticum ACNP-BC Head, Department of Psychological & Psychiatric Services
Acute Care Nurse Practitioner for Children & Families, Shriners Hospitals for Children,
Burn and Reconstructive Centers of America Shriners Burns Hospital, Galveston, TX, USA
Augusta, GA, USA
Esther Middelkoop PhD
Jeffrey Lisiecki MD Professor Skin Regeneration and Wound Healing
Resident, Plastic Surgery Director Association of Dutch Burn Centers
University of Michigan Plastic, Reconstructive and Hand Surgery Department,
Ann Arbor, MI, USA Red Cross Hospital, Beverwijk, the Netherlands
Amsterdam Movement Sciences, VU University Medical
Center
Amsterdam, the Netherlands
 List of Contributors xv

Stephen M Milner MBBS MD Andreas D Niederbichler MD

Professor of Plastic and Reconstructive Surgery Assistant Professor of Plastic Surgery, Burn Center
Director of the Johns Hopkins Burn Center Hanover Medical School
Director of the Michael D. Hendrix Burn Research Center Hanover, Germany
Johns Hopkins Bayview Medical Center
Baltimore, MD, USA William B Norbury MD
Assistant Professor
Ronald P Mlcak MBA PhD RRT FAARC Division of Plastic Surgery, Department of Surgery
Administrative Director, Shriners Hospitals for University of Texas Medical Branch
Children–Galveston Staff Surgeon, Shriners Hospital for Children
Associate Professor, School of Health Professions, Galveston, TX, USA
Department of Respiratory Care
University of Texas Medical Branch Sheila Ott OTR
Galveston, TX, USA Occupational Therapist
Department of Occupational Therapy
Naiem S. Moiemen MSc, FRCS(Plast) University of Texas Medical Branch
Director, the Scar Free Burns Research Centre. Galveston, TX, USA
Honorary Professor, University of Birmingham;
Consultant, Burns and Plastic Surgeon, University Christian Peterlik MD
Hospital Birmingham Anesthesiologist
Birmingham Children Hospital UKH Linz der AUVA
Birmingham, UK Department of Anesthesiology and Intensive Care
Linz, Austria
Stephen E Morris
Professor Bruce Philp MA (Cantab) BMBCh (Oxon)
Medical Director, Burn Center FRCS(I) FRCS(Plast)
Department of Surgery Consultant
University of Utah School of Medicine Burns, Laser and Reconstructive Plastic Surgeon
Salt Lake City, UT, USA St.Andrew’s Centre
Broomfield Hospital
David W Mozingo MD FACS Chelmsford, UK
Professor
Department of Surgery Craig Porter PhD
University of Florida College of Medicine Assistant Professor
Gainesville, FL, USA Department of Surgery, University of Texas Medical
Branch
Michael Muller MBBS MMedSci FRACS Shriners Hospitals for Children–Galveston
Associate Professor in Surgery, University of Queensland Galveston, TX, USA
Professor in Surgery, Bond University
Pre-Eminent Staff Specialist: General, Trauma and Burns Basil A Pruitt Jr MD FACS FCCM MCCM
Surgeon Clinical Professor
Royal Brisbane and Women’s Hospital Dr. Ferdinand P. Herff Chair in Surgery
Division of Surgery UT Health San Antonio
Brisbane, Queensland, Australia San Antonio, TX, USA

Robert F Mullins MD Ravi S Radhakrishnan MD MBA FACS

President and Medical Director Associate Professor
Burn and Reconstructive Centers of America Chief, Division of Pediatric Surgery
Augusta, GA, USA Departments of Surgery and Pediatrics
University of Texas Medical Branch
Kuzhali Muthumalaiappan PhD Galveston, TX, USA
Assistant Professor, Department of Surgery,
Burn and Shock Trauma Research Institute Ruth B Rimmer PhD
Loyola University Chicago, Stritch School of Medicine Chief Executive Officer
Maywood, IL, USA Care Plans for Life, LLC
Phoenix, AZ, USA
xvi List of Contributors

Laura Rosenberg PhD Linda E. Sousse, PhD MBA

Chief Clinical Psychologist Assistant Professor
Shriners Hospitals for Children Department of Surgery, University of Texas Medical
Clinical Assistant Professor Branch
Department of Psychiatry & Behavioral Sciences Shriners Hospitals for Children–Galveston
University of Texas Medical Branch Galveston, TX, USA
Galveston, TX, USA
Marcus Spies MD PhD
Marta Rosenberg PhD Head
Clinical Psychologist Department of Plastic, Hand, and Reconstructive Surgery
Shriners Hospitals for Children Hand Trauma Center (FESSH)
Clinical Assistant Professor Pediatric Trauma Center
Department of Psychiatry & Behavioral Sciences Breast Cancer Center
University of Texas Medical Branch Krankenhaus Barmherzige Brueder
Galveston, TX, USA Regensburg, Germany

Arthur P Sanford MD FACS Oscar E Suman PhD MS

Associate Professor of Surgery Professor, Associate Director of Research
Department of Surgery Department of Surgery, University of Texas Medical
Loyola University Medical Center Branch
Maywood, IL, USA Shriners Hospitals for Children–Galveston;
Professor
Kwabena O Sarpong MD MPH Associate Director of Research, Director of the Children’s
Child Abuse and General Pediatrics Wellness and Exercise Center
Associate Professor Of Pediatrics Shriners Hospitals for Children
Department of Pediatrics University of Texas Medical Branch
University of Texas Medical Branch Galveston, TX, USA
Consultant Physician
Shriners Children’s Hospital Fujio Suzuki PhD
Galveston, TX, USA Professor
Department of Internal Medicine/Infectious Diseases
Michael A Serghiou OTR MBA University of Texas Medical Branch
Clinical Care Specialist Galveston, TX, USA
Bio Med Sciences Inc.
Allentown, PA, USA Mark Talon, CRNA, MSN, DNP
Chief Nurse Anesthetist
Robert L Sheridan MD Shriners Hospital for Children
Medical Director of the Burn Service Galveston, TX, USA
Shriners Hospitals for Children
Boston, MA, USA Christopher R. Thomas MD
Robert L. Stubblefield Professor of Child Psychiatry
William C Sherman MD University of Texas Medical Branch
Burn Fellow Galveston, TX, USA
Shriner’s Hospital for Children
Galveston, TX, USA Tracy Toliver-Kinsky PhD
Professor
Edward R. Sherwood MD PhD Department of Anesthesiology
Cornelius Vanderbilt Professor University of Texas Medical Branch
Vice Chair for Research Scientific Staff
Department of Anesthesiology Shriners Hospitals for Children
Department of Pathology, Microbiology and Immunology Galveston, TX, USA
Vanderbilt University Medical Center
Nashville, TN, USA Edward E Tredget MD MSc FRCS(C)
Professor of Surgery
Lisa W Smith RPH BCPS Director of Surgical Research
Lead Burn Clinical Pharmacist University of Alberta
Doctors Hospital of Augusta Edmonton, Alberta, Canada
Augusta, GA, USA
 List of Contributors xvii

Stefan D Trocmé MD Felicia N Williams MD

Cornea Consultant, Professor of Ophthalmology (Ret.) Assistant Professor
Shriners Hospitals for Children Department of Surgery
MD Anderson Cancer Center North Carolina Jaycee Burn Center
Case Western Reserve University University of North Carolina, Chapel Hill
Galveston and Houston, TX, USA Chapel Hill, NC, USA

Lisa L Tropez-Arceneaux PsyD MSCP Stephen Williamson MBA CTBS

Pediatric Psychologist Tissue Bank Manager
New Orleans, LA, USA Shriners Hospitals for Children
APROQUEN Pediatric Burn Center Galveston, TX, USA
Department of Administration
International Consultant Steven E Wolf MD FACS
Managua, Nicaragua Golden Charity Guild Charles R. Baxter, MD Chair
Professor and Vice-Chairman for Research
Peter M Vogt MD PhD Chief, Burn Section, Department of Surgery
Professor and Head University of Texas Southwestern Medical Center
Department of Plastic, Hand and Reconstructive Surgery Editor-in Chief, Burns
Burn Center Dallas, TX, USA
Hanover Medical School
Hanover, Germany Lee C. Woodson MD PhD
Professor of Anesthesiology, University of Texas Medical
Charles D Voigt MD Branch
Burn Research Fellow, Chief of Anesthesia, Shriners Hospitals for Children
University of Texas Medical Branch Galveston, TX, USA
Shriners Hospitals for Children–Galveston
Galveston, TX, USA Sue M. Woodson PHD MLIS
Associate Director for User Services and Collections
David W Voigt MD William H Welch Medical Library
Co-Medical Director Saint Elizabeth’s Regional Burn and Johns Hopkins University
Wound Care Center Baltimore, MD, USA
Chief of Surgery, CHI Saint Elizabeth’s Regional Medical
Center Paul Wurzer MD
Lincoln, NE, USA Resident
Division of Plastic, Aesthetic and Reconstructive Surgery
Glen Warden MD MBA FACS Department of Surgery
Emeritus Chief of Staff Medical University of Graz
Shriners Hospitals for Children–Cincinnati Graz, Austria
Cincinatti, OH, USA
David Yngve MD
Shelley Wiechman PhD ABPP Professor Orthopaedic Surgery
Associate Professor, Harborview Medical Center Department General Surgery
University of Washington Shriners Burn Institute
Seattle, WA, USA Galveston, TX, USA

Mimmie Willebrand MD Ramón L. Zapata-Sirvent MD FACS

Associate Professor Burn Reconstruction Clinical and Research Fellow
Licensed Psychologist Department of Surgery
Department of Neuroscience, Psychiatry University of Texas Medical Branch
Uppsala University Shriners Hospital for Children
Uppsala, Sweden Galveston, TX, USA
Video Table of Contents
17 Diagnosis and Treatment of Inhalation Injury
LEE C WOODSON, LUDWIK K BRANSKI, PERENLEI ENKHBAATAR and
MARK TALON
Video 17.1: Severe Inhalation Injury and change of Oral to
Nasal Endotracheal tube with Bronchoscope
Video 17.2: Dynamic Airway Obstruction during Inhalation
50 Reconstruction of the Head and Neck After Burns
MATTHIAS B DONELAN and BRANKO BOJOVIC
Video 50.1: Demonstrating The Function of The Scars After
Treatment
Video 50.2: Demonstrating The Function of The Grafts After
Treatment

47 Burn Rehabilitation Along the Continuum of Care

MICHAEL A SERGHIOU, SHEILA OTT, CHRISTOPHER WHITEHEAD,
APRIL COWAN, SERINA MCENTIRE and OSCAR E SUMAN
Video 47.1: Burn Hand Splint
Video 47.2: Exercise Testing
Video 47.3: Face Mask Fabrication
Video 47.4: Preparatory Prosthetics

xviii
 List of Video Contributors
Branko Bojovic MD FACS Sheila Ott OTR
Chief of Plastic Surgery Occupational Therapist
Shriners Hospitals for Children–Boston Department of Occupational Therapy
Member of the Faculty of Surgery University of Texas Medical Branch
Harvard Medical School Galveston, TX, USA
Assistant in Surgery
Massachusetts General Hospital Michael A Serghiou OTR MBA
Boston, MA, USA Clinical Care Specialist
Bio Med Sciences Inc.
Ludwik K Branski MD Allentown, PA, USA
Assistant Professor
Department of Plastic Surgery Oscar E Suman PhD MS
University of Texas Medical Branch Professor, Associate Director of Research
Shriners Hospitals for Children–Galveston Department of Surgery, University of Texas Medical
Galveston, TX, USA Branch
Shriners Hospitals for Children–Galveston
April Cowan OTR OTD CHT Galveston, TX, USA
Assistant Professor Professor
School of Health Professions Associate Director of Research, Director of the Children’s
University of Texas Medical Branch Wellness and Exercise Center
Galveston, TX, USA Shriners Hospitals for Children
University of Texas Medical Branch
Matthias B Donelan MD Galveston, TX, USA
Chief of Staff
Shriners Hospitals for Children–Boston Mark Talon CRNA
Associate Clinical Professor of Surgery University of Texas Medical Branch
Harvard Medical School Galveston, TX, USA
Visiting Surgeon
Massachusetts General Hospital Christopher Whitehead PT
Boston, MA, USA Rehabilitation Services Department,
Shriner’s Hospital for Children – Galveston
Perenlei Enkhbaatar MD PhD Galveston, TX, USA
Charles Robert Allen Professor in Anesthesiology
Department of Anesthesiology, Lee C Woodson MD
University of Texas Medical Branch Chief of Anesthesia
Galveston, TX, USA Shriners Hospitals for Children
Galveston, TX, USA
Serina McEntire PhD
Associate Professor
Valdosta State University
Valdosta, GA, USA

xix
 1 A Brief History of Acute Burn
Care Management
LUDWIK K. BRANSKI, DAVID N. HERNDON, and ROBERT E. BARROW
The recognition of burns and their treatment is evident in
cave paintings that are more than 3500 years old. Docu-
mentation in the Egyptian Smith papyrus of 1500 BC advo-
cated the use of a salve of resin and honey for treating
burns.1 In 600 BC, the Chinese used tinctures and extracts
from tea leaves. Nearly 200 years later, Hippocrates
described the use of rendered pig fat and resin-impregnated
bulky dressings, which was alternated with warm vinegar
soaks augmented with tanning solutions made from oak
bark. Celsus, in the 1st century AD, mentioned the use of
wine and myrrh as a lotion for burns, most probably for
their bacteriostatic properties.1 Vinegar and exposure of the
open wound to air was used by Galen (130–210 AD) as a
means of treating burns, while the Arabian physician
Rhases recommended cold water for alleviating the pain
associated with burns. Ambroise Paré (1510–1590 AD),
who effectively treated burns with onions, was probably the
first to describe a procedure for early burn wound excision.
In 1607, Guilhelmus Fabricius Hildanus, a German
surgeon, published De Combustionibus, in which he dis-
cussed the pathophysiology of burns and made unique con-
tributions to the treatment of contractures. In 1797,
Edward Kentish published an essay describing pressure
dressings as a means to relieve burn pain and blisters.
Around this same time, Marjolin identified squamous cell
carcinomas that developed in chronic open burn wounds.
In the early 19th century, Guillaume Dupuytren (Fig. 1.1)
reviewed the care of 50 burn patients treated with occlusive
dressings and developed a classification of burn depth that
remains in use today.2 He was perhaps the first to recognize
gastric and duodenal ulceration as a complication of severe
burns, a problem that was discussed in more detail by
Curling of London in 1842.3 In 1843, the first hospital for
the treatment of large burns used a cottage on the grounds
of the Edinburgh Royal Infirmary.
Truman G. Blocker Jr. (Fig. 1.2) may have been the first
to demonstrate the value of the multidisciplinary team
approach to disaster burns when, on April 16, 1947, two
freighters loaded with ammonium nitrate fertilizer exploded
at a dock in Texas City, killing 560 people and injuring more
than 3000. At that time, Blocker mobilized the University
of Texas Medical Branch in Galveston, Texas, to treat the
arriving truckloads of casualties. This “Texas City Disaster”
is still known as the deadliest industrial accident in Ameri-
can history. Over the next 9 years, Truman and Virginia
Blocker followed more than 800 of these burn patients and
published a number of papers and government reports on
their findings.4–6 The Blockers became renowned for their
work in advancing burn care, with both receiving the
Harvey Allen Distinguished Service Award from the Ameri-
can Burn Association (ABA). Truman Blocker Jr. was also
recognized for his pioneering research in treating burns “by
cleansing, exposing the burn wounds to air, and feeding
them as much as they could tolerate.”7 In 1962, his dedica-
tion to treating burned children convinced the Shriners of
North America to build their first Burn Institute for Chil-
dren in Galveston, Texas.7
Between 1942 and 1952, shock, sepsis, and multiorgan
failure caused a 50% mortality rate in children with burns
covering 50% of their total body surface area (TBSA).8
Recently burn care in children has improved survival such
that a burn covering more than 95% TBSA can be survived
in more than 50% of cases.9 In the 1970s, Andrew M.
Munster (Fig. 1.3) became interested in measuring quality
of life after excisional surgery and other improvements led
to a dramatic decrease in mortality. First published in 1982,
his Burn Specific Health Scale became the foundation for
most modern studies in burns outcome.10 The scale has
since been updated and extended to children.11
Further improvements in burn care presented in this
brief historical review include excision and coverage of the
burn wound, control of infection, fluid resuscitation, nutri-
tional support, treatment of major inhalation injuries, and
support of the hypermetabolic response.
Early Excision
In the early 1940s, it was recognized that one of the most
effective therapies for reducing mortality from a major
thermal injury was the removal of burn eschar and imme-
diate wound closure.12 This approach had previously not
been practical in large burns owing to the associated high
rate of infection and blood loss. Between 1954 and 1959,
Douglas Jackson and colleagues at the Birmingham Acci-
dent Hospital advanced this technique in a series of pilot
and controlled trials starting with immediate fascial exci-
sion and grafting of small burn areas and eventually cover-
ing up to 65% of the TBSA with autograft and homograft
skin.13 In this breakthrough publication, Jackson concluded
that “with adequate safeguards, excision and grafting of
20% to 30% body surface area can be carried out on the
day of injury without increased risk to the patient.” This
technique, however, was far from being accepted by the
majority of burn surgeons, and delayed serial excision
remained the prevalent approach to large burns. It was
Zora Janzekovic (Fig. 1.4), working alone in Yugoslavia in
the 1960s, who developed the concept of removing deep
second-degree burns by tangential excision with a simple
uncalibrated knife. She treated 2615 patients with deep
second-degree burns by tangential excision of eschar
between the third and fifth days after burn and covered the
1
Another random document with
no related content on Scribd:
 TABLE

PROLOGUE 7
I. — DEUX HOMMES, DEUX CHIMÈRES 23
II. — LES CAVALIERS… 34
III. — … ET LEUR MONTURE 55
IV. — PROPOS ENTRE CIEL ET TERRE 64
V. — LE JOUR VIOLET 77
VI. — SUR LA PIERRE BRUNE 91
VII. — CEINTRAS ÉGARE SON OMBRE ET SA RAISON 101
VIII. — LA FACE AURÉOLÉE D’ÉTOILES 118
IX. — HEURES D’ATTENTE 130
X. — L’ÊTRE SE MONTRE 143
XI. — EXCURSIONS SOUTERRAINES 163
XII. — FAUX DÉPART 189
XIII. — L’AGONIE DE LA LUMIÈRE 206
XIV. — ÉCRIT SOUS LA DICTÉE DE LA MORT 226
ÉPILOGUE 233
 ACHEVÉ D’IMPRIMER
Le vingt-sept mai mil neuf cent sept
PAR

ARRAULT ET Cie
A TOURS
pour le
MERCVRE
DE
FRANCE
*** END OF THE PROJECT GUTENBERG EBOOK LE PEUPLE DU
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