CNS PATHOLOGY

DR PREETI SHARMA
MBBS, MD
GOLD MEDALLIST
 DEGENERATIVE DISORDERS PATHOLOGY

Ap plaque
Alzheimer’s disease MFTChevrofibrillary tangles
Tau protein
HIRANOBODIES
Parkinson’s disease INTELANIN
Latin
d Dopaminergic Neurons LEWYBODIES
ALS S O D mutation

Huntington disease CAG repeat EXON

THUNTINGTIN F UBIQUITIN
 NF T
FLAME
cell

A plaque
ON
Parkinson’s disease
Pale six

r
IO Melanin substantia
Nigra

0
Lewy
Body x
gyu dein
MCQ
Ubiquitin deposition is seen in which of the following
conditions?

A. Alzheimer’s disease
B. Huntington’s disease
C. Meningioma
D. NONE OF THE ABOVE
MCQ
Lewy bodies are composed of?

A. Tau protein
B. Alpha synuclein
C. Beta plaques
D. Actin
MCQ
Hirano bodies are composed of?

A. Tau protein
B. Alpha synuclein
C. Beta plaques
D. Actin
Brain Tumors- Grading
AMENT
● A
Atypia I
● M Mitosis II auto

● E Endothelial cells proliferation

● N Necrosis
Brain Tumors- Classification
Juvenile Pilocytic Astrocytoma GI
● Age CHILD
● Site CEREBELLUM
● Gross Cystic
● Microscopy
● Mutation
BRAF V6ODE

É O
an
y
Glioblastoma GII
● juts
Age
● Gross BUTTERFLY GLIOMA
● Microscopy
● Mutation
● Prognosis
Yj
Oligodendroglioma
● Microscopy FRIED EGG APPEARANCE
CHICKEN WIRE BLOOD VESSELS

● Mutation
IDH MUTANT TYPE
I
codelection
I
Ip 19g
Good response
CHEMOTH

My
to
Ependymoma CHILDREN
● Site 4th VENTRICLE

● Microscopy

Him tf

I
Medulloblastoma GI
● Age Is
● Site CEREBELLUM

● Microscopy

HOME 119,1 Biggest's

MB
sarcoma
 FLEXNER WINTER
STEINER
Rosettes 8338 ROSETTE
RB
f
O
t gg
PERIVASCULAR 0 HOMER
WRIGHT clear
yeOz
Epetdymoma
PR lumen
Meningioma

0,7
y
If
wnorina
PATTERN

O Psammoma
Bodies
y
Schwannoma

VEROCAYBIItj.gg

G
ANTONY ANTONY
B A
BEANK
Zrows of
I palisading
HYPO nuclei
Alot of cells
Hyper cellular
 CALCIFICATOI
C O m
I oligodendro
Meningioma
glioma
Craniopharyngiom nX
M I S M E
Inherited
Multiple
Schwannoma
I Ependym
OMG
Meningioma
MCQ
10 year old male child shows a well circumscribed
cystic lesion in the cerebellum. A mural nodule is
identified within the cystic lesion. Biopsy and
microscopic evaluation shows the following feature.
What is your diagnosis?

A. Oligodendroglioma

O
B. Glioblastoma
C. Meningioma
D. JPA
O
MCQ
A 55 year old man presents with seizures and muscle
weakness but no other neurological sign. CT scan
reveals a mass in the left cerebral hemisphere. Left
frontotemporal craniotomy is performed. Histological
examination of brain biopsy is shown. Diagnosis?

O
A. Oligodendroglioma
B. Glioblastoma
C. Meningioma
D. JPA
MCQ
A 33 year old female patient is a known case of
acoustic schwannoma. She also shows presence of
pigmented lesions over the trunk and lower back. On
radiological investigations she has non infiltrative
brain tumor showing areas of calcification. On biopsy

y
the tumor shows positivity for PR. Diagnosis?

A. Oligodendroglioma
B. Glioblastoma
C. Meningioma
D. JPA