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Toxicology in the Middle
Ages and Renaissance
This page intentionally left blank
Toxicology in the Middle
Ages and Renaissance
Edited by
Philip Wexler
Academic Press is an imprint of Elsevier
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No part of this publication may be reproduced or transmitted in any form or by any means, electronic or
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Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our
understanding, changes in research methods, professional practices, or medical treatment may become
necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using
any information, methods, compounds, or experiments described herein. In using such information or methods
they should be mindful of their own safety and the safety of others, including parties for whom they have a
professional responsibility.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any
liability for any injury and/or damage to persons or property as a matter of products liability, negligence or
otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the
material herein.
ISBN: 978-0-12-809554-6
Cover image credit: An alchemist in his laboratory. Oil painting by a follower of David Teniers the younger.
Wellcome Library, London
List of Contributors............................................................................. xi
Preface.............................................................................................. xiii
Acknowledgments ................................................................................xv
About the Editor................................................................................xvii
Acknowledgments............................................................................. 122
References......................................................................................... 122
Index................................................................................................. 167
LIST OF CONTRIBUTORS
Mohammad Abdollahi
School of Traditional Medicine, Tehran University of Medical
Sciences, Tehran, Iran
Mozhgan M. Ardestani
School of Traditional Medicine, Tehran University of Medical
Sciences, Tehran, Iran
Sheila Barker
The Medici Archive Project, Florence, Italy
Steven Bednarski
St. Jerome’s University in the University of Waterloo, Waterloo, ON,
Canada
Cathy Cobb
University of South Carolina, Aiken, SC, United States
Maria do Sameiro Barroso
Portuguese Medical Association, Lisbon, Portugal
Mike Dash
University of Cambridge, Cambridge, United Kingdom
Christopher J. Duffin
The Natural History Museum, London, United Kingdom
Benedetta F. Duramy
Golden Gate University School of Law, San Francisco, CA, USA
Mohammad M. Esfahani
School of Traditional Medicine, Tehran University of Medical
Sciences, Tehran, Iran
Gabriele Ferrario
Cambridge University Library, Cambridge, United Kingdom
Urs Leo Gantenbein
University of Zurich, Zurich, Switzerland
xii List of Contributors
Frederick Gibbs
University of New Mexico, Albuquerque, United States
Omar Habbal
Sultan Qaboos University, Muscat, Sultanate of Oman
Georgiana D. Hedesan
University of Oxford, Oxford, United Kingdom
Sverre Langård
Oslo University Hospital, Oslo, Norway
Chris Lavers
University of Nottingham, Nottingham, United Kingdom
Caley McCarthy
McGill University, Montreal, QC, Canada
Roja Rahimi
School of Traditional Medicine, Tehran University of Medical
Sciences, Tehran, Iran
Alain Touwaide
Institute for the Preservation of Medical Traditions, Washington, DC,
United States
Kathleen Walker-Meikle
University College London, London, United Kingdom
PREFACE
Avicenna and Rāzı̄, and their successors, did much to stimulate its
growth in the Middle East, with subsequent spread throughout
Europe. The Italian, Pietro d’Abano’s Liber de Venenis represents a
recapturing of toxicology’s Greek origins. Georgius Agricola, from
Saxony, the “father of minerology,” contributed to the systematic
study of mining and the diseases of miners. And, of course, Paracelsus
encapsulated so much about the toxic action of substances in a few
sentences, which tend to be abbreviated to “The dose makes the poi-
son.” While a bit of a simplification measured against current scientific
standards, this remains a powerfully true adage today. Urs Leo
Gantenbein who leads the ambitious Paracelsus Project at the
University of Zurich outlines this Renaissance figure’s significance to
toxicology.
During the Middle Ages and Renaissance, science made significant
strides in learning how toxic agents interact with the body. The authors
of the chapters herein are to be congratulated on bringing to life a
host of characters of toxicological significance, both nefarious practi-
tioners of poisoning, and brilliant scientists and scholars of the time
who contributed to a budding understanding of toxicology.
Philip Wexler
ACKNOWLEDGMENTS
§ 1.—Ceramics.
§ 2.—Metallurgy.
Even at the time to which we are carried back by the oldest of the
graves at Warka and Mugheir, metallurgy was already far advanced
in Chaldæa. Tools and weapons of stone are still found in those
tombs in great numbers;[374] but side by side with them we find
copper, bronze, lead, iron, and gold. Silver alone is absent.
Copper seems to have been the first of all the metals to attract
the notice of man, and to be manufactured by him. This is to be
accounted for partly by the frequency of its occurrence in its native
state, partly by the fact that it can be smelted at a comparatively low
temperature. Soft and ductile, copper has rendered many services to
man from a very early period, and, both in Chaldæa and the Nile
valley, he very soon learnt to add greatly to its hardness by mixing a
certain quantity of tin with it. Where did the latter material come
from? This question we can no more answer in the case of
Mesopotamia than in that of Egypt; no deposits of tin have yet been
discovered in the mountain chains of Kurdistan or Armenia.[375]
However this may be, the use of tin, and the knowledge of its
properties as an alloy with copper, dates from a very remote period
in the history of civilization. In its natural state, tin is always found in
combination, but the ore which contains it in the form of an oxide
does not look like ordinary rock; it is black and very dense; as soon
as attention was turned to such things it must have been noticed,
and no great heat was required to make it yield the metal it
contained. We do not know where the first experiments were made.
The uses of pure tin are very limited, and we cannot even guess how
the remarkable discovery was made that its addition in very small
quantities to copper would give the precious metal that we call
bronze. In the sepulchral furniture with which the oldest of the
Chaldæan tombs were filled we already find more bronze than pure
copper.[376]
Lead is rare. A jar of that metal, and the fragment of a pipe dug
up by Loftus at Mugheir may be mentioned.[377] It is curious that iron
though still far from common, was not unknown. Iron nowhere exists
in its native state on the surface of our planet, except in aerolites. Its
discovery and elimination from the ore requires more time and effort
and a far higher temperature than copper or tin. Those difficulties
had already been surmounted, but the smelting of iron ore was still
such a tedious operation that bronze was in much more common
use. Iron was looked upon as a precious metal; neither arms, nor
utensils, nor tools of any kind were made of it; it was employed
almost exclusively for personal ornaments, such as rings and
bracelets.[378]
Gold, which is found pure in the veins of certain rocks and in the
beds of mountain torrents, and in pieces of a size varying from that
of a grain of dust to nuggets of many pounds, must very soon have
attracted the attention of man, and excited his curiosity, by its colour
and brilliancy. We find it in the tombs mixed with objects of stone and
bronze. Round beads for necklaces, earrings and finger rings of not
inelegant design were made of it.