Alpha -fetoprotein, ana lbumi n- li

kegl ycopr ot einwi thamol ecularwei ghtof70000da ltons,isf or

medi nt hey olksa c,
non-di fferentiatedl iverc ell
s ,andt hef etalgas troint esti
nalt ract.70-95%ofpat ient swi thpr imar yhepat ocell
ular
carcinomaha v
eel ev a t
edAF Pv a l
ues .Thel a tert hes tageofnons emi noma t
ousger mc elltumor s
,thehi ghert heAF P
values. Humanc hor i
onicgonadot ropi n( hCG)andAF Par ei mpor tantpar ametersfores ti
mat i
ngt hesur vivalrateof
patientswi t
hadv anc ed,nons emi nomat ousger mc ellt
umor s.Noc orrelati
onbet weent heAF Pc oncent rati
onand
tumors i
ze, t
umorgr owt h,stageordegr eeofma l
igna ncyha ssof arbeendemons tr
a ted. Grea tl
yelevatedAF Pv al
ues
gener all
yi ndic
at epr imar yliverc ellcar ci
noma. Whenl ivermet as t
as i
sexists,t
heAF Pv aluesar egenerallybel ow350
-400I U/ mL .Ast heAF Pv aluesr isedur ingr egener a ti
onoft heliver,moder at
elyeleva tedv aluesa refoundi na l
cohol
-medi atedl iv
erc irrhosisa nda cutev ir
a lhepa ti
t i
sa swel lasi nca rr
iersofHBs Ag. Thedet ermi nati
onofAF Ptos creen
thegener alpopul ationf orc anc eri s
,howev er ,nott ober ecommended.El evatedAF Pc onc entr
at i
onsi nmat ernal
serum ora mniot i
cf l
uiddur ingpr egna ncyc a ni ndicates pinabi f
ida ,anencepha l
y,atresi
aoft heoe s
opha gusormul t
iple
pregna nc y.Mea s
ur ementofAF Pma kesac ont ri
but i
ont ot her i
s ka s
sessmentf ortri
s omy21( Downs yndr ome)i nt he
secondt r
ime st
e rofpr egna ncyt oge the rwi t
hhCG+βa ndot herpa rame t
e r
s,sucha sexa ctge st
a ti
onal agea ndma ternal
we i
ght .I
nat r
is
omy21a ffectedpr e gna ncyt hema t
e rnal s
e r
um c onc entrat
ionofAF Pi sde crease dwhe reast hema t
erna l
serum hCG+βc onc entrati
oni sa ppr oxi
ma telytwi cet henor ma lme dian.Ther i
skforat risomy21a ff
ectedpr e
gna ncyi n
thes econdt ri
me s
terc anbec alculatedbyas uita bl
es of t
wa reus i
ngt hea l
gor i
thm asde scri
be dbyWa l
da ndt her espectiv
e
assays pec i
fi
cpa ramet ers.

Spec
ifi
cat
ion
C2000

Sampl
ety
pe Ser
um/
Plas
ma

Sampl
evol
. 50uL

As
sayt
ime 36mi
nut
es

Tes
trange 0.
5-1000ng/
mL

Per
for
manc
e CV<8%

St
orage 2-8º
C

Shel
fli
fe 18mont
hs

Cal
i
brat
ion 90day
sVal
i
d

Per
for
manc
e
P/
yAF
Real mL
(ug/ )

Tar
getAF
P/(ng/
mL)

Or
der
ingi
nfor
mat
ion
RefNo. Tes
t/k
it
Al
pha-f
etoprot
ein(AF
P)
As
sayReagentKit(
CMIA) C2KA001 30or60