it Ac

Inflammation
DR PREETI SHARMA
MBBS, MD
tehran
GOLD MEDALLIST
Zio
Classification of Inflammation

MTIcell
I De ma

d atropsudomonas
f
lymphocytosis
I
Neutrophils
Events of Acute Inflammation

FEEITE.EE
I MRAT
 SEROTONIN
II HISTAMINE

sÉ
OF ANTE
IN FL

EEIE.gg
Fsygs Exudate
 Response
lameDiate3TAIÉT
 Ét
I II

Delaine
 Through cell by Vorganet
V
t
Eat Y mine
to it

ÉÉF a
 IRITCOTI
Cellular Events
BY
TT Endothelial
cell
CD 344

Mannix
MARGINATION
EPQ
1 e p
2 ROLLING SELECTING g YE
Cellular Events
Selectins

Peep
g
P selectin

Platelet, endothelial cells i

E selectin
Glycan
Endothelial cells

L selectin

E Leukocytes
 M
R

T
B
B

e
8
 M
R
A

t
T
8
ed
0

g
 5 8
Furey
 M
R
A
T
C
O
MY cosy'emmentospsonin C3b P

BONUS I
mak
To
itas
 M
R
A

NADPt
MIIenzyaf gge
MCQ

Basement membrane degradation is caused by:

A. Matrix metalloproteinases
B. Oxidases
C. Elastases
D. Hydroxylase
MCQ

Main feature of chemotaxis is:

A. Random movement of neutrophils

B. Adhesiveness to blood vessels
C. Phagocytosis
D. Unidirectional locomotion of neutrophils
Clinical Correlation
●
●
LAD
OF
Bruton’s hypogammaglobulinemia
● CHS
● CGD
Leukocyte Adhesion Defect
CLAD
O O

Inftegrin
t 932
t
Delatyedumb cord Bombay
BG
A B H Ag
Q

IgG Blood
x Defective
opsonisation
Boys MID
B cell defect

BTK gene defect

Chediak Higashi Syndrome
LET gene detect
4
GRAY

f
Emanagent

Khatami g
Is Decreased

granules
 Chronic Granulomatous Disease CGD
MIDI
Igi X
att X XLR Hox
P
AR
gp
47 PHOX
GP 67 PHOX
gp
CATALASE INFECTINS
113T test
Diagnosis screening
Test
Diagnostic IHR
 CATALASE ORGANISM

S P A C E
t
t t
t
s aureus Aspergillus Candida Enterobacter
Pseudomonas

BEING MADE
t
B anthrax MTB
Micrococcus
MCQ

19 month old male child presents with recurrent

infections. Peripheral blood smear shows neutrophilic
leukocytosis. Advanced studies show a defect in the
neutrophilic adhesion. Further the mother gives a
history of delayed umbilical cord stump shedding. The
child's defect is mostly commonly attributed to?

A. LAD 1
B. LAD 2
C. Bruton’s agammaglobulinemia
D. SCID
 I
NÉE

Serotonine
Lysosomal
enzymes
Preformed Mediators- Histamine, Serotonin

cell Mastells Tell Ftweetromattiel

Saxe
Function
a VASODILATION
b Red VASE
PERMEABILITY
C BRONCHO CONSTRICTION
Preformed Mediators- Lysosomal Enzymes
Lysozyme
Tyrannies s ÉTANULES 3 GRANULES
AZUROPHILIC S SPECIFIC C PARTICLES
GRANULES GRANULES
I 1
Spedific
MD Gelatinase
Ilyeloperoxidase Type II
collagenase
MCQ

Gelatinase is released by?

A. Primary granules
B. Specific granules
C. C particle
D. Azurophilic granules
Newly Synthesized Mediators- Chemokines
 CHEMOKINESI cystefe amino
acid

exc
t x P J
t t
Drat n ME
Detain
RANTES
Iymphotactin
Cfc meet
MCQ

C-C includes which of the following chemokines?

exc
A.
B.
O
IL-8
Eotaxin
C.
D
Fractalkine CX3C
D.
D
Lymphotactin c
 N e
Newly Synthesized Mediators- Cytokines

t I
O
IFN
No appetite

Source L F
By T
Leucocytes
Fibroblast THIcells
my Re GRANULOMA
Function Anti
VIRAL BRAIN formation
MULTIPLE
SCLEROSIS
AP
RIPEN
anTEN
 R P

t
capsular polysaccharide
t

Pneumococcus
of
MCQ

Most FIBROGENIC mediator:

A. TNF alpha
B. TGF beta
C. Cytokine
D. PG
Boog
Newly Synthesized Mediators- AA Metabolites

C
Newly Synthesized Mediators- COX
Newly Synthesized Mediators- LOX
Plasma Mediators
I
I clotting pathway
2 Kinmpathwayf Bradykin
vasodilation
3 Complement pathway PAIN

IIe
Bradykinin
Chronicle
t
MII
Chronic inflammation MY
MICROGLIA
ALVEOLAR MY DUST CELLS
KUPFFER CELLS
LITTORAL cells
MESANGIAL Cells
HOFFBEAUR Cells
OSTEOCLAST
synoviocytes Type A
 Components of Granuloma
subtype of chronicity
y

my
CASEOUS NECROSIS
Lymphocytic
collar OK Epitneuoid CELLS
if slipper shaped nucleus
I modified
NAKED
GRANULOMA Giantcell fusion ofMg my
SARCOIDOSIS
 Langhans Langerhans
Langhans Giant Cells
t I
ace Ag
presenting
cell

A HEE Skint
SHAPE
t
Touton Giant Cells I Lanthoma lipid disorder

WREATH
arrangement
Foriegn Body Giant Cell
eg Tale
suture

haphazard arrange
ofnuclei
Warthin Finkeldey Giant Cell W

In tr a nuclear

In tracytoplasmic
RS Cell
Hodgkin's lymphoma

owing
Owl Eye
as cement

1 1 11
PINI BLUE
Stellate Granuloma
d

cat scratch disease

Bartonella
Hensellae
LGV Trachoma
tis
Doughnut Granuloma

Q
Durck Granuloma CEREBRAL MALARIA Pf

Ft

HIE
FIELD STAIN
MCQ
ICHRomii.tn m0
Most important cell of a granuloma?

I
A. Giant cell
B. Macrophage
C. Lymphocytes
D. Epithelioid cells
MCQ
Find the correct match?

A. Langhans-2 touton-1 foreign body-3 RS cell- 4

B. Langhans-1 touton-3 foreign body-2 RS cell- 4
C. Langerhans-1 touton-4 foreign body-2 RS cell- 3
D.
I
Langhans-1 touton-4 foreign body-2 RS cell- 3
2 3 4

1
0008 2 3 4
MCQ

The granuloma shown below is associated with which

of the following diseases?

A. Cat scratch disease

B. LGV
C. Both a and b G
D. none
Wound Healing

Wound healing

Primary intention Secondary intention

Incision RTA
eg Eg
clean wound irregular dirty wound
SCAR
WOUND CONTRACTION Myofibroblast
Wound Healing Day
I
2
Day Event
3d
Day 0 BLOOD CLOT PLATELET
Day 1 getup
Day 2 BLOOD CLOT NEUTROPHILS
THIN EPITHELIAL LAYER
 Red Granulation Tissue
Wound Healing Blood vessels t
Day Event Halimark of
Day 3
GRANULATION TISSUE BEGINS Repair
COLLAGEN
BEGINS Starting III Col

t
Day 5 J

Day 21 Max COLI strongest

c
collagen
Wound Healing

● 100% strength?
NEVED MISTERNum
Excessive Wound Healing
KELOID Rx
1
TGIIÉE
A SCAR
I Hypertrophic
SCAR
aka PROUDFLEStm
Excessive Wound Healing

INTRALESIDNAC
O B
INJECTION
Of
STEROID
TRIAMINOLONE